| UniProt ID | MIC19_HUMAN | |
|---|---|---|
| UniProt AC | Q9NX63 | |
| Protein Name | MICOS complex subunit MIC19 | |
| Gene Name | CHCHD3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 227 | |
| Subcellular Localization |
Mitochondrion inner membrane Lipid-anchor Intermembrane side . Cytoplasm . Nucleus . Mitochondrion . |
|
| Protein Description | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology. [PubMed: 25781180] | |
| Protein Sequence | MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDEELKRRVAEELALEQAKKESEDQKRLKQAKELDRERAAANEQLTRAILRERICSEEERAKAKHLARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFKRYESHPVCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQSMLEKGG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Myristoylation | ------MGGTTSTRR ------CCCCCCCCE | 25255805 | ||
| 11 | Phosphorylation | TTSTRRVTFEADENE CCCCCEEEEECCCCC | - | ||
| 29 | Phosphorylation | VVKGIRLSENVIDRM EEECEEECHHHHHHH | 30266825 | ||
| 35 | Methylation | LSENVIDRMKESSPS ECHHHHHHHHHCCCC | - | ||
| 39 | Phosphorylation | VIDRMKESSPSGSKS HHHHHHHCCCCCCCH | 26074081 | ||
| 40 | Phosphorylation | IDRMKESSPSGSKSQ HHHHHHCCCCCCCHH | 26074081 | ||
| 42 | Phosphorylation | RMKESSPSGSKSQRY HHHHCCCCCCCHHCC | 26074081 | ||
| 44 | Phosphorylation | KESSPSGSKSQRYSG HHCCCCCCCHHCCCC | 26074081 | ||
| 44 | O-linked_Glycosylation | KESSPSGSKSQRYSG HHCCCCCCCHHCCCC | 28411811 | ||
| 46 | Phosphorylation | SSPSGSKSQRYSGAY CCCCCCCHHCCCCCC | 23927012 | ||
| 49 | Phosphorylation | SGSKSQRYSGAYGAS CCCCHHCCCCCCCCC | 19664994 | ||
| 50 | Phosphorylation | GSKSQRYSGAYGASV CCCHHCCCCCCCCCC | 29255136 | ||
| 53 | Phosphorylation | SQRYSGAYGASVSDE HHCCCCCCCCCCCHH | 30266825 | ||
| 56 | Phosphorylation | YSGAYGASVSDEELK CCCCCCCCCCHHHHH | 30266825 | ||
| 58 | Phosphorylation | GAYGASVSDEELKRR CCCCCCCCHHHHHHH | 23927012 | ||
| 63 | Ubiquitination | SVSDEELKRRVAEEL CCCHHHHHHHHHHHH | 21906983 | ||
| 63 | Acetylation | SVSDEELKRRVAEEL CCCHHHHHHHHHHHH | 26051181 | ||
| 63 | 2-Hydroxyisobutyrylation | SVSDEELKRRVAEEL CCCHHHHHHHHHHHH | - | ||
| 76 | Succinylation | ELALEQAKKESEDQK HHHHHHHHHHCHHHH | 23954790 | ||
| 76 | Ubiquitination | ELALEQAKKESEDQK HHHHHHHHHHCHHHH | - | ||
| 76 | Malonylation | ELALEQAKKESEDQK HHHHHHHHHHCHHHH | 26320211 | ||
| 76 | Acetylation | ELALEQAKKESEDQK HHHHHHHHHHCHHHH | 25953088 | ||
| 77 | Ubiquitination | LALEQAKKESEDQKR HHHHHHHHHCHHHHH | - | ||
| 79 | Phosphorylation | LEQAKKESEDQKRLK HHHHHHHCHHHHHHH | 30108239 | ||
| 113 | Phosphorylation | ILRERICSEEERAKA HHHHHHCCHHHHHHH | 27273156 | ||
| 136 | Ubiquitination | EKDRVLKKQDAFYKE HHHHHHHHHHHHHHH | - | ||
| 136 | Malonylation | EKDRVLKKQDAFYKE HHHHHHHHHHHHHHH | 26320211 | ||
| 136 | 2-Hydroxyisobutyrylation | EKDRVLKKQDAFYKE HHHHHHHHHHHHHHH | - | ||
| 141 | Phosphorylation | LKKQDAFYKEQLARL HHHHHHHHHHHHHHH | - | ||
| 141 | Ubiquitination | LKKQDAFYKEQLARL HHHHHHHHHHHHHHH | - | ||
| 142 | Acetylation | KKQDAFYKEQLARLE HHHHHHHHHHHHHHH | 19608861 | ||
