AINX_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AINX_HUMAN
• UniProt AC: Q16352
• Protein Name: Alpha-internexin
• Gene Name: INA
• Organism: Homo sapiens (Human).
• Sequence Length: 499
• Protein Description: Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges..
• Protein Sequence: MSFGSEHYLCSSSSYRKVFGDGSRLSARLSGAGGAGGFRSQSLSRSNVASSAACSSASSLGLGLAYRRPPASDGLDLSQAAARTNEYKIIRTNEKEQLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQRHAEPSRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQRLRARCEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVTVAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDSIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSISGLNPLPNPSYLLPPRILSATTSKVSSTGLSLKKEEEEEEASKVASKKTSQIGESFEEILEETVISTKKTEKSNIEETTISSQKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSFGSEHYL ------CCCCCCCEE	38.01	27732954
5	Phosphorylation	---MSFGSEHYLCSS ---CCCCCCCEECCC	21.13	27732954
8	Phosphorylation	MSFGSEHYLCSSSSY CCCCCCCEECCCHHC	12.83	26552605
11	Phosphorylation	GSEHYLCSSSSYRKV CCCCEECCCHHCCCH	30.57	26552605
12	Phosphorylation	SEHYLCSSSSYRKVF CCCEECCCHHCCCHH	23.47	26552605
13	Phosphorylation	EHYLCSSSSYRKVFG CCEECCCHHCCCHHC	18.33	26552605
14	Phosphorylation	HYLCSSSSYRKVFGD CEECCCHHCCCHHCC	30.79	26552605
15	Phosphorylation	YLCSSSSYRKVFGDG EECCCHHCCCHHCCC	19.19	26552605
23	Phosphorylation	RKVFGDGSRLSARLS CCHHCCCCHHHHHHC	34.48	28348404
26	Phosphorylation	FGDGSRLSARLSGAG HCCCCHHHHHHCCCC	15.38	32142685
30	Phosphorylation	SRLSARLSGAGGAGG CHHHHHHCCCCCCCC	22.50	29691806
40	Phosphorylation	GGAGGFRSQSLSRSN CCCCCCCCCCCCCCC	23.12	22210691
42	Phosphorylation	AGGFRSQSLSRSNVA CCCCCCCCCCCCCCC	29.56	22210691
44	Phosphorylation	GFRSQSLSRSNVASS CCCCCCCCCCCCCCH	38.62	22210691
46	Phosphorylation	RSQSLSRSNVASSAA CCCCCCCCCCCCHHH	32.07	29978859
50	O-linked_Glycosylation	LSRSNVASSAACSSA CCCCCCCCHHHHHHH	19.07	30379171
50	Phosphorylation	LSRSNVASSAACSSA CCCCCCCCHHHHHHH	19.07	29978859
51	Phosphorylation	SRSNVASSAACSSAS CCCCCCCHHHHHHHH	15.33	29978859
55	O-linked_Glycosylation	VASSAACSSASSLGL CCCHHHHHHHHHHCC	24.98	30379171
55	Phosphorylation	VASSAACSSASSLGL CCCHHHHHHHHHHCC	24.98	24076635
56	Phosphorylation	ASSAACSSASSLGLG CCHHHHHHHHHHCCC	31.86	24076635
58	Phosphorylation	SAACSSASSLGLGLA HHHHHHHHHHCCCCC	28.22	29978859
59	Phosphorylation	AACSSASSLGLGLAY HHHHHHHHHCCCCCC	26.60	24076635
66	Phosphorylation	SLGLGLAYRRPPASD HHCCCCCCCCCCCCC	16.52	29978859
72	Phosphorylation	AYRRPPASDGLDLSQ CCCCCCCCCCCCHHH	37.68	27732954
72	O-linked_Glycosylation	AYRRPPASDGLDLSQ CCCCCCCCCCCCHHH	37.68	30379171
78	Phosphorylation	ASDGLDLSQAAARTN CCCCCCHHHHHHHCC	19.89	27732954
95	Ubiquitination	KIIRTNEKEQLQGLN EEEECCHHHHHCCCH	53.48	29967540
95	2-Hydroxyisobutyrylation	KIIRTNEKEQLQGLN EEEECCHHHHHCCCH	53.48	-
104	Methylation	QLQGLNDRFAVFIEK HHCCCHHHHHHHHHH	21.98	115480323
111	2-Hydroxyisobutyrylation	RFAVFIEKVHQLETQ HHHHHHHHHHHHHHH	39.95	-
215	Ubiquitination	LARLDLEKKVESLLD HHHHCHHHHHHHHHH	70.21	33845483
216	2-Hydroxyisobutyrylation	ARLDLEKKVESLLDE HHHCHHHHHHHHHHH	41.69	-
216	Ubiquitination	ARLDLEKKVESLLDE HHHCHHHHHHHHHHH	41.69	33845483
