| UniProt ID | KLHL7_HUMAN | |
|---|---|---|
| UniProt AC | Q8IXQ5 | |
| Protein Name | Kelch-like protein 7 | |
| Gene Name | KLHL7 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 586 | |
| Subcellular Localization | Nucleus . Cytoplasm . Colocalizes with CUL3 in punctate structures at the perinuclear region of the cytoplasm. | |
| Protein Description | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination.. | |
| Protein Sequence | MAASGVEKSSKKKTEKKLAAREEAKLLAGFMGVMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRAFPVTSCLICVVDTCGANEETLET | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | O-linked_Glycosylation | ----MAASGVEKSSK ----CCCCCCCCCCC | 33.56 | 30379171 | |
| 5 (in isoform 2) | O-linked_Glycosylation | - | 27.20 | 30379171 | |
| 21 | Dimethylation | TEKKLAAREEAKLLA HHHHHHHHHHHHHHH | 36.36 | - | |
| 21 | Methylation | TEKKLAAREEAKLLA HHHHHHHHHHHHHHH | 36.36 | 24376927 | |
| 38 | Dimethylation | MGVMNNMRKQKTLCD HHHHHHHHHHHCHHH | 40.14 | - | |
| 38 | Methylation | MGVMNNMRKQKTLCD HHHHHHHHHHHCHHH | 40.14 | 24376935 | |
| 74 | Phosphorylation | HFFNLMFTTNMLESK HHHHHHHCCCCCCCC | 11.86 | 26503514 | |
| 75 | Phosphorylation | FFNLMFTTNMLESKS HHHHHHCCCCCCCCC | 13.83 | 26503514 | |
| 80 | Phosphorylation | FTTNMLESKSFEVEL HCCCCCCCCCEEEEE | 29.64 | 26503514 | |
| 82 | Phosphorylation | TNMLESKSFEVELKD CCCCCCCCEEEEECC | 35.60 | 25003641 | |
| 130 | Ubiquitination | QYQIEPVKKMCVDFL HHCCHHHHHHHHHHH | 45.57 | 21906983 | |
| 166 (in isoform 2) | Ubiquitination | - | 47.18 | - | |
| 174 | Phosphorylation | DFIHQHFTEVYKTDE HHHHHHHHHHCCCCC | 23.55 | - | |
| 188 | Ubiquitination | EFLQLDVKRVTHLLN CCHHCHHHHHHHHHC | 40.60 | 21906983 | |
| 198 | Phosphorylation | THLLNQDTLTVRAED HHHHCCCCEEEEEHH | 17.98 | 20068231 | |
| 200 | Phosphorylation | LLNQDTLTVRAEDQV HHCCCCEEEEEHHHH | 15.27 | 20068231 | |
| 208 | Phosphorylation | VRAEDQVYDAAVRWL EEEHHHHHHHHHHHH | 8.33 | 27642862 | |
| 239 | Phosphorylation | KVRFPLISKNFLSKT HCCCCCCCCCCCCCC | 29.27 | 21406692 | |
| 240 | Ubiquitination | VRFPLISKNFLSKTV CCCCCCCCCCCCCCC | 44.73 | - | |
| 245 | Ubiquitination | ISKNFLSKTVQAEPL CCCCCCCCCCCCCCH | 55.66 | - | |
| 261 | Ubiquitination | QDNPECLKMVISGMR CCCHHHHHHHHHHCC | 42.66 | - | |
| 273 | Phosphorylation | GMRYHLLSPEDREEL HCCEECCCHHHHHHH | 32.38 | 29214152 | |
| 312 | Ubiquitination | SCRYFNPKDYSWTDI CCCCCCCCCCCCCCC | 71.10 | - | |
| 359 | Ubiquitination | MDCYNVVKDSWYSKL CCCCHHHCCCHHHHC | 41.59 | - | |
| 365 | Ubiquitination | VKDSWYSKLGPPTPR HCCCHHHHCCCCCCH | 41.59 | - | |
| 370 | Phosphorylation | YSKLGPPTPRDSLAA HHHCCCCCCHHHHHH | 33.80 | 24719451 | |
| 413 | Ubiquitination | RTESWHTKPSMLTQR CCCCCCCCHHHHCCC | 23.39 | 21906983 | |
| 415 | Phosphorylation | ESWHTKPSMLTQRCS CCCCCCHHHHCCCCC | 28.16 | 20860994 | |
| 418 | Phosphorylation | HTKPSMLTQRCSHGM CCCHHHHCCCCCCCE | 12.82 | 20860994 | |
| 472 | Ubiquitination | CPMIEARKNHGLVFV HHHHHHHHHCCEEEE | 61.41 | - | |
| 480 | Ubiquitination | NHGLVFVKDKIFAVG HCCEEEECCEEEEEC | 41.67 | - | |
| 482 (in isoform 2) | Ubiquitination | - | 33.72 | - | |
| 495 (in isoform 2) | Ubiquitination | - | 4.03 | 21890473 | |
| 495 | Ubiquitination | GQNGLGGLDNVEYYD CCCCCCCCCCCEEEE | 4.03 | 21890473 | |
| 504 | Ubiquitination | NVEYYDIKLNEWKMV CCEEEEEEECEEEEE | 42.22 | 21906983 | |
| 517 | Ubiquitination | MVSPMPWKGVTVKCA EECCCCCCCCEEECC | 37.32 | 21890473 | |
| 517 (in isoform 1) | Ubiquitination | - | 37.32 | 21890473 | |
| 520 | Phosphorylation | PMPWKGVTVKCAAVG CCCCCCCEEECCHHH | 23.94 | - | |
| 538 (in isoform 2) | Ubiquitination | - | 22.91 | - | |
| 550 | Phosphorylation | GHILEYNTETDKWVA HHHHEEECCCCCCCC | 39.08 | - | |
| 560 | Ubiquitination | DKWVANSKVRAFPVT CCCCCCCCCCCCCCC | 35.23 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KLHL7_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KLHL7_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KLHL7_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CUL3_HUMAN | CUL3 | physical | 21828050 | |
| RBX1_HUMAN | RBX1 | physical | 21828050 | |
| KLHL7_HUMAN | KLHL7 | physical | 21828050 | |
| UBC_HUMAN | UBC | physical | 21828050 | |
| GLI3_HUMAN | GLI3 | physical | 27173435 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 612943 | Retinitis pigmentosa 42 (RP42) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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