NMRL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NMRL1_HUMAN
• UniProt AC: Q9HBL8
• Protein Name: NmrA-like family domain-containing protein 1
• Gene Name: NMRAL1
• Organism: Homo sapiens (Human).
• Sequence Length: 299
• Subcellular Localization: Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Under normal redox growth conditions localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP(+) ratios.
• Protein Description: Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer..
• Protein Sequence: MVDKKLVVVFGGTGAQGGSVARTLLEDGTFKVRVVTRNPRKKAAKELRLQGAEVVQGDQDDQVIMELALNGAYATFIVTNYWESCSQEQEVKQGKLLADLARRLGLHYVVYSGLENIKKLTAGRLAAAHFDGKGEVEEYFRDIGVPMTSVRLPCYFENLLSHFLPQKAPDGKSYLLSLPTGDVPMDGMSVSDLGPVVLSLLKMPEKYVGQNIGLSTCRHTAEEYAALLTKHTRKVVHDAKMTPEDYEKLGFPGARDLANMFRFYALRPDRDIELTLRLNPKALTLDQWLEQHKGDFNLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Sumoylation	---MVDKKLVVVFGG ---CCCCEEEEEECC	41.89	-
5	Sumoylation	---MVDKKLVVVFGG ---CCCCEEEEEECC	41.89	-
31	Ubiquitination	LLEDGTFKVRVVTRN HHCCCEEEEEEEECC	29.03	-
95	Ubiquitination	EQEVKQGKLLADLAR HHHHHHCHHHHHHHH	37.52	-
118	Ubiquitination	YSGLENIKKLTAGRL CCCHHHHHHHHHHCC	54.00	-
119	Ubiquitination	SGLENIKKLTAGRLA CCHHHHHHHHHHCCC	47.47	-
133	Ubiquitination	AAAHFDGKGEVEEYF CCHHCCCCCCHHHHH	54.46	21906983
139	Phosphorylation	GKGEVEEYFRDIGVP CCCCHHHHHHHHCCC	7.15	27642862
167	Ubiquitination	LSHFLPQKAPDGKSY HHHCCCCCCCCCCEE	61.01	-
169	Ubiquitination	HFLPQKAPDGKSYLL HCCCCCCCCCCEEEE	58.90	21890473
173	Phosphorylation	QKAPDGKSYLLSLPT CCCCCCCEEEEECCC	26.92	20068231
174	Phosphorylation	KAPDGKSYLLSLPTG CCCCCCEEEEECCCC	18.36	20068231
177	Phosphorylation	DGKSYLLSLPTGDVP CCCEEEEECCCCCCC	29.70	20068231
180	Phosphorylation	SYLLSLPTGDVPMDG EEEEECCCCCCCCCC	51.84	20068231
189	Phosphorylation	DVPMDGMSVSDLGPV CCCCCCCCHHHHHHH	24.81	20068231
191	Phosphorylation	PMDGMSVSDLGPVVL CCCCCCHHHHHHHHH	21.58	20068231
199	Phosphorylation	DLGPVVLSLLKMPEK HHHHHHHHHHCCCHH	21.75	24719451
206	Ubiquitination	SLLKMPEKYVGQNIG HHHCCCHHHCCCCCC	39.09	-
207	Phosphorylation	LLKMPEKYVGQNIGL HHCCCHHHCCCCCCC	14.25	22817900
215	Phosphorylation	VGQNIGLSTCRHTAE CCCCCCCCCCCCCHH	21.90	28857561
216	Phosphorylation	GQNIGLSTCRHTAEE CCCCCCCCCCCCHHH	20.71	28857561
230	Ubiquitination	EYAALLTKHTRKVVH HHHHHHHHHHHHHHC	42.84	-
234	Ubiquitination	LLTKHTRKVVHDAKM HHHHHHHHHHCCCCC	50.17	-
240	Ubiquitination	RKVVHDAKMTPEDYE HHHHCCCCCCHHHHH	49.73	-
248	Ubiquitination	MTPEDYEKLGFPGAR CCHHHHHHHCCCCHH	47.91	-
281	Ubiquitination	LTLRLNPKALTLDQW EEEEECCCCEEHHHH	55.76	21890473
293	Ubiquitination	DQWLEQHKGDFNLL- HHHHHHCCCCCCCC-	60.93	-
317	Ubiquitination	------------------------- -------------------------		21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NMRL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NMRL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NMRL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COMD1_HUMAN	COMMD1	physical	19433587
TRAF3_HUMAN	TRAF3	physical	24763515

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.