dbPTM

ATM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ATM_HUMAN
UniProt AC	Q13315
Protein Name	Serine-protein kinase ATM
Gene Name	ATM
Organism	Homo sapiens (Human).
Sequence Length	3056
Subcellular Localization	Nucleus . Cytoplasmic vesicle . Primarily nuclear. Found also in endocytic vesicles in association with beta-adaptin.
Protein Description	Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response..
Protein Sequence	MSLVLNDLLICCRQLEHDRATERKKEVEKFKRLIRDPETIKHLDRHSDSKQGKYLNWDAVFRFLQKYIQKETECLRIAKPNVSASTQASRQKKMQEISSLVKYFIKCANRRAPRLKCQELLNYIMDTVKDSSNGAIYGADCSNILLKDILSVRKYWCEISQQQWLELFSVYFRLYLKPSQDVHRVLVARIIHAVTKGCCSQTDGLNSKFLDFFSKAIQCARQEKSSSGLNHILAALTIFLKTLAVNFRIRVCELGDEILPTLLYIWTQHRLNDSLKEVIIELFQLQIYIHHPKGAKTQEKGAYESTKWRSILYNLYDLLVNEISHIGSRGKYSSGFRNIAVKENLIELMADICHQVFNEDTRSLEISQSYTTTQRESSDYSVPCKRKKIELGWEVIKDHLQKSQNDFDLVPWLQIATQLISKYPASLPNCELSPLLMILSQLLPQQRHGERTPYVLRCLTEVALCQDKRSNLESSQKSDLLKLWNKIWCITFRGISSEQIQAENFGLLGAIIQGSLVEVDREFWKLFTGSACRPSCPAVCCLTLALTTSIVPGTVKMGIEQNMCEVNRSFSLKESIMKWLLFYQLEGDLENSTEVPPILHSNFPHLVLEKILVSLTMKNCKAAMNFFQSVPECEHHQKDKEELSFSEVEELFLQTTFDKMDFLTIVRECGIEKHQSSIGFSVHQNLKESLDRCLLGLSEQLLNNYSSEITNSETLVRCSRLLVGVLGCYCYMGVIAEEEAYKSELFQKAKSLMQCAGESITLFKNKTNEEFRIGSLRNMMQLCTRCLSNCTKKSPNKIASGFFLRLLTSKLMNDIADICKSLASFIKKPFDRGEVESMEDDTNGNLMEVEDQSSMNLFNDYPDSSVSDANEPGESQSTIGAINPLAEEYLSKQDLLFLDMLKFLCLCVTTAQTNTVSFRAADIRRKLLMLIDSSTLEPTKSLHLHMYLMLLKELPGEEYPLPMEDVLELLKPLSNVCSLYRRDQDVCKTILNHVLHVVKNLGQSNMDSENTRDAQGQFLTVIGAFWHLTKERKYIFSVRMALVNCLKTLLEADPYSKWAILNVMGKDFPVNEVFTQFLADNHHQVRMLAAESINRLFQDTKGDSSRLLKALPLKLQQTAFENAYLKAQEGMREMSHSAENPETLDEIYNRKSVLLTLIAVVLSCSPICEKQALFALCKSVKENGLEPHLVKKVLEKVSETFGYRRLEDFMASHLDYLVLEWLNLQDTEYNLSSFPFILLNYTNIEDFYRSCYKVLIPHLVIRSHFDEVKSIANQIQEDWKSLLTDCFPKILVNILPYFAYEGTRDSGMAQQRETATKVYDMLKSENLLGKQIDHLFISNLPEIVVELLMTLHEPANSSASQSTDLCDFSGDLDPAPNPPHFPSHVIKATFAYISNCHKTKLKSILEILSKSPDSYQKILLAICEQAAETNNVYKKHRILKIYHLFVSLLLKDIKSGLGGAWAFVLRDVIYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNKDNENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTRLEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAVGSCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKELQWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRFDKENPFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQTVLPYLIHDILLQDTNESWRNLLSTHVQGFFTSCLRHFSQTSRSTTPANLDSESEHFFRCCLDKKSQRTMLAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQEKRSLAFEEGSQSTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQALQNLGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLLREHKIQTNRYTVKVQRELELDELALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLCSLWLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQLAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKPEVARRSRITKNVPKQSSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLDATQWKTQRKGINIPADQPITKLKNLEDVVVPTMEIKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSLVLNDLL ------CCHHHHHHH	38.19	22223895
39	Phosphorylation	RLIRDPETIKHLDRH HHHCCHHHHHHHHCC	40.49	30576142
41	Ubiquitination	IRDPETIKHLDRHSD HCCHHHHHHHHCCCC	45.60	-
47	Phosphorylation	IKHLDRHSDSKQGKY HHHHHCCCCCCCCCC	44.46	27251275
49	Phosphorylation	HLDRHSDSKQGKYLN HHHCCCCCCCCCCCC	29.87	27251275
53	Acetylation	HSDSKQGKYLNWDAV CCCCCCCCCCCHHHH	44.03	26051181
53	Ubiquitination	HSDSKQGKYLNWDAV CCCCCCCCCCCHHHH	44.03	-
54	Phosphorylation	SDSKQGKYLNWDAVF CCCCCCCCCCHHHHH	16.46	-
66	Ubiquitination	AVFRFLQKYIQKETE HHHHHHHHHHHHHHH	46.60	-
70	Ubiquitination	FLQKYIQKETECLRI HHHHHHHHHHHHHHH	57.98	-
