| UniProt ID | BANP_HUMAN | |
|---|---|---|
| UniProt AC | Q8N9N5 | |
| Protein Name | Protein BANP | |
| Gene Name | BANP | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 519 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity).. | |
| Protein Sequence | MMSEHDLADVVQIAVEDLSPDHPVVLENHVVTDEDEPALKRQRLEINCQDPSIKTICLRLDSIEAKLQALEATCKSLEEKLDLVTNKQHSPIQVPMVAGSPLGATQTCNKVRCVVPQTTVILNNDRQNAIVAKMEDPLSNRAPDSLENVISNAVPGRRQNTIVVKVPGQEDSHHEDGESGSEASDSVSSCGQAGSQSIGSNVTLITLNSEEDYPNGTWLGDENNPEMRVRCAIIPSDMLHISTNCRTAEKMALTLLDYLFHREVQAVSNLSGQGKHGKKQLDPLTIYGIRCHLFYKFGITESDWYRIKQSIDSKCRTAWRRKQRGQSLAVKSFSRRTPNSSSYCPSEPMMSTPPPASELPQPQPQPQALHYALANAQQVQIHQIGEDGQVQVGHLHIAQVPQGEQVQITQDSEGNLQIHHVGQDGQLLEATRIPCLLAPSVFKASSGQVLQGAQLIAVASSDPAAAGVDGSPLQGSDIQVQYVQLAPVSDHTAGAQTAEALQPTLQPEMQLEHGAIQIQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 19 | Phosphorylation | QIAVEDLSPDHPVVL HHHHHHCCCCCCEEE | 40.37 | 26074081 | |
| 32 | Phosphorylation | VLENHVVTDEDEPAL EEECCEECCCCCHHH | 32.36 | 26074081 | |
| 55 | Phosphorylation | CQDPSIKTICLRLDS CCCCCHHHHEEEHHH | 18.43 | 26074081 | |
| 62 | Phosphorylation | TICLRLDSIEAKLQA HHEEEHHHHHHHHHH | 27.24 | 26074081 | |
| 73 | Phosphorylation | KLQALEATCKSLEEK HHHHHHHHHHHHHHH | 15.87 | 26074081 | |
| 75 | Ubiquitination | QALEATCKSLEEKLD HHHHHHHHHHHHHHH | 54.44 | - | |
| 80 | Ubiquitination | TCKSLEEKLDLVTNK HHHHHHHHHHHHCCC | 37.62 | - | |
| 85 | Phosphorylation | EEKLDLVTNKQHSPI HHHHHHHCCCCCCCC | 43.95 | 21712546 | |
| 87 | Ubiquitination | KLDLVTNKQHSPIQV HHHHHCCCCCCCCCC | 39.77 | - | |
| 89 (in isoform 3) | Phosphorylation | - | 36.83 | 20068231 | |
| 90 | Phosphorylation | LVTNKQHSPIQVPMV HHCCCCCCCCCCCEE | 22.62 | 23401153 | |
| 91 (in isoform 3) | Phosphorylation | - | 20.93 | 20068231 | |
| 100 | Phosphorylation | QVPMVAGSPLGATQT CCCEECCCCCCCCCC | 13.76 | 23401153 | |
| 105 | Phosphorylation | AGSPLGATQTCNKVR CCCCCCCCCCCCEEE | 23.71 | 30108239 | |
| 107 | Phosphorylation | SPLGATQTCNKVRCV CCCCCCCCCCEEEEE | 17.43 | 30108239 | |
| 113 (in isoform 4) | Phosphorylation | - | 3.97 | 20068231 | |
| 113 (in isoform 2) | Phosphorylation | - | 3.97 | 20068231 | |
| 113 (in isoform 6) | Phosphorylation | - | 3.97 | 20068231 | |
| 115 (in isoform 4) | Phosphorylation | - | 3.13 | 20068231 | |
| 115 (in isoform 6) | Phosphorylation | - | 3.13 | 20068231 | |
| 115 (in isoform 2) | Phosphorylation | - | 3.13 | 20068231 | |
| 119 (in isoform 5) | Phosphorylation | - | 10.57 | 20068231 | |
| 121 (in isoform 5) | Phosphorylation | - | 2.98 | 20068231 | |
| 133 | Sumoylation | RQNAIVAKMEDPLSN CCCEEEEECCCCHHC | 31.74 | 28112733 | |
| 133 | Ubiquitination | RQNAIVAKMEDPLSN CCCEEEEECCCCHHC | 31.74 | - | |
| 139 | Phosphorylation | AKMEDPLSNRAPDSL EECCCCHHCCCCCHH | 29.65 | 20058876 | |
| 145 | Phosphorylation | LSNRAPDSLENVISN HHCCCCCHHHHHHHH | 36.20 | 25849741 | |
| 151 | Phosphorylation | DSLENVISNAVPGRR CHHHHHHHHCCCCCC | 17.91 | - | |
| 275 | Ubiquitination | SNLSGQGKHGKKQLD HCCCCCCCCCCCCCC | 41.10 | 19608861 | |
| 275 | Acetylation | SNLSGQGKHGKKQLD HCCCCCCCCCCCCCC | 41.10 | 26051181 | |
| 278 | Ubiquitination | SGQGKHGKKQLDPLT CCCCCCCCCCCCCEE | 36.75 | - | |
| 279 | Ubiquitination | GQGKHGKKQLDPLTI CCCCCCCCCCCCEEE | 61.76 | - | |
| 287 | Phosphorylation | QLDPLTIYGIRCHLF CCCCEEEEEEEEEEE | 10.98 | - | |
| 308 | Ubiquitination | ESDWYRIKQSIDSKC HHHHHHHHHHHCHHH | 29.06 | - | |
| 324 | Methylation | TAWRRKQRGQSLAVK HHHHHHHHCCCEEEE | 48.42 | - | |
| 327 | Phosphorylation | RRKQRGQSLAVKSFS HHHHHCCCEEEEECC | 22.56 | - | |
| 331 | Ubiquitination | RGQSLAVKSFSRRTP HCCCEEEEECCCCCC | 39.93 | - | |
| 331 | Acetylation | RGQSLAVKSFSRRTP HCCCEEEEECCCCCC | 39.93 | 25953088 | |
| 334 | Phosphorylation | SLAVKSFSRRTPNSS CEEEEECCCCCCCCC | 28.13 | 17081983 | |
| 337 | Phosphorylation | VKSFSRRTPNSSSYC EEECCCCCCCCCCCC | 26.22 | - | |
| 352 | Phosphorylation | PSEPMMSTPPPASEL CCCCCCCCCCCHHHC | 23.17 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 337 | T | Phosphorylation | Kinase | MAPK1 | P28482 | GPS |
| 337 | T | Phosphorylation | Kinase | MAPK3 | P27361 | GPS |
| 352 | T | Phosphorylation | Kinase | MAPK1 | P28482 | GPS |
| 352 | T | Phosphorylation | Kinase | MAPK3 | P27361 | GPS |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BANP_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BANP_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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