GCP6_HUMAN - dbPTM
GCP6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GCP6_HUMAN
UniProt AC Q96RT7
Protein Name Gamma-tubulin complex component 6
Gene Name TUBGCP6
Organism Homo sapiens (Human).
Sequence Length 1819
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .
Protein Description Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome..
Protein Sequence MASITQLFDDLCEALLPAAKTHLGQRSVNRKRAKRSLKKVAYNALFTNLFQDETQQLQPDMSKLPARNKILMLSFDLRVGGLGPKADRLEELVEELEAAPCCPLLEVGSVLDLLVQLAGSGPPQVLPRKRDYFLNNKHVGRNVPYSGYDCDDLSVFEMDVQSLISREECLCHSMIQETLQVMEAAPGTGLPTVGLFSFGDPCGDRFERDTRVSLFGALVHSRTYDMDVRLGLPPVPDNADLSGLAIKVPPSVDQWEDEGFQSASNLTPDSQSEPSVTPDVDLWEAALTYEASKRRCWERVGCPPGHREEPYLTEAGRDAFDKFCRLHQGELQLLAGGVLQAPQPVLVKECELVKDVLNVLIGVVSATFSLCQPAQAFVVKRGVHVSGASPESISSLLSEVAEYGTCYTRLSHFSLQPVLDSLYSKGLVFQAFTSGLRRYLQYYRACVLSTPPTLSLLTIGFLFKKLGRQLRYLAELCGVGAVLPGTCGGGPRAAFPTGVKLLSYLYQEALHNCSNEHYPVLLSLLKTSCEPYTRFIHDWVYSGVFRDAYGEFMIQVNHEYLSFRDKLYWTHGYVLISKEVEDCVPVFLKHIAHDIYVCGKTINLLKLCCPRHYLCWSDVPVPRISVIFSLEELKEIEKDCAVYVGRMERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSAEAARREQKALWRIQRHRLESARLRFLLEDEKHIQEMLKAVSEAHQPQEPPDVLLSVHPQVTSPGPEHPEGGQGCDSGSAEQHSPAWDGWNRPGLLTPQPLKPLAVGAGGRGLQQAEGARPFSDSLSIGDFLPVGPGAEPSVQTGMVPLLEVALQTINLDLPPSAPGEAPAAASTQPSRPQEYDFSTVLRPAVATSPAPGPLQAAECSLGSSGLQLWEDSCGKMDACGSASRETLLPSHPPRRAALEEGSSQPTERLFGQVSGGGLPTGDYASEIAPTRPRWNTHGHVSDASIRVGENVSDVAPTQPRWNTHGHVSNASISLGESVSDVAPTRPRWNIHGHVSNASIRVGENVSDVAPTRPRWNTHGHVSNASIRVGENVSDVAPTRPRWNTHGHVSDASISLGESVSDMAPARPRWNTHGHVSDASISLGESVSDMAPTRPRWNTHGHVSDTSIRVGENVSDVAPIRSRCNTHGHVSDASISLGEPVSDVVSTRPRWNTHVPIPPPHMVLGALSPEAEPNTPRPQQSPPGHTSQSALSLGAQSTVLDCGPRLPVEVGPSLSSPSSGCGEGSISVGENVSDVAPTQPWWPNTPGDSVSEELGPGRSGDTEDLSPNWPLNSQEDTAAQSSPGRGEEAEASAAEAQGGEQAYLAGLAGQYHLERYPDSYESMSEPPIAHLLRPVLPRAFAFPVDPQVQSAADETAVQLSELLTLPVLMKRSITAPLAAHISLVNKAAVDYFFVELHLEAHYEALRHFLLMEDGEFAQSLSDLLFEKLGAGQTPGELLNPLVLNSVLSKALQCSLHGDTPHASNLSLALKYLPEVFAPNAPDVLSCLELRYKVDWPLNIVITEGCVSKYSGVFSFLLQLKLMMWALKDVCFHLKRTALLSHMAGSVQFRQLQLFKHEMQHFVKVIQGYIANQILHVTWCEFRARLATVGDLEEIQRAHAEYLHKAVFRGLLTEKAAPVMNVIHSIFSLVLKFRSQLISQAWGPPGGPRGAEHPNFALMQQSYNTFKYYSHFLFKVVTKLVNRGYQPHLEDFLLRINFNNYYQDA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
42PhosphorylationRSLKKVAYNALFTNL
HHHHHHHHHHHHHHH		12.1722210691
54PhosphorylationTNLFQDETQQLQPDM
HHHCCHHHHHHCCCH		29.8822210691
62PhosphorylationQQLQPDMSKLPARNK
HHHCCCHHHCCCCCC		38.1222210691
129UbiquitinationPPQVLPRKRDYFLNN
CCCCCCCCCCCCCCC		47.91-
137 (in isoform 3)Ubiquitination-38.3021906983
137 (in isoform 2)Ubiquitination-38.3021906983
137 (in isoform 1)Ubiquitination-38.3021906983
137UbiquitinationRDYFLNNKHVGRNVP
CCCCCCCCCCCCCCC		38.3022817900
162PhosphorylationVFEMDVQSLISREEC
EEEHHHHHHHCHHHH		27.7624719451