72	Phosphorylation	QKYIQKETECLRIAK HHHHHHHHHHHHHCC	38.75	17525332
79	Ubiquitination	TECLRIAKPNVSAST HHHHHHCCCCCCCCH	34.45	-
83	Phosphorylation	RIAKPNVSASTQASR HHCCCCCCCCHHHHH	24.12	25159151
85	Phosphorylation	AKPNVSASTQASRQK CCCCCCCCHHHHHHH	17.34	17525332
86	Phosphorylation	KPNVSASTQASRQKK CCCCCCCHHHHHHHH	28.06	17525332
89	Phosphorylation	VSASTQASRQKKMQE CCCCHHHHHHHHHHH	25.98	20068231
98	Phosphorylation	QKKMQEISSLVKYFI HHHHHHHHHHHHHHH	19.50	28060719
99	Phosphorylation	KKMQEISSLVKYFIK HHHHHHHHHHHHHHH	42.73	28060719
106	Ubiquitination	SLVKYFIKCANRRAP HHHHHHHHHHCCCCC	19.86	-
116	Ubiquitination	NRRAPRLKCQELLNY CCCCCHHHHHHHHHH	34.84	-
147	Ubiquitination	DCSNILLKDILSVRK CCHHHHHHHHHHHHH	39.00	-
177	Ubiquitination	VYFRLYLKPSQDVHR HHHHHHCCCCCCHHH	29.12	-
196	Ubiquitination	RIIHAVTKGCCSQTD HHHHHHHCCCCCCCC	43.27	-
200	Phosphorylation	AVTKGCCSQTDGLNS HHHCCCCCCCCCCCH	39.94	-
202	Phosphorylation	TKGCCSQTDGLNSKF HCCCCCCCCCCCHHH	18.75	-
208	Ubiquitination	QTDGLNSKFLDFFSK CCCCCCHHHHHHHHH	49.20	-
214	Phosphorylation	SKFLDFFSKAIQCAR HHHHHHHHHHHHHHH	22.59	-
215	Ubiquitination	KFLDFFSKAIQCARQ HHHHHHHHHHHHHHH	44.33	-
225	Phosphorylation	QCARQEKSSSGLNHI HHHHHHHCCCHHHHH	29.05	22210691
226	Phosphorylation	CARQEKSSSGLNHIL HHHHHHCCCHHHHHH	39.22	22210691
237	Phosphorylation	NHILAALTIFLKTLA HHHHHHHHHHHHHHH	12.64	22210691
297	Phosphorylation	HHPKGAKTQEKGAYE CCCCCCCCCCCCCCC	41.23	-
303	Phosphorylation	KTQEKGAYESTKWRS CCCCCCCCCCHHHHH	21.05	-
305	Phosphorylation	QEKGAYESTKWRSIL CCCCCCCCHHHHHHH	23.70	-
307	Ubiquitination	KGAYESTKWRSILYN CCCCCCHHHHHHHHH	50.30	-
310	Phosphorylation	YESTKWRSILYNLYD CCCHHHHHHHHHHHH	18.81	-
313	Phosphorylation	TKWRSILYNLYDLLV HHHHHHHHHHHHHHH	11.06	-
331	Ubiquitination	SHIGSRGKYSSGFRN CCCCCCCCCCCCCCC	40.63	-
332	Phosphorylation	HIGSRGKYSSGFRNI CCCCCCCCCCCCCCH	15.76	-
333	Phosphorylation	IGSRGKYSSGFRNIA CCCCCCCCCCCCCHH	27.72	28555341
363	Phosphorylation	VFNEDTRSLEISQSY HHCCCCCCEEEECCC	32.23	29523821
367	Phosphorylation	DTRSLEISQSYTTTQ CCCCEEEECCCCCCC	12.05	17525332
369	Phosphorylation	RSLEISQSYTTTQRE CCEEEECCCCCCCCC	20.04	29978859
370	Phosphorylation	SLEISQSYTTTQRES CEEEECCCCCCCCCC	10.64	-
371	Phosphorylation	LEISQSYTTTQRESS EEEECCCCCCCCCCC	28.72	29523821
372	Phosphorylation	EISQSYTTTQRESSD EEECCCCCCCCCCCC	16.82	29978859
373	Phosphorylation	ISQSYTTTQRESSDY EECCCCCCCCCCCCC	20.16	17525332
378	Phosphorylation	TTTQRESSDYSVPCK CCCCCCCCCCCCCCC	35.50	28796482
380	Phosphorylation	TQRESSDYSVPCKRK CCCCCCCCCCCCCCC	17.32	25884760
381	Phosphorylation	QRESSDYSVPCKRKK CCCCCCCCCCCCCCH	25.27	25884760
385	Ubiquitination	SDYSVPCKRKKIELG CCCCCCCCCCHHHHC	62.27	-
397	Ubiquitination	ELGWEVIKDHLQKSQ HHCHHHHHHHHHHCC	44.25	-
421	Phosphorylation	QIATQLISKYPASLP HHHHHHHHHCCCCCC	34.43	24719451
440	Phosphorylation	SPLLMILSQLLPQQR HHHHHHHHHHCCCCC	14.09	22817900
468	Ubiquitination	EVALCQDKRSNLESS HHHHCCCHHCCCCHH	31.67	-
477	Ubiquitination	SNLESSQKSDLLKLW CCCCHHCHHHHHHHH	48.13	-
535	Phosphorylation	TGSACRPSCPAVCCL CCCCCCCCCHHHHHH	17.24	19369195
569	Phosphorylation	NMCEVNRSFSLKESI CCCCCCCCCCHHHHH	17.62	23401153
571	Phosphorylation	CEVNRSFSLKESIMK CCCCCCCCHHHHHHH	39.52	30108239
573	Ubiquitination	VNRSFSLKESIMKWL CCCCCCHHHHHHHHH	48.49	-
601	O-linked_Glycosylation	EVPPILHSNFPHLVL CCCCCCCCCCCHHHH	36.40	22759405
614	Phosphorylation	VLEKILVSLTMKNCK HHHHHHHHHHHHHHH	18.06	29978859
616	Phosphorylation	EKILVSLTMKNCKAA HHHHHHHHHHHHHHH	20.70	29978859
629	Phosphorylation	AAMNFFQSVPECEHH HHHHHHHCCCCCHHC	34.19	29978859
