| UniProt ID | OSGI1_HUMAN | |
|---|---|---|
| UniProt AC | Q9UJX0 | |
| Protein Name | Oxidative stress-induced growth inhibitor 1 | |
| Gene Name | OSGIN1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 560 | |
| Subcellular Localization | ||
| Protein Description | Regulates the differentiation and proliferation of normal cells through the regulation of cell death.. | |
| Protein Sequence | MGKWRPRGCCRGNMQCRQEVPATLTSSELFSTRNQPQPQPQPLLADAPVPWAVASRMCLTPGQGCGHQGQDEGPLPAPSPPPAMSSSRKDHLGASSSEPLPVIIVGNGPSGICLSYLLSGYTPYTKPDAIHPHPLLQRKLTEAPGVSILDQDLDYLSEGLEGRSQSPVALLFDALLRPDTDFGGNMKSVLTWKHRKEHAIPHVVLGRNLPGGAWHSIEGSMVILSQGQWMGLPDLEVKDWMQKKRRGLRNSRATAGDIAHYYRDYVVKKGLGHNFVSGAVVTAVEWGTPDPSSCGAQDSSPLFQVSGFLTRNQAQQPFSLWARNVVLATGTFDSPARLGIPGEALPFIHHELSALEAATRVGAVTPASDPVLIIGAGLSAADAVLYARHYNIPVIHAFRRAVDDPGLVFNQLPKMLYPEYHKVHQMMREQSILSPSPYEGYRSLPRHQLLCFKEDCQAVFQDLEGVEKVFGVSLVLVLIGSHPDLSFLPGAGADFAVDPDQPLSAKRNPIDVDPFTYQSTRQEGLYAMGPLAGDNFVRFVQGGALAVASSLLRKETRKPP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 12 | Phosphorylation | RPRGCCRGNMQCRQE CCCCCCCCCCHHCCC | 21.76 | 24275569 | |
| 56 (in isoform 2) | Ubiquitination | - | 15.31 | - | |
| 56 | Ubiquitination | VPWAVASRMCLTPGQ CCHHHHCCCCCCCCC | 15.31 | 23503661 | |
| 95 | Phosphorylation | RKDHLGASSSEPLPV CCCCCCCCCCCCCCE | 32.38 | 14570898 | |
| 110 | Ubiquitination | IIVGNGPSGICLSYL EEECCCCCHHHHHHH | 42.03 | 29967540 | |
| 113 | Ubiquitination | GNGPSGICLSYLLSG CCCCCHHHHHHHHCC | 2.05 | 29967540 | |
| 139 | Ubiquitination | PHPLLQRKLTEAPGV CCHHHHCCCCCCCCC | 46.96 | - | |
| 155 | Ubiquitination | ILDQDLDYLSEGLEG EHHCCHHHHHHCCCC | 21.30 | 22817900 | |
| 160 (in isoform 2) | Ubiquitination | - | 5.75 | 21906983 | |
| 160 | Ubiquitination | LDYLSEGLEGRSQSP HHHHHHCCCCCCCCH | 5.75 | 22817900 | |
| 161 | Ubiquitination | DYLSEGLEGRSQSPV HHHHHCCCCCCCCHH | 64.52 | 22817900 | |
| 180 | Phosphorylation | DALLRPDTDFGGNMK HHHHCCCCCCCCCCC | 35.59 | - | |
| 185 (in isoform 2) | Ubiquitination | - | 34.78 | 21906983 | |
| 185 | Ubiquitination | PDTDFGGNMKSVLTW CCCCCCCCCCCEEEE | 34.78 | 22817900 | |
| 186 | Ubiquitination | DTDFGGNMKSVLTWK CCCCCCCCCCEEEEC | 3.76 | 22817900 | |
| 193 | Ubiquitination | MKSVLTWKHRKEHAI CCCEEEECCCHHCCC | 28.44 | - | |
| 243 (in isoform 1) | Ubiquitination | - | 31.94 | 21906983 | |
| 243 | Ubiquitination | EVKDWMQKKRRGLRN HHHHHHHHHHHCCCC | 31.94 | 21906983 | |
| 268 (in isoform 1) | Ubiquitination | - | 30.95 | 21906983 | |
| 268 | Ubiquitination | YYRDYVVKKGLGHNF HHHHHHHHHCCCCCC | 30.95 | 21906983 | |
| 331 (in isoform 2) | Ubiquitination | - | 21.66 | 21906983 | |
| 331 | Ubiquitination | NVVLATGTFDSPARL CEEEEECCCCCCHHH | 21.66 | 22817900 | |
| 339 | Ubiquitination | FDSPARLGIPGEALP CCCCHHHCCCCCHHH | 20.63 | 22817900 | |
| 339 (in isoform 2) | Ubiquitination | - | 20.63 | 21906983 | |
| 370 (in isoform 2) | Ubiquitination | - | 21.96 | 21906983 | |
| 370 | Ubiquitination | AVTPASDPVLIIGAG CCCCCCCCEEEECCC | 21.96 | 22817900 | |
| 414 (in isoform 1) | Ubiquitination | - | 50.56 | 21906983 | |
| 414 | Ubiquitination | LVFNQLPKMLYPEYH CHHHCCHHHHCHHHH | 50.56 | 21906983 | |
| 422 (in isoform 1) | Ubiquitination | - | 40.28 | 21906983 | |
| 422 | Ubiquitination | MLYPEYHKVHQMMRE HHCHHHHHHHHHHHH | 40.28 | 21906983 | |
| 431 | Phosphorylation | HQMMREQSILSPSPY HHHHHHCCCCCCCCC | 22.27 | - | |
| 453 | Ubiquitination | RHQLLCFKEDCQAVF HHHEEEEHHHHHHHH | 52.20 | 2190698 | |
| 453 (in isoform 1) | Ubiquitination | - | 52.20 | 21906983 | |
| 549 | Phosphorylation | GGALAVASSLLRKET HHHHHHHHHHHHHHC | 18.21 | 22210691 | |
| 550 | Phosphorylation | GALAVASSLLRKETR HHHHHHHHHHHHHCC | 22.99 | 24719451 | |
| 556 | Phosphorylation | SSLLRKETRKPP--- HHHHHHHCCCCC--- | 47.21 | 22210691 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of OSGI1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of OSGI1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of OSGI1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CCD33_HUMAN | CCDC33 | physical | 25416956 | |
| LNX1_HUMAN | LNX1 | physical | 25416956 | |
| SAXO1_HUMAN | FAM154A | physical | 25416956 | |
| INCA1_HUMAN | INCA1 | physical | 25416956 | |
| KS6A6_HUMAN | RPS6KA6 | physical | 26186194 | |
| BTBD1_HUMAN | BTBD1 | physical | 26186194 | |
| BTBD2_HUMAN | BTBD2 | physical | 26186194 | |
| KS6A6_HUMAN | RPS6KA6 | physical | 28514442 | |
| BTBD1_HUMAN | BTBD1 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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