RECQ4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RECQ4_HUMAN
• UniProt AC: O94761
• Protein Name: ATP-dependent DNA helicase Q4
• Gene Name: RECQL4
• Organism: Homo sapiens (Human).
• Sequence Length: 1208
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: DNA-dependent ATPase. May modulate chromosome segregation..
• Protein Sequence: MERLRDVRERLQAWERAFRRQRGRRPSQDDVEAAPEETRALYREYRTLKRTTGQAGGGLRSSESLPAAAEEAPEPRCWGPHLNRAATKSPQSTPGRSRQGSVPDYGQRLKANLKGTLQAGPALGRRPWPLGRASSKASTPKPPGTGPVPSFAEKVSDEPPQLPEPQPRPGRLQHLQASLSQRLGSLDPGWLQRCHSEVPDFLGAPKACRPDLGSEESQLLIPGESAVLGPGAGSQGPEASAFQEVSIRVGSPQPSSSGGEKRRWNEEPWESPAQVQQESSQAGPPSEGAGAVAVEEDPPGEPVQAQPPQPCSSPSNPRYHGLSPSSQARAGKAEGTAPLHIFPRLARHDRGNYVRLNMKQKHYVRGRALRSRLLRKQAWKQKWRKKGECFGGGGATVTTKESCFLNEQFDHWAAQCPRPASEEDTDAVGPEPLVPSPQPVPEVPSLDPTVLPLYSLGPSGQLAETPAEVFQALEQLGHQAFRPGQERAVMRILSGISTLLVLPTGAGKSLCYQLPALLYSRRSPCLTLVVSPLLSLMDDQVSGLPPCLKAACIHSGMTRKQRESVLQKIRAAQVHVLMLTPEALVGAGGLPPAAQLPPVAFACIDEAHCLSQWSHNFRPCYLRVCKVLRERMGVHCFLGLTATATRRTASDVAQHLAVAEEPDLHGPAPVPTNLHLSVSMDRDTDQALLTLLQGKRFQNLDSIIIYCNRREDTERIAALLRTCLHAAWVPGSGGRAPKTTAEAYHAGMCSRERRRVQRAFMQGQLRVVVATVAFGMGLDRPDVRAVLHLGLPPSFESYVQAVGRAGRDGQPAHCHLFLQPQGEDLRELRRHVHADSTDFLAVKRLVQRVFPACTCTCTRPPSEQEGAVGGERPVPKYPPQEAEQLSHQAAPGPRRVCMGHERALPIQLTVQALDMPEEAIETLLCYLELHPHHWLELLATTYTHCRLNCPGGPAQLQALAHRCPPLAVCLAQQLPEDPGQGSSSVEFDMVKLVDSMGWELASVRRALCQLQWDHEPRTGVRRGTGVLVEFSELAFHLRSPGDLTAEEKDQICDFLYGRVQARERQALARLRRTFQAFHSVAFPSCGPCLEQQDEERSTRLKDLLGRYFEEEEGQEPGGMEDAQGPEPGQARLQDWEDQVRCDIRQFLSLRPEEKFSSRAVARIFHGIGSPCYPAQVYGQDRRFWRKYLHLSFHALVGLATEELLQVAR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	RQRGRRPSQDDVEAA HHCCCCCCHHHHHCC	44.42	28102081
38	Phosphorylation	VEAAPEETRALYREY HHCCHHHHHHHHHHH	21.41	28985074
61	Phosphorylation	QAGGGLRSSESLPAA CCCCCCCCCCCCCCH	43.42	28555341
62	Phosphorylation	AGGGLRSSESLPAAA CCCCCCCCCCCCCHH	25.44	28555341
87	Phosphorylation	PHLNRAATKSPQSTP HHHCCCCCCCCCCCC	30.94	30266825
89	Phosphorylation	LNRAATKSPQSTPGR HCCCCCCCCCCCCCC	25.14	25849741
89	Phosphorylation	LNRAATKSPQSTPGR HCCCCCCCCCCCCCC	25.14	30266825
93	Phosphorylation	ATKSPQSTPGRSRQG CCCCCCCCCCCCCCC	32.88	30266825
93	O-linked_Glycosylation	ATKSPQSTPGRSRQG CCCCCCCCCCCCCCC	32.88	30379171
93	Phosphorylation	ATKSPQSTPGRSRQG CCCCCCCCCCCCCCC	32.88	22115753
97	Phosphorylation	PQSTPGRSRQGSVPD CCCCCCCCCCCCCCC	34.57	27251275
101	Phosphorylation	PGRSRQGSVPDYGQR CCCCCCCCCCCHHHH	23.34	25159151
101	Phosphorylation	PGRSRQGSVPDYGQR CCCCCCCCCCCHHHH	23.34	25627689
105	Phosphorylation	RQGSVPDYGQRLKAN CCCCCCCHHHHHHHH	14.75	28985074
110	Methylation	PDYGQRLKANLKGTL CCHHHHHHHHHCCCC	37.10	-
114	Methylation	QRLKANLKGTLQAGP HHHHHHHCCCCCCCC	50.05	24129315
116	Phosphorylation	LKANLKGTLQAGPAL HHHHHCCCCCCCCCC	17.70	28555341
138	Phosphorylation	GRASSKASTPKPPGT CCCCCCCCCCCCCCC	49.32	25627689
139	Phosphorylation	RASSKASTPKPPGTG CCCCCCCCCCCCCCC	39.94	28674419
150	Phosphorylation	PGTGPVPSFAEKVSD CCCCCCCCHHHHHCC	37.00	24719451
178	Phosphorylation	RLQHLQASLSQRLGS HHHHHHHHHHHHHCC	18.65	29523821
180	Phosphorylation	QHLQASLSQRLGSLD HHHHHHHHHHHCCCC	15.68	23917254
185	Phosphorylation	SLSQRLGSLDPGWLQ HHHHHHCCCCHHHHH	33.90	28348404
234	Phosphorylation	VLGPGAGSQGPEASA CCCCCCCCCCCCCCC	31.28	-
