EP400_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EP400_HUMAN
• UniProt AC: Q96L91
• Protein Name: E1A-binding protein p400
• Gene Name: EP400
• Organism: Homo sapiens (Human).
• Sequence Length: 3159
• Subcellular Localization: Nucleus .
• Protein Description: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome..
• Protein Sequence: MHHGTGPQNVQHQLQRSRACPGSEGEEQPAHPNPPPSPAAPFAPSASPSAPQSPSYQIQQLMNRSPATGQNVNITLQSVGPVVGGNQQITLAPLPLPSPTSPGFQFSAQPRRFEHGSPSYIQVTSPLSQQVQTQSPTQPSPGPGQALQNVRAGAPGPGLGLCSSSPTGGFVDASVLVRQISLSPSSGGHFVFQDGSGLTQIAQGAQVQLQHPGTPITVRERRPSQPHTQSGGTIHHLGPQSPAAAGGAGLQPLASPSHITTANLPPQISSIIQGQLVQQQQVLQGPPLPRPLGFERTPGVLLPGAGGAAGFGMTSPPPPTSPSRTAVPPGLSSLPLTSVGNTGMKKVPKKLEEIPPASPEMAQMRKQCLDYHYQEMQALKEVFKEYLIELFFLQHFQGNMMDFLAFKKKHYAPLQAYLRQNDLDIEEEEEEEEEEEEKSEVINDEVKVVTGKDGQTGTPVAIATQLPPKVSAAFSSQQQPFQQALAGSLVAGAGSTVETDLFKRQQAMPSTGMAEQSKRPRLEVGHQGVVFQHPGADAGVPLQQLMPTAQGGMPPTPQAAQLAGQRQSQQQYDPSTGPPVQNAASLHTPLPQLPGRLPPAGVPTAALSSALQFAQQPQVVEAQTQLQIPVKTQQPNVPIPAPPSSQLPIPPSQPAQLALHVPTPGKVQVQASQLSSLPQMVASTRLPVDPAPPCPRPLPTSSTSSLAPVSGSGPGPSPARSSPVNRPSSATNKALSPVTSRTPGVVASAPTKPQSPAQNATSSQDSSQDTLTEQITLENQVHQRIAELRKAGLWSQRRLPKLQEAPRPKSHWDYLLEEMQWMATDFAQERRWKVAAAKKLVRTVVRHHEEKQLREERGKKEEQSRLRRIAASTAREIECFWSNIEQVVEIKLRVELEEKRKKALNLQKVSRRGKELRPKGFDALQESSLDSGMSGRKRKASISLTDDEVDDEEETIEEEEANEGVVDHQTELSNLAKEAELPLLDLMKLYEGAFLPSSQWPRPKPDGEDTSGEEDADDCPGDRESRKDLVLIDSLFIMDQFKAAERMNIGKPNAKDIADVTAVAEAILPKGSARVTTSVKFNAPSLLYGALRDYQKIGLDWLAKLYRKNLNGILADEAGLGKTVQIIAFFAHLACNEGNWGPHLVVVRSCNILKWELELKRWCPGLKILSYIGSHRELKAKRQEWAEPNSFHVCITSYTQFFRGLTAFTRVRWKCLVIDEMQRVKGMTERHWEAVFTLQSQQRLLLIDSPLHNTFLELWTMVHFLVPGISRPYLSSPLRAPSEESQDYYHKVVIRLHRVTQPFILRRTKRDVEKQLTKKYEHVLKCRLSNRQKALYEDVILQPGTQEALKSGHFVNVLSILVRLQRICNHPGLVEPRHPGSSYVAGPLEYPSASLILKALERDFWKEADLSMFDLIGLENKITRHEAELLSKKKIPRKLMEEISTSAAPAARPAAAKLKASRLFQPVQYGQKPEGRTVAFPSTHPPRTAAPTTASAAPQGPLRGRPPIATFSANPEAKAAAAPFQTSQASASAPRHQPASASSTAASPAHPAKLRAQTTAQASTPGQPPPQPQAPSHAAGQSALPQRLVLPSQAQARLPSGEVVKIAQLASITGPQSRVAQPETPVTLQFQGSKFTLSHSQLRQLTAGQPLQLQGSVLQIVSAPGQPYLRAPGPVVMQTVSQAGAVHGALGSKPPAGGPSPAPLTPQVGVPGRVAVNALAVGEPGTASKPASPIGGPTQEEKTRLLKERLDQIYLVNERRCSQAPVYGRDLLRICALPSHGRVQWRGSLDGRRGKEAGPAHSYTSSSESPSELMLTLCRCGESLQDVIDRVAFVIPPVVAAPPSLRVPRPPPLYSHRMRILRQGLREHAAPYFQQLRQTTAPRLLQFPELRLVQFDSGKLEALAILLQKLKSEGRRVLILSQMILMLDILEMFLNFHYLTYVRIDENASSEQRQELMRSFNRDRRIFCAILSTHSRTTGINLVEADTVVFYDNDLNPVMDAKAQEWCDRIGRCKDIHIYRLVSGNSIEEKLLKNGTKDLIREVAAQGNDYSMAFLTQRTIQELFEVYSPMDDAGFPVKAEEFVVLSQEPSVTETIAPKIARPFIEALKSIEYLEEDAQKSAQEGVLGPHTDALSSDSENMPCDEEPSQLEELADFMEQLTPIEKYALNYLELFHTSIEQEKERNSEDAVMTAVRAWEFWNLKTLQEREARLRLEQEEAELLTYTREDAYSMEYVYEDVDGQTEVMPLWTPPTPPQDDSDIYLDSVMCLMYEATPIPEAKLPPVYVRKERKRHKTDPSAAGRKKKQRHGEAVVPPRSLFDRATPGLLKIRREGKEQKKNILLKQQVPFAKPLPTFAKPTAEPGQDNPEWLISEDWALLQAVKQLLELPLNLTIVSPAHTPNWDLVSDVVNSCSRIYRSSKQCRNRYENVIIPREEGKSKNNRPLRTSQIYAQDENATHTQLYTSHFDLMKMTAGKRSPPIKPLLGMNPFQKNPKHASVLAESGINYDKPLPPIQVASLRAERIAKEKKALADQQKAQQPAVAQPPPPQPQPPPPPQQPPPPLPQPQAAGSQPPAGPPAVQPQPQPQPQTQPQPVQAPAKAQPAITTGGSAAVLAGTIKTSVTGTSMPTGAVSGNVIVNTIAGVPAATFQSINKRLASPVAPGALTTPGGSAPAQVVHTQPPPRAVGSPATATPDLVSMATTQGVRAVTSVTASAVVTTNLTPVQTPARSLVPQVSQATGVQLPGKTITPAHFQLLRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTTTTSQVQVPQIQGQAQSPAQIKAVGKLTPEHLIKMQKQKLQMPPQPPPPQAQSAPPQPTAQVQVQTSQPPQQQSPQLTTVTAPRPGALLTGTTVANLQVARLTRVPTSQLQAQGQMQTQAPQPAQVALAKPPVVSVPAAVVSSPGVTTLPMNVAGISVAIGQPQKAAGQTVVAQPVHMQQLLKLKQQAVQQQKAIQPQAAQGPAAVQQKITAQQITTPGAQQKVAYAAQPALKTQFLTTPISQAQKLAGAQQVQTQIQVAKLPQVVQQQTPVASIQQVASASQQASPQTVALTQATAAGQQVQMIPAVTATAQVVQQKLIQQQVVTTASAPLQTPGAPNPAQVPASSDSPSQQPKLQMRVPAVRLKTPTKPPCQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	AHPNPPPSPAAPFAP CCCCCCCCCCCCCCC	32.70	30576142
37 (in isoform 2)	Phosphorylation	-	32.70	27251275
45	Phosphorylation	PAAPFAPSASPSAPQ CCCCCCCCCCCCCCC	37.64	28348404
47	Phosphorylation	APFAPSASPSAPQSP CCCCCCCCCCCCCCC	24.59	28348404
49	Phosphorylation	FAPSASPSAPQSPSY CCCCCCCCCCCCCHH	50.51	23663014
53	Phosphorylation	ASPSAPQSPSYQIQQ CCCCCCCCCHHHHHH	18.11	23663014
53 (in isoform 2)	Phosphorylation	-	18.11	27251275
55	Phosphorylation	PSAPQSPSYQIQQLM CCCCCCCHHHHHHHH	34.61	23663014
56	Phosphorylation	SAPQSPSYQIQQLMN CCCCCCHHHHHHHHH	17.02	23663014
65	Phosphorylation	IQQLMNRSPATGQNV HHHHHHCCCCCCCCC	17.55	26074081
98	Phosphorylation	LAPLPLPSPTSPGFQ EEECCCCCCCCCCCC	48.79	26074081
100	Phosphorylation	PLPLPSPTSPGFQFS ECCCCCCCCCCCCCC	52.47	26074081
101	Phosphorylation	LPLPSPTSPGFQFSA CCCCCCCCCCCCCCC	26.81	26074081
117	Phosphorylation	PRRFEHGSPSYIQVT CCCCCCCCCCEEEEC	16.75	28450419
119	Phosphorylation	RFEHGSPSYIQVTSP CCCCCCCCEEEECCC	36.24	28450419
120	Phosphorylation	FEHGSPSYIQVTSPL CCCCCCCEEEECCCC	9.96	28450419
124	Phosphorylation	SPSYIQVTSPLSQQV CCCEEEECCCCHHCC	14.30	30108239
125	Phosphorylation	PSYIQVTSPLSQQVQ CCEEEECCCCHHCCC	25.61	28450419