165PhosphorylationMDVQSLISREECLCH
HHHHHHHCHHHHHHH		38.6424719451
173PhosphorylationREECLCHSMIQETLQ
HHHHHHHHHHHHHHH		19.3127251275
178PhosphorylationCHSMIQETLQVMEAA
HHHHHHHHHHHHHHC		13.2027251275
188PhosphorylationVMEAAPGTGLPTVGL
HHHHCCCCCCCCEEE		34.1927251275
210PhosphorylationGDRFERDTRVSLFGA
CCCCCHHHHHHHHHH		38.9121712546
213PhosphorylationFERDTRVSLFGALVH
CCHHHHHHHHHHHHH		18.0729214152
242PhosphorylationVPDNADLSGLAIKVP
CCCCCCCCCCEEECC		32.1022067460
322UbiquitinationAGRDAFDKFCRLHQG
HCHHHHHHHHHHCCC		39.65-
389PhosphorylationGVHVSGASPESISSL
CCCCCCCCHHHHHHH		32.50-
439PhosphorylationFTSGLRRYLQYYRAC
HHHHHHHHHHHHHHH		7.5422817900
442PhosphorylationGLRRYLQYYRACVLS
HHHHHHHHHHHHHHC		7.7222817900
443PhosphorylationLRRYLQYYRACVLST
HHHHHHHHHHHHHCC		4.4522817900
523PhosphorylationEHYPVLLSLLKTSCE
CCHHHHHHHHHHCCC		27.7424719451
568PhosphorylationLSFRDKLYWTHGYVL
CCHHHEEEEECCEEE		17.6329759185
577PhosphorylationTHGYVLISKEVEDCV
ECCEEEEECCHHHHH		20.7129759185
629PhosphorylationPRISVIFSLEELKEI
CCEEEEEEHHHHHHH		24.6022817900
638UbiquitinationEELKEIEKDCAVYVG
HHHHHHHHHHHHHHH		64.8629967540
654PhosphorylationMERVARHSSVSKEEK
HHHHHHHCCCCHHHH		27.2122067460
655PhosphorylationERVARHSSVSKEEKE
HHHHHHCCCCHHHHH		25.0430624053
657PhosphorylationVARHSSVSKEEKELR
HHHHCCCCHHHHHHH		35.9822067460
669UbiquitinationELRMEIAKQELIAHA
HHHHHHHHHHHHHHH		50.39-
693PhosphorylationALSDRQMSERMALDA
HHCHHHHHHHHHHHH		17.45-
710UbiquitinationREQFQRLKEQFVKDQ
HHHHHHHHHHHHHHH		52.2229967540
715UbiquitinationRLKEQFVKDQERRQA
HHHHHHHHHHHHHHH		55.7924816145
746UbiquitinationRDRERRLKSLEEELE
HHHHHHHHHHHHHHH		51.7029967540
764PhosphorylationRQALVDHYSKLSAEA
HHHHHHHHHHHHHHH		11.7529759185
766UbiquitinationALVDHYSKLSAEAAR
HHHHHHHHHHHHHHH		39.0229967540
824PhosphorylationEPPDVLLSVHPQVTS
CCCCEEEEECCCCCC		17.7726074081
830PhosphorylationLSVHPQVTSPGPEHP
EEECCCCCCCCCCCC		24.7726074081
831PhosphorylationSVHPQVTSPGPEHPE
EECCCCCCCCCCCCC		29.0626074081
852PhosphorylationSGSAEQHSPAWDGWN
CCCCCCCCCCCCCCC		18.9222067460
865PhosphorylationWNRPGLLTPQPLKPL
CCCCCCCCCCCCCCC		25.5622067460
955PhosphorylationPQEYDFSTVLRPAVA
CCCCCCCCCCCCCCC		24.4524719451
963PhosphorylationVLRPAVATSPAPGPL
CCCCCCCCCCCCCCC		28.7526074081
964PhosphorylationLRPAVATSPAPGPLQ
CCCCCCCCCCCCCCC		14.8826074081
997PhosphorylationGKMDACGSASRETLL
CCCCCCCCCCHHHCC		23.9728555341
1030PhosphorylationERLFGQVSGGGLPTG
HHHHCCCCCCCCCCC		24.6728555341
1036PhosphorylationVSGGGLPTGDYASEI
CCCCCCCCCCCHHHC		47.9628796482
1039PhosphorylationGGLPTGDYASEIAPT
CCCCCCCCHHHCCCC		17.2428796482
1041PhosphorylationLPTGDYASEIAPTRP
CCCCCCHHHCCCCCC		24.2528796482
1046PhosphorylationYASEIAPTRPRWNTH
CHHHCCCCCCCCCCC		44.2628796482
1057PhosphorylationWNTHGHVSDASIRVG
CCCCCCCCCCEEEEC		23.0628348404
1068PhosphorylationIRVGENVSDVAPTQP