644	Phosphorylation	QKDKEELSFSEVEEL CCCHHHCCHHHHHHH	29.97	-
646	Phosphorylation	DKEELSFSEVEELFL CHHHCCHHHHHHHHH	37.04	-
673	Acetylation	VRECGIEKHQSSIGF HHHHCCCCCCCCCCC	45.05	26051181
673	Ubiquitination	VRECGIEKHQSSIGF HHHHCCCCCCCCCCC	45.05	-
748	Ubiquitination	YKSELFQKAKSLMQC HHHHHHHHHHHHHHH	50.91	-
750	Ubiquitination	SELFQKAKSLMQCAG HHHHHHHHHHHHHCH	51.67	-
764	Ubiquitination	GESITLFKNKTNEEF HHCEEEEECCCCCCC	61.72	-
766	Ubiquitination	SITLFKNKTNEEFRI CEEEEECCCCCCCHH	54.00	-
775	Phosphorylation	NEEFRIGSLRNMMQL CCCCHHHHHHHHHHH	23.06	24719451
794	Phosphorylation	LSNCTKKSPNKIASG HHHCCCCCCCHHHHH	34.95	22817900
800	Phosphorylation	KSPNKIASGFFLRLL CCCCHHHHHHHHHHH	39.34	20068231
808	Phosphorylation	GFFLRLLTSKLMNDI HHHHHHHHHHHHHHH	28.54	20068231
809	Phosphorylation	FFLRLLTSKLMNDIA HHHHHHHHHHHHHHH	24.62	20068231
810	Ubiquitination	FLRLLTSKLMNDIAD HHHHHHHHHHHHHHH	46.66	-
820	Ubiquitination	NDIADICKSLASFIK HHHHHHHHHHHHHHC	49.16	-
821	Phosphorylation	DIADICKSLASFIKK HHHHHHHHHHHHHCC	25.42	30576142
824	Phosphorylation	DICKSLASFIKKPFD HHHHHHHHHHCCCCC	32.56	24719451
926	Ubiquitination	RAADIRRKLLMLIDS CHHHHHHHHHHHHCC	35.80	-
935	Phosphorylation	LMLIDSSTLEPTKSL HHHHCCCCCCCCHHH	38.81	24425749
941	O-linked_Glycosylation	STLEPTKSLHLHMYL CCCCCCHHHHHHHHH	24.41	22759405
947	Phosphorylation	KSLHLHMYLMLLKEL HHHHHHHHHHHHHCC	4.35	24425749
980	Phosphorylation	LSNVCSLYRRDQDVC HHHHHHHHHCCHHHH	6.31	-
988	Ubiquitination	RRDQDVCKTILNHVL HCCHHHHHHHHHHHH	38.15	-
1057	Ubiquitination	LEADPYSKWAILNVM HHHCCCCCHHHHHHC	34.50	-
1101	Ubiquitination	NRLFQDTKGDSSRLL HHHHCCCCCCHHHHH	69.85	-
1104	Phosphorylation	FQDTKGDSSRLLKAL HCCCCCCHHHHHHHH	26.48	23663014
1105	Phosphorylation	QDTKGDSSRLLKALP CCCCCCHHHHHHHHC	31.52	23663014
1109	Ubiquitination	GDSSRLLKALPLKLQ CCHHHHHHHHCHHHH	53.09	-
1109 (in isoform 1)	Ubiquitination	-	53.09	21890473
1114	Ubiquitination	LLKALPLKLQQTAFE HHHHHCHHHHHHHHH	42.16	-
1114 (in isoform 1)	Ubiquitination	-	42.16	21890473
1118	Phosphorylation	LPLKLQQTAFENAYL HCHHHHHHHHHHHHH	21.98	22210691
1126	Methylation	AFENAYLKAQEGMRE HHHHHHHHHHHHHHH	35.03	-
1126	Ubiquitination	AFENAYLKAQEGMRE HHHHHHHHHHHHHHH	35.03	-
1135	Phosphorylation	QEGMREMSHSAENPE HHHHHHCCCCCCCHH	14.99	22210691
1137	Phosphorylation	GMREMSHSAENPETL HHHHCCCCCCCHHHH	29.94	22210691
1143	Phosphorylation	HSAENPETLDEIYNR CCCCCHHHHHHHHCH	40.54	22210691
1148	Phosphorylation	PETLDEIYNRKSVLL HHHHHHHHCHHHHHH	13.58	30576142
1181	Ubiquitination	FALCKSVKENGLEPH HHHHHHHHHCCCCHH	53.18	-
1196	Ubiquitination	LVKKVLEKVSETFGY HHHHHHHHHHHHHCC	47.07	-
1269	Ubiquitination	RSHFDEVKSIANQIQ HHCHHHHHHHHHHHH	33.81	-
1280	Ubiquitination	NQIQEDWKSLLTDCF HHHHHHHHHHHHHHH	43.47	-
1317	Ubiquitination	QQRETATKVYDMLKS HHHHHHHHHHHHHHC	36.01	-
1323	Ubiquitination	TKVYDMLKSENLLGK HHHHHHHHCCCCCCH	49.43	-
1398	Ubiquitination	AYISNCHKTKLKSIL HHHHCCCHHHHHHHH	49.94	-
1403	Phosphorylation	CHKTKLKSILEILSK CCHHHHHHHHHHHHC	42.73	-
1410	Ubiquitination	SILEILSKSPDSYQK HHHHHHHCCCCHHHH	63.66	-
1572	Ubiquitination	FPDHVVFKDLRITQQ CCCCEEEECCEEHHH	44.22	-
1572 (in isoform 1)	Ubiquitination	-	44.22	21890473
1580	Ubiquitination	DLRITQQKIKYSRGP CCEEHHHHHHHCCCC	31.20	-
1615	Ubiquitination	LTRLEGLKDLRRQLE CCCCCCHHHHHHHHH	66.62	-
1625	Ubiquitination	RRQLELHKDQMVDIM HHHHHHCHHHHHHHH	63.38	-
1655	Phosphorylation	VVNLLQLSKMAINHT HHHHHHHHHHHCCCC	13.87	20068231
1656	Methylation	VNLLQLSKMAINHTG HHHHHHHHHHCCCCC	40.73	-
1656	Ubiquitination	VNLLQLSKMAINHTG HHHHHHHHHHCCCCC	40.73	-
