CEP44_HUMAN - dbPTM
CEP44_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CEP44_HUMAN
UniProt AC Q9C0F1
Protein Name Centrosomal protein of 44 kDa
Gene Name CEP44
Organism Homo sapiens (Human).
Sequence Length 390
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Midbody . Localizes to centrosomes, spindle poles, and weakly in midbody.
Protein Description
Protein Sequence MATGDLKRSLRNLEQVLRLLNYPEEVDCVGLIKGDPAASLPIISYSFTSYSPYVTELIMESNVELIAKNDLRFIDAVYKLLRDQFNYKPILTKKQFIQCGFAEWKIQIVCDILNCVMKKHKELSSLQKIPSQQRKKISSGKSEPPLGNEKISAEAVGVDISGRFMTSGKKKAVVIRHLYNEDNVDISEDTLSPITDVNEAVDVSDLNATEIKMPEVKVPEIKAEQQDVNVNPEITALQTMLAECQENLKKLTSIEKRLDCLEQKMKGKVMVDENTWTNLLSRVTLLETEMLLSKKNDEFIEFNEVSEDYASCSDMDLLNPHRKSEVERPASIPLSSGYSTASSDSTPRASTVNYCGLNEISEETTIQKMERMKKMFEETAELLKCPNHYL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
22PhosphorylationQVLRLLNYPEEVDCV
HHHHHCCCCCCCCEE		16.40-
88UbiquitinationLRDQFNYKPILTKKQ
HHHHCCCCCCCCHHH		27.0429967540
93UbiquitinationNYKPILTKKQFIQCG
CCCCCCCHHHHHHCC		40.9229967540
94UbiquitinationYKPILTKKQFIQCGF
CCCCCCHHHHHHCCC		45.25-
119UbiquitinationILNCVMKKHKELSSL
HHHHHHHHHHHHHHH		41.6429967540
121UbiquitinationNCVMKKHKELSSLQK
HHHHHHHHHHHHHCC		70.0529967540
124PhosphorylationMKKHKELSSLQKIPS
HHHHHHHHHHCCCCH		30.0529214152
125PhosphorylationKKHKELSSLQKIPSQ
HHHHHHHHHCCCCHH		47.6629214152
128UbiquitinationKELSSLQKIPSQQRK
HHHHHHCCCCHHHHH		62.9729967540
131PhosphorylationSSLQKIPSQQRKKIS
HHHCCCCHHHHHCCC		42.28-
150UbiquitinationEPPLGNEKISAEAVG
CCCCCCCCCCCEEEC		46.0629967540
161PhosphorylationEAVGVDISGRFMTSG
EEECEEECCCEECCC		21.3228555341
166PhosphorylationDISGRFMTSGKKKAV
EECCCEECCCCCEEE		31.4529449344
167PhosphorylationISGRFMTSGKKKAVV
ECCCEECCCCCEEEE		36.5129449344
178UbiquitinationKAVVIRHLYNEDNVD
EEEEEECCCCCCCCC		3.3622817900
179UbiquitinationAVVIRHLYNEDNVDI
EEEEECCCCCCCCCC		15.4722817900
187PhosphorylationNEDNVDISEDTLSPI
CCCCCCCCCCCCCCC		25.5928348404
190PhosphorylationNVDISEDTLSPITDV
CCCCCCCCCCCCCCH		25.6928348404
192PhosphorylationDISEDTLSPITDVNE
CCCCCCCCCCCCHHC		19.1528348404
195PhosphorylationEDTLSPITDVNEAVD
CCCCCCCCCHHCCCC		36.9628348404
222UbiquitinationEVKVPEIKAEQQDVN
CCCCCCCCHHHCCCC		44.1829967540
249UbiquitinationAECQENLKKLTSIEK
HHHHHHHHHHHHHHH		58.2729967540
256UbiquitinationKKLTSIEKRLDCLEQ
HHHHHHHHHHHHHHH		57.5029967540
264MalonylationRLDCLEQKMKGKVMV
HHHHHHHHHCCCEEE		32.9526320211
264AcetylationRLDCLEQKMKGKVMV
HHHHHHHHHCCCEEE		32.9525953088
264UbiquitinationRLDCLEQKMKGKVMV
