| UniProt ID | PTN_HUMAN | |
|---|---|---|
| UniProt AC | P21246 | |
| Protein Name | Pleiotrophin | |
| Gene Name | PTN | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 168 | |
| Subcellular Localization | Secreted . | |
| Protein Description | Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. [PubMed: 1768439] | |
| Protein Sequence | MQAQQYQQQRRKFAAAFLAFIFILAAVDTAEAGKKEKPEKKVKKSDCGEWQWSVCVPTSGDCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTGSLKRALHNAECQKTVTISKPCGKLTKPKPQAESKKKKKEGKKQEKMLD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 45 | Phosphorylation | PEKKVKKSDCGEWQW CCCCCCHHHCCCEEE | 32.20 | 30631047 | |
| 53 | Phosphorylation | DCGEWQWSVCVPTSG HCCCEEEEEEEECCC | 7.19 | 30631047 | |
| 59 | Phosphorylation | WSVCVPTSGDCGLGT EEEEEECCCCCCCCC | 26.94 | 30631047 | |
| 66 | Phosphorylation | SGDCGLGTREGTRTG CCCCCCCCCCCCCCH | 30.50 | 30631047 | |
| 101 | Phosphorylation | QFGAECKYQFQAWGE HHCCEEEEEEEECCC | 26.64 | - | |
| 113 | Phosphorylation | WGECDLNTALKTRTG CCCCCHHHHHHHCCC | 40.44 | - | |
| 121 | Phosphorylation | ALKTRTGSLKRALHN HHHHCCCHHHHHHHH | 30.06 | 24719451 | |
| 134 | Phosphorylation | HNAECQKTVTISKPC HHHCCCCEEEEECCC | 9.30 | - | |
| 153 | Phosphorylation | KPKPQAESKKKKKEG CCCCCHHHHHHHHHC | 53.44 | 22912867 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PTN_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PTN_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PTN_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CHD3_HUMAN | CHD3 | physical | 16169070 | |
| PTPRZ_HUMAN | PTPRZ1 | physical | 10706604 | |
| CTNB1_HUMAN | CTNNB1 | physical | 10706604 | |
| GA45G_HUMAN | GADD45G | physical | 15383276 | |
| FEZ1_HUMAN | FEZ1 | physical | 15383276 | |
| PTN_HUMAN | PTN | physical | 15383276 | |
| PIAS4_HUMAN | PIAS4 | physical | 15383276 | |
| GASP2_HUMAN | GPRASP2 | physical | 15383276 | |
| T22D1_HUMAN | TSC22D1 | physical | 21988832 | |
| SGTA_HUMAN | SGTA | physical | 21988832 | |
| UBQL1_HUMAN | UBQLN1 | physical | 21988832 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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