128	Phosphorylation	IQVTSPLSQQVQTQS EEECCCCHHCCCCCC	23.19	28464451
133	Phosphorylation	PLSQQVQTQSPTQPS CCHHCCCCCCCCCCC	31.96	28450419
135	Phosphorylation	SQQVQTQSPTQPSPG HHCCCCCCCCCCCCC	33.05	28464451
137	Phosphorylation	QVQTQSPTQPSPGPG CCCCCCCCCCCCCCC	59.36	28464451
140	Phosphorylation	TQSPTQPSPGPGQAL CCCCCCCCCCCCHHH	32.44	28450419
151	Methylation	GQALQNVRAGAPGPG CHHHHHHCCCCCCCC	34.55	-
163	Phosphorylation	GPGLGLCSSSPTGGF CCCCCCCCCCCCCCC	38.60	28464451
163 (in isoform 2)	Phosphorylation	-	38.60	24719451
164	Phosphorylation	PGLGLCSSSPTGGFV CCCCCCCCCCCCCCC	39.06	26657352
165	Phosphorylation	GLGLCSSSPTGGFVD CCCCCCCCCCCCCCC	15.36	28464451
165 (in isoform 2)	Phosphorylation	-	15.36	27251275
167	Phosphorylation	GLCSSSPTGGFVDAS CCCCCCCCCCCCCHH	52.46	28464451
174	Phosphorylation	TGGFVDASVLVRQIS CCCCCCHHHEEEEEE	16.12	24732914
181	Phosphorylation	SVLVRQISLSPSSGG HHEEEEEEECCCCCC	17.92	27362937
181 (in isoform 2)	Phosphorylation	-	17.92	27251275
183	Phosphorylation	LVRQISLSPSSGGHF EEEEEEECCCCCCEE	18.88	27362937
183 (in isoform 2)	Phosphorylation	-	18.88	27251275
185	Phosphorylation	RQISLSPSSGGHFVF EEEEECCCCCCEEEE	37.93	28450419
186	Phosphorylation	QISLSPSSGGHFVFQ EEEECCCCCCEEEEE	52.78	28450419
196	Phosphorylation	HFVFQDGSGLTQIAQ EEEEECCCCCCEEEC	38.63	28450419
199	Phosphorylation	FQDGSGLTQIAQGAQ EECCCCCCEEECCCE	22.81	28464451
214	Phosphorylation	VQLQHPGTPITVRER EEECCCCCCCEEEEC	18.90	20068231
217	Phosphorylation	QHPGTPITVRERRPS CCCCCCCEEEECCCC	18.08	20068231
219	Methylation	PGTPITVRERRPSQP CCCCCEEEECCCCCC	24.05	-
221	Methylation	TPITVRERRPSQPHT CCCEEEECCCCCCCC	45.29	-
224	Phosphorylation	TVRERRPSQPHTQSG EEEECCCCCCCCCCC	55.31	20068231
233	Phosphorylation	PHTQSGGTIHHLGPQ CCCCCCCEEEECCCC	22.21	-
297	Phosphorylation	RPLGFERTPGVLLPG CCCCCCCCCCEEECC	19.73	23403867
314	Phosphorylation	GAAGFGMTSPPPPTS CCCCCCCCCCCCCCC	38.16	30266825
315	Phosphorylation	AAGFGMTSPPPPTSP CCCCCCCCCCCCCCC	26.90	23927012
315 (in isoform 2)	Phosphorylation	-	26.90	27251275
320	Phosphorylation	MTSPPPPTSPSRTAV CCCCCCCCCCCCCCC	60.07	23927012
320 (in isoform 2)	Phosphorylation	-	60.07	27251275
321	Phosphorylation	TSPPPPTSPSRTAVP CCCCCCCCCCCCCCC	27.01	23927012
321 (in isoform 2)	Phosphorylation	-	27.01	24719451
323	Phosphorylation	PPPPTSPSRTAVPPG CCCCCCCCCCCCCCC	41.87	30266825
325	Phosphorylation	PPTSPSRTAVPPGLS CCCCCCCCCCCCCCC	36.02	26074081
332	Phosphorylation	TAVPPGLSSLPLTSV CCCCCCCCCCCCCCC	35.43	28555341