HHHHHHHHHCCCEEE		32.9529967540
268UbiquitinationLEQKMKGKVMVDENT
HHHHHCCCEEECCCH		22.9522505724
294UbiquitinationETEMLLSKKNDEFIE
HHHHHHCCCCCCCCC		56.4122817900
295UbiquitinationTEMLLSKKNDEFIEF
HHHHHCCCCCCCCCH		67.2822817900
306PhosphorylationFIEFNEVSEDYASCS
CCCHHHCCCCHHCCC		20.6928796482
309PhosphorylationFNEVSEDYASCSDMD
HHHCCCCHHCCCCHH		9.0728796482
311PhosphorylationEVSEDYASCSDMDLL
HCCCCHHCCCCHHHC		14.1328796482
313PhosphorylationSEDYASCSDMDLLNP
CCCHHCCCCHHHCCC		33.2128796482
323UbiquitinationDLLNPHRKSEVERPA
HHCCCCCCCCCCCCC		48.1929967540
324PhosphorylationLLNPHRKSEVERPAS
HCCCCCCCCCCCCCC		47.0025159151
331PhosphorylationSEVERPASIPLSSGY
CCCCCCCCCCCCCCC		27.6725159151
335O-linked_GlycosylationRPASIPLSSGYSTAS
CCCCCCCCCCCCCCC		19.1623301498
335PhosphorylationRPASIPLSSGYSTAS
CCCCCCCCCCCCCCC		19.1626074081
336PhosphorylationPASIPLSSGYSTASS
CCCCCCCCCCCCCCC		49.8128796482
338PhosphorylationSIPLSSGYSTASSDS
CCCCCCCCCCCCCCC		12.5628796482
339PhosphorylationIPLSSGYSTASSDST
CCCCCCCCCCCCCCC		22.4828796482
340PhosphorylationPLSSGYSTASSDSTP
CCCCCCCCCCCCCCC		23.2928796482
342PhosphorylationSSGYSTASSDSTPRA
CCCCCCCCCCCCCCC		34.4628796482
343PhosphorylationSGYSTASSDSTPRAS
CCCCCCCCCCCCCCC		32.8728450419
345PhosphorylationYSTASSDSTPRASTV
CCCCCCCCCCCCCCC		42.1128450419
346PhosphorylationSTASSDSTPRASTVN
CCCCCCCCCCCCCCC		23.0625159151
350PhosphorylationSDSTPRASTVNYCGL
CCCCCCCCCCCCCCC		33.8826074081
351PhosphorylationDSTPRASTVNYCGLN
CCCCCCCCCCCCCCC		16.2826074081
354PhosphorylationPRASTVNYCGLNEIS
CCCCCCCCCCCCCCC		5.4228796482
368UbiquitinationSEETTIQKMERMKKM
CCHHHHHHHHHHHHH		38.5929967540
374UbiquitinationQKMERMKKMFEETAE
HHHHHHHHHHHHHHH		39.2129967540
379PhosphorylationMKKMFEETAELLKCP
HHHHHHHHHHHHCCC		20.4523532336
384MethylationEETAELLKCPNHYL-
HHHHHHHCCCCCCC-		61.34-
384UbiquitinationEETAELLKCPNHYL-
HHHHHHHCCCCCCC-		61.3422505724
389PhosphorylationLLKCPNHYL------
HHCCCCCCC------		22.28-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CEP44_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CEP44_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CEP44_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SPERT_HUMANSPERTphysical
16189514
F161A_HUMANFAM161Aphysical
25416956
ING5_HUMANING5physical
25416956
ZN587_HUMANZNF587physical
25416956
TRI41_HUMANTRIM41physical
25416956
DHX57_HUMANDHX57physical
25416956
MR1L1_HUMANMRFAP1L1physical
25416956
HAUS1_HUMANHAUS1physical
25416956
ZN417_HUMANZNF417physical