1662	Phosphorylation	SKMAINHTGEKEVLE HHHHCCCCCHHHHHH	42.41	20068231
1665	Ubiquitination	AINHTGEKEVLEAVG HCCCCCHHHHHHHHH	55.24	-
1673	Phosphorylation	EVLEAVGSCLGEVGP HHHHHHHHHHCCCCC	10.28	-
1692	Ubiquitination	TIAIQHSKDASYTKA HHEEECCCCCCHHHH	56.01	-
1698	Ubiquitination	SKDASYTKALKLFED CCCCCHHHHHHHHCC	43.41	-
1701	Ubiquitination	ASYTKALKLFEDKEL CCHHHHHHHHCCCCH	56.86	-
1717	Phosphorylation	WTFIMLTYLNNTLVE HHHHHHHHCCCCHHH	11.94	22817900
1731	O-linked_Glycosylation	EDCVKVRSAAVTCLK HHHHHHHHHHHHHHH	24.46	22759405
1738	Ubiquitination	SAAVTCLKNILATKT HHHHHHHHHHHHHCC	44.05	-
1744	Ubiquitination	LKNILATKTGHSFWE HHHHHHHCCCCCHHH	47.07	-
1745	Phosphorylation	KNILATKTGHSFWEI HHHHHHCCCCCHHHH	35.45	24719451
1753	Phosphorylation	GHSFWEIYKMTTDPM CCCHHHHHHCCCCHH	5.34	22817900
1763	Phosphorylation	TTDPMLAYLQPFRTS CCCHHHHHHHCCCCC	11.25	29759185
1770	Phosphorylation	YLQPFRTSRKKFLEV HHHCCCCCCHHHHCC	37.53	24719451
1772	Ubiquitination	QPFRTSRKKFLEVPR HCCCCCCHHHHCCCC	47.87	-
1773	Ubiquitination	PFRTSRKKFLEVPRF CCCCCCHHHHCCCCC	54.81	-
1782	Ubiquitination	LEVPRFDKENPFEGL HCCCCCCCCCCCCCC	57.59	-
1828	Ubiquitination	CEILQLLKPMCEVKT HHHHHHHHHHHCCCC	39.02	-
1878	Phosphorylation	TSCLRHFSQTSRSTT HHHHHHHHHCCCCCC	26.82	28450419
1880	Phosphorylation	CLRHFSQTSRSTTPA HHHHHHHCCCCCCCC	25.55	28450419
1881	Phosphorylation	LRHFSQTSRSTTPAN HHHHHHCCCCCCCCC	19.32	28450419
1883	Phosphorylation	HFSQTSRSTTPANLD HHHHCCCCCCCCCCC	36.08	23401153
1884	Phosphorylation	FSQTSRSTTPANLDS HHHCCCCCCCCCCCC	35.37	29255136
1885	Phosphorylation	SQTSRSTTPANLDSE HHCCCCCCCCCCCCC	22.96	23401153
1891	Phosphorylation	TTPANLDSESEHFFR CCCCCCCCCCHHHHH	46.30	23401153
1893	Phosphorylation	PANLDSESEHFFRCC CCCCCCCCHHHHHHH	40.08	23927012
1908	Phosphorylation	LDKKSQRTMLAVVDY CCCCCHHHHHHHHHH	14.65	-
1915	Phosphorylation	TMLAVVDYMRRQKRP HHHHHHHHHHHCCCC	4.86	-
1974	Phosphorylation	MDDQEKRSLAFEEGS CCHHHHHHHHHHCCC	34.81	25850435
1981	Phosphorylation	SLAFEEGSQSTTISS HHHHHCCCCCCCHHH	24.44	17525332
1983	Phosphorylation	AFEEGSQSTTISSLS HHHCCCCCCCHHHHC	40.67	17525332
1984	Phosphorylation	FEEGSQSTTISSLSE HHCCCCCCCHHHHCH	20.19	30266825
1985	Phosphorylation	EEGSQSTTISSLSEK HCCCCCCCHHHHCHH	26.81	17525332
1987	Phosphorylation	GSQSTTISSLSEKSK CCCCCCHHHHCHHHH	24.12	16906133
1988	Phosphorylation	SQSTTISSLSEKSKE CCCCCHHHHCHHHHH	31.87	30301811
1992	Ubiquitination	TISSLSEKSKEETGI CHHHHCHHHHHHHCC	75.91	-
1993	Phosphorylation	ISSLSEKSKEETGIS HHHHCHHHHHHHCCC	41.05	28450419
1994	Ubiquitination	SSLSEKSKEETGISL HHHCHHHHHHHCCCH	71.31	-
1997	Phosphorylation	SEKSKEETGISLQDL CHHHHHHHCCCHHHH	40.69	28450419
2000	Phosphorylation	SKEETGISLQDLLLE HHHHHCCCHHHHHHH	22.71	28450419
2019	Phosphorylation	IGEPDSLYGCGGGKM HCCCCCCCCCCCCCC	17.83	21552520
2025	Ubiquitination	LYGCGGGKMLQPITR CCCCCCCCCCCCCCC	39.45	-
2031	Phosphorylation	GKMLQPITRLRTYEH CCCCCCCCCCCCCCC	30.27	22817900
2089	Ubiquitination	KGLDYENKDWCPELE HCCCCCCCCCCHHHH	40.44	-
2148	Ubiquitination	STFYESLKYARVKEV HHHHHHHHHHCHHHH	46.25	-
2148 (in isoform 1)	Ubiquitination	-	46.25	21890473
2153	Ubiquitination	SLKYARVKEVEEMCK HHHHHCHHHHHHHHH	50.95	-
2160	Ubiquitination	KEVEEMCKRSLESVY HHHHHHHHHHHHHHH	43.65	-
2162	Phosphorylation	VEEMCKRSLESVYSL HHHHHHHHHHHHHHH	23.22	23663014
2165	Phosphorylation	MCKRSLESVYSLYPT HHHHHHHHHHHHHHH	31.48	23663014
2167	Phosphorylation	KRSLESVYSLYPTLS HHHHHHHHHHHHHHH	11.39	23663014
2168	Phosphorylation	RSLESVYSLYPTLSR HHHHHHHHHHHHHHH	21.19	23663014
2170	Phosphorylation	LESVYSLYPTLSRLQ HHHHHHHHHHHHHHH	6.55	23663014
