dbPTM

LZTS2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LZTS2_HUMAN
UniProt AC	Q9BRK4
Protein Name	Leucine zipper putative tumor suppressor 2 {ECO:0000255\|HAMAP-Rule:MF_03026}
Gene Name	LZTS2 {ECO:0000255\|HAMAP-Rule:MF_03026}
Organism	Homo sapiens (Human).
Sequence Length	669
Subcellular Localization	Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis.
Protein Description	Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin..
Protein Sequence	MAIVQTLPVPLEPAPEAATAPQAPVMGSVSSLISGRPCPGGPAPPRHHGPPGPTFFRQQDGLLRGGYEAQEPLCPAVPPRKAVPVTSFTYINEDFRTESPPSPSSDVEDAREQRAHNAHLRGPPPKLIPVSGKLEKNMEKILIRPTAFKPVLPKPRGAPSLPSFMGPRATGLSGSQGSLTQLFGGPASSSSSSSSSSAADKPLAFSGWASGCPSGTLSDSGRNSLSSLPTYSTGGAEPTTSSPGGHLPSHGSGRGALPGPARGVPTGPSHSDSGRSSSSKSTGSLGGRVAGGLLGSGTRASPDSSSCGERSPPPPPPPPSDEALLHCVLEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQAPCICLEEITATEI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
67	Phosphorylation	DGLLRGGYEAQEPLC CCCCCCCCCCCCCCC	15.77	27642862
86	Phosphorylation	PRKAVPVTSFTYINE CCCCCCCCEEEEECC	16.44	30177828
87	Phosphorylation	RKAVPVTSFTYINED CCCCCCCEEEEECCC	18.80	30177828
89	Phosphorylation	AVPVTSFTYINEDFR CCCCCEEEEECCCCC	24.22	28102081
90	Phosphorylation	VPVTSFTYINEDFRT CCCCEEEEECCCCCC	10.35	27642862
97	Phosphorylation	YINEDFRTESPPSPS EECCCCCCCCCCCCC	40.59	29255136
99	Phosphorylation	NEDFRTESPPSPSSD CCCCCCCCCCCCCCC	41.31	29255136
102	Phosphorylation	FRTESPPSPSSDVED CCCCCCCCCCCCHHH	40.58	29255136
104	Phosphorylation	TESPPSPSSDVEDAR CCCCCCCCCCHHHHH	43.43	29255136
105	Phosphorylation	ESPPSPSSDVEDARE CCCCCCCCCHHHHHH	49.40	29255136
160	Phosphorylation	PKPRGAPSLPSFMGP CCCCCCCCCCCCCCC	52.99	28857561
163	Phosphorylation	RGAPSLPSFMGPRAT CCCCCCCCCCCCCCC	32.91	28857561
168	Methylation	LPSFMGPRATGLSGS CCCCCCCCCCCCCCC	38.77	115482459
173	Phosphorylation	GPRATGLSGSQGSLT CCCCCCCCCCCCCCH	37.43	27282143
175	Phosphorylation	RATGLSGSQGSLTQL CCCCCCCCCCCCHHH	28.17	27050516
178	Phosphorylation	GLSGSQGSLTQLFGG CCCCCCCCCHHHHCC	22.17	27282143
180	Phosphorylation	SGSQGSLTQLFGGPA CCCCCCCHHHHCCCC	25.56	27282143
190	Phosphorylation	FGGPASSSSSSSSSS HCCCCCCCCCCCCCC	31.57	-
191	Phosphorylation	GGPASSSSSSSSSSA CCCCCCCCCCCCCCC	35.87	-
192	Phosphorylation	GPASSSSSSSSSSAA CCCCCCCCCCCCCCC	35.87	-
193	Phosphorylation	PASSSSSSSSSSAAD CCCCCCCCCCCCCCC	35.87	-
224	Phosphorylation	LSDSGRNSLSSLPTY CCCCCCCCHHCCCCC	28.41	24732914
226	Phosphorylation	DSGRNSLSSLPTYST CCCCCCHHCCCCCCC	29.65	24732914
227	Phosphorylation	SGRNSLSSLPTYSTG CCCCCHHCCCCCCCC	43.60	24732914
230	Phosphorylation	NSLSSLPTYSTGGAE CCHHCCCCCCCCCCC	35.08	24732914
231	Phosphorylation	SLSSLPTYSTGGAEP CHHCCCCCCCCCCCC	11.42	24732914
232	Phosphorylation	LSSLPTYSTGGAEPT HHCCCCCCCCCCCCC	24.05	24732914
233	Phosphorylation	SSLPTYSTGGAEPTT HCCCCCCCCCCCCCC	29.26	24732914
239	Phosphorylation	STGGAEPTTSSPGGH CCCCCCCCCCCCCCC	30.71	24732914
240	Phosphorylation	TGGAEPTTSSPGGHL CCCCCCCCCCCCCCC	37.61	24732914
241	Phosphorylation	GGAEPTTSSPGGHLP CCCCCCCCCCCCCCC	36.69	24732914
242	Phosphorylation	GAEPTTSSPGGHLPS CCCCCCCCCCCCCCC	26.02	24732914
