dbPTM

ASPP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ASPP2_HUMAN
UniProt AC	Q13625
Protein Name	Apoptosis-stimulating of p53 protein 2
Gene Name	TP53BP2
Organism	Homo sapiens (Human).
Sequence Length	1128
Subcellular Localization	Cytoplasm, perinuclear region. Nucleus. Predominantly found in the perinuclear region. Some small fraction is nuclear. Sequester in the cytoplasm on overexpression of DDX42.
Protein Description	Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42..
Protein Sequence	MMPMFLTVYLSNNEQHFTEVPVTPETICRDVVDLCKEPGESDCHLAEVWCGSERPVADNERMFDVLQRFGSQRNEVRFFLRHERPPGRDIVSGPRSQDPSLKRNGVKVPGEYRRKENGVNSPRMDLTLAELQEMASRQQQQIEAQQQLLATKEQRLKFLKQQDQRQQQQVAEQEKLKRLKEIAENQEAKLKKVRALKGHVEQKRLSNGKLVEEIEQMNNLFQQKQRELVLAVSKVEELTRQLEMLKNGRIDSHHDNQSAVAELDRLYKELQLRNKLNQEQNAKLQQQRECLNKRNSEVAVMDKRVNELRDRLWKKKAALQQKENLPVSSDGNLPQQAASAPSRVAAVGPYIQSSTMPRMPSRPELLVKPALPDGSLVIQASEGPMKIQTLPNMRSGAASQTKGSKIHPVGPDWSPSNADLFPSQGSASVPQSTGNALDQVDDGEVPLREKEKKVRPFSMFDAVDQSNAPPSFGTLRKNQSSEDILRDAQVANKNVAKVPPPVPTKPKQINLPYFGQTNQPPSDIKPDGSSQQLSTVVPSMGTKPKPAGQQPRVLLSPSIPSVGQDQTLSPGSKQESPPAAAVRPFTPQPSKDTLLPPFRKPQTVAASSIYSMYTQQQAPGKNFQQAVQSALTKTHTRGPHFSSVYGKPVIAAAQNQQQHPENIYSNSQGKPGSPEPETEPVSSVQENHENERIPRPLSPTKLLPFLSNPYRNQSDADLEALRKKLSNAPRPLKKRSSITEPEGPNGPNIQKLLYQRTTIAAMETISVPSYPSKSASVTASSESPVEIQNPYLHVEPEKEVVSLVPESLSPEDVGNASTENSDMPAPSPGLDYEPEGVPDNSPNLQNNPEEPNPEAPHVLDVYLEEYPPYPPPPYPSGEPEGPGEDSVSMRPPEITGQVSLPPGKRTNLRKTGSERIAHGMRVKFNPLALLLDSSLEGEFDLVQRIIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFAMTYSDMQTAADKCEEMEEGYTQCSQFLYGVQEKMGIMNKGVIYALWDYEPQNDDELPMKEGDCMTIIHREDEDEIEWWWARLNDKEGYVPRNLLGLYPRIKPRQRSLA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MMPMFLTVYLSNNE -CCCEEEEEEECCCC	8.88	23401153
9	Phosphorylation	MPMFLTVYLSNNEQH CCEEEEEEECCCCEE	10.12	24043423
11	Phosphorylation	MFLTVYLSNNEQHFT EEEEEEECCCCEEEE	21.66	24043423
18	Phosphorylation	SNNEQHFTEVPVTPE CCCCEEEEECCCCHH	33.67	24043423
23	Phosphorylation	HFTEVPVTPETICRD EEEECCCCHHHHHHH	14.88	24043423
26	Phosphorylation	EVPVTPETICRDVVD ECCCCHHHHHHHHHH	26.95	23401153
29	Ubiquitination	VTPETICRDVVDLCK CCHHHHHHHHHHHHC	35.59	23000965
29 (in isoform 2)	Ubiquitination	-	35.59	21890473
34	Ubiquitination	ICRDVVDLCKEPGES HHHHHHHHHCCCCCC	2.80	23000965
37	Ubiquitination	DVVDLCKEPGESDCH HHHHHHCCCCCCCCE	58.50	29967540
52	Ubiquitination	LAEVWCGSERPVADN EEEEECCCCCCCCCH	27.57	32015554
57	Ubiquitination	CGSERPVADNERMFD CCCCCCCCCHHHHHH	19.32	24816145
66	Ubiquitination	NERMFDVLQRFGSQR HHHHHHHHHHHCCCC	3.05	32015554
71	Phosphorylation	DVLQRFGSQRNEVRF HHHHHHCCCCCEEEH	24.21	28102081
