| UniProt ID | CD2B2_HUMAN | |
|---|---|---|
| UniProt AC | O95400 | |
| Protein Name | CD2 antigen cytoplasmic tail-binding protein 2 | |
| Gene Name | CD2BP2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 341 | |
| Subcellular Localization | Cytoplasm. Nucleus. Predominantly nuclear. | |
| Protein Description | Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly.. | |
| Protein Sequence | MPKRKVTFQGVGDEEDEDEIIVPKKKLVDPVAGSGGPGSRFKGKHSLDSDEEEDDDDGGSSKYDILASEDVEGQEAATLPSEGGVRITPFNLQEEMEEGHFDADGNYFLNRDAQIRDSWLDNIDWVKIRERPPGQRQASDSEEEDSLGQTSMSAQALLEGLLELLLPRETVAGALRRLGARGGGKGRKGPGQPSSPQRLDRLSGLADQMVARGNLGVYQETRERLAMRLKGLGCQTLGPHNPTPPPSLDMFAEELAEEELETPTPTQRGEAESRGDGLVDVMWEYKWENTGDAELYGPFTSAQMQTWVSEGYFPDGVYCRKLDPPGGQFYNSKRIDFDLYT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MPKRKVTFQGVGDE -CCCCEEEEECCCCC | 17.18 | 24719451 | |
| 24 | Ubiquitination | EDEIIVPKKKLVDPV CCCEEEECHHCCCCC | 52.20 | - | |
| 26 | Acetylation | EIIVPKKKLVDPVAG CEEEECHHCCCCCCC | 60.93 | 26051181 | |
| 26 | Sumoylation | EIIVPKKKLVDPVAG CEEEECHHCCCCCCC | 60.93 | 28112733 | |
| 26 | Sumoylation | EIIVPKKKLVDPVAG CEEEECHHCCCCCCC | 60.93 | - | |
| 34 | Phosphorylation | LVDPVAGSGGPGSRF CCCCCCCCCCCCCCC | 30.73 | 25159151 | |
| 39 | Phosphorylation | AGSGGPGSRFKGKHS CCCCCCCCCCCCCCC | 37.36 | 26074081 | |
| 39 | O-linked_Glycosylation | AGSGGPGSRFKGKHS CCCCCCCCCCCCCCC | 37.36 | 29351928 | |
| 44 | Acetylation | PGSRFKGKHSLDSDE CCCCCCCCCCCCCCC | 30.52 | - | |
| 46 | Phosphorylation | SRFKGKHSLDSDEEE CCCCCCCCCCCCCCC | 37.04 | 22167270 | |
| 49 | Phosphorylation | KGKHSLDSDEEEDDD CCCCCCCCCCCCCCC | 52.82 | 22167270 | |
| 60 | Phosphorylation | EDDDDGGSSKYDILA CCCCCCCCCHHEEEE | 29.23 | 22167270 | |
| 61 | Phosphorylation | DDDDGGSSKYDILAS CCCCCCCCHHEEEEE | 38.21 | 22167270 | |
| 63 | Phosphorylation | DDGGSSKYDILASED CCCCCCHHEEEEECC | 15.34 | 30576142 | |
| 68 | Phosphorylation | SKYDILASEDVEGQE CHHEEEEECCCCCCC | 30.77 | 28464451 | |
| 78 | Phosphorylation | VEGQEAATLPSEGGV CCCCCCCCCCCCCCE | 46.37 | 23927012 | |
| 81 | Phosphorylation | QEAATLPSEGGVRIT CCCCCCCCCCCEEEC | 52.57 | 23927012 | |
| 88 | Phosphorylation | SEGGVRITPFNLQEE CCCCEEECCCCCCHH | 15.97 | 26074081 | |
| 107 | Phosphorylation | HFDADGNYFLNRDAQ CCCCCCCEECCCCCC | 18.25 | - | |
| 118 | Phosphorylation | RDAQIRDSWLDNIDW CCCCCCCHHHHCCCE | 21.49 | 25159151 | |
| 127 | Ubiquitination | LDNIDWVKIRERPPG HHCCCEEEEECCCCC | 31.62 | - | |
| 139 | Phosphorylation | PPGQRQASDSEEEDS CCCCCCCCCCCCCCC | 33.07 | 20363803 | |
| 141 | Phosphorylation | GQRQASDSEEEDSLG CCCCCCCCCCCCCCC | 44.40 | 20363803 | |
| 146 | Phosphorylation | SDSEEEDSLGQTSMS CCCCCCCCCCCCCHH | 37.36 | 21406692 | |
| 150 | Phosphorylation | EEDSLGQTSMSAQAL CCCCCCCCCHHHHHH | 25.30 | 29116813 | |
| 151 | Phosphorylation | EDSLGQTSMSAQALL CCCCCCCCHHHHHHH | 11.67 | 29116813 | |
| 153 | Phosphorylation | SLGQTSMSAQALLEG CCCCCCHHHHHHHHH | 19.59 | 28464451 | |
| 176 | Methylation | ETVAGALRRLGARGG HHHHHHHHHHHHCCC | 31.10 | - | |
| 181 | Methylation | ALRRLGARGGGKGRK HHHHHHHCCCCCCCC | 42.35 | - | |
