dbPTM

TSSC4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TSSC4_HUMAN
UniProt AC	Q9Y5U2
Protein Name	Protein TSSC4
Gene Name	TSSC4
Organism	Homo sapiens (Human).
Sequence Length	329
Subcellular Localization
Protein Description
Protein Sequence	MAEAGTGEPSPSVEGEHGTEYDTLPSDTVSLSDSDSDLSLPGGAEVEALSPMGLPGEEDSGPDEPPSPPSGLLPATVQPFHLRGMSSTFSQRSRDIFDCLEGAARRAPSSVAHTSMSDNGGFKRPLAPSGRSPVEGLGRAHRSPASPRVPPVPDYVAHPERWTKYSLEDVTEVSEQSNQATALAFLGSQSLAAPTDCVSSFNQDPSSCGEGRVIFTKPVRGVEARHERKRVLGKVGEPGRGGLGNPATDRGEGPVELAHLAGPGSPEAEEWGSHHGGLQEVEALSGSVHSGSVPGLPPVETVGFHGSRKRSRDHFRNKSSSPEDPGAEV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6 (in isoform 2)	Phosphorylation	-	45.48	24043423
12 (in isoform 2)	Phosphorylation	-	36.82	24043423
22 (in isoform 2)	Phosphorylation	-	35.22	24043423
23 (in isoform 2)	Phosphorylation	-	39.40	24043423
24 (in isoform 2)	Phosphorylation	-	3.32	24043423
26 (in isoform 2)	Phosphorylation	-	49.37	24043423
34	Phosphorylation	DTVSLSDSDSDLSLP CCEECCCCCCCCCCC	35.32	24275569
60	Phosphorylation	GLPGEEDSGPDEPPS CCCCCCCCCCCCCCC	56.35	-
67	Phosphorylation	SGPDEPPSPPSGLLP CCCCCCCCCCCCCCC	61.22	-
68	Phosphorylation	GPDEPPSPPSGLLPA CCCCCCCCCCCCCCC	32.61	32142685
86	Phosphorylation	PFHLRGMSSTFSQRS CEECCCCCCCCCHHH	29.11	18212344
87	Phosphorylation	FHLRGMSSTFSQRSR EECCCCCCCCCHHHH	25.28	21712546
88	Phosphorylation	HLRGMSSTFSQRSRD ECCCCCCCCCHHHHH	21.72	23186163
90	Phosphorylation	RGMSSTFSQRSRDIF CCCCCCCCHHHHHHH	25.44	10072438
93	Phosphorylation	SSTFSQRSRDIFDCL CCCCCHHHHHHHHHH	27.03	22617229
109	Phosphorylation	GAARRAPSSVAHTSM HHHHHCCCCCCCCCC	36.14	28555341
110	O-linked_Glycosylation	AARRAPSSVAHTSMS HHHHCCCCCCCCCCC	23.43	31492838
115	Phosphorylation	PSSVAHTSMSDNGGF CCCCCCCCCCCCCCC	13.36	28555341
117	Phosphorylation	SVAHTSMSDNGGFKR CCCCCCCCCCCCCCC	27.91	28555341
129	Phosphorylation	FKRPLAPSGRSPVEG CCCCCCCCCCCCCCC	41.03	28176443
132	Phosphorylation	PLAPSGRSPVEGLGR CCCCCCCCCCCCCCC	36.50	22167270
139	Methylation	SPVEGLGRAHRSPAS CCCCCCCCCCCCCCC	32.06	24391071
143	Phosphorylation	GLGRAHRSPASPRVP CCCCCCCCCCCCCCC	18.23	25159151
146	Phosphorylation	RAHRSPASPRVPPVP CCCCCCCCCCCCCCC	19.34	23401153
153	Acetylation	SPRVPPVPDYVAHPE CCCCCCCCCCCCCHH	32.75	19608861
153	Ubiquitination	SPRVPPVPDYVAHPE CCCCCCCCCCCCCHH	32.75	33845483
155	Phosphorylation	RVPPVPDYVAHPERW CCCCCCCCCCCHHHH	8.08	24732914
170	Ubiquitination	TKYSLEDVTEVSEQS CCCCHHHHHHHHHHH	3.43	24816145
217	Ubiquitination	EGRVIFTKPVRGVEA CCEEEEECCCCCCCH	30.66	33845483
217	Acetylation	EGRVIFTKPVRGVEA CCEEEEECCCCCCCH	30.66	19608861
220	Methylation	VIFTKPVRGVEARHE EEEECCCCCCCHHHH	52.55	80702383
234	Ubiquitination	ERKRVLGKVGEPGRG HHHHHHCCCCCCCCC	42.79	24816145
