SESD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SESD1_HUMAN
• UniProt AC: Q86VW0
• Protein Name: SEC14 domain and spectrin repeat-containing protein 1
• Gene Name: SESTD1
• Organism: Homo sapiens (Human).
• Sequence Length: 696
• Protein Description: May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1..
• Protein Sequence: MEASVILPILKKKLAFLSGGKDRRSGLILTIPLCLEQTNMDELSVTLDYLLSIPSEKCKARGFTVIVDGRKSQWNVVKTVVVMLQNVVPAEVSLVCVVKPDEFWDKKVTHFCFWKEKDRLGFEVILVSANKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELALINNGSDKGNQQEKERSVDLNFLPSVDPETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDELLAQPQVMKLLDSLREQYTRYQEVCRQRSKRTQLEEIQQKVMQVVNWLEGPGSEQLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQLSDVCYRQASQLEFRQNLLQAALEFHGVAQDLSQQLDGLLGMLCVDVAPADGASIQQTLKLLEEKLKSVDVGLQGLREKGQGLLDQISNQASWAYGKDVTIENKENVDHIQGVMEDMQLRKQRCEDMVDVRRLKMLQMVQLFKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLEKHRKFVDVAQSTYDYGRQLLQATVVLCQSLRCTSRSSGDTLPRLNRVWKQFTIASEERVHRLEMAIAFHSNAEKILQDCPEEPEAINDEEQFDEIEAVGKSLLDRLTVPVVYPDGTEQYFGSPSDMASTAENIRDRMKLVNLKRQQLRHPEMVTTES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	IPLCLEQTNMDELSV EEEHHHHCCHHHHHH	24.12	22210691
55	Phosphorylation	DYLLSIPSEKCKARG HHHHHCCHHHHCCCC	48.28	22210691
168	Ubiquitination	LVFEKFTKESTSLLD HHHHHCCHHHHHHHH	53.45	-
170	Phosphorylation	FEKFTKESTSLLDEL HHHCCHHHHHHHHHH	25.50	27251275
171	Phosphorylation	EKFTKESTSLLDELA HHCCHHHHHHHHHHH	25.20	27251275
172	Phosphorylation	KFTKESTSLLDELAL HCCHHHHHHHHHHHH	35.89	27251275
186	Ubiquitination	LINNGSDKGNQQEKE HHCCCCCCCCHHHHH	62.55	-
253	Phosphorylation	QVMKLLDSLREQYTR HHHHHHHHHHHHHHH	29.33	24719451
258	Phosphorylation	LDSLREQYTRYQEVC HHHHHHHHHHHHHHH	6.61	24719451
261	Phosphorylation	LREQYTRYQEVCRQR HHHHHHHHHHHHHHH	10.96	18083107
305	Phosphorylation	AQWGIGDSIRASQAL HHHCCHHHHHHHHHH	14.57	24076635
423	Ubiquitination	TLKLLEEKLKSVDVG HHHHHHHHHHHCCCC	52.41	-
455	Ubiquitination	QASWAYGKDVTIENK CHHHHHCCCCEECCC	36.03	-
535	Ubiquitination	GDDAQETKVLLEKHR CCCHHHHHHHHHHHH	30.08	-
640	Phosphorylation	EIEAVGKSLLDRLTV HHHHHHHHHHHHCCC	28.38	24275569
646	Phosphorylation	KSLLDRLTVPVVYPD HHHHHHCCCCEECCC	24.53	19835603
651	Phosphorylation	RLTVPVVYPDGTEQY HCCCCEECCCCCCCC	8.88	19835603
655	Phosphorylation	PVVYPDGTEQYFGSP CEECCCCCCCCCCCH	27.56	19835603
658	Phosphorylation	YPDGTEQYFGSPSDM CCCCCCCCCCCHHHH	12.04	19835603
661	Phosphorylation	GTEQYFGSPSDMAST CCCCCCCCHHHHHHH	16.01	19835603
663	Phosphorylation	EQYFGSPSDMASTAE CCCCCCHHHHHHHHH	41.54	19835603
667	Phosphorylation	GSPSDMASTAENIRD CCHHHHHHHHHHHHH	22.85	19835603
668	Phosphorylation	SPSDMASTAENIRDR CHHHHHHHHHHHHHH	28.58	19835603

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SESD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SESD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SESD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GELS_HUMAN	GSN	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.