77 (in isoform 3)	Phosphorylation	-	15.49	27251275
91	Ubiquitination	RPPGRDIVSGPRSQD CCCCCCCCCCCCCCC	6.75	21890473
92	Phosphorylation	PPGRDIVSGPRSQDP CCCCCCCCCCCCCCC	43.33	73269199
96	Phosphorylation	DIVSGPRSQDPSLKR CCCCCCCCCCCCHHC	41.91	28555341
96	Ubiquitination	DIVSGPRSQDPSLKR CCCCCCCCCCCCHHC	41.91	23000965
100	Phosphorylation	GPRSQDPSLKRNGVK CCCCCCCCHHCCCCC	55.61	24719451
101	Ubiquitination	PRSQDPSLKRNGVKV CCCCCCCHHCCCCCC	8.01	23000965
101 (in isoform 2)	Ubiquitination	-	8.01	21890473
106 (in isoform 3)	Phosphorylation	-	6.88	24719451
111	Ubiquitination	NGVKVPGEYRRKENG CCCCCCCHHHCHHCC	29.78	32015554
111 (in isoform 2)	Ubiquitination	-	29.78	-
119	Ubiquitination	YRRKENGVNSPRMDL HHCHHCCCCCCCHHC	10.92	24816145
121	Phosphorylation	RKENGVNSPRMDLTL CHHCCCCCCCHHCHH	16.10	22199227
123	Ubiquitination	ENGVNSPRMDLTLAE HCCCCCCCHHCHHHH	30.94	32015554
127	Phosphorylation	NSPRMDLTLAELQEM CCCCHHCHHHHHHHH	21.47	22199227
127 (in isoform 3)	Phosphorylation	-	21.47	24719451
136	O-linked_Glycosylation	AELQEMASRQQQQIE HHHHHHHHHHHHHHH	29.34	30379171
136	Phosphorylation	AELQEMASRQQQQIE HHHHHHHHHHHHHHH	29.34	22199227
145	Ubiquitination	QQQQIEAQQQLLATK HHHHHHHHHHHHHHH	20.82	32015554
152	Ubiquitination	QQQLLATKEQRLKFL HHHHHHHHHHHHHHH	46.36	27667366
152 (in isoform 1)	Ubiquitination	-	46.36	21890473
158	Ubiquitination	TKEQRLKFLKQQDQR HHHHHHHHHHHHHHH	14.09	21890473
158	Ubiquitination	TKEQRLKFLKQQDQR HHHHHHHHHHHHHHH	14.09	23000965
158 (in isoform 3)	Ubiquitination	-	14.09	-
160	Ubiquitination	EQRLKFLKQQDQRQQ HHHHHHHHHHHHHHH	49.39	32015554
160 (in isoform 2)	Ubiquitination	-	49.39	21890473
163	Ubiquitination	LKFLKQQDQRQQQQV HHHHHHHHHHHHHHH	43.04	21890473
166	Ubiquitination	LKQQDQRQQQQVAEQ HHHHHHHHHHHHHHH	39.54	29967540
173	Ubiquitination	QQQQVAEQEKLKRLK HHHHHHHHHHHHHHH	43.30	23503661
180	Ubiquitination	QEKLKRLKEIAENQE HHHHHHHHHHHHCHH	51.62	32015554
181	Ubiquitination	EKLKRLKEIAENQEA HHHHHHHHHHHCHHH	52.61	32015554
186	Ubiquitination	LKEIAENQEAKLKKV HHHHHHCHHHHHHHH	43.46	24816145
189	2-Hydroxyisobutyrylation	IAENQEAKLKKVRAL HHHCHHHHHHHHHHH	61.15	-
195	Ubiquitination	AKLKKVRALKGHVEQ HHHHHHHHHHHHHHH	19.33	32015554
199	Ubiquitination	KVRALKGHVEQKRLS HHHHHHHHHHHHHHC	20.53	32015554
206	Phosphorylation	HVEQKRLSNGKLVEE HHHHHHHCCCCHHHH	47.79	28464451
212 (in isoform 3)	Phosphorylation	-	64.79	24719451
214	Ubiquitination	NGKLVEEIEQMNNLF CCCHHHHHHHHHHHH	2.56	27667366
222	Ubiquitination	EQMNNLFQQKQRELV HHHHHHHHHHHHHHH	53.37	24816145
224	Ubiquitination	MNNLFQQKQRELVLA HHHHHHHHHHHHHHH	40.31	21906983
224 (in isoform 1)	Ubiquitination	-	40.31	21890473
230	Ubiquitination	QKQRELVLAVSKVEE HHHHHHHHHHHHHHH	6.43	21890473