342	Phosphorylation	PLTSVGNTGMKKVPK CCCCCCCCCCCCCCC	32.49	28555341
345	Acetylation	SVGNTGMKKVPKKLE CCCCCCCCCCCCCHH	52.55	70937
346	Acetylation	VGNTGMKKVPKKLEE CCCCCCCCCCCCHHH	55.68	87873
346	Ubiquitination	VGNTGMKKVPKKLEE CCCCCCCCCCCCHHH	55.68	-
358	Phosphorylation	LEEIPPASPEMAQMR HHHCCCCCHHHHHHH	27.45	25159151
358 (in isoform 2)	Phosphorylation	-	27.45	24719451
386	Phosphorylation	LKEVFKEYLIELFFL HHHHHHHHHHHHHHH	17.36	-
409	Ubiquitination	DFLAFKKKHYAPLQA HHHHHHHHHCHHHHH	42.30	29967540
439 (in isoform 3)	Phosphorylation	-	40.14	19053533
439 (in isoform 5)	Phosphorylation	-	40.14	19053533
451 (in isoform 3)	Phosphorylation	-	17.91	19053533
451 (in isoform 5)	Phosphorylation	-	17.91	19053533
452	Acetylation	EVKVVTGKDGQTGTP CEEEEECCCCCCCCE	49.69	26051181
517	Phosphorylation	STGMAEQSKRPRLEV CCCCCCCCCCCCCCC	23.33	22210691
518	Acetylation	TGMAEQSKRPRLEVG CCCCCCCCCCCCCCC	67.14	25953088
685	Phosphorylation	PQMVASTRLPVDPAP CHHHHCCCCCCCCCC	34.20	18452278
686 (in isoform 2)	Phosphorylation	-	4.99	24719451
693 (in isoform 2)	Phosphorylation	-	42.73	27251275
700	Phosphorylation	PCPRPLPTSSTSSLA CCCCCCCCCCCCCCC	42.89	19664995
700 (in isoform 2)	Phosphorylation	-	42.89	24719451
705	Phosphorylation	LPTSSTSSLAPVSGS CCCCCCCCCCCCCCC	28.74	26074081
710	O-linked_Glycosylation	TSSLAPVSGSGPGPS CCCCCCCCCCCCCCC	26.61	30059200
710	Phosphorylation	TSSLAPVSGSGPGPS CCCCCCCCCCCCCCC	26.61	27174698
712	Phosphorylation	SLAPVSGSGPGPSPA CCCCCCCCCCCCCCC	34.02	29255136
717	Phosphorylation	SGSGPGPSPARSSPV CCCCCCCCCCCCCCC	36.79	25849741
719	Phosphorylation	SGPGPSPARSSPVNR CCCCCCCCCCCCCCC	28.46	18669648
719 (in isoform 2)	Phosphorylation	-	28.46	27251275
721	Phosphorylation	PGPSPARSSPVNRPS CCCCCCCCCCCCCCC	40.89	23401153
722	Phosphorylation	GPSPARSSPVNRPSS CCCCCCCCCCCCCCH	27.58	25159151
728	Phosphorylation	SSPVNRPSSATNKAL CCCCCCCCHHCCCCC	29.39	21955146
729	Phosphorylation	SPVNRPSSATNKALS CCCCCCCHHCCCCCC	41.62	20363803
731	Phosphorylation	VNRPSSATNKALSPV CCCCCHHCCCCCCCC	38.92	27174698
733	Acetylation	RPSSATNKALSPVTS CCCHHCCCCCCCCCC	46.48	25953088
736	Phosphorylation	SATNKALSPVTSRTP HHCCCCCCCCCCCCC	23.37	29255136
739	Phosphorylation	NKALSPVTSRTPGVV CCCCCCCCCCCCCCE	18.84	30266825
740	Phosphorylation	KALSPVTSRTPGVVA CCCCCCCCCCCCCEE	34.10	30266825
742	Phosphorylation	LSPVTSRTPGVVASA CCCCCCCCCCCEECC	24.94	26055452
748	Phosphorylation	RTPGVVASAPTKPQS CCCCCEECCCCCCCC	24.15	28464451
