AGAP3_HUMAN - dbPTM
AGAP3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AGAP3_HUMAN
UniProt AC Q96P47
Protein Name Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3
Gene Name AGAP3
Organism Homo sapiens (Human).
Sequence Length 875
Subcellular Localization Cytoplasm . In cells upon oxidative stress or in brains of Machado-Joseph disease patients, translocates to PML nuclear bodies.
Protein Description GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway..
Protein Sequence MNFQAGGGQSPQQQQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLIERIEDLALQNQIREHVISIEDSFVNSQEWTLSRSVPELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASEVPMVLVGTQDAISAANPRVIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKKQQLAIGPCKSLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASSTPTPIRKQSKRRSNIFTSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNKEWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTSPRANGLSVERSNTQLGGGTGAPHSASSASLHSERPLSSSAWAGPRPEGLHQRSCSVSSADQWSEATTSLPPGMQHPASGPAEVLSSSPKLDPPPSPHSNRKKHRRKKSTGTPRPDGPSSATEEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNAALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGLAPTPNREPANGTNPSAELHRSPSLL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
42PhosphorylationAEIQRFESVHPNIYA
HHHHHHHCCCCHHHH		24.0224719451
51PhosphorylationHPNIYAIYDLIERIE
CCHHHHHHHHHHHHH		9.1324719451
78 (in isoform 4)Phosphorylation-8.5724719451
87 (in isoform 4)Phosphorylation-44.8024719451
111PhosphorylationKSALVHRYLTGTYVQ
CCHHHHHHHHCCEEE		8.1720068231
113PhosphorylationALVHRYLTGTYVQEE
HHHHHHHHCCEEEEE		20.6720068231
115PhosphorylationVHRYLTGTYVQEESP
HHHHHHCCEEEEECC		18.4520068231
116PhosphorylationHRYLTGTYVQEESPE
HHHHHCCEEEEECCC		11.0720068231
121PhosphorylationGTYVQEESPEGGRFK
CCEEEEECCCCCCCE		27.7421815630
147PhosphorylationLLIRDEGGPPELQFA
EEEECCCCCHHHHHH		32.3220068231
157 (in isoform 4)Phosphorylation-2.6524719451
157PhosphorylationELQFAAWVDAVVFVF
HHHHHHHCCEEEEEE		2.6520068231
184PhosphorylationNYFLRLCSFRNASEV
HHHHHHHCCCCCCCC		31.6524719451
219PhosphorylationDSRARKLSTDLKRCT
HHHHHHHCCHHHHCC		23.94-
220 (in isoform 4)Phosphorylation-56.6524719451
318PhosphorylationQRELRIETIAASSTP
HHCEEEEEHHHCCCC		17.3423403867
322PhosphorylationRIETIAASSTPTPIR
EEEEHHHCCCCCCCC		26.2329255136
323PhosphorylationIETIAASSTPTPIRK
EEEHHHCCCCCCCCC		33.4129255136
324PhosphorylationETIAASSTPTPIRKQ
EEHHHCCCCCCCCCC		28.7829255136
326 (in isoform 3)Phosphorylation-31.2825159151
326PhosphorylationIAASSTPTPIRKQSK
HHHCCCCCCCCCCHH		31.2829255136
332PhosphorylationPTPIRKQSKRRSNIF
CCCCCCCHHHHCCCC		31.0324117733
336PhosphorylationRKQSKRRSNIFTSRK
CCCHHHHCCCCCCCC		38.0121712546
343MethylationSNIFTSRKGADLDRE
CCCCCCCCCCCCCHH		59.21-
359PhosphorylationKAAECKVDSIGSGRA
HHHCCCCCCCCCCCC		21.7419413330
359 (in isoform 4)Phosphorylation-21.7424719451
360PhosphorylationAAECKVDSIGSGRAI
HHCCCCCCCCCCCCE		31.6619413330
362 (in isoform 6)Phosphorylation-28.1825159151
362 (in isoform 4)Phosphorylation-28.1824719451
362PhosphorylationECKVDSIGSGRAIPI