230	Ubiquitination	QKQRELVLAVSKVEE HHHHHHHHHHHHHHH	6.43	23000965
234	Ubiquitination	ELVLAVSKVEELTRQ HHHHHHHHHHHHHHH	47.25	-
238	Phosphorylation	AVSKVEELTRQLEML HHHHHHHHHHHHHHH	2.79	32142685
240	Ubiquitination	SKVEELTRQLEMLKN HHHHHHHHHHHHHHC	52.27	32015554
245	Ubiquitination	LTRQLEMLKNGRIDS HHHHHHHHHCCCCCC	2.59	32015554
252	Phosphorylation	LKNGRIDSHHDNQSA HHCCCCCCCCCCHHH	21.98	28555341
252	Ubiquitination	LKNGRIDSHHDNQSA HHCCCCCCCCCCHHH	21.98	32015554
265	Methylation	SAVAELDRLYKELQL HHHHHHHHHHHHHHH	53.17	-
273 (in isoform 3)	Phosphorylation	-	25.85	27642862
274	Ubiquitination	YKELQLRNKLNQEQN HHHHHHHHHCCHHHH	62.85	32015554
275	Ubiquitination	KELQLRNKLNQEQNA HHHHHHHHCCHHHHH	42.24	-
281	Ubiquitination	NKLNQEQNAKLQQQR HHCCHHHHHHHHHHH	37.99	27667366
283	Ubiquitination	LNQEQNAKLQQQREC CCHHHHHHHHHHHHH	55.14	21906983
289	Ubiquitination	AKLQQQRECLNKRNS HHHHHHHHHHHHHHC	38.73	32015554
291 (in isoform 2)	Phosphorylation	-	7.88	-
296	Phosphorylation	ECLNKRNSEVAVMDK HHHHHHHCHHHHHHH	37.16	46155951
302 (in isoform 3)	Phosphorylation	-	29.07	27251275
309	Ubiquitination	DKRVNELRDRLWKKK HHHHHHHHHHHHHHH	22.33	32015554
328	O-linked_Glycosylation	QKENLPVSSDGNLPQ HHHCCCCCCCCCCCH	22.29	30379171
328	Phosphorylation	QKENLPVSSDGNLPQ HHHCCCCCCCCCCCH	22.29	20068231
328	Ubiquitination	QKENLPVSSDGNLPQ HHHCCCCCCCCCCCH	22.29	32015554
329	O-linked_Glycosylation	KENLPVSSDGNLPQQ HHCCCCCCCCCCCHH	50.17	30379171
329	Phosphorylation	KENLPVSSDGNLPQQ HHCCCCCCCCCCCHH	50.17	20068231
335	Phosphorylation	SSDGNLPQQAASAPS CCCCCCCHHHHCCCC	49.03	32142685
339	O-linked_Glycosylation	NLPQQAASAPSRVAA CCCHHHHCCCCCEEE	43.67	30379171
350	Phosphorylation	RVAAVGPYIQSSTMP CEEECCHHHCCCCCC	12.98	21945579
353	Phosphorylation	AVGPYIQSSTMPRMP ECCHHHCCCCCCCCC	20.44	21945579
354	Phosphorylation	VGPYIQSSTMPRMPS CCHHHCCCCCCCCCC	16.61	21945579
354	Ubiquitination	VGPYIQSSTMPRMPS CCHHHCCCCCCCCCC	16.61	24816145
355	Phosphorylation	GPYIQSSTMPRMPSR CHHHCCCCCCCCCCC	36.12	21945579
356	Sulfoxidation	PYIQSSTMPRMPSRP HHHCCCCCCCCCCCC	1.83	21406390
357	Phosphorylation	YIQSSTMPRMPSRPE HHCCCCCCCCCCCCC	29.52	32645325
357 (in isoform 2)	Phosphorylation	-	29.52	-
359 (in isoform 3)	Phosphorylation	-	2.66	24719451
361	Phosphorylation	STMPRMPSRPELLVK CCCCCCCCCCCEEEE	51.64	22329733
367	Phosphorylation	PSRPELLVKPALPDG CCCCCEEEECCCCCC	12.48	32142685
367 (in isoform 3)	Phosphorylation	-	12.48	24719451
370	Ubiquitination	PELLVKPALPDGSLV CCEEEECCCCCCCEE	26.47	29967540
374	Ubiquitination	VKPALPDGSLVIQAS EECCCCCCCEEEEEC	22.42	32015554
389	Phosphorylation	EGPMKIQTLPNMRSG CCCCEEECCCCCCCC	47.89	54885459