751	Phosphorylation	GVVASAPTKPQSPAQ CCEECCCCCCCCCCC	55.89	29496963
752	Acetylation	VVASAPTKPQSPAQN CEECCCCCCCCCCCC	39.75	26051181
755	Phosphorylation	SAPTKPQSPAQNATS CCCCCCCCCCCCCCC	30.63	30278072
761	Phosphorylation	QSPAQNATSSQDSSQ CCCCCCCCCCCCCCC	36.14	27174698
762	Phosphorylation	SPAQNATSSQDSSQD CCCCCCCCCCCCCCC	24.48	27174698
763	Phosphorylation	PAQNATSSQDSSQDT CCCCCCCCCCCCCCH	33.38	27174698
766	Phosphorylation	NATSSQDSSQDTLTE CCCCCCCCCCCHHHH	23.43	27174698
767	Phosphorylation	ATSSQDSSQDTLTEQ CCCCCCCCCCHHHHH	40.12	27174698
770	Phosphorylation	SQDSSQDTLTEQITL CCCCCCCHHHHHHHH	28.13	27174698
772	Phosphorylation	DSSQDTLTEQITLEN CCCCCHHHHHHHHHH	28.12	27080861
776	Phosphorylation	DTLTEQITLENQVHQ CHHHHHHHHHHHHHH	27.93	27080861
828 (in isoform 2)	Phosphorylation	-	44.73	27251275
864	Phosphorylation	RGKKEEQSRLRRIAA HCHHHHHHHHHHHHH	36.24	27251275
866	Ubiquitination	KKEEQSRLRRIAAST HHHHHHHHHHHHHHH	5.37	29967540
872	Ubiquitination	RLRRIAASTAREIEC HHHHHHHHHHHHHHH	17.36	29967540
883	Ubiquitination	EIECFWSNIEQVVEI HHHHHHHCHHHHHHH	32.20	29967540
892 (in isoform 2)	Phosphorylation	-	10.22	27251275
899	Ubiquitination	LRVELEEKRKKALNL HHHCHHHHHHHHHCH	61.21	-
905	Phosphorylation	EKRKKALNLQKVSRR HHHHHHHCHHHHHHC	45.33	17081983
905 (in isoform 2)	Phosphorylation	-	45.33	27251275
907	Phosphorylation	RKKALNLQKVSRRGK HHHHHCHHHHHHCCC	42.93	17081983
908	Acetylation	KKALNLQKVSRRGKE HHHHCHHHHHHCCCC	45.39	25953088
908	Ubiquitination	KKALNLQKVSRRGKE HHHHCHHHHHHCCCC	45.39	-
909	Phosphorylation	KALNLQKVSRRGKEL HHHCHHHHHHCCCCC	3.29	17081983
909 (in isoform 2)	Phosphorylation	-	3.29	27251275
914	Acetylation	QKVSRRGKELRPKGF HHHHHCCCCCCCCCC	52.33	26051181
919	Acetylation	RGKELRPKGFDALQE CCCCCCCCCCHHHHH	66.82	26051181
919	Phosphorylation	RGKELRPKGFDALQE CCCCCCCCCCHHHHH	66.82	17081983
919 (in isoform 2)	Phosphorylation	-	66.82	27251275
927	Phosphorylation	GFDALQESSLDSGMS CCHHHHHCCCCCCCC	24.20	30108239
928	Phosphorylation	FDALQESSLDSGMSG CHHHHHCCCCCCCCC	35.13	30108239
931	Phosphorylation	LQESSLDSGMSGRKR HHHCCCCCCCCCCCC	41.51	28258704
934	Phosphorylation	SSLDSGMSGRKRKAS CCCCCCCCCCCCEEE	38.68	28258704
937	Phosphorylation	DSGMSGRKRKASISL CCCCCCCCCEEEEEC	62.87	17081983
941	Phosphorylation	SGRKRKASISLTDDE CCCCCEEEEECCCCC	18.75	25159151
943	Phosphorylation	RKRKASISLTDDEVD CCCEEEEECCCCCCC	23.79	25159151
945	Phosphorylation	RKASISLTDDEVDDE CEEEEECCCCCCCCH	34.31	25159151