| 194 | Phosphorylation | RKGPGQPSSPQRLDR CCCCCCCCCHHHHHH | 46.92 | 29255136 | |
| 195 | Phosphorylation | KGPGQPSSPQRLDRL CCCCCCCCHHHHHHH | 31.56 | 29255136 | |
| 203 | Phosphorylation | PQRLDRLSGLADQMV HHHHHHHHHHHHHHH | 32.43 | 23090842 | |
| 209 | Sulfoxidation | LSGLADQMVARGNLG HHHHHHHHHHHCCCC | 2.34 | 21406390 | |
| 236 | Phosphorylation | LKGLGCQTLGPHNPT HCCCCCCCCCCCCCC | 37.45 | 29496963 | |
| 243 | Phosphorylation | TLGPHNPTPPPSLDM CCCCCCCCCCCCHHH | 54.46 | 25159151 | |
| 247 | Phosphorylation | HNPTPPPSLDMFAEE CCCCCCCCHHHHHHH | 42.65 | 25159151 | |
| 262 | Phosphorylation | LAEEELETPTPTQRG HHHHHHCCCCCCCCC | 45.12 | 27174698 | |
| 264 | Phosphorylation | EEELETPTPTQRGEA HHHHCCCCCCCCCCH | 46.52 | 25159151 | |
| 266 | Phosphorylation | ELETPTPTQRGEAES HHCCCCCCCCCCHHH | 33.12 | 27174698 | |
| 273 | Phosphorylation | TQRGEAESRGDGLVD CCCCCHHHCCCCCEE | 48.92 | 27174698 | |
| 321 | Sumoylation | PDGVYCRKLDPPGGQ CCCCEEEECCCCCCC | 54.39 | - | |
| 321 | Ubiquitination | PDGVYCRKLDPPGGQ CCCCEEEECCCCCCC | 54.39 | - | |
| 330 | Phosphorylation | DPPGGQFYNSKRIDF CCCCCCCCCCCCCCE | 15.61 | - | |
| 332 | Phosphorylation | PGGQFYNSKRIDFDL CCCCCCCCCCCCEEC | 16.36 | - | |
| 333 | Acetylation | GGQFYNSKRIDFDLY CCCCCCCCCCCEECC | 50.13 | 25953088 | |
| 333 | Ubiquitination | GGQFYNSKRIDFDLY CCCCCCCCCCCEECC | 50.13 | - | |
| 341 | Phosphorylation | RIDFDLYT------- CCCEECCC------- | 39.16 | 21712546 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CD2B2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CD2B2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CD2B2_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194, AND MASSSPECTROMETRY. | |
| "Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography."; Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.; Proteomics 8:1346-1361(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, AND MASSSPECTROMETRY. | |
| "A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-118, AND MASSSPECTROMETRY. | |
| "Phosphorylation analysis of primary human T lymphocytes usingsequential IMAC and titanium oxide enrichment."; Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.; J. Proteome Res. 7:5167-5176(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, AND MASSSPECTROMETRY. | |
| "Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46, AND MASSSPECTROMETRY. | |
| "Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, AND MASSSPECTROMETRY. | |
| "Quantitative phosphoproteome profiling of Wnt3a-mediated signalingnetwork: indicating the involvement of ribonucleoside-diphosphatereductase M2 subunit phosphorylation at residue serine 20 in canonicalWnt signal transduction."; Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S.,Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R.; Mol. Cell. Proteomics 6:1952-1967(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, AND MASSSPECTROMETRY. | |
| "Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-195, AND MASSSPECTROMETRY. | |
| "Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49 AND SER-195, AND MASSSPECTROMETRY. | |
