RPGR1_HUMAN - dbPTM
RPGR1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RPGR1_HUMAN
UniProt AC Q96KN7
Protein Name X-linked retinitis pigmentosa GTPase regulator-interacting protein 1
Gene Name RPGRIP1
Organism Homo sapiens (Human).
Sequence Length 1286
Subcellular Localization Cell projection, cilium . Situated between the axonemal microtubules and the plasma membrane.
Protein Description May function as scaffolding protein. Required for normal location of RPGR at the connecting cilium of photoreceptor cells. Required for normal disk morphogenesis and disk organization in the outer segment of photoreceptor cells and for survival of photoreceptor cells..
Protein Sequence MSHLVDPTSGDLPVRDIDAIPLVLPASKGKNMKTQPPLSRMNREELEDSFFRLREDHMLVKELSWKQQDEIKRLRTTLLRLTAAGRDLRVAEEAAPLSETARRGQKAGWRQRLSMHQRPQMHRLQGHFHCVGPASPRRAQPRVQVGHRQLHTAGAPVPEKPKRGPRDRLSYTAPPSFKEHATNENRGEVASKPSELVSGSNSIISFSSVISMAKPIGLCMPNSAHIMASNTMQVEEPPKSPEKMWPKDENFEQRSSLECAQKAAELRASIKEKVELIRLKKLLHERNASLVMTKAQLTEVQEAYETLLQKNQGILSAAHEALLKQVNELRAELKEESKKAVSLKSQLEDVSILQMTLKEFQERVEDLEKERKLLNDNYDKLLESMLDSSDSSSQPHWSNELIAEQLQQQVSQLQDQLDAELEDKRKVLLELSREKAQNEDLKLEVTNILQKHKQEVELLQNAATISQPPDRQSEPATHPAVLQENTQIEPSEPKNQEEKKLSQVLNELQVSHAETTLELEKTRDMLILQRKINVCYQEELEAMMTKADNDNRDHKEKLERLTRLLDLKNNRIKQLEGILRSHDLPTSEQLKDVAYGTRPLSLCLETLPAHGDEDKVDISLLHQGENLFELHIHQAFLTSAALAQAGDTQPTTFCTYSFYDFETHCTPLSVGPQPLYDFTSQYVMETDSLFLHYLQEASARLDIHQAMASEHSTLAAGWICFDRVLETVEKVHGLATLIGAGGEEFGVLEYWMRLRFPIKPSLQACNKRKKAQVYLSTDVLGGRKAQEEEFRSESWEPQNELWIEITKCCGLRSRWLGTQPSPYAVYRFFTFSDHDTAIIPASNNPYFRDQARFPVLVTSDLDHYLRREALSIHVFDDEDLEPGSYLGRARVPLLPLAKNESIKGDFNLTDPAEKPNGSIQVQLDWKFPYIPPESFLKPEAQTKGKDTKDSSKISSEEEKASFPSQDQMASPEVPIEAGQYRSKRKPPHGGERKEKEHQVVSYSRRKHGKRIGVQGKNRMEYLSLNILNGNTPEQVNYTEWKFSETNSFIGDGFKNQHEEEEMTLSHSALKQKEPLHPVNDKESSEQGSEVSEAQTTDSDDVIVPPMSQKYPKADSEKMCIEIVSLAFYPEAEVMSDENIKQVYVEYKFYDLPLSETETPVSLRKPRAGEEIHFHFSKVIDLDPQEQQGRRRFLFDMLNGQDPDQGHLKFTVVSDPLDEEKKECEEVGYAYLQLWQILESGRDILEQELDIVSPEDLATPIGRLKVSLQAAAVLHAIYKEMTEDLFS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationSHLVDPTSGDLPVRD
CCCCCCCCCCCCCCC		35.38-
27PhosphorylationIPLVLPASKGKNMKT
EEEEEECCCCCCCCC		39.7532142685
34PhosphorylationSKGKNMKTQPPLSRM
CCCCCCCCCCCHHHC		35.2228348404
39PhosphorylationMKTQPPLSRMNREEL
CCCCCCHHHCCHHHH		34.9528348404
49PhosphorylationNREELEDSFFRLRED
CHHHHHHHHHHHHHH		19.5324719451
76PhosphorylationDEIKRLRTTLLRLTA
HHHHHHHHHHHHHHH		26.79-
135PhosphorylationFHCVGPASPRRAQPR
EEECCCCCCCCCCCC		23.2929449344
273UbiquitinationLRASIKEKVELIRLK
HHHHHHHHHHHHHHH		35.6929967540
502PhosphorylationNQEEKKLSQVLNELQ
CHHHHHHHHHHHHHH		27.4218077418
511PhosphorylationVLNELQVSHAETTLE
HHHHHHHCCCCHHHH		12.2018077418
522PhosphorylationTTLELEKTRDMLILQ
HHHHHHHHHHHHHHH		23.6418077418
536PhosphorylationQRKINVCYQEELEAM
HHHHHHHHHHHHHHH		18.06-
581PhosphorylationQLEGILRSHDLPTSE
HHHHHHHCCCCCCHH		20.2229759185
823PhosphorylationLGTQPSPYAVYRFFT
CCCCCCCCEEEEEEE		17.03-
826PhosphorylationQPSPYAVYRFFTFSD
CCCCCEEEEEEECCC		8.11-
846PhosphorylationIPASNNPYFRDQARF
