PTPRZ_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTPRZ_HUMAN
• UniProt AC: P23471
• Protein Name: Receptor-type tyrosine-protein phosphatase zeta
• Gene Name: PTPRZ1
• Organism: Homo sapiens (Human).
• Sequence Length: 2315
• Subcellular Localization: Isoform 1: Cell membrane; Single-pass type I membrane protein. Secreted. A secreted form is apparently generated by shedding of the extracellular domain..; Isoform 2: Secreted .
• Protein Description: Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity)..
• Protein Sequence: MRILKRFLACIQLLCVCRLDWANGYYRQQRKLVEEIGWSYTGALNQKNWGKKYPTCNSPKQSPINIDEDLTQVNVNLKKLKFQGWDKTSLENTFIHNTGKTVEINLTNDYRVSGGVSEMVFKASKITFHWGKCNMSSDGSEHSLEGQKFPLEMQIYCFDADRFSSFEEAVKGKGKLRALSILFEVGTEENLDFKAIIDGVESVSRFGKQAALDPFILLNLLPNSTDKYYIYNGSLTSPPCTDTVDWIVFKDTVSISESQLAVFCEVLTMQQSGYVMLMDYLQNNFREQQYKFSRQVFSSYTGKEEIHEAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKHEFLTDGYQDLGAILNNLLPNMSYVLQIVAICTNGLYGKYSDQLIVDMPTDNPELDLFPELIGTEEIIKEEEEGKDIEEGAIVNPGRDSATNQIRKKEPQISTTTHYNRIGTKYNEAKTNRSPTRGSEFSGKGDVPNTSLNSTSQPVTKLATEKDISLTSQTVTELPPHTVEGTSASLNDGSKTVLRSPHMNLSGTAESLNTVSITEYEEESLLTSFKLDTGAEDSSGSSPATSAIPFISENISQGYIFSSENPETITYDVLIPESARNASEDSTSSGSEESLKDPSMEGNVWFPSSTDITAQPDVGSGRESFLQTNYTEIRVDESEKTTKSFSAGPVMSQGPSVTDLEMPHYSTFAYFPTEVTPHAFTPSSRQQDLVSTVNVVYSQTTQPVYNGETPLQPSYSSEVFPLVTPLLLDNQILNTTPAASSSDSALHATPVFPSVDVSFESILSSYDGAPLLPFSSASFSSELFRHLHTVSQILPQVTSATESDKVPLHASLPVAGGDLLLEPSLAQYSDVLSTTHAASETLEFGSESGVLYKTLMFSQVEPPSSDAMMHARSSGPEPSYALSDNEGSQHIFTVSYSSAIPVHDSVGVTYQGSLFSGPSHIPIPKSSLITPTASLLQPTHALSGDGEWSGASSDSEFLLPDTDGLTALNISSPVSVAEFTYTTSVFGDDNKALSKSEIIYGNETELQIPSFNEMVYPSESTVMPNMYDNVNKLNASLQETSVSISSTKGMFPGSLAHTTTKVFDHEISQVPENNFSVQPTHTVSQASGDTSLKPVLSANSEPASSDPASSEMLSPSTQLLFYETSASFSTEVLLQPSFQASDVDTLLKTVLPAVPSDPILVETPKVDKISSTMLHLIVSNSASSENMLHSTSVPVFDVSPTSHMHSASLQGLTISYASEKYEPVLLKSESSHQVVPSLYSNDELFQTANLEINQAHPPKGRHVFATPVLSIDEPLNTLINKLIHSDEILTSTKSSVTGKVFAGIPTVASDTFVSTDHSVPIGNGHVAITAVSPHRDGSVTSTKLLFPSKATSELSHSAKSDAGLVGGGEDGDTDDDGDDDDDDRGSDGLSIHKCMSCSSYRESQEKVMNDSDTHENSLMDQNNPISYSLSENSEEDNRVTSVSSDSQTGMDRSPGKSPSANGLSQKHNDGKEENDIQTGSALLPLSPESKAWAVLTSDEESGSGQGTSDSLNENETSTDFSFADTNEKDADGILAAGDSEITPGFPQSPTSSVTSENSEVFHVSEAEASNSSHESRIGLAEGLESEKKAVIPLVIVSALTFICLVVLVGILIYWRKCFQTAHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSLDSNGAALPDGNIAESLESLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	Phosphorylation	QKNWGKKYPTCNSPK CCCCCCCCCCCCCCC	13.78	24719451