251	Phosphorylation	EVSIRVGSPQPSSSG EEEEEECCCCCCCCC	19.94	23401153
255	Phosphorylation	RVGSPQPSSSGGEKR EECCCCCCCCCCCCC	31.71	22199227
256	Phosphorylation	VGSPQPSSSGGEKRR ECCCCCCCCCCCCCC	39.42	29396449
257	Phosphorylation	GSPQPSSSGGEKRRW CCCCCCCCCCCCCCC	55.97	29396449
261	Ubiquitination	PSSSGGEKRRWNEEP CCCCCCCCCCCCCCC	51.00	29967540
319	Phosphorylation	SSPSNPRYHGLSPSS CCCCCCCCCCCCHHH	11.07	28450419
323	Phosphorylation	NPRYHGLSPSSQARA CCCCCCCCHHHHHHC	27.59	30266825
325	Phosphorylation	RYHGLSPSSQARAGK CCCCCCHHHHHHCCC	31.54	30266825
326	Phosphorylation	YHGLSPSSQARAGKA CCCCCHHHHHHCCCC	31.10	30266825
332	Ubiquitination	SSQARAGKAEGTAPL HHHHHCCCCCCCCCC	42.13	-
332	Sumoylation	SSQARAGKAEGTAPL HHHHHCCCCCCCCCC	42.13	-
332	Sumoylation	SSQARAGKAEGTAPL HHHHHCCCCCCCCCC	42.13	-
353	Phosphorylation	ARHDRGNYVRLNMKQ HHCCCCCEEECCCCC	6.97	-
376	Acetylation	LRSRLLRKQAWKQKW HHHHHHHHHHHHHHH	44.32	19299466
380	Acetylation	LLRKQAWKQKWRKKG HHHHHHHHHHHHHCC	45.04	19299466
382	Acetylation	RKQAWKQKWRKKGEC HHHHHHHHHHHCCCC	45.28	19299466
385	Ubiquitination	AWKQKWRKKGECFGG HHHHHHHHCCCCCCC	65.11	-
385	Acetylation	AWKQKWRKKGECFGG HHHHHHHHCCCCCCC	65.11	19299466
386	Acetylation	WKQKWRKKGECFGGG HHHHHHHCCCCCCCC	51.90	19299466
386	Ubiquitination	WKQKWRKKGECFGGG HHHHHHHCCCCCCCC	51.90	33845483
509	Phosphorylation	LPTGAGKSLCYQLPA CCCCCCHHHHHHHHH	23.82	25278378
512	Phosphorylation	GAGKSLCYQLPALLY CCCHHHHHHHHHHHH	20.55	25278378
519	Phosphorylation	YQLPALLYSRRSPCL HHHHHHHHCCCCCHH	10.86	25278378
520	Phosphorylation	QLPALLYSRRSPCLT HHHHHHHCCCCCHHH	22.61	24719451
568	Ubiquitination	QRESVLQKIRAAQVH HHHHHHHHHHHHHCE	29.96	-
695	Ubiquitination	LLTLLQGKRFQNLDS HHHHHCCCCCCCCCE	36.76	21906983
732	Phosphorylation	HAAWVPGSGGRAPKT HHHCCCCCCCCCCCC	31.81	21712546
738	Ubiquitination	GSGGRAPKTTAEAYH CCCCCCCCCHHHHHH	58.48	-
771	Phosphorylation	QLRVVVATVAFGMGL CHHHHHHHHHHCCCC	10.76	-
794	Phosphorylation	LHLGLPPSFESYVQA HHCCCCCCHHHHHHH	39.44	24719451
797	Phosphorylation	GLPPSFESYVQAVGR CCCCCHHHHHHHHHC	28.70	24719451
843	Ubiquitination	STDFLAVKRLVQRVF CCCHHHHHHHHHHHC	34.11	21906983
862	Phosphorylation	CTCTRPPSEQEGAVG EEECCCCCCCCCCCC	55.37	28348404
1048	Ubiquitination	GDLTAEEKDQICDFL CCCCHHHHHHHHHHH	46.57	-
1056	Phosphorylation	DQICDFLYGRVQARE HHHHHHHHHHHHHHH	11.68	25147952
1101	Ubiquitination	EERSTRLKDLLGRYF HHHHHHHHHHHHHHH	42.93	21906983
1148	Phosphorylation	CDIRQFLSLRPEEKF HCHHHHHCCCCHHHH	24.50	22985185
1154	Ubiquitination	LSLRPEEKFSSRAVA HCCCCHHHHCHHHHH	49.21	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
89	S	Phosphorylation	Kinase	CDK1	P06493	PSP
89	S	Phosphorylation	Kinase	CDK2	P24941	PSP
251	S	Phosphorylation	Kinase	CDK1	P06493	PSP
251	S	Phosphorylation	Kinase	CDK2	P24941	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RECQ4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RECQ4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBR1_HUMAN	UBR1	physical	15317757
UBR2_HUMAN	UBR2	physical	15317757

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 268400: Rothmund-Thomson syndrome (RTS)
• 266280: RAPADILINO syndrome (RAPADILINOS)
• 218600: Baller-Gerold syndrome (BGS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.