219	Phosphorylation	DLEKKVESLLDELAF CHHHHHHHHHHHHHH	36.90	-
272	Phosphorylation	LREIRAQYESLAAKN HHHHHHHHHHHHHHH	13.39	-
287	Phosphorylation	LQSAEEWYKSKFANL CCCHHHHHHHHHCCH	14.52	-
288	Ubiquitination	QSAEEWYKSKFANLN CCHHHHHHHHHCCHH	48.52	32142685
290	Acetylation	AEEWYKSKFANLNEQ HHHHHHHHHCCHHHH	44.32	19608861
290	Ubiquitination	AEEWYKSKFANLNEQ HHHHHHHHHCCHHHH	44.32	19608861
302	Phosphorylation	NEQAARSTEAIRASR HHHHHHHHHHHHHHH	24.71	26425664
308	Phosphorylation	STEAIRASREEIHEY HHHHHHHHHHHHHHH	30.31	26425664
323	Phosphorylation	RRQLQARTIEIEGLR HHHHHHHEEEEECCC	26.44	30576142
335	Phosphorylation	GLRGANESLERQILE CCCCCCHHHHHHHHH	35.02	22617229
369	2-Hydroxyisobutyrylation	ENDLRNTKSEMARHL HHHHHHCHHHHHHHH	48.22	-
377	Methylation	SEMARHLREYQDLLN HHHHHHHHHHHHHHC	34.16	-
379	Phosphorylation	MARHLREYQDLLNVK HHHHHHHHHHHHCHH	10.82	21253578
396	Phosphorylation	LDIEIAAYRKLLEGE HHHHHHHHHHHHCCC	10.16	-
405	Phosphorylation	KLLEGEETRFSTSGL HHHCCCCCEECCCCC	32.48	21815630
408	Phosphorylation	EGEETRFSTSGLSIS CCCCCEECCCCCCCC	20.55	24076635
415	O-linked_Glycosylation	STSGLSISGLNPLPN CCCCCCCCCCCCCCC	33.57	30379171
415	Phosphorylation	STSGLSISGLNPLPN CCCCCCCCCCCCCCC	33.57	26657352
424	Phosphorylation	LNPLPNPSYLLPPRI CCCCCCHHHCCCHHH	34.74	26657352
425	Phosphorylation	NPLPNPSYLLPPRIL CCCCCHHHCCCHHHH	17.32	26657352
433	Phosphorylation	LLPPRILSATTSKVS CCCHHHHHHCCCCHH	22.62	32142685
435	Phosphorylation	PPRILSATTSKVSST CHHHHHHCCCCHHHC	28.38	24076635
436	Phosphorylation	PRILSATTSKVSSTG HHHHHHCCCCHHHCC	26.68	24076635
437	Phosphorylation	RILSATTSKVSSTGL HHHHHCCCCHHHCCC	27.06	24076635
438	Ubiquitination	ILSATTSKVSSTGLS HHHHCCCCHHHCCCC	44.00	32142685
440	O-linked_Glycosylation	SATTSKVSSTGLSLK HHCCCCHHHCCCCCC	26.39	30379171
440	Phosphorylation	SATTSKVSSTGLSLK HHCCCCHHHCCCCCC	26.39	26657352
441	Phosphorylation	ATTSKVSSTGLSLKK HCCCCHHHCCCCCCH	29.49	26657352
442	Phosphorylation	TTSKVSSTGLSLKKE CCCCHHHCCCCCCHH	34.34	26657352
445	Phosphorylation	KVSSTGLSLKKEEEE CHHHCCCCCCHHHHH	39.21	24719451
447	2-Hydroxyisobutyrylation	SSTGLSLKKEEEEEE HHCCCCCCHHHHHHH	55.55	-
447	Ubiquitination	SSTGLSLKKEEEEEE HHCCCCCCHHHHHHH	55.55	32142685
463	Phosphorylation	SKVASKKTSQIGESF HHHHHHHHHHHCHHH	29.60	27732954
464	Phosphorylation	KVASKKTSQIGESFE HHHHHHHHHHCHHHH	28.78	27732954
469	Phosphorylation	KTSQIGESFEEILEE HHHHHCHHHHHHHHH	32.51	29691806
483	Acetylation	ETVISTKKTEKSNIE HHHHCCCCCCCCCCC	63.10	19811059
486	Ubiquitination	ISTKKTEKSNIEETT HCCCCCCCCCCCCCC	54.77	32142685
487	Phosphorylation	STKKTEKSNIEETTI CCCCCCCCCCCCCCC	36.49	27732954
493	O-linked_Glycosylation	KSNIEETTISSQKI- CCCCCCCCCCCCCC-	23.34	30379171
496	Phosphorylation	IEETTISSQKI---- CCCCCCCCCCC----	31.48	17525332
498	Acetylation	ETTISSQKI------ CCCCCCCCC------	52.94	30586113

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AINX_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AINX_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AINX_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of AINX_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-290, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-496, AND MASSSPECTROMETRY.
PubMed: 17525332