| 142 | 2-Hydroxyisobutyrylation | KKQDAFYKEQLARLE HHHHHHHHHHHHHHH | - | ||
| 142 | Ubiquitination | KKQDAFYKEQLARLE HHHHHHHHHHHHHHH | 21890473 | ||
| 147 | Acetylation | FYKEQLARLEERSSE HHHHHHHHHHHHCHH | 19608861 | ||
| 147 | Ubiquitination | FYKEQLARLEERSSE HHHHHHHHHHHHCHH | 19608861 | ||
| 159 | Phosphorylation | SSEFYRVTTEQYQKA CHHHHHHCHHHHHHH | 25219547 | ||
| 160 | Phosphorylation | SEFYRVTTEQYQKAA HHHHHHCHHHHHHHH | 25219547 | ||
| 163 | Phosphorylation | YRVTTEQYQKAAEEV HHHCHHHHHHHHHHH | 25219547 | ||
| 165 | Acetylation | VTTEQYQKAAEEVEA HCHHHHHHHHHHHHH | 26051181 | ||
| 165 | Ubiquitination | VTTEQYQKAAEEVEA HCHHHHHHHHHHHHH | 21890473 | ||
| 170 | Ubiquitination | YQKAAEEVEAKFKRY HHHHHHHHHHHHHHH | - | ||
| 173 | Acetylation | AAEEVEAKFKRYESH HHHHHHHHHHHHCCC | 25825284 | ||
| 177 | Phosphorylation | VEAKFKRYESHPVCA HHHHHHHHCCCCHHH | 28152594 | ||
| 178 | Ubiquitination | EAKFKRYESHPVCAD HHHHHHHCCCCHHHH | - | ||
| 178 | Acetylation | EAKFKRYESHPVCAD HHHHHHHCCCCHHHH | - | ||
| 179 | Phosphorylation | AKFKRYESHPVCADL HHHHHHCCCCHHHHH | 28152594 | ||
| 182 | Phosphorylation | KRYESHPVCADLQAK HHHCCCCHHHHHHHH | - | ||
| 189 | 2-Hydroxyisobutyrylation | VCADLQAKILQCYRE HHHHHHHHHHHHHHH | - | ||
| 189 | Ubiquitination | VCADLQAKILQCYRE HHHHHHHHHHHHHHH | 21890473 | ||
| 189 | Acetylation | VCADLQAKILQCYRE HHHHHHHHHHHHHHH | 25953088 | ||
| 194 | Phosphorylation | QAKILQCYRENTHQT HHHHHHHHHHCCCCH | 24641631 | ||
| 194 | Ubiquitination | QAKILQCYRENTHQT HHHHHHHHHHCCCCH | - | ||
| 198 | Phosphorylation | LQCYRENTHQTLKCS HHHHHHCCCCHHHHH | 26437602 | ||
| 201 | Phosphorylation | YRENTHQTLKCSALA HHHCCCCHHHHHHHH | 24641631 | ||
| 203 | Acetylation | ENTHQTLKCSALATQ HCCCCHHHHHHHHHH | 26051181 | ||
| 203 | Malonylation | ENTHQTLKCSALATQ HCCCCHHHHHHHHHH | 26320211 | ||
| 219 | Acetylation | MHCVNHAKQSMLEKG HHHHHHHHHHHHHCC | 26051181 | ||
| 230 | Ubiquitination | LEKGG---------- HHCCC---------- | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 11 | T | Phosphorylation | Kinase | PRKACA | P17612 | GPS |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MIC19_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MIC19_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| KR412_HUMAN | KRTAP4-12 | physical | 16189514 | |
| SMD3_HUMAN | SNRPD3 | physical | 22939629 | |
| FANCL_HUMAN | FANCL | physical | 25416956 | |
| RPGR1_HUMAN | RPGRIP1 | physical | 25416956 | |
| CCD33_HUMAN | CCDC33 | physical | 25416956 | |
| USBP1_HUMAN | USHBP1 | physical | 25416956 | |
| LZTS2_HUMAN | LZTS2 | physical | 25416956 | |
| RAB3I_HUMAN | RAB3IP | physical | 25416956 | |
| ADIP_HUMAN | SSX2IP | physical | 25416956 | |
| K1C40_HUMAN | KRT40 | physical | 25416956 | |
| SPERT_HUMAN | SPERT | physical | 25416956 | |
| NT2NL_HUMAN | NOTCH2NL | physical | 25416956 | |
| NDUA8_HUMAN | NDUFA8 | physical | 26344197 | |
| RAB8A_HUMAN | RAB8A | physical | 27173435 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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