55	Phosphorylation	NWGKKYPTCNSPKQS CCCCCCCCCCCCCCC	22.64	24719451
60	Acetylation	YPTCNSPKQSPINID CCCCCCCCCCCCCCC	64.33	19828889
78	Acetylation	TQVNVNLKKLKFQGW CEECCCHHHCEECCC	51.35	19828897
101	Phosphorylation	FIHNTGKTVEINLTN EEECCCCEEEEECCC	25.39	30622161
105	N-linked_Glycosylation	TGKTVEINLTNDYRV CCCEEEEECCCCCEE	27.57	16335952
107	Phosphorylation	KTVEINLTNDYRVSG CEEEEECCCCCEECC	22.89	30622161
107	O-linked_Glycosylation	KTVEINLTNDYRVSG CEEEEECCCCCEECC	22.89	28657654
134	N-linked_Glycosylation	TFHWGKCNMSSDGSE EEEEECCCCCCCCCC	36.54	UniProtKB CARBOHYD
136	Phosphorylation	HWGKCNMSSDGSEHS EEECCCCCCCCCCCC	15.99	-
156	Phosphorylation	FPLEMQIYCFDADRF CCCEEEEEEEEHHHC	3.11	28270605
164	Phosphorylation	CFDADRFSSFEEAVK EEEHHHCCCHHHHHC	34.70	28270605
165	Phosphorylation	FDADRFSSFEEAVKG EEHHHCCCHHHHHCC	33.68	28270605
187	Phosphorylation	SILFEVGTEENLDFK HHHEECCCCCCCCHH	45.35	23879269
223	N-linked_Glycosylation	ILLNLLPNSTDKYYI HHHHCCCCCCCCEEE	58.47	UniProtKB CARBOHYD
232	N-linked_Glycosylation	TDKYYIYNGSLTSPP CCCEEEECCCCCCCC	24.82	UniProtKB CARBOHYD
293	Phosphorylation	REQQYKFSRQVFSSY HHHHHHHHHHHHHHC	20.04	24719451
324	N-linked_Glycosylation	NVQADPENYTSLLVT CCCCCCCCCCEEEEE	51.26	UniProtKB CARBOHYD
381	N-linked_Glycosylation	ILNNLLPNMSYVLQI HHHHHCCCHHHHHHH	31.81	UniProtKB CARBOHYD
479	O-linked_Glycosylation	TKYNEAKTNRSPTRG CCCCCCCCCCCCCCC	42.80	55827771
482	O-linked_Glycosylation	NEAKTNRSPTRGSEF CCCCCCCCCCCCCCC	32.47	55827777
484	O-linked_Glycosylation	AKTNRSPTRGSEFSG CCCCCCCCCCCCCCC	49.24	55827783
497	N-linked_Glycosylation	SGKGDVPNTSLNSTS CCCCCCCCCCCCCCC	41.99	UniProtKB CARBOHYD
501	N-linked_Glycosylation	DVPNTSLNSTSQPVT CCCCCCCCCCCCCCC	42.90	UniProtKB CARBOHYD
544	Phosphorylation	SLNDGSKTVLRSPHM ECCCCCCEEEECCCC	26.86	24719451
552	N-linked_Glycosylation	VLRSPHMNLSGTAES EEECCCCCCCCCCCC	28.20	UniProtKB CARBOHYD
587	O-linked_Glycosylation	DTGAEDSSGSSPATS CCCCCCCCCCCCCCC	55.82	-
600	O-linked_Glycosylation	TSAIPFISENISQGY CCCCCCCCCCCCCCE	25.60	55834893
602	N-linked_Glycosylation	AIPFISENISQGYIF CCCCCCCCCCCCEEE	32.21	UniProtKB CARBOHYD
604	O-linked_Glycosylation	PFISENISQGYIFSS CCCCCCCCCCEEECC	29.18	55834899
629	N-linked_Glycosylation	LIPESARNASEDSTS ECCHHHCCCCCCCCC	47.75	UniProtKB CARBOHYD
637	O-linked_Glycosylation	ASEDSTSSGSEESLK CCCCCCCCCCHHHHC	46.56	-
637	Phosphorylation	ASEDSTSSGSEESLK CCCCCCCCCCHHHHC	46.56	-