CCCCCCCCCCCCEEE		28.1820068231
372 (in isoform 4)Phosphorylation-13.9124719451
372PhosphorylationRAIPIKQGILLKRSG
CCEEECCCEEEEECC		13.9118669648
390PhosphorylationNKEWKKKYVTLCDNG
CHHHHHHEEEECCCC		13.93-
435PhosphorylationGKRLPRATPATAPGT
CCCCCCCCCCCCCCC		18.0923403867
438PhosphorylationLPRATPATAPGTSPR
CCCCCCCCCCCCCCC		34.2930266825
442PhosphorylationTPATAPGTSPRANGL
CCCCCCCCCCCCCCC		34.2023459991
443PhosphorylationPATAPGTSPRANGLS
CCCCCCCCCCCCCCE		20.5030266825
450PhosphorylationSPRANGLSVERSNTQ
CCCCCCCEEECCCCC		24.2729255136
462PhosphorylationNTQLGGGTGAPHSAS
CCCCCCCCCCCCCCC		33.1827251275
467PhosphorylationGGTGAPHSASSASLH
CCCCCCCCCCCCCCC		28.8727251275
469PhosphorylationTGAPHSASSASLHSE
CCCCCCCCCCCCCCC		29.4727251275
470PhosphorylationGAPHSASSASLHSER
CCCCCCCCCCCCCCC		22.9227251275
472PhosphorylationPHSASSASLHSERPL
CCCCCCCCCCCCCCC		28.6727251275
478PhosphorylationASLHSERPLSSSAWA
CCCCCCCCCCCCCCC		32.3219664995
478 (in isoform 4)Phosphorylation-32.3224719451
479PhosphorylationSLHSERPLSSSAWAG
CCCCCCCCCCCCCCC		10.9816964243
479 (in isoform 4)Phosphorylation-10.9827251275
480PhosphorylationLHSERPLSSSAWAGP
CCCCCCCCCCCCCCC		25.5726552605
481PhosphorylationHSERPLSSSAWAGPR
CCCCCCCCCCCCCCC		31.5826552605
482PhosphorylationSERPLSSSAWAGPRP
CCCCCCCCCCCCCCC		25.1826552605
486 (in isoform 4)Phosphorylation-14.1927251275
496PhosphorylationPEGLHQRSCSVSSAD
CCCCCCCCCCCCCHH		12.2727080861
498PhosphorylationGLHQRSCSVSSADQW
CCCCCCCCCCCHHHH		26.7027080861
498 (in isoform 4)Phosphorylation-26.7027251275
500PhosphorylationHQRSCSVSSADQWSE
CCCCCCCCCHHHHHH		11.9627080861
501PhosphorylationQRSCSVSSADQWSEA
CCCCCCCCHHHHHHC		33.4427080861
534 (in isoform 4)Phosphorylation-60.8427251275
537 (in isoform 4)Phosphorylation-66.9227251275
538PhosphorylationPKLDPPPSPHSNRKK
CCCCCCCCCCCCCHH		40.8130266825
541PhosphorylationDPPPSPHSNRKKHRR
CCCCCCCCCCHHHCC		41.5423927012
551PhosphorylationKKHRRKKSTGTPRPD
HHHCCCCCCCCCCCC		34.7924275569
574 (in isoform 4)Phosphorylation-3.0624719451
676PhosphorylationRHLGAHLSRVRSLDL
HHHHHHHHCCCCCCC		20.89-
732AcetylationKERWIRAKYEQKLFL
HHHHHHHHHHHHEEE		39.207234275
825PhosphorylationRGLTPLAYARRAGSQ
CCCCHHHHHHHCCCH		14.3418083107
862PhosphorylationNREPANGTNPSAELH
CCCCCCCCCCCHHHH		43.7027251275
865PhosphorylationPANGTNPSAELHRSP
CCCCCCCCHHHHCCC		36.1227251275
871PhosphorylationPSAELHRSPSLL---
CCHHHHCCCCCC---		14.2126074081
873PhosphorylationAELHRSPSLL-----
HHHHCCCCCC-----		43.4826074081
901 (in isoform 4)Phosphorylation-27251275
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AGAP3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AGAP3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AGAP3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of AGAP3_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AGAP3_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-324; THR-326 ANDSER-336, AND MASS SPECTROMETRY.
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-443, AND MASSSPECTROMETRY.

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