SDCG3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SDCG3_HUMAN
• UniProt AC: Q96C92
• Protein Name: Serologically defined colon cancer antigen 3
• Gene Name: SDCCAG3
• Organism: Homo sapiens (Human).
• Sequence Length: 435
• Subcellular Localization: Cytoplasm . Midbody . Early endosome . Recycling endosome . During cytokinesis colocalized with PTPN13 at the midbody (PubMed:23108400). Colocalizes in a WASHC2-dependent manner with the retromer CSC complex at endosomes (PubMed:25278552).
• Protein Description: May be involved in modulation of TNF response. May be involved in presentation of TNFRSF1A on the cell surface (By similarity). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. [PubMed: 25278552 Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1]
• Protein Sequence: MSGYQRRPGATPLSRARSLAIPDAPAFYERRSCLPQLNCERPHGRDLDSPFFGIRPAFMCYVPSPVLASVGDTDFGYGKGKCSKQSPSGAHGTHFGDDRFEDLEEANPFSFREFLKTKNLGLSKEDPASRIYAKEASRHSLGLDHNSPPSQTGGYGLEYQQPFFEDPTGAGDLLDEEEDEDTGWSGAYLPSAIEQTHPERVPAGTSPCSTYLSFFSTPSELAGPESLPSWALSDTDSRVSPASPAGSPSADFAVHGESLGDRHLRTLQISYDALKDENSKLRRKLNEVQSFSEAQTEMVRTLERKLEAKMIKEESDYHDLESVVQQVEQNLELMTKRAVKAENHVVKLKQEISLLQAQVSNFQRENEALRCGQGASLTVVKQNADVALQNLRVVMNSAQASIKQLVSGAETLNLVAEILKSIDRISEVKDEEEDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66 (in isoform 3)	Ubiquitination	-	9.05	21890473
101 (in isoform 2)	Ubiquitination	-	63.68	21890473
124 (in isoform 1)	Ubiquitination	-	71.79	21890473
222 (in isoform 3)	Ubiquitination	-	27.69	21890473
257 (in isoform 2)	Ubiquitination	-	28.10	21890473
280 (in isoform 1)	Ubiquitination	-	58.56	21890473
291 (in isoform 3)	Ubiquitination	-	4.23	21890473
326 (in isoform 2)	Ubiquitination	-	29.16	21890473
349 (in isoform 1)	Ubiquitination	-	39.92	21890473
371 (in isoform 3)	Ubiquitination	-	5.06	21890473
406 (in isoform 2)	Ubiquitination	-	4.61	21890473
429 (in isoform 1)	Ubiquitination	-	56.20	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SDCG3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SDCG3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SDCG3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHD3_HUMAN	CHD3	physical	16169070
GIT1_HUMAN	GIT1	physical	16169070
VIME_HUMAN	VIM	physical	16169070
A4_HUMAN	APP	physical	21832049
TFPT_HUMAN	TFPT	physical	25416956
AP1M1_HUMAN	AP1M1	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243 AND SER-247, ANDMASS SPECTROMETRY.
PubMed: 19690332

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-243 AND SER-247, ANDMASS SPECTROMETRY.
PubMed: 18669648