395	Phosphorylation	QTLPNMRSGAASQTK ECCCCCCCCCCCCCC	23.24	22210691
399	Phosphorylation	NMRSGAASQTKGSKI CCCCCCCCCCCCCCC	37.54	22210691
401	Phosphorylation	RSGAASQTKGSKIHP CCCCCCCCCCCCCCC	34.57	22210691
414	Phosphorylation	HPVGPDWSPSNADLF CCCCCCCCCCCCCCC	26.32	30576142
416	Phosphorylation	VGPDWSPSNADLFPS CCCCCCCCCCCCCCC	38.85	28348404
416	Ubiquitination	VGPDWSPSNADLFPS CCCCCCCCCCCCCCC	38.85	24816145
420	Phosphorylation	WSPSNADLFPSQGSA CCCCCCCCCCCCCCC	6.72	18669648
423	Phosphorylation	SNADLFPSQGSASVP CCCCCCCCCCCCCCC	39.58	26471730
426	Phosphorylation	DLFPSQGSASVPQST CCCCCCCCCCCCCCC	15.10	26471730
428	Phosphorylation	FPSQGSASVPQSTGN CCCCCCCCCCCCCCC	35.71	26471730
432	Phosphorylation	GSASVPQSTGNALDQ CCCCCCCCCCCHHHC	32.01	26853621
433	Phosphorylation	SASVPQSTGNALDQV CCCCCCCCCCHHHCC	29.25	26471730
433 (in isoform 2)	Phosphorylation	-	29.25	-
435	Phosphorylation	SVPQSTGNALDQVDD CCCCCCCCHHHCCCC	37.10	32142685
435 (in isoform 2)	Phosphorylation	-	37.10	-
446 (in isoform 2)	Phosphorylation	-	22.77	-
449 (in isoform 2)	Phosphorylation	-	73.57	-
458	Phosphorylation	EKKVRPFSMFDAVDQ HCCCCCCCHHCCCCC	22.63	26657352
464	Phosphorylation	FSMFDAVDQSNAPPS CCHHCCCCCCCCCCC	48.16	32142685
464 (in isoform 3)	Phosphorylation	-	48.16	24719451
466	Phosphorylation	MFDAVDQSNAPPSFG HHCCCCCCCCCCCCC	30.42	26657352
471	Phosphorylation	DQSNAPPSFGTLRKN CCCCCCCCCCCCCCC	34.94	46155957
474	Phosphorylation	NAPPSFGTLRKNQSS CCCCCCCCCCCCCCH	22.75	45281621
480	Phosphorylation	GTLRKNQSSEDILRD CCCCCCCCHHHHHHH	45.12	19664994
481	Phosphorylation	TLRKNQSSEDILRDA CCCCCCCHHHHHHHH	29.53	30266825
483	Ubiquitination	RKNQSSEDILRDAQV CCCCCHHHHHHHHHH	47.36	24816145
486	Phosphorylation	QSSEDILRDAQVANK CCHHHHHHHHHHHCC	37.24	19664994
486 (in isoform 3)	Phosphorylation	-	37.24	24719451
499	Ubiquitination	NKNVAKVPPPVPTKP CCCCCCCCCCCCCCC	27.11	29967540
529	Phosphorylation	SDIKPDGSSQQLSTV CCCCCCCCCHHHHEE	32.14	21406692
530	Phosphorylation	DIKPDGSSQQLSTVV CCCCCCCCHHHHEEC	27.72	21406692
534	Phosphorylation	DGSSQQLSTVVPSMG CCCCHHHHEECCCCC	18.15	21406692
535	Phosphorylation	GSSQQLSTVVPSMGT CCCHHHHEECCCCCC	33.83	21406692
539	Phosphorylation	QLSTVVPSMGTKPKP HHHEECCCCCCCCCC	20.45	21406692
542	Phosphorylation	TVVPSMGTKPKPAGQ EECCCCCCCCCCCCC	35.22	21406692
550 (in isoform 2)	Phosphorylation	-	27.18	-
556	Phosphorylation	QQPRVLLSPSIPSVG CCCEEEEECCCCCCC	16.67	30266825
558	Phosphorylation	PRVLLSPSIPSVGQD CEEEEECCCCCCCCC	43.70	30266825
561	Phosphorylation	LLSPSIPSVGQDQTL EEECCCCCCCCCCCC	36.89	30266825
562	Phosphorylation	LSPSIPSVGQDQTLS EECCCCCCCCCCCCC	7.19	15144186
562 (in isoform 3)	Phosphorylation	-	7.19	24719451
