KLH36_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLH36_HUMAN
• UniProt AC: Q8N4N3
• Protein Name: Kelch-like protein 36
• Gene Name: KLHL36
• Organism: Homo sapiens (Human).
• Sequence Length: 616
• Protein Description: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins..
• Protein Sequence: MMEGSRQTRVSRPYKISESSKVYRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQPEREAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANCEGFIEEAVRYHNNLAAQPVMQTKRTALRTNQERLLFVGGEVSERCLELSDDTCYLDAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDDNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFSKTVQVYDREADKWSRGVDLPKAIAGGSACVCALEPRPEDKKKKGKGKRHQDRGQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MMEGSRQTRVSR ---CCCCCCCCCCCC	14.12	26074081
8	Phosphorylation	MMEGSRQTRVSRPYK CCCCCCCCCCCCCEE	31.74	26074081
11	Phosphorylation	GSRQTRVSRPYKISE CCCCCCCCCCEECCC	25.01	23403867
14	Phosphorylation	QTRVSRPYKISESSK CCCCCCCEECCCCCC	21.61	23403867
17	Phosphorylation	VSRPYKISESSKVYR CCCCEECCCCCCCEE	27.55	23898821
19	Phosphorylation	RPYKISESSKVYRWA CCEECCCCCCCEEEC	28.77	23403867
20	Phosphorylation	PYKISESSKVYRWAD CEECCCCCCCEEECC	23.30	23403867
93	Phosphorylation	EVELIGASYIGLKAV HHHHHCHHHHCHHHH	16.45	24719451
94	Phosphorylation	VELIGASYIGLKAVV HHHHCHHHHCHHHHH	9.85	24719451
159	Phosphorylation	QELASIYSLKRLDAF HHHHHHHCHHHCHHH	26.24	24719451
196	Phosphorylation	SMQKLCVYLSSSEVQ CHHHHHHHHCCHHHH	10.40	29888752
198	Phosphorylation	QKLCVYLSSSEVQRE HHHHHHHCCHHHHHH	17.71	29888752
199	Phosphorylation	KLCVYLSSSEVQREC HHHHHHCCHHHHHHH	28.11	29888752
200	Phosphorylation	LCVYLSSSEVQRECE HHHHHCCHHHHHHHH	38.11	29888752
250	Ubiquitination	NDLLHRVKPAVCSLL CCHHHHCCHHHHHHC	27.50	27667366
286	Ubiquitination	AQPVMQTKRTALRTN CCCCCCHHHHHHHCC	30.75	21906983
286 (in isoform 1)	Ubiquitination	-	30.75	21906983
286 (in isoform 2)	Ubiquitination	-	30.75	21906983
327	Ubiquitination	AKSEQWVKETPLPAR CCCHHHHHHCCCCCC	53.57	21906983
327 (in isoform 1)	Ubiquitination	-	53.57	21906983
327 (in isoform 2)	Ubiquitination	-	53.57	21906983
382	Phosphorylation	KQWIKVASMNQRRVD HHEEEEECCCCCCCC	22.66	29523821
420	Ubiquitination	SVETYSPKTDSWSYV CEEECCCCCCCCCHH	60.05	22817900
420 (in isoform 1)	Ubiquitination	-	60.05	21906983
440	Phosphorylation	FTYGHAGTIYKDFVY CCCCCCCEEEEEEEE	23.16	-
607	Acetylation	EDKKKKGKGKRHQDR HHHCCCCCCCCCCCC	70.86	164393

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLH36_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLH36_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLH36_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL3_HUMAN	CUL3	physical	28514442
TPP2_HUMAN	TPP2	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442
AINX_HUMAN	INA	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.