240	Methylation	GKVGEPGRGGLGNPA CCCCCCCCCCCCCCC	46.88	24394933
257	Phosphorylation	RGEGPVELAHLAGPG CCCCCEEEHHHCCCC	3.56	33259812
265	Phosphorylation	AHLAGPGSPEAEEWG HHHCCCCCHHHHHHH	23.77	26074081
307	Phosphorylation	ETVGFHGSRKRSRDH EEEEECCCCHHCHHH	26.51	20068231
319	Phosphorylation	RDHFRNKSSSPEDPG HHHHCCCCCCCCCCC	39.33	23401153
320	Phosphorylation	DHFRNKSSSPEDPGA HHHCCCCCCCCCCCC	52.07	23401153
321	Phosphorylation	HFRNKSSSPEDPGAE HHCCCCCCCCCCCCC	39.12	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TSSC4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TSSC4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TSSC4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
WDR70_HUMAN	WDR70	physical	22939629
RNF31_HUMAN	RNF31	physical	25416956
GMCL1_HUMAN	GMCL1	physical	25416956
CEP76_HUMAN	CEP76	physical	25416956
RED_HUMAN	IK	physical	26186194
SNR40_HUMAN	SNRNP40	physical	26186194
PRP6_HUMAN	PRPF6	physical	26186194
U520_HUMAN	SNRNP200	physical	26186194
PRP8_HUMAN	PRPF8	physical	26186194
TFP11_HUMAN	TFIP11	physical	26186194
U5S1_HUMAN	EFTUD2	physical	26186194
SYF1_HUMAN	XAB2	physical	26186194
C19L2_HUMAN	CWF19L2	physical	26186194
GPTC1_HUMAN	GPATCH1	physical	26186194
P4R3A_HUMAN	SMEK1	physical	26186194
DHX35_HUMAN	DHX35	physical	26186194
PAXB1_HUMAN	PAXBP1	physical	26186194
CRNL1_HUMAN	CRNKL1	physical	26186194
C19L1_HUMAN	CWF19L1	physical	26186194
BUD31_HUMAN	BUD31	physical	26186194
CDC5L_HUMAN	CDC5L	physical	26186194
AQR_HUMAN	AQR	physical	26186194
WDR83_HUMAN	WDR83	physical	26186194
ZNHI2_HUMAN	ZNHIT2	physical	26186194
SNW1_HUMAN	SNW1	physical	26186194
AAR2_HUMAN	AAR2	physical	26186194
TPM1_HUMAN	TPM1	physical	26186194
ECD_HUMAN	ECD	physical	26186194
RSRC1_HUMAN	RSRC1	physical	26186194
EAPP_HUMAN	EAPP	physical	26186194
SMD2_HUMAN	SNRPD2	physical	26186194
PRP17_HUMAN	CDC40	physical	26186194
CCD12_HUMAN	CCDC12	physical	26186194
RBM22_HUMAN	RBM22	physical	26186194
CD2B2_HUMAN	CD2BP2	physical	26186194
SYF2_HUMAN	SYF2	physical	26186194
TXN4A_HUMAN	TXNL4A	physical	26186194
SPF27_HUMAN	BCAS2	physical	26186194
ISY1_HUMAN	ISY1	physical	26186194
PP4R2_HUMAN	PPP4R2	physical	26186194
IMA4_HUMAN	KPNA3	physical	21516116
EAPP_HUMAN	EAPP	physical	28514442
ECD_HUMAN	ECD	physical	28514442
AAR2_HUMAN	AAR2	physical	28514442
CD2B2_HUMAN	CD2BP2	physical	28514442
GPTC1_HUMAN	GPATCH1	physical	28514442
SNR40_HUMAN	SNRNP40	physical	28514442
C19L2_HUMAN	CWF19L2	physical	28514442
PAXB1_HUMAN	PAXBP1	physical	28514442
SYF2_HUMAN	SYF2	physical	28514442
DHX35_HUMAN	DHX35	physical	28514442
SYF1_HUMAN	XAB2	physical	28514442
PRP17_HUMAN	CDC40	physical	28514442
WDR83_HUMAN	WDR83	physical	28514442