249	Phosphorylation	SPGGHLPSHGSGRGA CCCCCCCCCCCCCCC	47.01	24732914
252	Phosphorylation	GHLPSHGSGRGALPG CCCCCCCCCCCCCCC	21.64	24732914
254	Methylation	LPSHGSGRGALPGPA CCCCCCCCCCCCCCC	28.98	54557205
269	Phosphorylation	RGVPTGPSHSDSGRS CCCCCCCCCCCCCCC	36.65	30266825
271	Phosphorylation	VPTGPSHSDSGRSSS CCCCCCCCCCCCCCC	37.50	30266825
273	Phosphorylation	TGPSHSDSGRSSSSK CCCCCCCCCCCCCCC	38.84	30266825
276	Phosphorylation	SHSDSGRSSSSKSTG CCCCCCCCCCCCCCC	37.79	23403867
277	Phosphorylation	HSDSGRSSSSKSTGS CCCCCCCCCCCCCCC	36.95	23403867
278	Phosphorylation	SDSGRSSSSKSTGSL CCCCCCCCCCCCCCC	42.93	23403867
279	Phosphorylation	DSGRSSSSKSTGSLG CCCCCCCCCCCCCCC	32.35	23403867
281	Phosphorylation	GRSSSSKSTGSLGGR CCCCCCCCCCCCCCC	39.69	23898821
282	Phosphorylation	RSSSSKSTGSLGGRV CCCCCCCCCCCCCCC	34.23	23898821
296	Phosphorylation	VAGGLLGSGTRASPD CCCCCCCCCCCCCCC	36.64	19664994
298	Phosphorylation	GGLLGSGTRASPDSS CCCCCCCCCCCCCCC	25.43	30266825
301	Phosphorylation	LGSGTRASPDSSSCG CCCCCCCCCCCCCCC	26.42	30266825
304	Phosphorylation	GTRASPDSSSCGERS CCCCCCCCCCCCCCC	27.77	30266825
305	Phosphorylation	TRASPDSSSCGERSP CCCCCCCCCCCCCCC	36.71	23663014
306	Phosphorylation	RASPDSSSCGERSPP CCCCCCCCCCCCCCC	30.05	23663014
311	Phosphorylation	SSSCGERSPPPPPPP CCCCCCCCCCCCCCC	37.14	30266825
320	Phosphorylation	PPPPPPPSDEALLHC CCCCCCCCHHHHHHH	54.58	27080861
346	Phosphorylation	ELQQLRDSLDENEAT HHHHHHHHCCCCHHH	31.14	26657352
358	Phosphorylation	EATMCQAYEERQRHW HHHHHHHHHHHHHHH	7.76	29978859
401	Ubiquitination	VFQLQQEKRQLQDDF HHHHHHHHHHCHHHH	40.90	-
451	Phosphorylation	CQKSGEISLLKQQLK HHHHHHHHHHHHHHH	24.28	24719451
484	Phosphorylation	ALREARATLRVSEGR HHHHHHHHHHHCHHH	15.00	18785766
526	Ubiquitination	EAEQLREKAGQLDAE HHHHHHHHHCCCCHH	51.92	-
546	Phosphorylation	EPPVPPATADPFLLA CCCCCCCCCCCCEEC	37.05	-
555	Phosphorylation	DPFLLAESDEAKVQR CCCEECCCCHHHHHH	34.83	-
559	Ubiquitination	LAESDEAKVQRAAAG ECCCCHHHHHHHHCC	36.53	-
570	Phosphorylation	AAAGVGGSLRAQVER HHCCCCHHHHHHHHH	14.57	30266825
607	Methylation	RLAWQAEKEQVIRYQ HHHHHHHHHHHHHHH	57.36	23644510
607	"N6,N6-dimethyllysine"	RLAWQAEKEQVIRYQ HHHHHHHHHHHHHHH	57.36	-
615	Ubiquitination	EQVIRYQKQLQHNYI HHHHHHHHHHHHHHH	44.00	21890473
615	Acetylation	EQVIRYQKQLQHNYI HHHHHHHHHHHHHHH	44.00	19820359
639	Phosphorylation	EQELQQLSLELEARE HHHHHHHHHHHHHHH	18.56	28122231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LZTS2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LZTS2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LZTS2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RHXF2_HUMAN	RHOXF2	physical	16189514
YTDC1_HUMAN	YTHDC1	physical	21988832
ZMAT1_HUMAN	ZMAT1	physical	25416956
ZGPAT_HUMAN	ZGPAT	physical	25416956
BEX2_HUMAN	BEX2	physical	25416956
SMIM3_HUMAN	SMIM3	physical	25416956
FBF1_HUMAN	FBF1	physical	25416956
DGC6L_HUMAN	DGCR6L	physical	25416956
ATPF2_HUMAN	ATPAF2	physical	25416956
ZMY19_HUMAN	ZMYND19	physical	25416956
FRMD6_HUMAN	FRMD6	physical	25416956
MB213_HUMAN	MAB21L3	physical	25416956
ZN572_HUMAN	ZNF572	physical	25416956
C19L2_HUMAN	CWF19L2	physical	25416956
ZN417_HUMAN	ZNF417	physical	25416956