2172	Phosphorylation	SVYSLYPTLSRLQAI HHHHHHHHHHHHHHH	24.65	23663014
2174	Phosphorylation	YSLYPTLSRLQAIGE HHHHHHHHHHHHHHC	33.16	23663014
2184	Phosphorylation	QAIGELESIGELFSR HHHHCHHHHHHHHHC	48.82	22210691
2199	Phosphorylation	SVTHRQLSEVYIKWQ CCCHHHHHHHHHHHH	19.37	24719451
2202	Phosphorylation	HRQLSEVYIKWQKHS HHHHHHHHHHHHHHH	7.85	24719451
2207	Ubiquitination	EVYIKWQKHSQLLKD HHHHHHHHHHHHHCC	44.07	-
2242	Phosphorylation	MEKEMDNSQRECIKD HHHCCCHHHHHHHHH	26.76	23898821
2248	Ubiquitination	NSQRECIKDILTKHL HHHHHHHHHHHHHHH	50.83	-
2266	Ubiquitination	SILARTFKNTQLPER HHHHHHCCCCCCCHH	59.48	-
2303	Ubiquitination	AQVFWAKKEQSLALS CHHHHHHHHHHHHHH	53.92	-
2310	Phosphorylation	KEQSLALSILKQMIK HHHHHHHHHHHHHHH	21.92	24719451
2318	Ubiquitination	ILKQMIKKLDASCAA HHHHHHHHHCHHHHC	40.45	-
2385	Ubiquitination	ELRNGKMKAFLSLAR HHHHCCHHHHHHHHH	39.20	-
2404	Phosphorylation	QYQRIENYMKSSEFE HHHHHHHHHHCCHHC	7.98	25072903
2406	Ubiquitination	QRIENYMKSSEFENK HHHHHHHHCCHHCCH	40.23	-
2407	Phosphorylation	RIENYMKSSEFENKQ HHHHHHHCCHHCCHH	20.69	25072903
2408	Phosphorylation	IENYMKSSEFENKQA HHHHHHCCHHCCHHH	40.56	25072903
2413	Ubiquitination	KSSEFENKQALLKRA HCCHHCCHHHHHHHH	29.74	-
2421	Ubiquitination	QALLKRAKEEVGLLR HHHHHHHHHHHCHHH	59.44	-
2431	Ubiquitination	VGLLREHKIQTNRYT HCHHHHHCCCCCCEE	31.58	-
2440	Acetylation	QTNRYTVKVQRELEL CCCCEEEEEEHHHHH	25.50	25953088
2440	Ubiquitination	QTNRYTVKVQRELEL CCCCEEEEEEHHHHH	25.50	-
2505	Ubiquitination	SEVNGMMKRDGMKIP CHHCCCCCCCCCCCC	38.14	-
2515	Ubiquitination	GMKIPTYKFLPLMYQ CCCCCHHHHHHHHHH	42.79	-
2589	Ubiquitination	RITKNVPKQSSQLDE CCCCCCCCCCCCCCH	59.54	-
2592	Phosphorylation	KNVPKQSSQLDEDRT CCCCCCCCCCCHHHH	32.06	-
2608	O-linked_Glycosylation	AANRIICTIRSRRPQ HHHHHHHHHHCCCHH	14.71	22759405
2643	Methylation	TQWKTQRKGINIPAD CHHCHHCCCCCCCCC	55.09	23644510
2643	Ubiquitination	TQWKTQRKGINIPAD CHHCHHCCCCCCCCC	55.09	-
2655	Ubiquitination	PADQPITKLKNLEDV CCCCCCCCCCCHHHC	59.17	-
2657	Ubiquitination	DQPITKLKNLEDVVV CCCCCCCCCHHHCEE	62.13	-
2674	Phosphorylation	MEIKVDHTGEYGNLV EEEEECCCCCCCCEE	27.52	24260401
2677	Phosphorylation	KVDHTGEYGNLVTIQ EECCCCCCCCEEEEE	16.80	24260401
2682	Phosphorylation	GEYGNLVTIQSFKAE CCCCCEEEEEEEEEE	19.23	24260401
2710	Ubiquitination	DCVGSDGKERRQLVK EECCCCHHHHHHHHC	53.70	-
2751	Phosphorylation	ETRKRKLTICTYKVV HHHCCCEEEEEEEEE	19.62	-
2755	Phosphorylation	RKLTICTYKVVPLSQ CCEEEEEEEEEEHHH	9.43	23403867
2789	Ubiquitination	NNEDGAHKRYRPNDF CCCCCCCCCCCCCCC	51.06	-
2803	Ubiquitination	FSAFQCQKKMMEVQK CCHHHHHHHHHHHHH	50.71	-
2812	Phosphorylation	MMEVQKKSFEEKYEV HHHHHHHHHHHHHHH	44.95	24719451
2848	Ubiquitination	DPAIWFEKRLAYTRS CHHHHHHHHHHCCHH	43.15	-
2969	Phosphorylation	MNPLKALYLQQRPED CCHHHHHHHCCCCCC	13.81	-
2992	Ubiquitination	NADDQECKRNLSDID CCCHHHHHHHHHHHH	43.50	-
2996	Phosphorylation	QECKRNLSDIDQSFN HHHHHHHHHHHHHHH	35.75	25159151
3001	Phosphorylation	NLSDIDQSFNKVAER HHHHHHHHHHHHHHH	27.34	27732954
3004	Ubiquitination	DIDQSFNKVAERVLM HHHHHHHHHHHHHHH	40.59	-
3016	Acetylation	VLMRLQEKLKGVEEG HHHHHHHHHCCCCCC	42.40	17923702
3053	Ubiquitination	SRLFPGWKAWV---- HHHCCCCCCCC----	37.98	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
367	S	Phosphorylation	Kinase	ATM	Q13315	PSP
370	Y	Phosphorylation	Kinase	EGFR	P00533	PSP
440	S	Phosphorylation	Kinase	ATM	Q13315	PSP
794	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
1403	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS
1885	T	Phosphorylation	Kinase	ATM	Q13315	PSP
1893	S	Phosphorylation	Kinase	ATM	Q13315	PSP