564	Phosphorylation	PSIPSVGQDQTLSPG CCCCCCCCCCCCCCC	37.17	32142685
567	Phosphorylation	PSVGQDQTLSPGSKQ CCCCCCCCCCCCCCC	37.18	30266825
569	Phosphorylation	VGQDQTLSPGSKQES CCCCCCCCCCCCCCC	30.51	30266825
572	Phosphorylation	DQTLSPGSKQESPPA CCCCCCCCCCCCCCC	34.25	29255136
575	Phosphorylation	LSPGSKQESPPAAAV CCCCCCCCCCCCCCC	69.79	15144186
575 (in isoform 2)	Phosphorylation	-	69.79	-
575 (in isoform 3)	Phosphorylation	-	69.79	27251275
576	Phosphorylation	SPGSKQESPPAAAVR CCCCCCCCCCCCCCC	33.42	30266825
577 (in isoform 2)	Phosphorylation	-	23.07	-
578	Phosphorylation	GSKQESPPAAAVRPF CCCCCCCCCCCCCCC	43.75	20068231
582 (in isoform 3)	Phosphorylation	-	7.38	24719451
586	Phosphorylation	AAAVRPFTPQPSKDT CCCCCCCCCCCCCCC	24.56	30576142
590	Phosphorylation	RPFTPQPSKDTLLPP CCCCCCCCCCCCCCC	37.61	23312004
592 (in isoform 3)	Phosphorylation	-	47.10	27251275
601	Ubiquitination	LLPPFRKPQTVAASS CCCCCCCCCCHHHHH	30.71	29967540
603	Phosphorylation	PPFRKPQTVAASSIY CCCCCCCCHHHHHHH	22.19	26356563
607	Phosphorylation	KPQTVAASSIYSMYT CCCCHHHHHHHHHHH	13.92	26356563
608	O-linked_Glycosylation	PQTVAASSIYSMYTQ CCCHHHHHHHHHHHC	22.33	30379171
608	Phosphorylation	PQTVAASSIYSMYTQ CCCHHHHHHHHHHHC	22.33	28442448
610	Phosphorylation	TVAASSIYSMYTQQQ CHHHHHHHHHHHCCC	6.85	28796482
611	Phosphorylation	VAASSIYSMYTQQQA HHHHHHHHHHHCCCC	12.02	28796482
613	Phosphorylation	ASSIYSMYTQQQAPG HHHHHHHHHCCCCCC	8.75	28796482
613 (in isoform 2)	Phosphorylation	-	8.75	-
614	Phosphorylation	SSIYSMYTQQQAPGK HHHHHHHHCCCCCCC	15.97	28442448
614 (in isoform 2)	Phosphorylation	-	15.97	-
616 (in isoform 3)	Phosphorylation	-	33.34	27642862
619 (in isoform 3)	Phosphorylation	-	50.37	27642862
620 (in isoform 3)	Phosphorylation	-	40.32	27642862
642	Phosphorylation	HTRGPHFSSVYGKPV CCCCCCHHHHHCCHH	18.83	20068231
643	Phosphorylation	TRGPHFSSVYGKPVI CCCCCHHHHHCCHHH	20.58	28464451
645	Phosphorylation	GPHFSSVYGKPVIAA CCCHHHHHCCHHHHH	22.75	20068231
651 (in isoform 3)	Phosphorylation	-	9.29	27642862
664	Phosphorylation	QQHPENIYSNSQGKP HHCCCCCCCCCCCCC	17.24	23065
665	Phosphorylation	QHPENIYSNSQGKPG HCCCCCCCCCCCCCC	26.63	50558139
667	Phosphorylation	PENIYSNSQGKPGSP CCCCCCCCCCCCCCC	34.08	50558147
673	Phosphorylation	NSQGKPGSPEPETEP CCCCCCCCCCCCCCC	34.32	29255136
678	Phosphorylation	PGSPEPETEPVSSVQ CCCCCCCCCCCCCHH	57.20	23663014
679	Phosphorylation	GSPEPETEPVSSVQE CCCCCCCCCCCCHHH	41.88	20068231
682	Phosphorylation	EPETEPVSSVQENHE CCCCCCCCCHHHCCC	35.19	20068231
683	Phosphorylation	PETEPVSSVQENHEN CCCCCCCCHHHCCCC	28.22	21406692
698	Phosphorylation	ERIPRPLSPTKLLPF CCCCCCCCHHHHHHC	32.95	29255136