955	Phosphorylation	EVDDEEETIEEEEAN CCCCHHHHHCHHHHH	36.65	17081983
970	Phosphorylation	EGVVDHQTELSNLAK HCCCCHHHHHHHHHH	35.16	21406692
973	Phosphorylation	VDHQTELSNLAKEAE CCHHHHHHHHHHHCC	24.46	21406692
974 (in isoform 2)	Phosphorylation	-	57.55	27251275
975	Phosphorylation	HQTELSNLAKEAELP HHHHHHHHHHHCCCC	6.91	18452278
975 (in isoform 2)	Phosphorylation	-	6.91	27251275
990	Phosphorylation	LLDLMKLYEGAFLPS HHHHHHHHCCCCCCC	13.54	23927012
997	Phosphorylation	YEGAFLPSSQWPRPK HCCCCCCCCCCCCCC	36.99	25137130
998	Phosphorylation	EGAFLPSSQWPRPKP CCCCCCCCCCCCCCC	47.17	25137130
1010	Phosphorylation	PKPDGEDTSGEEDAD CCCCCCCCCCCCCCC	34.04	23401153
1011	Phosphorylation	KPDGEDTSGEEDADD CCCCCCCCCCCCCCC	57.43	23401153
1023 (in isoform 3)	Ubiquitination	-	50.10	21890473
1025	Phosphorylation	DCPGDRESRKDLVLI CCCCCHHHHHHEEEE	45.59	23927012
1060	Ubiquitination	NAKDIADVTAVAEAI CHHHHHHHHHHHHHH	2.46	21890473
1060 (in isoform 2)	Ubiquitination	-	2.46	21890473
1060 (in isoform 4)	Ubiquitination	-	2.46	21890473
1070	Ubiquitination	VAEAILPKGSARVTT HHHHHCCCCCCEEEE	63.15	-
1072	Ubiquitination	EAILPKGSARVTTSV HHHCCCCCCEEEEEE	21.01	29967540
1096	Ubiquitination	GALRDYQKIGLDWLA HHHHHHHHHCHHHHH	32.29	21890473
1096 (in isoform 1)	Ubiquitination	-	32.29	21890473
1122	Acetylation	ADEAGLGKTVQIIAF CCCCCCCHHHHHHHH	51.03	12436561
1190	Phosphorylation	QEWAEPNSFHVCITS HHHCCCCCEEEEEEE	27.69	-
1209	Phosphorylation	FRGLTAFTRVRWKCL HCCCHHHHHHHEEEE	26.28	-
1218 (in isoform 3)	Ubiquitination	-	2.09	21890473
1228	Phosphorylation	MQRVKGMTERHWEAV HHHHCCCCHHHHEEE	38.24	22210691
1255	Ubiquitination	DSPLHNTFLELWTMV CCCCHHHHHHHHHHH	6.39	21890473
1255 (in isoform 2)	Ubiquitination	-	6.39	21890473
1255 (in isoform 4)	Ubiquitination	-	6.39	21890473
1273	Phosphorylation	VPGISRPYLSSPLRA CCCCCCCCCCCCCCC	20.36	24117733
1275	Phosphorylation	GISRPYLSSPLRAPS CCCCCCCCCCCCCCC	24.86	24117733
1276	Phosphorylation	ISRPYLSSPLRAPSE CCCCCCCCCCCCCCH	25.92	24117733
1291	Ubiquitination	ESQDYYHKVVIRLHR HHCCHHHHHHHHHHH	23.29	21890473
1291 (in isoform 1)	Ubiquitination	-	23.29	21890473
1297	Ubiquitination	HKVVIRLHRVTQPFI HHHHHHHHHCCCCCH	16.59	29967540
1314	Ubiquitination	RTKRDVEKQLTKKYE HCHHHHHHHHHHHHH	50.92	-
1319	Ubiquitination	VEKQLTKKYEHVLKC HHHHHHHHHHHHHHH	51.11	-
1325 (in isoform 3)	Ubiquitination	-	19.07	21890473
1333	Ubiquitination	CRLSNRQKALYEDVI HHHCCCCHHHHHCEE	36.80	-
1348 (in isoform 3)	Ubiquitination	-	15.52	21890473