25416956
TXLNA_HUMANTXLNAphysical
25416956
SPERT_HUMANSPERTphysical
25416956
BEND7_HUMANBEND7physical
25416956
CE57L_HUMANCEP57L1physical
25416956
ANR28_HUMANANKRD28physical
26638075
ANR52_HUMANANKRD52physical
26638075
AP3M1_HUMANAP3M1physical
26638075
APBB1_HUMANAPBB1physical
26638075
SKAP_HUMANKNSTRNphysical
26638075
CAMP1_HUMANCAMSAP1physical
26638075
C2D1A_HUMANCC2D1Aphysical
26638075
CC85C_HUMANCCDC85Cphysical
26638075
CE170_HUMANCEP170physical
26638075
CEP85_HUMANCEP85physical
26638075
DCTN2_HUMANDCTN2physical
26638075
DNJA1_HUMANDNAJA1physical
26638075
DVL1_HUMANDVL1physical
26638075
DVL2_HUMANDVL2physical
26638075
DVL3_HUMANDVL3physical
26638075
ECD_HUMANECDphysical
26638075
EXOC4_HUMANEXOC4physical
26638075
FR1OP_HUMANFGFR1OPphysical
26638075
FOXO3_HUMANFOXO3physical
26638075
GPTC1_HUMANGPATCH1physical
26638075
HAUS1_HUMANHAUS1physical
26638075
HAUS3_HUMANHAUS3physical
26638075
HAUS5_HUMANHAUS5physical
26638075
HAUS6_HUMANHAUS6physical
26638075
HAUS7_HUMANHAUS7physical
26638075
HAUS8_HUMANHAUS8physical
26638075
IBTK_HUMANIBTKphysical
26638075
LRC49_HUMANLRRC49physical
26638075
LTV1_HUMANLTV1physical
26638075
MA7D3_HUMANMAP7D3physical
26638075
PHOCN_HUMANMOB4physical
26638075
NCK2_HUMANNCK2physical
26638075
NEDD1_HUMANNEDD1physical
26638075
NRBF2_HUMANNRBF2physical
26638075
OFD1_HUMANOFD1physical
26638075
PASK_HUMANPASKphysical
26638075
PKN2_HUMANPKN2physical
26638075
PPP6_HUMANPPP6Cphysical
26638075
PP6R1_HUMANPPP6R1physical
26638075
PP6R3_HUMANPPP6R3physical
26638075
RGPD3_HUMANRGPD3physical
26638075
SIR1_HUMANSIRT1physical
26638075
SMG7_HUMANSMG7physical
26638075
SPAG5_HUMANSPAG5physical
26638075
TBK1_HUMANTBK1physical
26638075
TCHP_HUMANTCHPphysical
26638075
TNIP1_HUMANTNIP1physical
26638075
TNR6B_HUMANTNRC6Bphysical
26638075
TNR6C_HUMANTNRC6Cphysical
26638075
ASPP2_HUMANTP53BP2physical
26638075
TRIP6_HUMANTRIP6physical
26638075
TTK_HUMANTTKphysical
26638075
TXLNG_HUMANTXLNGphysical
26638075
WDR62_HUMANWDR62physical
26638075
WDR83_HUMANWDR83physical
26638075
XRN1_HUMANXRN1physical
26638075
ZC21A_HUMANZC2HC1Aphysical
26638075
ZC3HF_HUMANZC3H15physical
26638075
ZN598_HUMANZNF598physical
26638075
RECK_HUMANRECKphysical
21516116
KLHL7_HUMANKLHL7physical
27173435
GLI3_HUMANGLI3physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CEP44_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-346, AND MASSSPECTROMETRY.

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