BTBD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BTBD2_HUMAN
• UniProt AC: Q9BX70
• Protein Name: BTB/POZ domain-containing protein 2
• Gene Name: BTBD2
• Organism: Homo sapiens (Human).
• Sequence Length: 525
• Subcellular Localization: Cytoplasm . Localizes to punctate or elongated cytoplasmic bodies.
• Protein Sequence: MAAGGSGGRASCPPGVGVGPGTGGSPGPSANAAATPAPGNAAAAAAAAAAAAAAPGPTPPAPPGPGTDAQAAGAERAEEAAGPGAAALQREAAYNWQASKPTVQERFAFLFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWSEAECQRQQLQVTPENRRKVLGKALGLIRFPLMTIEEFAAGPAQSGILVDREVVSLFLHFTVNPKPRVEFIDRPRCCLRGKECSINRFQQVESRWGYSGTSDRIRFSVNKRIFVVGFGLYGSIHGPTDYQVNIQIIHTDSNTVLGQNDTGFSCDGSASTFRVMFKEPVEVLPNVNYTACATLKGPDSHYGTKGLRKVTHESPTTGAKTCFTFCYAAGNNNGTSVEDGQIPEVIFYT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
100 (in isoform 1)	Ubiquitination	-	47.96	21890473
100	Ubiquitination	AYNWQASKPTVQERF HHCCCCCCCCHHHHH	47.96	22817900
160 (in isoform 2)	Ubiquitination	-	33.94	21890473
160	Ubiquitination	GMATTSTEIELPDVE CCCCCCCEEECCCCC	33.94	21890473
164	Ubiquitination	TSTEIELPDVEPAAF CCCEEECCCCCHHHH	30.70	21890473
214	Ubiquitination	AHCVEFLKKNLRADN HHHHHHHHHCCCCCC	44.96	32015554
215	Ubiquitination	HCVEFLKKNLRADNA HHHHHHHHCCCCCCH	64.46	-
308	Ubiquitination	VTPENRRKVLGKALG CCHHHHHHHHHHHHH	38.28	22817900
312 (in isoform 1)	Ubiquitination	-	35.96	21890473
312	Ubiquitination	NRRKVLGKALGLIRF HHHHHHHHHHHHCCC	35.96	22817900
333	Ubiquitination	EFAAGPAQSGILVDR HHHCCCCCCCCEECH	45.37	21890473
337	Ubiquitination	GPAQSGILVDREVVS CCCCCCCEECHHHHE	3.60	22817900
370	Ubiquitination	PRCCLRGKECSINRF CCCCCCCCCCEECCC	49.46	33845483
472	Ubiquitination	YTACATLKGPDSHYG EEEEEECCCCCCCCC	65.13	29901268
481	Ubiquitination	PDSHYGTKGLRKVTH CCCCCCCCCCEEECC	52.14	27667366
481 (in isoform 1)	Ubiquitination	-	52.14	21890473
485	Ubiquitination	YGTKGLRKVTHESPT CCCCCCEEECCCCCC	57.43	33845483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BTBD2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BTBD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BTBD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ERG28_HUMAN	C14orf1	physical	16169070
GBP2_HUMAN	GBP2	physical	16169070
GDF9_HUMAN	GDF9	physical	16169070
CC90B_HUMAN	CCDC90B	physical	16169070
IGS21_HUMAN	IGSF21	physical	16169070
PTN_HUMAN	PTN	physical	16169070
CSN6_HUMAN	COPS6	physical	16169070
RBM48_HUMAN	RBM48	physical	16169070
SETB1_HUMAN	SETDB1	physical	16169070
UBR1_HUMAN	UBR1	physical	16169070
DPYL1_HUMAN	CRMP1	physical	16169070
G3P_HUMAN	GAPDH	physical	16169070
TLE1_HUMAN	TLE1	physical	16169070
P53_HUMAN	TP53	physical	16169070
U119A_HUMAN	UNC119	physical	16169070
BRD7_HUMAN	BRD7	physical	16169070
EF1A1_HUMAN	EEF1A1	physical	16169070
TOP1_HUMAN	TOP1	physical	11818025
CUL3_HUMAN	CUL3	physical	19295130
CDK2_HUMAN	CDK2	physical	21988832
IMA1_HUMAN	KPNA2	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.