1362	Ubiquitination	VNVLSILVRLQRICN HHHHHHHHHHHHHHC	5.67	21963094
1362 (in isoform 2)	Ubiquitination	-	5.67	21890473
1362 (in isoform 4)	Ubiquitination	-	5.67	21890473
1385	Ubiquitination	HPGSSYVAGPLEYPS CCCCCCCCCCCCCCC	12.97	29967540
1385 (in isoform 2)	Ubiquitination	-	12.97	21890473
1385 (in isoform 4)	Ubiquitination	-	12.97	21890473
1396	Ubiquitination	EYPSASLILKALERD CCCCHHHHHHHHHHH	3.25	23503661
1397	Ubiquitination	YPSASLILKALERDF CCCHHHHHHHHHHHH	3.01	23503661
1398	Ubiquitination	PSASLILKALERDFW CCHHHHHHHHHHHHH	43.88	21906983
1398 (in isoform 1)	Ubiquitination	-	43.88	21890473
1402	Ubiquitination	LILKALERDFWKEAD HHHHHHHHHHHHHCC	45.32	23503661
1402 (in isoform 2)	Ubiquitination	-	45.32	-
1421	Ubiquitination	DLIGLENKITRHEAE HHHCCCCCCCHHHHH	35.76	21906983
1421 (in isoform 1)	Ubiquitination	-	35.76	21890473
1431	Phosphorylation	RHEAELLSKKKIPRK HHHHHHHHCCCCCHH	55.86	21406692
1436	Acetylation	LLSKKKIPRKLMEEI HHHCCCCCHHHHHHH	35.91	19608861
1436	Ubiquitination	LLSKKKIPRKLMEEI HHHCCCCCHHHHHHH	35.91	32015554
1457	Acetylation	AARPAAAKLKASRLF CCCHHHHHHHHHHHC	45.88	20167786
1459	Methylation	RPAAAKLKASRLFQP CHHHHHHHHHHHCCC	43.54	116253509
1472	Acetylation	QPVQYGQKPEGRTVA CCCCCCCCCCCCEEE	40.45	19608861
1472	Ubiquitination	QPVQYGQKPEGRTVA CCCCCCCCCCCCEEE	40.45	-
1482	Phosphorylation	GRTVAFPSTHPPRTA CCEEECCCCCCCCCC	32.66	-
1483	Phosphorylation	RTVAFPSTHPPRTAA CEEECCCCCCCCCCC	38.34	-
1488	O-linked_Glycosylation	PSTHPPRTAAPTTAS CCCCCCCCCCCCCCC	32.71	30059200
1511	Phosphorylation	GRPPIATFSANPEAK CCCCEEEEECCHHHH	4.86	17924679
1511 (in isoform 2)	Phosphorylation	-	4.86	24719451
1517	Acetylation	TFSANPEAKAAAAPF EEECCHHHHHHCCCC	14.19	19608861
1517	Ubiquitination	TFSANPEAKAAAAPF EEECCHHHHHHCCCC	14.19	29967540
1517 (in isoform 4)	Ubiquitination	-	14.19	21890473
1527	O-linked_Glycosylation	AAAPFQTSQASASAP HCCCCCCCCCCCCCC	16.99	30059200
1530	Phosphorylation	PFQTSQASASAPRHQ CCCCCCCCCCCCCCC	18.34	28555341
1540	O-linked_Glycosylation	APRHQPASASSTAAS CCCCCCCCCCCCCCC	35.05	30059200
1540	Phosphorylation	APRHQPASASSTAAS CCCCCCCCCCCCCCC	35.05	24732914
1542	Phosphorylation	RHQPASASSTAASPA CCCCCCCCCCCCCCC	26.23	24732914
1543	Phosphorylation	HQPASASSTAASPAH CCCCCCCCCCCCCCC	23.06	25627689
1544	Phosphorylation	QPASASSTAASPAHP CCCCCCCCCCCCCCH	24.61	24732914
1547	Phosphorylation	SASSTAASPAHPAKL CCCCCCCCCCCHHHH	21.84	25159151
1553	Acetylation	ASPAHPAKLRAQTTA CCCCCHHHHHCCCCC	42.85	23954790
