GASP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GASP2_HUMAN
• UniProt AC: Q96D09
• Protein Name: G-protein coupled receptor-associated sorting protein 2
• Gene Name: GPRASP2
• Organism: Homo sapiens (Human).
• Sequence Length: 838
• Protein Description: May play a role in regulation of a variety of G-protein coupled receptors..
• Protein Sequence: MTGAEIEPSAQAKPEKKAGEEVIAGPERENDVPLVVRPKVRTQATTGARPKTETKSVPAARPKTEAQAMSGARPKTEVQVMGGARPKTEAQGITGARPKTDARAVGGARSKTDAKAIPGARPKDEAQAWAQSEFGTEAVSQAEGVSQTNAVAWPLATAESGSVTKSKGLSMDRELVNVDAETFPGTQGQKGIQPWFGPGEETNMGSWCYSRPRAREEASNESGFWSADETSTASSFWTGEETSVRSWPREESNTRSRHRAKHQTNPRSRPRSKQEAYVDSWSGSEDEASNPFSFWVGENTNNLFRPRVREEANIRSKLRTNREDCFESESEDEFYKQSWVLPGEEANSRFRHRDKEDPNTALKLRAQKDVDSDRVKQEPRFEEEVIIGSWFWAEKEASLEGGASAICESEPGTEEGAIGGSAYWAEEKSSLGAVAREEAKPESEEEAIFGSWFWDRDEACFDLNPCPVYKVSDRFRDAAEELNASSRPQTWDEVTVEFKPGLFHGVGFRSTSPFGIPEEASEMLEAKPKNLELSPEGEEQESLLQPDQPSPEFTFQYDPSYRSVREIREHLRARESAESESWSCSCIQCELKIGSEEFEEFLLLMDKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSLIETLLNYPSSRVRTSFLENMIHMAPPYPNLNMIETFICQVCEETLAHSVDSLEQLTGIRMLRHLTMTIDYHTLIANYMSGFLSLLTTANARTKFHVLKMLLNLSENPAVAKKLFSAKALSIFVGLFNIEETNDNIQIVIKMFQNISNIIKSGKMSLIDDDFSLEPLISAFREFEELAKQLQAQIDNQNDPEVGQQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTGAEIEPS ------CCCCCCCCC	45.13	23401153
39	Ubiquitination	VPLVVRPKVRTQATT CCEEECCCCCCCCCC	33.51	21890473
42	Phosphorylation	VVRPKVRTQATTGAR EECCCCCCCCCCCCC	26.08	-
52	Phosphorylation	TTGARPKTETKSVPA CCCCCCCCCCCCCCC	52.12	-
54	Phosphorylation	GARPKTETKSVPAAR CCCCCCCCCCCCCCC	33.57	26657352
64	Phosphorylation	VPAARPKTEAQAMSG CCCCCCCHHHHHHCC	38.96	-
70	Phosphorylation	KTEAQAMSGARPKTE CHHHHHHCCCCCCCE	32.11	-
76	Phosphorylation	MSGARPKTEVQVMGG HCCCCCCCEEEEECC	44.03	-
100	Phosphorylation	ITGARPKTDARAVGG CCCCCCCCCCCCCCC	37.26	23312004
170	Phosphorylation	VTKSKGLSMDRELVN CCCCCCCCCCCEEEE	27.57	24719451
186	Phosphorylation	DAETFPGTQGQKGIQ CCCCCCCCCCCCCCC	29.75	22210691
219	Phosphorylation	PRAREEASNESGFWS CCHHHHHCCCCCCCC	44.39	30266825
222	Phosphorylation	REEASNESGFWSADE HHHHCCCCCCCCCCC	43.47	30266825
226	Phosphorylation	SNESGFWSADETSTA CCCCCCCCCCCCCCC	24.47	30266825
230	Phosphorylation	GFWSADETSTASSFW CCCCCCCCCCCCCCC	31.74	30266825
231	Phosphorylation	FWSADETSTASSFWT CCCCCCCCCCCCCCC	21.67	30266825
232	Phosphorylation	WSADETSTASSFWTG CCCCCCCCCCCCCCC	37.67	30266825
234	Phosphorylation	ADETSTASSFWTGEE CCCCCCCCCCCCCCC	26.59	30266825
235	Phosphorylation	DETSTASSFWTGEET CCCCCCCCCCCCCCC	23.49	30266825
246	Phosphorylation	GEETSVRSWPREESN CCCCCCCCCCCCCCC	39.00	27251275
277	Phosphorylation	PRSKQEAYVDSWSGS CCCCCHHEECCCCCC	12.20	28102081
280	Phosphorylation	KQEAYVDSWSGSEDE CCHHEECCCCCCCCC	17.07	29523821
282	Phosphorylation	EAYVDSWSGSEDEAS HHEECCCCCCCCCCC	36.07	22777824
284	Phosphorylation	YVDSWSGSEDEASNP EECCCCCCCCCCCCC	36.04	22777824
289	Phosphorylation	SGSEDEASNPFSFWV CCCCCCCCCCCCEEE	42.88	29523821
320	Phosphorylation	NIRSKLRTNREDCFE HHHHHCCCCHHHHCC	49.41	29978859
328	Phosphorylation	NREDCFESESEDEFY CHHHHCCCCCHHHHH	26.60	22617229
330	Phosphorylation	EDCFESESEDEFYKQ HHHCCCCCHHHHHHH	60.68	22617229