EECCCCCCCCCCCCC		17.23-
858PhosphorylationARFPVLVTSDLDHYL
CCCCEEECCCHHHHH		16.6228348404
859PhosphorylationRFPVLVTSDLDHYLR
CCCEEECCCHHHHHH		28.7928348404
864PhosphorylationVTSDLDHYLRREALS
ECCCHHHHHHHHCEE		11.1118083107
929PhosphorylationQLDWKFPYIPPESFL
EEEEECCCCCHHHHC		29.2318083107
934PhosphorylationFPYIPPESFLKPEAQ
CCCCCHHHHCCHHHC		41.4724719451
947PhosphorylationAQTKGKDTKDSSKIS
HCCCCCCCCCHHHCC		39.99-
1001PhosphorylationEKEHQVVSYSRRKHG
CCCCEEEEEEHHHCC		20.66-
1002PhosphorylationKEHQVVSYSRRKHGK
CCCEEEEEEHHHCCC		8.45-
1003PhosphorylationEHQVVSYSRRKHGKR
CCEEEEEEHHHCCCC		20.36-
10162-HydroxyisobutyrylationKRIGVQGKNRMEYLS
CCEECCCCCHHHEEE		25.04-
1091PhosphorylationSEQGSEVSEAQTTDS
CCCCCCCCCCCCCCC		24.14-
1115PhosphorylationQKYPKADSEKMCIEI
CCCCCCCCHHCCCHH		43.93-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RPGR1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RPGR1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RPGR1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RPGR_HUMANRPGRphysical
10958648
CBX8_HUMANCBX8physical
25416956
P66B_HUMANGATAD2Bphysical
25416956
CC146_HUMANCCDC146physical
25416956
TRIB3_HUMANTRIB3physical
25416956
AEN_HUMANAENphysical
25416956
SCNM1_HUMANSCNM1physical
25416956
CSPP1_HUMANCSPP1physical
25416956
RP25L_HUMANRPP25Lphysical
25416956
ZN417_HUMANZNF417physical
25416956
ZN564_HUMANZNF564physical
25416956
ACDSB_HUMANACADSBphysical
26638075
PUR8_HUMANADSLphysical
26638075
CCD22_HUMANCCDC22physical
26638075
CEP85_HUMANCEP85physical
26638075
DLG5_HUMANDLG5physical
26638075
ECD_HUMANECDphysical
26638075
HAUS8_HUMANHAUS8physical
26638075
DHB4_HUMANHSD17B4physical
26638075
IBTK_HUMANIBTKphysical
26638075
IFT74_HUMANIFT74physical
26638075
IPO5_HUMANIPO5physical
26638075
K1671_HUMANKIAA1671physical
26638075
KIF14_HUMANKIF14physical
26638075
NP1L1_HUMANNAP1L1physical
26638075
NP1L4_HUMANNAP1L4physical
26638075
NPHP4_HUMANNPHP4physical
26638075
RBM8A_HUMANRBM8Aphysical
26638075
RPGR_HUMANRPGRphysical
26638075
SDCG3_HUMANSDCCAG3physical
26638075
ASPP2_HUMANTP53BP2physical
26638075
UN45A_HUMANUNC45Aphysical
26638075
WDR83_HUMANWDR83physical
26638075
CP131_HUMANCEP131physical
26638075
COMD2_HUMANCOMMD2physical
26638075
CSPP1_HUMANCSPP1physical
26638075
GPTC1_HUMANGPATCH1physical
26638075
HAUS6_HUMANHAUS6physical
26638075
IPO7_HUMANIPO7physical
26638075
IPO8_HUMANIPO8physical
26638075
IPO9_HUMANIPO9physical
26638075
MKL1_HUMANMKL1physical
26638075
NEK4_HUMANNEK4physical
26638075
OFD1_HUMANOFD1physical
26638075
PCM1_HUMANPCM1physical
26638075
TNR6B_HUMANTNRC6Bphysical
26638075
TRI37_HUMANTRIM37physical
26638075
RPGR_HUMANRPGRphysical
27173435
NEK4_HUMANNEK4physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
613826Leber congenital amaurosis 6 (LCA6)
608194Cone-rod dystrophy 13 (CORD13)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RPGR1_HUMAN

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Related Literatures of Post-Translational Modification

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