639	Phosphorylation	EDSTSSGSEESLKDP CCCCCCCCHHHHCCC	39.89	-
677	N-linked_Glycosylation	RESFLQTNYTEIRVD HHHHHCCCCEEEEEC	28.86	UniProtKB CARBOHYD
686	O-linked_Glycosylation	TEIRVDESEKTTKSF EEEEECCCCCCCCCC	39.67	55826247
689	O-linked_Glycosylation	RVDESEKTTKSFSAG EECCCCCCCCCCCCC	35.09	55826253
690	O-linked_Glycosylation	VDESEKTTKSFSAGP ECCCCCCCCCCCCCC	35.44	55826259
700	Phosphorylation	FSAGPVMSQGPSVTD CCCCCCCCCCCCCCC	32.02	26657352
721	O-linked_Glycosylation	STFAYFPTEVTPHAF EEEEECCCCCCCCCC	32.94	55828989
724	O-linked_Glycosylation	AYFPTEVTPHAFTPS EECCCCCCCCCCCCC	11.79	55828995
997	O-linked_Glycosylation	LSGDGEWSGASSDSE CCCCCCCCCCCCCCC	21.85	-
1017	N-linked_Glycosylation	TDGLTALNISSPVSV CCCCEEEECCCCCEE	29.63	UniProtKB CARBOHYD
1050	N-linked_Glycosylation	KSEIIYGNETELQIP CCEEEECCCCEEECC	35.72	UniProtKB CARBOHYD
1082	N-linked_Glycosylation	YDNVNKLNASLQETS HCCHHHHCHHHHHCE	29.14	UniProtKB CARBOHYD
1122	N-linked_Glycosylation	ISQVPENNFSVQPTH HHCCCCCCCCCCCCC	28.98	UniProtKB CARBOHYD
1211	Phosphorylation	SDPILVETPKVDKIS CCCEEECCCCCCCCC	22.41	-
1338	O-linked_Glycosylation	IHSDEILTSTKSSVT HCCCHHHHCCCCCCC	39.76	55831031
1339	O-linked_Glycosylation	HSDEILTSTKSSVTG CCCHHHHCCCCCCCC	30.32	55831035
1340	O-linked_Glycosylation	SDEILTSTKSSVTGK CCHHHHCCCCCCCCC	29.70	55831041
1396	O-linked_Glycosylation	STKLLFPSKATSELS EEEEECCCCCCCCCC	27.82	55823807
1399	Phosphorylation	LLFPSKATSELSHSA EECCCCCCCCCCCCC	26.86	28270605
1400	Phosphorylation	LFPSKATSELSHSAK ECCCCCCCCCCCCCC	41.21	28270605
1403	Phosphorylation	SKATSELSHSAKSDA CCCCCCCCCCCCCCC	16.02	28270605
1405	Phosphorylation	ATSELSHSAKSDAGL CCCCCCCCCCCCCCC	33.73	28270605
1421	Phosphorylation	GGGEDGDTDDDGDDD CCCCCCCCCCCCCCC	47.02	-
1457	N-linked_Glycosylation	ESQEKVMNDSDTHEN HHHHHHHCCCCHHCC	48.93	UniProtKB CARBOHYD
1478	Phosphorylation	NPISYSLSENSEEDN CCCCEECCCCCCCCC	28.88	25332170
1481	Phosphorylation	SYSLSENSEEDNRVT CEECCCCCCCCCCCE	38.01	25332170
1545	Phosphorylation	KAWAVLTSDEESGSG CCEEEEECCCCCCCC	38.57	29759185
1549	O-linked_Glycosylation	VLTSDEESGSGQGTS EEECCCCCCCCCCCC	35.89	-
1551	O-linked_Glycosylation	TSDEESGSGQGTSDS ECCCCCCCCCCCCCC	36.90	-
1562	N-linked_Glycosylation	TSDSLNENETSTDFS CCCCCCCCCCCCCCC	57.69	UniProtKB CARBOHYD
1618	N-linked_Glycosylation	VSEAEASNSSHESRI ECHHHHCCCCCHHHH	55.36	UniProtKB CARBOHYD
1668	Phosphorylation	YWRKCFQTAHFYLED HHHHHHCHHCEECCC	11.22	-