335	Phosphorylation	SESEDEFYKQSWVLP CCCHHHHHHHHCCCC	13.18	22617229
443	Phosphorylation	REEAKPESEEEAIFG CHHCCCCCHHHHHHC	59.85	27732954
510	Phosphorylation	FHGVGFRSTSPFGIP CCCCCCCCCCCCCCC	30.86	29255136
511	Phosphorylation	HGVGFRSTSPFGIPE CCCCCCCCCCCCCCH	35.84	29255136
512	Phosphorylation	GVGFRSTSPFGIPEE CCCCCCCCCCCCCHH	21.34	29255136
521	Phosphorylation	FGIPEEASEMLEAKP CCCCHHHHHHHHCCC	27.15	23403867
534	Phosphorylation	KPKNLELSPEGEEQE CCCCCCCCCCCHHHH	16.13	29523821
542	Phosphorylation	PEGEEQESLLQPDQP CCCHHHHHHCCCCCC	33.79	29523821
550	Phosphorylation	LLQPDQPSPEFTFQY HCCCCCCCCCCEEEC	31.28	29523821
554	Phosphorylation	DQPSPEFTFQYDPSY CCCCCCCEEECCCCC	14.25	29523821
557	Phosphorylation	SPEFTFQYDPSYRSV CCCCEEECCCCCHHH	26.15	29523821
617	Phosphorylation	DPFIHEISKIAMGMR CHHHHHHHHHHHHHC	18.28	-
618	Ubiquitination	PFIHEISKIAMGMRS HHHHHHHHHHHHHCC	39.90	-
641	Phosphorylation	IRDSGVVSLIETLLN HHHHCHHHHHHHHHC	22.63	22210691
645	Phosphorylation	GVVSLIETLLNYPSS CHHHHHHHHHCCCCH	29.56	-
649	Phosphorylation	LIETLLNYPSSRVRT HHHHHHCCCCHHHHH	12.40	22817900
652	Phosphorylation	TLLNYPSSRVRTSFL HHHCCCCHHHHHHHH	30.23	22210691
746	Phosphorylation	LKMLLNLSENPAVAK HHHHHHCCCCHHHHH	33.96	-
762	Phosphorylation	LFSAKALSIFVGLFN HHHHHHHHHHHHHHC	20.88	22817900
788	Phosphorylation	IKMFQNISNIIKSGK HHHHHHHHHHHHHCC	29.53	28060719
792	Ubiquitination	QNISNIIKSGKMSLI HHHHHHHHHCCCCCC	49.73	-
810	Phosphorylation	FSLEPLISAFREFEE CCHHHHHHHHHHHHH	29.10	24719451
820	Ubiquitination	REFEELAKQLQAQID HHHHHHHHHHHHHHH	65.25	-
838	Phosphorylation	DPEVGQQS------- CCHHCCCC-------	34.01	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GASP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GASP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GASP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LRIF1_HUMAN	LRIF1	physical	15383276
THIOM_HUMAN	TXN2	physical	21988832
THIO_HUMAN	TXN	physical	21988832
KS6A5_HUMAN	RPS6KA5	physical	21988832
MYOTI_HUMAN	MYOT	physical	21988832
AGO1_HUMAN	AGO1	physical	24778252
AGO2_HUMAN	AGO2	physical	24778252
ALMS1_HUMAN	ALMS1	physical	24778252
AP1G1_HUMAN	AP1G1	physical	24778252
AP1M1_HUMAN	AP1M1	physical	24778252
ASPM_HUMAN	ASPM	physical	24778252
NEPRO_HUMAN	C3orf17	physical	24778252
TAP26_HUMAN	CCDC59	physical	24778252
CCDC8_HUMAN	CCDC8	physical	24778252
CDC73_HUMAN	CDC73	physical	24778252
MIC19_HUMAN	CHCHD3	physical	24778252
COPE_HUMAN	COPE	physical	24778252
DIM1_HUMAN	DIMT1	physical	24778252
EIF3E_HUMAN	EIF3E	physical	24778252
UIF_HUMAN	FYTTD1	physical	24778252
GASP1_HUMAN	GPRASP1	physical	24778252
KEAP1_HUMAN	KEAP1	physical	24778252
LMNB2_HUMAN	LMNB2	physical	24778252
MAP7_HUMAN	MAP7	physical	24778252
MLF2_HUMAN	MLF2	physical	24778252
MYO9B_HUMAN	MYO9B	physical	24778252
NDUS7_HUMAN	NDUFS7	physical	24778252
PLPL6_HUMAN	PNPLA6	physical	24778252
RAF1_HUMAN	RAF1	physical	24778252
TCF25_HUMAN	TCF25	physical	24778252
TMM43_HUMAN	TMEM43	physical	24778252
TRI32_HUMAN	TRIM32	physical	24778252
WDR18_HUMAN	WDR18	physical	24778252
CF206_HUMAN	C6orf165	physical	25416956
CF206_HUMAN	C6orf165	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.