| UniProt ID | MXR2_YEAST | |
|---|---|---|
| UniProt AC | P25566 | |
| Protein Name | Peptide methionine sulfoxide reductase 2 | |
| Gene Name | MXR2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 168 | |
| Subcellular Localization | ||
| Protein Description | Methionine-R-sulfoxide reductase which catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins. Plays a protective role against oxidative stress by restoring activity to proteins that have been inactivated by methionine oxidation. Protects iron-sulfur clusters from oxidative inactivation along with MXR1. Involved in the regulation of lifespan.. | |
| Protein Sequence | MNKWSRLYVITVRRTFPGRRNIVLTQYWNKSKKMSDESNDVKWNDALTPLQLMVLRDKATERPNTGAYLHTNESGVYHCANCDRPLYSSKAKFDARCGWPAFYEEVSPGAITYHRDNSLMPARVEICCARCGGHLGHVFEGEGWKQLLNLPKDTRHCVNSASLNLKKD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 152 | Acetylation | KQLLNLPKDTRHCVN HHHHCCCCCHHHHHH | 74.93 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MXR2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MXR2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MXR2_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ATG19_YEAST | ATG19 | physical | 18719252 | |
| AMPL_YEAST | APE1 | physical | 18719252 | |
| FRMSR_YEAST | YKL069W | genetic | 19049972 | |
| GRPE_YEAST | MGE1 | physical | 25428986 | |
| GRPE_YEAST | MGE1 | genetic | 25428986 | |
| CALM_YEAST | CMD1 | genetic | 27708008 | |
| MED8_YEAST | MED8 | genetic | 27708008 | |
| KIN28_YEAST | KIN28 | genetic | 27708008 | |
| ZPR1_YEAST | ZPR1 | genetic | 27708008 | |
| RRP4_YEAST | RRP4 | genetic | 27708008 | |
| CDC12_YEAST | CDC12 | genetic | 27708008 | |
| FIP1_YEAST | FIP1 | genetic | 27708008 | |
| MED4_YEAST | MED4 | genetic | 27708008 | |
| CLP1_YEAST | CLP1 | genetic | 27708008 | |
| TFCP2_HUMAN | TFCP2 | physical | 27107014 | |
| BANP_HUMAN | BANP | physical | 27107014 | |
| RBPMS_HUMAN | RBPMS | physical | 27107014 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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