CCD12_HUMAN	CCDC12	physical	28514442
CRNL1_HUMAN	CRNKL1	physical	28514442
ZNHI2_HUMAN	ZNHIT2	physical	28514442
BUD31_HUMAN	BUD31	physical	28514442
TFP11_HUMAN	TFIP11	physical	28514442
AQR_HUMAN	AQR	physical	28514442
P4R3A_HUMAN	SMEK1	physical	28514442
ISY1_HUMAN	ISY1	physical	28514442
PP4R2_HUMAN	PPP4R2	physical	28514442
PRP6_HUMAN	PRPF6	physical	28514442
RED_HUMAN	IK	physical	28514442
U520_HUMAN	SNRNP200	physical	28514442
RSRC1_HUMAN	RSRC1	physical	28514442
PRP8_HUMAN	PRPF8	physical	28514442
U5S1_HUMAN	EFTUD2	physical	28514442
RBM22_HUMAN	RBM22	physical	28514442
PPIE_HUMAN	PPIE	physical	28514442
CDC5L_HUMAN	CDC5L	physical	28514442
IDE_HUMAN	IDE	physical	28514442
SMD2_HUMAN	SNRPD2	physical	28514442
TPM1_HUMAN	TPM1	physical	28514442
SNW1_HUMAN	SNW1	physical	28514442
C19L1_HUMAN	CWF19L1	physical	28514442
TXN4A_HUMAN	TXNL4A	physical	28514442
AAR2_HUMAN	AAR2	physical	28561026
AQR_HUMAN	AQR	physical	28561026
CD2B2_HUMAN	CD2BP2	physical	28561026
CDC5L_HUMAN	CDC5L	physical	28561026
CWC22_HUMAN	CWC22	physical	28561026
DDX23_HUMAN	DDX23	physical	28561026
DHX35_HUMAN	DHX35	physical	28561026
PRP16_HUMAN	DHX38	physical	28561026
DHX8_HUMAN	DHX8	physical	28561026
EAPP_HUMAN	EAPP	physical	28561026
ECD_HUMAN	ECD	physical	28561026
U5S1_HUMAN	EFTUD2	physical	28561026
GPTC1_HUMAN	GPATCH1	physical	28561026
HSF1_HUMAN	HSF1	physical	28561026
MFAP1_HUMAN	MFAP1	physical	28561026
MTA2_HUMAN	MTA2	physical	28561026
NCDN_HUMAN	NCDN	physical	28561026
PLRG1_HUMAN	PLRG1	physical	28561026
PRP19_HUMAN	PRPF19	physical	28561026
PR38A_HUMAN	PRPF38A	physical	28561026
PRP6_HUMAN	PRPF6	physical	28561026
PRP8_HUMAN	PRPF8	physical	28561026
RUVB1_HUMAN	RUVBL1	physical	28561026
RUVB2_HUMAN	RUVBL2	physical	28561026
S7A6O_HUMAN	SLC7A6OS	physical	28561026
SLU7_HUMAN	SLU7	physical	28561026
U520_HUMAN	SNRNP200	physical	28561026
SNR40_HUMAN	SNRNP40	physical	28561026
RSMB_HUMAN	SNRPB	physical	28561026
SMD1_HUMAN	SNRPD1	physical	28561026
SMD2_HUMAN	SNRPD2	physical	28561026
SMD3_HUMAN	SNRPD3	physical	28561026
TSSC4_HUMAN	TSSC4	physical	28561026
SYF1_HUMAN	XAB2	physical	28561026
ZNHI2_HUMAN	ZNHIT2	physical	28561026
PRP17_HUMAN	CDC40	physical	28561026
CRNL1_HUMAN	CRNKL1	physical	28561026
ISY1_HUMAN	ISY1	physical	28561026
SNW1_HUMAN	SNW1	physical	28561026

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TSSC4_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-217, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132; SER-143 ANDSER-146, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129, AND MASSSPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321, AND MASSSPECTROMETRY.	15302935 [Abstract]