CC146_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CC146_HUMAN
• UniProt AC: Q8IYE0
• Protein Name: Coiled-coil domain-containing protein 146
• Gene Name: CCDC146
• Organism: Homo sapiens (Human).
• Sequence Length: 955
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Localized to only one centriole identified as the mother centriole by co-staining with CEP164.
• Protein Sequence: MEDSSTDTEKEEEEEKDEKDQEPIYAIVPTINIQDERFVDLSETPAFIFLHELHAMGKLPGTRMAALKAKYTLLHDAVMSTQESEVQLLQNAKRFTEQIQQQQFHLQQADNFPEAFSTEVSKMREQLLKYQNEYNAVKEREFHNQYRLNSLKEEKIIIVKEFEKITKPGEMEKKMKILRESTEELRKEIMQKKLEIKNLREDLASKQKQLLKEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQEVKTLNDSLKKVENKVSAIVDEKENVIKEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLNLRNSLIDKQNYHDELSRKQREKERDFRNLRKMELLLKVSWDALRQTQALHQRLLLEMEAIPKDDSTLSERRRELHKEVEVAKRNLAQQKIISEMESKLVEQQLAEENKLLKEQENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLREFAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNVTIRESMQNDVRKIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNESGVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRSLDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKKEEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELSMKQALTIELQKEVREKEDFIFTCNSRIEKGLPLNKEIEKEWLKVLRDEEMHALAIAEKSQEFLEADNRQLPNGVYTTAEQRPNAYIPEADATLPLPKPYGALAPFKPSEPGANMRHIRKPVIKPVEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MEDSSTDTEKEE ---CCCCCCCCHHHH	42.50	-
8	Phosphorylation	MEDSSTDTEKEEEEE CCCCCCCCHHHHHHH	49.39	-
62	Phosphorylation	AMGKLPGTRMAALKA HCCCCCHHHHHHHHH	18.48	24719451
166	Phosphorylation	VKEFEKITKPGEMEK EEEHHHCCCCCHHHH	42.10	29083192
181	Phosphorylation	KMKILRESTEELRKE HHHHHHHCHHHHHHH	34.38	26074081
182	Phosphorylation	MKILRESTEELRKEI HHHHHHCHHHHHHHH	28.82	26074081
252	Acetylation	IEKITRKKVEMEKKK HHHHCHHCCHHHHHH	39.89	30587505
258	Acetylation	KKVEMEKKKIVLEQE HCCHHHHHHHHHHHH	34.13	30587509
268	Phosphorylation	VLEQEVKTLNDSLKK HHHHHHHHHHHHHHH	35.65	27251275
351	Phosphorylation	QNYHDELSRKQREKE CCHHHHHHHHHHHHH	35.07	-
462	Phosphorylation	VVNLLRMTQIKIDEK HHHHHHHHCCCCCHH	22.25	-
493	Acetylation	IVKEMKAKDLEIRIH HHHHHHHCCCCEEEE	58.28	30587513
543	Ubiquitination	HQKVNEIKERHKMSL HHHHHHHHHHHCCCH	42.38	-
559	Phosphorylation	ELEILRNSAVSQERK HHHHHHHHHHCHHHH	24.50	24719451
809	Phosphorylation	LAKKMNGYQRRIKNA HHHHHCHHHHHHHHH	8.21	-
817	Phosphorylation	QRRIKNATEKMMALV HHHHHHHHHHHHHHH	45.60	-
828	Phosphorylation	MALVAELSMKQALTI HHHHHHHHHHHHHHH	18.55	25072903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CC146_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CC146_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CC146_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RINT1_HUMAN	RINT1	physical	25416956
CC136_HUMAN	CCDC136	physical	25416956
CEP44_HUMAN	CEP44	physical	25416956
T22D4_HUMAN	TSC22D4	physical	25416956
USBP1_HUMAN	USHBP1	physical	25416956
DTBP1_HUMAN	DTNBP1	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
SPERT_HUMAN	SPERT	physical	25416956
GEMI_HUMAN	GMNN	physical	26186194
RAB3I_HUMAN	RAB3IP	physical	26186194
TRAF1_HUMAN	TRAF1	physical	21516116
GEMI_HUMAN	GMNN	physical	28514442
RAB3I_HUMAN	RAB3IP	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.