700	Phosphorylation	IPRPLSPTKLLPFLS CCCCCCHHHHHHCCC	30.83	29255136
704	Phosphorylation	LSPTKLLPFLSNPYR CCHHHHHHCCCCCCC	38.27	20068231
704 (in isoform 3)	Phosphorylation	-	38.27	24719451
706	Phosphorylation	PTKLLPFLSNPYRNQ HHHHHHCCCCCCCCC	4.58	19651622
707	Phosphorylation	TKLLPFLSNPYRNQS HHHHHCCCCCCCCCC	35.82	26434776
710	Phosphorylation	LPFLSNPYRNQSDAD HHCCCCCCCCCCHHH	26.84	24732914
713 (in isoform 3)	Phosphorylation	-	33.42	27251275
714	Phosphorylation	SNPYRNQSDADLEAL CCCCCCCCHHHHHHH	38.01	30576142
716 (in isoform 3)	Phosphorylation	-	28.65	27642862
720 (in isoform 3)	Phosphorylation	-	21.69	24719451
730	Ubiquitination	KKLSNAPRPLKKRSS HHHHCCCCCCCCCCC	46.93	29967540
736	Phosphorylation	PRPLKKRSSITEPEG CCCCCCCCCCCCCCC	34.66	30266825
737	Phosphorylation	RPLKKRSSITEPEGP CCCCCCCCCCCCCCC	37.25	29255136
739	Phosphorylation	LKKRSSITEPEGPNG CCCCCCCCCCCCCCC	47.65	30266825
742	Phosphorylation	RSSITEPEGPNGPNI CCCCCCCCCCCCCCH	79.60	18669648
743	Phosphorylation	SSITEPEGPNGPNIQ CCCCCCCCCCCCCHH	31.52	18669648
743 (in isoform 3)	Phosphorylation	-	31.52	24719451
754	Phosphorylation	PNIQKLLYQRTTIAA CCHHHHHHHHHHEEE	13.34	28857561
757	Phosphorylation	QKLLYQRTTIAAMET HHHHHHHHHEEEEEE	13.66	28857561
758	Phosphorylation	KLLYQRTTIAAMETI HHHHHHHHEEEEEEE	15.71	28857561
770	Phosphorylation	ETISVPSYPSKSASV EEECCCCCCCCCCCC	12.88	28857561
774	Phosphorylation	VPSYPSKSASVTASS CCCCCCCCCCCCCCC	30.07	21945579
776	Phosphorylation	SYPSKSASVTASSES CCCCCCCCCCCCCCC	27.39	21945579
778	Phosphorylation	PSKSASVTASSESPV CCCCCCCCCCCCCCC	20.51	21945579
780	Phosphorylation	KSASVTASSESPVEI CCCCCCCCCCCCCEE	25.85	21945579
781	Phosphorylation	SASVTASSESPVEIQ CCCCCCCCCCCCEEC	39.36	21945579
783	Phosphorylation	SVTASSESPVEIQNP CCCCCCCCCCEECCC	35.87	21945579
786 (in isoform 3)	Phosphorylation	-	42.09	27642862
789 (in isoform 3)	Phosphorylation	-	32.61	27642862
791	Phosphorylation	PVEIQNPYLHVEPEK CCEECCCCCCCCCCH	19.59	21945579
797 (in isoform 3)	Phosphorylation	-	48.63	27642862
807	Phosphorylation	VVSLVPESLSPEDVG HEEECCCCCCHHHCC	28.25	22468782
818	Phosphorylation	EDVGNASTENSDMPA HHCCCCCCCCCCCCC	36.45	22468782
827	Phosphorylation	NSDMPAPSPGLDYEP CCCCCCCCCCCCCCC	33.43	61990205
832	Phosphorylation	APSPGLDYEPEGVPD CCCCCCCCCCCCCCC	38.12	22468782
869	Phosphorylation	YLEEYPPYPPPPYPS EHHCCCCCCCCCCCC	24.70	73493803
874	Phosphorylation	PPYPPPPYPSGEPEG CCCCCCCCCCCCCCC	18.79	73493801
947	Phosphorylation	DLVQRIIYEVDDPSL HHHHHHEEECCCCCC	13.92	46155987

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
827	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	SIAH2	O43255	PMID:23644657

