NAA35_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NAA35_HUMAN
• UniProt AC: Q5VZE5
• Protein Name: N-alpha-acetyltransferase 35, NatC auxiliary subunit
• Gene Name: NAA35
• Organism: Homo sapiens (Human).
• Sequence Length: 725
• Subcellular Localization: Cytoplasm .
• Protein Description: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells..
• Protein Sequence: MVMKASVDDDDSGWELSMPEKMEKSNTNWVDITQDFEEACRELKLGELLHDKLFGLFEAMSAIEMMDPKMDAGMIGNQVNRKVLNFEQAIKDGTIKIKDLTLPELIGIMDTCFCCLITWLEGHSLAQTVFTCLYIHNPDFIEDPAMKAFALGILKICDIAREKVNKAAVFEEEDFQSMTYGFKMANSVTDLRVTGMLKDVEDDMQRRVKSTRSRQGEERDPEVELEHQQCLAVFSRVKFTRVLLTVLIAFTKKETSAVAEAQKLMVQAADLLSAIHNSLHHGIQAQNDTTKGDHPIMMGFEPLVNQRLLPPTFPRYAKIIKREEMVNYFARLIDRIKTVCEVVNLTNLHCILDFFCEFSEQSPCVLSRSLLQTTFLVDNKKVFGTHLMQDMVKDALRSFVSPPVLSPKCYLYNNHQAKDCIDSFVTHCVRPFCSLIQIHGHNRARQRDKLGHILEEFATLQDEAEKVDAALHTMLLKQEPQRQHLACLGTWVLYHNLRIMIQYLLSGFELELYSMHEYYYIYWYLSEFLYAWLMSTLSRADGSQMAEERIMEEQQKGRSSKKTKKKKKVRPLSREITMSQAYQNMCAGMFKTMVAFDMDGKVRKPKFELDSEQVRYEHRFAPFNSVMTPPPVHYLQFKEMSDLNKYSPPPQSPELYVAASKHFQQAKMILENIPNPDHEVNRILKVAKPNFVVMKLLAGGHKKESKVPPEFDFSAHKYFPVVKLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MVMKASVDDDDSG --CCCCCCCCCCCCC	22.14	25159151
12	Phosphorylation	ASVDDDDSGWELSMP CCCCCCCCCCEECCC	53.45	23403867
17	Phosphorylation	DDSGWELSMPEKMEK CCCCCEECCCHHHCC	22.30	23403867
21	Ubiquitination	WELSMPEKMEKSNTN CEECCCHHHCCCCCC	46.63	-
44	Acetylation	EEACRELKLGELLHD HHHHHHCCHHHHHHH	50.09	23236377
44	Ubiquitination	EEACRELKLGELLHD HHHHHHCCHHHHHHH	50.09	-
91	Ubiquitination	LNFEQAIKDGTIKIK CCHHHHHCCCCEEEE	53.79	-
184	Sulfoxidation	SMTYGFKMANSVTDL HHHHHHHHCCCCCCC	3.89	21406390
187	Phosphorylation	YGFKMANSVTDLRVT HHHHHCCCCCCCCCC	19.49	14702039
189	Phosphorylation	FKMANSVTDLRVTGM HHHCCCCCCCCCCCC	29.18	23186163
210	O-linked_Glycosylation	DMQRRVKSTRSRQGE HHHHHHHHHHHCCCC	26.62	30379171
213	O-linked_Glycosylation	RRVKSTRSRQGEERD HHHHHHHHCCCCCCC	29.10	30379171
240	Phosphorylation	VFSRVKFTRVLLTVL HHHHHHHHHHHHHHH	17.72	-
255	Phosphorylation	IAFTKKETSAVAEAQ HHHHCHHCHHHHHHH	30.76	-
256	Phosphorylation	AFTKKETSAVAEAQK HHHCHHCHHHHHHHH	23.10	-
380	Ubiquitination	TTFLVDNKKVFGTHL EEEEECCCEECCHHH	45.94	-
381	Ubiquitination	TFLVDNKKVFGTHLM EEEECCCEECCHHHH	49.39	-
393	Ubiquitination	HLMQDMVKDALRSFV HHHHHHHHHHHHHCC	30.55	-
408	Ubiquitination	SPPVLSPKCYLYNNH CCCCCCCCEEEECCC	31.94	-
638	Ubiquitination	PVHYLQFKEMSDLNK CCEEEEEECHHHHCC	39.28	-
647	Phosphorylation	MSDLNKYSPPPQSPE HHHHCCCCCCCCCHH	32.32	25159151
652	Phosphorylation	KYSPPPQSPELYVAA CCCCCCCCHHHHHHH	26.56	28985074
661	Ubiquitination	ELYVAASKHFQQAKM HHHHHHHHHHHHHHH	43.65	-
706	Ubiquitination	GGHKKESKVPPEFDF CCCCCCCCCCCCCCC	60.91	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NAA35_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NAA35_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NAA35_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NAA35_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.