1981	S	Phosphorylation	Kinase	ATM	Q13315	PSP
1981	S	Phosphorylation	Kinase	ATM	Q13315	GPS
1981	S	Phosphorylation	Kinase	ATR	Q13535	PSP
2996	S	Phosphorylation	Kinase	ATM	Q13315	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
367	S	Phosphorylation	12556884
Autophosphorylation on Ser-367, Ser-1893, Ser-1981 correlates with DNA damage-mediated activation of the kinase.
1893	S	Phosphorylation	12556884
Autophosphorylation on Ser-367, Ser-1893, Ser-1981 correlates with DNA damage-mediated activation of the kinase.
1981	S	Acetylation	12556884
Acetylation, on DNA damage, is required for activation of the kinase activity, dimer-monomer transition, and subsequent autophosphorylation on Ser-1981.
1981	S	Phosphorylation	12556884
Acetylation, on DNA damage, is required for activation of the kinase activity, dimer-monomer transition, and subsequent autophosphorylation on Ser-1981.
1981	S	Phosphorylation	12556884
Autophosphorylation on Ser-367, Ser-1893, Ser-1981 correlates with DNA damage-mediated activation of the kinase.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
2310	Phosphorylation	2307 (3)	L ⇒ V;F	rs56009889	Alzheimer's disease (late onset)	28714976

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ABL1_HUMAN	ABL1	physical	9168117
CTIP_HUMAN	RBBP8	physical	10910365
BRCA1_HUMAN	BRCA1	physical	10866324
FACD2_HUMAN	FANCD2	physical	12086603
SMC1A_HUMAN	SMC1A	physical	11877376
P53_HUMAN	TP53	physical	15632067
BLM_HUMAN	BLM	physical	10783165
P53_HUMAN	TP53	physical	15159397
P53_HUMAN	TP53	physical	9843217
AP3B2_MOUSE	Ap3b2	physical	9707615
AP1B1_MOUSE	Ap1b1	physical	9707615
P53_HUMAN	TP53	genetic	9135004
BLM_HUMAN	BLM	physical	12034743
AP1B1_HUMAN	AP1B1	physical	10608806
ATM_HUMAN	ATM	physical	10608806
BRCA1_HUMAN	BRCA1	physical	10608806
CHK1_HUMAN	CHEK1	physical	10608806
E4F1_HUMAN	E4F1	physical	10608806
4EBP1_HUMAN	EIF4EBP1	physical	10608806
DNLI4_HUMAN	LIG4	physical	10608806
MRE11_HUMAN	MRE11A	physical	10608806
NBN_HUMAN	NBN	physical	10608806
RAD17_HUMAN	RAD17	physical	10608806
CTIP_HUMAN	RBBP8	physical	10608806
P53_HUMAN	TP53	physical	10608806
WRN_HUMAN	WRN	physical	10608806
BRCA1_HUMAN	BRCA1	physical	10550055
BRCA1_HUMAN	BRCA1	physical	11114888
BRCA2_HUMAN	BRCA2	physical	15199141
CHK1_MOUSE	Chek1	physical	15632067
H2AX_MOUSE	H2afx	physical	15632067
TP53B_HUMAN	TP53BP1	physical	12447390
ABL1_HUMAN	ABL1	physical	10212258
RAD51_HUMAN	RAD51	physical	10212258
RFC1_HUMAN	RFC1	physical	10783165
MCM2_HUMAN	MCM2	physical	15210935
TP53B_HUMAN	TP53BP1	physical	12697768
TERF1_HUMAN	TERF1	physical	11375976
ABL1_HUMAN	ABL1	physical	11375976
PEX5_HUMAN	PEX5	physical	10567403
PRKDC_HUMAN	PRKDC	physical	10464290
RAD17_HUMAN	RAD17	physical	11418864
RIR2B_HUMAN	RRM2B	physical	19015526
XPC_HUMAN	XPC	physical	19805520
SNF5_HUMAN	SMARCB1	physical	19805520
HUWE1_HUMAN	HUWE1	physical	17478428
UBP34_HUMAN	USP34	physical	17478428
MED1_HUMAN	MED1	physical	17478428
FANCI_HUMAN	FANCI	physical	17478428
SMC3_HUMAN	SMC3	physical	17478428
TAOK3_HUMAN	TAOK3	physical	17478428
TYDP1_HUMAN	TDP1	physical	17478428
TP53B_HUMAN	TP53BP1	physical	18996087
CXXC5_HUMAN	CXXC5	physical	19557330
DDX1_HUMAN	DDX1	physical	18710941
VHL_HUMAN	VHL	physical	16678111
KAT8_HUMAN	KAT8	physical	15923642
ATF2_HUMAN	ATF2	physical	15916964
H2AX_HUMAN	H2AFX	physical	18344987
BRCA1_HUMAN	BRCA1	physical	18344987
RAD17_HUMAN	RAD17	physical	18344987
FOXO3_HUMAN	FOXO3	physical	18344987
HDAC1_HUMAN	HDAC1	physical	10531300