EEECCCHHHCCCCCC		37.6420860994
1084PhosphorylationWNTHGHVSNASISLG
CCCCCCCCCCEEECC		22.4727080861
1087PhosphorylationHGHVSNASISLGESV
CCCCCCCEEECCCCH		19.5727080861
1111PhosphorylationWNIHGHVSNASIRVG
CEEEEECCCCEEEEC		22.4727080861
1114PhosphorylationHGHVSNASIRVGENV
EEECCCCEEEECCCH		18.3827080861
1122PhosphorylationIRVGENVSDVAPTRP
EEECCCHHHCCCCCC		37.6428555341
1138PhosphorylationWNTHGHVSNASIRVG
CCCCCCCCCCEEEEC		22.4727080861
1141PhosphorylationHGHVSNASIRVGENV
CCCCCCCEEEECCCH		18.3827080861
1149PhosphorylationIRVGENVSDVAPTRP
EEECCCHHHCCCCCC		37.6428555341
1208PhosphorylationSVSDMAPTRPRWNTH
CHHHCCCCCCCCCCC		43.7130576142
1222PhosphorylationHGHVSDTSIRVGENV
CCCCCCCEEEECCCH		17.2528555341
1230PhosphorylationIRVGENVSDVAPIRS
EEECCCHHHCCCCHH		37.6420860994
1237PhosphorylationSDVAPIRSRCNTHGH
HHCCCCHHHCCCCCC		41.7428555341
1283PhosphorylationHMVLGALSPEAEPNT
CEEECCCCCCCCCCC		21.8422067460
1290PhosphorylationSPEAEPNTPRPQQSP
CCCCCCCCCCCCCCC		31.2426074081
1296PhosphorylationNTPRPQQSPPGHTSQ
CCCCCCCCCCCCCCH		28.0226074081
1301PhosphorylationQQSPPGHTSQSALSL
CCCCCCCCCHHHHHC		34.0826074081
1302PhosphorylationQSPPGHTSQSALSLG
CCCCCCCCHHHHHCC		19.2326074081
1304PhosphorylationPPGHTSQSALSLGAQ
CCCCCCHHHHHCCCC		30.8326074081
1307PhosphorylationHTSQSALSLGAQSTV
CCCHHHHHCCCCCEE		25.1926074081
1312PhosphorylationALSLGAQSTVLDCGP
HHHCCCCCEEECCCC		21.6826074081
1313PhosphorylationLSLGAQSTVLDCGPR
HHCCCCCEEECCCCC		17.0126074081
1374PhosphorylationEELGPGRSGDTEDLS
CCCCCCCCCCCCCCC		47.1124275569
1381PhosphorylationSGDTEDLSPNWPLNS
CCCCCCCCCCCCCCC		28.6324275569
1396PhosphorylationQEDTAAQSSPGRGEE
HHCCCCCCCCCCCHH		33.5026471730
1397PhosphorylationEDTAAQSSPGRGEEA
HCCCCCCCCCCCHHH		21.2017182859
1606PhosphorylationLSCLELRYKVDWPLN
HHHHHHHCCCCCCEE		28.1729083192
1617PhosphorylationWPLNIVITEGCVSKY
CCEEEEEEECHHHHC		18.5429083192
1622PhosphorylationVITEGCVSKYSGVFS
EEEECHHHHCCCHHH		29.9229083192
1655PhosphorylationLKRTALLSHMAGSVQ
HHHHHHHHHHHCCHH		16.44-
1727PhosphorylationAVFRGLLTEKAAPVM
HHHHHHCCCCHHHHH		40.25-
1742PhosphorylationNVIHSIFSLVLKFRS
HHHHHHHHHHHHHHH		18.85-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GCP6_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GCP6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GCP6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TBG1_HUMANTUBG1physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
251270Microcephaly and chorioretinopathy, autosomal recessive, 1 (MCCRP1)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GCP6_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-629, AND MASSSPECTROMETRY.
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-439 AND TYR-443, ANDMASS SPECTROMETRY.

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