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ASPP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ASPP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BCL2_HUMAN	BCL2	physical	8668206
UBP4_HUMAN	USP4	physical	16169070
RM20_HUMAN	MRPL20	physical	16169070
EF1A1_HUMAN	EEF1A1	physical	16169070
KIF5A_HUMAN	KIF5A	physical	16169070
PTN_HUMAN	PTN	physical	16169070
UT14A_HUMAN	UTP14A	physical	16169070
U119A_HUMAN	UNC119	physical	16169070
YAP1_HUMAN	YAP1	physical	11278422
YAP1_CHICK	YAP1	physical	11278422
P53_HUMAN	TP53	physical	8016121
P53_HUMAN	TP53	physical	8668206
ULA1_HUMAN	NAE1	physical	12694406
SIAH2_HUMAN	SIAH2	physical	23644657
BCL2_HUMAN	BCL2	physical	18719108
ZNF26_HUMAN	ZNF26	physical	25416956
TCL1A_HUMAN	TCL1A	physical	25416956
LMO4_HUMAN	LMO4	physical	25416956
TRAF4_HUMAN	TRAF4	physical	25416956
TANK_HUMAN	TANK	physical	25416956
NDC80_HUMAN	NDC80	physical	25416956
BAIP2_HUMAN	BAIAP2	physical	25416956
NXF1_HUMAN	NXF1	physical	25416956
HNRL1_HUMAN	HNRNPUL1	physical	25416956
PRP31_HUMAN	PRPF31	physical	25416956
UBS3A_HUMAN	UBASH3A	physical	25416956
DCNL1_HUMAN	DCUN1D1	physical	25416956
TB22B_HUMAN	TBC1D22B	physical	25416956
MTMRE_HUMAN	MTMR14	physical	25416956
OTUB2_HUMAN	OTUB2	physical	25416956
CCD92_HUMAN	CCDC92	physical	25416956
PKHN1_HUMAN	PLEKHN1	physical	25416956
ZGPAT_HUMAN	ZGPAT	physical	25416956
ATPF2_HUMAN	ATPAF2	physical	25416956
ADIP_HUMAN	SSX2IP	physical	25416956
C19L2_HUMAN	CWF19L2	physical	25416956
TXLNA_HUMAN	TXLNA	physical	25416956
NUTM1_HUMAN	NUTM1	physical	25416956
EP300_HUMAN	EP300	physical	21513714
P53_HUMAN	TP53	physical	21513714
ANXA1_HUMAN	ANXA1	physical	24366813
CC85B_HUMAN	CCDC85B	physical	24366813
CC85C_HUMAN	CCDC85C	physical	24366813
CPVL_HUMAN	CPVL	physical	24366813
HS105_HUMAN	HSPH1	physical	24366813
HSP74_HUMAN	HSPA4	physical	24366813
IPP2_HUMAN	PPP1R2	physical	24366813
PARD3_HUMAN	PARD3	physical	24366813
PP1A_HUMAN	PPP1CA	physical	24366813
PP1B_HUMAN	PPP1CB	physical	24366813
PP1G_HUMAN	PPP1CC	physical	24366813
RASF7_HUMAN	RASSF7	physical	24366813
RASF8_HUMAN	RASSF8	physical	24366813
RASF9_HUMAN	RASSF9	physical	24366813
ITCH_HUMAN	ITCH	physical	25436413
YAP1_HUMAN	YAP1	physical	25436413
APCL_HUMAN	APC2	physical	10646860
PARD3_HUMAN	PARD3	physical	28400336
ITCH_HUMAN	ITCH	physical	28400336

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ASPP2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480 AND SER-556, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480; SER-556; SER-569AND SER-698, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-698, AND MASSSPECTROMETRY.	17081983 [Abstract]