CHK2_HUMAN	CHEK2	physical	15064416
P53_HUMAN	TP53	physical	15064416
PARP1_HUMAN	PARP1	physical	17428792
ABL1_HUMAN	ABL1	physical	17409407
P53_HUMAN	TP53	physical	17409407
MCM3_MOUSE	Mcm3	physical	17244605
BMI1_HUMAN	BMI1	physical	20668194
CHD4_HUMAN	CHD4	physical	21219611
MDC1_HUMAN	MDC1	physical	18006705
EXO1_HUMAN	EXO1	physical	20019063
E2F1_HUMAN	E2F1	physical	11459832
P53_HUMAN	TP53	physical	11459832
ABL1_HUMAN	ABL1	physical	20798688
P53_HUMAN	TP53	physical	21383020
SMC1A_HUMAN	SMC1A	physical	11877377
P53_HUMAN	TP53	physical	19965871
DYRK2_HUMAN	DYRK2	physical	19965871
TRAF6_HUMAN	TRAF6	physical	20932475
ATM_HUMAN	ATM	physical	20360068
TCL1A_HUMAN	TCL1A	physical	22065599
CHK2_HUMAN	CHEK2	physical	10973490
NBN_HUMAN	NBN	physical	15758953
MRE11_HUMAN	MRE11A	physical	15758953
KAT5_HUMAN	KAT5	physical	19783983
BRE1A_HUMAN	RNF20	physical	21362549
BRE1B_HUMAN	RNF40	physical	21362549
TELO2_HUMAN	TELO2	physical	18160036
TERF1_HUMAN	TERF1	physical	18160036
EIF3E_HUMAN	EIF3E	physical	22508697
NBN_HUMAN	NBN	physical	22464731
KAT5_HUMAN	KAT5	physical	16141325
MDC1_HUMAN	MDC1	physical	12607005
KAT5_HUMAN	KAT5	physical	21704408
NEMO_HUMAN	IKBKG	physical	16497931
BRAT1_HUMAN	BRAT1	physical	16452482
PTPA_HUMAN	PPP2R4	physical	16452482
DCAF1_HUMAN	VPRBP	physical	22184063
H2AX_HUMAN	H2AFX	physical	22184063
DCR1C_HUMAN	DCLRE1C	physical	15456891
TOPB1_HUMAN	TOPBP1	physical	19023333
MDM2_HUMAN	MDM2	physical	22976441
KC1D_HUMAN	CSNK1D	physical	22976441
SOCS1_HUMAN	SOCS1	physical	20005840
SMAD7_HUMAN	SMAD7	physical	17172861
MK14_HUMAN	MAPK14	physical	17172861
XPA_HUMAN	XPA	physical	16540648
ATM_HUMAN	ATM	physical	16858402
CDN2C_HUMAN	CDKN2C	physical	15680327
CHK1_HUMAN	CHEK1	physical	12676583
P53_HUMAN	TP53	physical	15790808
ATM_HUMAN	ATM	physical	15790808
CHK2_HUMAN	CHEK2	physical	15790808
CHK2_HUMAN	CHEK2	physical	10744722
P53_HUMAN	TP53	physical	10744722
DAXX_HUMAN	DAXX	physical	23405218
TERF2_HUMAN	TERF2	physical	15314656
TERF1_HUMAN	TERF1	physical	15314656
SPSB1_HUMAN	SPSB1	physical	18449195
BID_MOUSE	Bid	physical	16122425
BID_MOUSE	Bid	physical	16122426
4EBP1_HUMAN	EIF4EBP1	physical	10713094
P53_HUMAN	TP53	physical	10713094
CHK2_HUMAN	CHEK2	physical	10713094
RFA1_HUMAN	RPA1	physical	10713094
RFA2_HUMAN	RPA2	physical	10713094
1A02_HUMAN	HLA-A	physical	20064447
1A03_HUMAN	HLA-A	physical	20064447
1A01_HUMAN	HLA-A	physical	20064447
1A26_HUMAN	HLA-A	physical	20064447
NAC8_ARATH	SOG1	physical	23907539
P53_HUMAN	TP53	physical	23907539
SPOP_HUMAN	SPOP	physical	24451148
BCL10_HUMAN	BCL10	physical	24732096
TIF1B_HUMAN	TRIM28	physical	23096706
MAGC2_HUMAN	MAGEC2	physical	23096706
TF65_HUMAN	RELA	physical	24957606
CDK9_HUMAN	CDK9	physical	24957606
RPB1_HUMAN	POLR2A	physical	24957606
XPC_HUMAN	XPC	physical	23422745
HIF1A_HUMAN	HIF1A	physical	21095582
ABL1_HUMAN	ABL1	physical	9168116
RPB1_HUMAN	POLR2A	physical	9168116
CREB1_HUMAN	CREB1	physical	15073328
ZEB1_HUMAN	ZEB1	physical	25086746
P53_HUMAN	TP53	physical	25086746
TTI1_HUMAN	TTI1	physical	20810650
RAP2A_HUMAN	RAP2A	physical	26186194
GNA11_HUMAN	GNA11	physical	26186194
RASF1_HUMAN	RASSF1	physical	10608806
AP3B1_HUMAN	AP3B1	physical	10608806
BCAS3_HUMAN	BCAS3	physical	25640309
ERRFI_HUMAN	ERRFI1	physical	25640309
IL24_HUMAN	IL24	physical	25640309
MTA3_HUMAN	MTA3	physical	25640309
ARY2_HUMAN	NAT2	physical	25640309
OSGI1_HUMAN	OSGIN1	physical	25640309
TFF1_HUMAN	TFF1	physical	25640309
NSD3_HUMAN	WHSC1L1	physical	25640309
ACL6B_HUMAN	ACTL6B	physical	25640309
