OTUB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OTUB2_HUMAN
• UniProt AC: Q96DC9
• Protein Name: Ubiquitin thioesterase OTUB2
• Gene Name: OTUB2
• Organism: Homo sapiens (Human).
• Sequence Length: 234
• Protein Description: Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains..
• Protein Sequence: MSETSFNLISEKCDILSILRDHPENRIYRRKIEELSKRFTAIRKTKGDGNCFYRALGYSYLESLLGKSREIFKFKERVLQTPNDLLAAGFEEHKFRNFFNAFYSVVELVEKDGSVSSLLKVFNDQSASDHIVQFLRLLTSAFIRNRADFFRHFIDEEMDIKDFCTHEVEPMATECDHIQITALSQALSIALQVEYVDEMDTALNHHVFPEAATPSVYLLYKTSHYNILYAADKH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSETSFNLI ------CCHHHHHHH	49.97	25693802
4	Phosphorylation	----MSETSFNLISE ----CCHHHHHHHHH	31.17	25693802
5	Phosphorylation	---MSETSFNLISEK ---CCHHHHHHHHHC	14.21	25693802
10	Phosphorylation	ETSFNLISEKCDILS HHHHHHHHHCCCHHH	33.88	24719451
40	O-linked_Glycosylation	EELSKRFTAIRKTKG HHHHHHHHHHHCCCC	25.80	30379171
94	Ubiquitination	AAGFEEHKFRNFFNA HCCCCHHHHHHHHHH	49.66	23000965
94 (in isoform 1)	Ubiquitination	-	49.66	21890473
95	Ubiquitination	AGFEEHKFRNFFNAF CCCCHHHHHHHHHHH	9.24	21890473
112	Ubiquitination	VVELVEKDGSVSSLL HHHHHHHCCCHHHHH	40.88	21890473
114	Phosphorylation	ELVEKDGSVSSLLKV HHHHHCCCHHHHHHH	29.03	30622161
116	Phosphorylation	VEKDGSVSSLLKVFN HHHCCCHHHHHHHHC	19.57	30622161
117	Phosphorylation	EKDGSVSSLLKVFND HHCCCHHHHHHHHCC	35.25	24719451
222	Phosphorylation	SVYLLYKTSHYNILY CEEEEEECCCCCEEE	13.74	30622161
223	Phosphorylation	VYLLYKTSHYNILYA EEEEEECCCCCEEEE	21.59	30622161

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OTUB2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OTUB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OTUB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GTF2I_HUMAN	GTF2I	physical	19615732
UBE2N_HUMAN	UBE2N	physical	20725033
TRAF3_HUMAN	TRAF3	physical	19996094
TRAF6_HUMAN	TRAF6	physical	19996094
MAVS_HUMAN	MAVS	physical	19996094
A4_HUMAN	APP	physical	21832049
TRI27_HUMAN	TRIM27	physical	23105109
TRAF6_HUMAN	TRAF6	physical	23105109
TRI25_HUMAN	TRIM25	physical	23105109
TRI26_HUMAN	TRIM26	physical	23105109
HOIL1_HUMAN	RBCK1	physical	23105109
TRIM2_HUMAN	TRIM2	physical	23105109
RN126_HUMAN	RNF126	physical	23105109
TRI39_HUMAN	TRIM39	physical	23105109
TRIM8_HUMAN	TRIM8	physical	23105109
TRIM5_HUMAN	TRIM5	physical	23105109
NMRL1_HUMAN	NMRAL1	physical	24763515
UBC_HUMAN	UBC	physical	18954305
UBC_HUMAN	UBC	physical	23827681
LZTS2_HUMAN	LZTS2	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
UBC_HUMAN	UBC	physical	25590432

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.