ZMAT2_HUMAN	ZMAT2	physical	25416956
SH3R2_HUMAN	SH3RF2	physical	25416956
CF206_HUMAN	C6orf165	physical	25416956
SNX31_HUMAN	SNX31	physical	25416956
PPR18_HUMAN	PPP1R18	physical	25416956
SPA24_HUMAN	SPATA24	physical	25416956
ZBT38_HUMAN	ZBTB38	physical	25416956
MORN3_HUMAN	MORN3	physical	25416956
RTP5_HUMAN	RTP5	physical	25416956
CE57L_HUMAN	CEP57L1	physical	25416956
TRI42_HUMAN	TRIM42	physical	25416956
LZTS1_HUMAN	LZTS1	physical	26186194
SI1L1_HUMAN	SIPA1L1	physical	26186194
DHX16_HUMAN	DHX16	physical	26186194
SI1L2_HUMAN	SIPA1L2	physical	26186194
SESD1_HUMAN	SESTD1	physical	26186194
NUD15_HUMAN	NUDT15	physical	26186194
ISCA1_HUMAN	ISCA1	physical	26186194
DYR1A_HUMAN	DYRK1A	physical	26186194
PI42C_HUMAN	PIP4K2C	physical	26186194
EAPP_HUMAN	EAPP	physical	26186194
TRAF5_HUMAN	TRAF5	physical	26186194
TTLL4_HUMAN	TTLL4	physical	26186194
TSSC4_HUMAN	TSSC4	physical	26186194
PP16A_HUMAN	PPP1R16A	physical	21516116
LZTS1_HUMAN	LZTS1	physical	28514442
SESD1_HUMAN	SESTD1	physical	28514442
DYR1B_HUMAN	DYRK1B	physical	28514442
SI1L2_HUMAN	SIPA1L2	physical	28514442
ADIP_HUMAN	SSX2IP	physical	28514442
TTLL4_HUMAN	TTLL4	physical	28514442
AGAP3_HUMAN	AGAP3	physical	28514442
ELOA1_HUMAN	TCEB3	physical	28514442
TROAP_HUMAN	TROAP	physical	28514442
PI42C_HUMAN	PIP4K2C	physical	28514442
PI42B_HUMAN	PIP4K2B	physical	28514442
M18BP_HUMAN	MIS18BP1	physical	28514442
SOGA1_HUMAN	SOGA1	physical	28514442
AGAP1_HUMAN	AGAP1	physical	28514442
NBN_HUMAN	NBN	physical	28514442
DYR1A_HUMAN	DYRK1A	physical	28514442
SI1L3_HUMAN	SIPA1L3	physical	28514442
ZN644_HUMAN	ZNF644	physical	28514442
CPSF4_HUMAN	CPSF4	physical	28514442
AMPD2_HUMAN	AMPD2	physical	28514442
HIPK2_HUMAN	HIPK2	physical	28514442
NUD15_HUMAN	NUDT15	physical	28514442
EAPP_HUMAN	EAPP	physical	28514442
C2CD5_HUMAN	C2CD5	physical	28514442
ISCA1_HUMAN	ISCA1	physical	28514442
ZMYM1_HUMAN	ZMYM1	physical	28514442
CP131_HUMAN	CEP131	physical	28514442
PI42A_HUMAN	PIP4K2A	physical	28514442
SI1L1_HUMAN	SIPA1L1	physical	28514442
KIF7_HUMAN	KIF7	physical	28514442
RPA34_HUMAN	CD3EAP	physical	28514442
WDR33_HUMAN	WDR33	physical	28514442
CNDH2_HUMAN	NCAPH2	physical	28514442
RPA49_HUMAN	POLR1E	physical	28514442
CE290_HUMAN	CEP290	physical	28514442
MTMR5_HUMAN	SBF1	physical	28514442
PLCG1_HUMAN	PLCG1	physical	28514442
TTC31_HUMAN	TTC31	physical	28514442
HIC2_HUMAN	HIC2	physical	28514442
ACD11_HUMAN	ACAD11	physical	28514442
ERCC3_HUMAN	ERCC3	physical	28514442
ZMYM6_HUMAN	ZMYM6	physical	28514442
SMC2_HUMAN	SMC2	physical	28514442
MYO9A_HUMAN	MYO9A	physical	28514442
TSSC4_HUMAN	TSSC4	physical	28514442
CCD12_HUMAN	CCDC12	physical	28514442
CTC1_HUMAN	CTC1	physical	28514442
CNDD3_HUMAN	NCAPD3	physical	28514442
RFIP5_HUMAN	RAB11FIP5	physical	28514442
RECQ4_HUMAN	RECQL4	physical	28514442
CRNL1_HUMAN	CRNKL1	physical	28514442
ASPM_HUMAN	ASPM	physical	28514442
APC_HUMAN	APC	physical	28514442
TF2H1_HUMAN	GTF2H1	physical	28514442
Z324A_HUMAN	ZNF324	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LZTS2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-570, AND MASSSPECTROMETRY.	19369195 [Abstract]