NREP_HUMAN	NREP	physical	25640309
HEMH_HUMAN	FECH	physical	25640309
HSP7C_HUMAN	HSPA8	physical	25640309
MAP1S_HUMAN	MAP1S	physical	25640309
NU4M_HUMAN	ND4	physical	25640309
NR4A1_HUMAN	NR4A1	physical	25640309
ZN821_HUMAN	ZNF821	physical	25640309
MTRR_HUMAN	MTRR	physical	26496610
NDUA8_HUMAN	NDUFA8	physical	26496610
NRDC_HUMAN	NRD1	physical	26496610
TAF1_HUMAN	TAF1	physical	26496610
BAG6_HUMAN	BAG6	physical	26496610
MTMR3_HUMAN	MTMR3	physical	26496610
NOLC1_HUMAN	NOLC1	physical	26496610
ZER1_HUMAN	ZER1	physical	26496610
SRSF8_HUMAN	SRSF8	physical	26496610
DCA13_HUMAN	DCAF13	physical	26496610
MINK1_HUMAN	MINK1	physical	26496610
RBM47_HUMAN	RBM47	physical	26496610
ODR4_HUMAN	C1orf27	physical	26496610
P3H2_HUMAN	P3H2	physical	26496610
BHE41_HUMAN	BHLHE41	physical	26496610
C99L2_HUMAN	CD99L2	physical	26496610
UTP15_HUMAN	UTP15	physical	26496610
BANP_HUMAN	BANP	physical	25299772
PEX5_HUMAN	PEX5	physical	26344566
KDM2A_HUMAN	KDM2A	physical	25823024
RANB9_HUMAN	RANBP9	physical	26943034
SETD2_HUMAN	SETD2	genetic	28319113
KDM6A_HUMAN	KDM6A	genetic	28319113
SMO_HUMAN	SMO	genetic	28319113
VHL_HUMAN	VHL	genetic	28319113
CHK1_HUMAN	CHEK1	genetic	28319113
MDM2_HUMAN	MDM2	physical	27462439
UCHL3_HUMAN	UCHL3	physical	27941124
P53_HUMAN	TP53	physical	24469230
P53_HUMAN	TP53	physical	14744854
KPCA_HUMAN	PRKCA	genetic	27438146
FEN1_HUMAN	FEN1	genetic	28628639
H2AX_HUMAN	H2AFX	physical	27918549
FOXO1_HUMAN	FOXO1	physical	27559048
P53_HUMAN	TP53	physical	27559048
TIF1B_HUMAN	TRIM28	physical	28249048

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
208900	Ataxia telangiectasia (AT)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00201	Caffeine

Regulatory Network of ATM_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"DNA damage-induced acetylation of lysine 3016 of ATM activates ATMkinase activity."; Sun Y., Xu Y., Roy K., Price B.D.; Mol. Cell. Biol. 27:8502-8509(2007). Cited for: ACETYLATION AT LYS-3016, FUNCTION, AND MUTAGENESIS OF LYS-3016 ANDLYS-3018.	17923702 [Abstract]
Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1883; SER-1981 ANDSER-2996, AND MASS SPECTROMETRY.	19369195 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1981 AND SER-2996, ANDMASS SPECTROMETRY.	18691976 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-72; SER-85; THR-86;SER-367; THR-373; SER-1981 AND THR-1985, AND MASS SPECTROMETRY.	17525332 [Abstract]
"Involvement of novel autophosphorylation sites in ATM activation."; Kozlov S.V., Graham M.E., Peng C., Chen P., Robinson P.J., Lavin M.F.; EMBO J. 25:3504-3514(2006). Cited for: AUTOPHOSPHORYLATION AT SER-367; SER-1893 AND SER-1981, FUNCTION, MASSSPECTROMETRY, AND MUTAGENESIS OF SER-367; SER-1893 AND SER-1981.	16858402 [Abstract]
"A role for the Tip60 histone acetyltransferase in the acetylation andactivation of ATM."; Sun Y., Jiang X., Chen S., Fernandes N., Price B.D.; Proc. Natl. Acad. Sci. U.S.A. 102:13182-13187(2005). Cited for: INTERACTION WITH HTATIP, AUTOPHOSPHORYLATION AT SER-1981, ANDACETYLATION.	16141325 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1981, AND MASSSPECTROMETRY.	15302935 [Abstract]
"DNA damage activates ATM through intermolecular autophosphorylationand dimer dissociation."; Bakkenist C.J., Kastan M.B.; Nature 421:499-506(2003). Cited for: AUTOPHOSPHORYLATION AT SER-1981, SUBUNIT, FUNCTION, AND MUTAGENESIS OFSER-1981.	12556884 [Abstract]

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