1672	Phosphorylation	CFQTAHFYLEDSTSP HHCHHCEECCCCCCC	10.18	-
1683	Phosphorylation	STSPRVISTPPTPIF CCCCCEECCCCCCCC	31.81	25850435
1684	Phosphorylation	TSPRVISTPPTPIFP CCCCEECCCCCCCCC	23.35	25850435
1687	Phosphorylation	RVISTPPTPIFPISD CEECCCCCCCCCCCC	30.16	25850435
1693	Phosphorylation	PTPIFPISDDVGAIP CCCCCCCCCCCCCEE	28.17	21406692
1756	Phosphorylation	DNKHKNRYINIVAYD CCCCCCCEEEEEEEC	14.02	24173317
1762	Phosphorylation	RYINIVAYDHSRVKL CEEEEEEECCCHHHH	11.86	24173317
1871	Phosphorylation	YYTVRNFTLRNTKIK EEEECCEEECCCEEC	28.49	24719451
1998	Phosphorylation	EAILSKETEVLDSHI HHHHCCCCHHHHHHH	34.82	24719451
2021	Phosphorylation	IPGPAGKTKLEKQFQ CCCCCCHHHHHHHHH	39.69	24719451
2031	Phosphorylation	EKQFQLLSQSNIQQS HHHHHHHHHCCCCHH	39.91	29978859
2033	Phosphorylation	QFQLLSQSNIQQSDY HHHHHHHCCCCHHHH	32.31	29978859
2038	Phosphorylation	SQSNIQQSDYSAALK HHCCCCHHHHHHHHH	23.34	29978859
2040	Phosphorylation	SNIQQSDYSAALKQC CCCCHHHHHHHHHHH	12.88	29978859
2041	Phosphorylation	NIQQSDYSAALKQCN CCCHHHHHHHHHHHH	16.44	29978859
2054	Phosphorylation	CNREKNRTSSIIPVE HHHHCCCCCCEEEEC	35.90	20639409
2055	Phosphorylation	NREKNRTSSIIPVER HHHCCCCCCEEEECH	19.12	8387522
2056	Phosphorylation	REKNRTSSIIPVERS HHCCCCCCEEEECHH	24.75	20639409
2179	Phosphorylation	LEATQDDYVLEVRHF HHHHCCCEEEEEEEC	18.41	24927040
2199	Phosphorylation	PNPDSPISKTFELIS CCCCCCCHHHHHHHH	29.09	-
2237	Phosphorylation	AGTFCALTTLMHQLE HHHHHHHHHHHHHHH	10.19	30377224
2238	Phosphorylation	GTFCALTTLMHQLEK HHHHHHHHHHHHHHH	23.96	30377224
2276	Phosphorylation	IEQYQFLYKVILSLV HHHHHHHHHHHHHHH	12.42	-
2281	Phosphorylation	FLYKVILSLVSTRQE HHHHHHHHHHHCCCC	18.66	21712546
2284	Phosphorylation	KVILSLVSTRQEENP HHHHHHHHCCCCCCC	24.14	22496350
2285	Phosphorylation	VILSLVSTRQEENPS HHHHHHHCCCCCCCC	28.97	18452278

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTPRZ_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTPRZ_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTPRZ_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CNTN1_HUMAN	CNTN1	physical	12700241
CTNB1_HUMAN	CTNNB1	physical	10706604
VEGFA_HUMAN	VEGFA	physical	25644401
PTN_HUMAN	PTN	physical	25644401

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry.";
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.;
J. Proteome Res. 4:2070-2080(2005).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-105, AND MASSSPECTROMETRY.
PubMed: 16335952