1555	Methylation	PAHPAKLRAQTTAQA CCCHHHHHCCCCCCC	24.76	115486201
1559	Phosphorylation	AKLRAQTTAQASTPG HHHHCCCCCCCCCCC	12.51	21712546
1561 (in isoform 3)	Ubiquitination	-	33.48	21890473
1564	Phosphorylation	QTTAQASTPGQPPPQ CCCCCCCCCCCCCCC	34.16	21712546
1569	Ubiquitination	ASTPGQPPPQPQAPS CCCCCCCCCCCCCCC	32.07	29967540
1588 (in isoform 2)	Phosphorylation	-	3.80	27251275
1597	Methylation	LPSQAQARLPSGEVV CCHHHHHCCCCCCEE	34.74	54557783
1598	Acetylation	PSQAQARLPSGEVVK CHHHHHCCCCCCEEE	4.42	19608861
1598	Ubiquitination	PSQAQARLPSGEVVK CHHHHHCCCCCCEEE	4.42	21890473
1598 (in isoform 2)	Ubiquitination	-	4.42	21890473
1600	Phosphorylation	QAQARLPSGEVVKIA HHHHCCCCCCEEEEE	52.78	20068231
1604 (in isoform 2)	Phosphorylation	-	3.02	27251275
1605	Ubiquitination	LPSGEVVKIAQLASI CCCCCEEEEEHHHHC	37.18	-
1612 (in isoform 4)	Ubiquitination	-	4.25	21890473
1624	Phosphorylation	SRVAQPETPVTLQFQ CCCCCCCCCEEEEEC	29.73	24173317
1627	O-linked_Glycosylation	AQPETPVTLQFQGSK CCCCCCEEEEECCCE	18.95	30059200
1634	Acetylation	TLQFQGSKFTLSHSQ EEEECCCEEECCHHH	49.55	23954790
1634	Ubiquitination	TLQFQGSKFTLSHSQ EEEECCCEEECCHHH	49.55	21890473
1634 (in isoform 1)	Ubiquitination	-	49.55	21890473
1638	Phosphorylation	QGSKFTLSHSQLRQL CCCEEECCHHHHHHC	20.31	23186163
1640	Phosphorylation	SKFTLSHSQLRQLTA CEEECCHHHHHHCCC	27.77	23186163
1656 (in isoform 3)	Ubiquitination	-	13.49	21890473
1657	Ubiquitination	PLQLQGSVLQIVSAP CCEECCCEEEEEECC	6.12	22817900
1690 (in isoform 2)	Phosphorylation	-	10.61	24719451
1692	Phosphorylation	AVHGALGSKPPAGGP CCCHHCCCCCCCCCC	42.72	18669648
1692 (in isoform 2)	Phosphorylation	-	42.72	27251275
1693	Ubiquitination	VHGALGSKPPAGGPS CCHHCCCCCCCCCCC	53.90	-
1693 (in isoform 2)	Ubiquitination	-	53.90	21890473
1696	Phosphorylation	ALGSKPPAGGPSPAP HCCCCCCCCCCCCCC	44.07	32142685
1696 (in isoform 2)	Phosphorylation	-	44.07	24719451
1700	Phosphorylation	KPPAGGPSPAPLTPQ CCCCCCCCCCCCCCC	36.65	-
1702	Phosphorylation	PAGGPSPAPLTPQVG CCCCCCCCCCCCCCC	18.97	18452278
1706	Ubiquitination	PSPAPLTPQVGVPGR CCCCCCCCCCCCCCC	34.25	29967540
1726	Phosphorylation	LAVGEPGTASKPASP EEECCCCCCCCCCCC	38.17	23401153
1728	Phosphorylation	VGEPGTASKPASPIG ECCCCCCCCCCCCCC	38.72	29255136
1729	Acetylation	GEPGTASKPASPIGG CCCCCCCCCCCCCCC	41.98	26051181
1729	Ubiquitination	GEPGTASKPASPIGG CCCCCCCCCCCCCCC	41.98	21906983
1729 (in isoform 1)	Ubiquitination	-	41.98	21890473
1732	Phosphorylation	GTASKPASPIGGPTQ CCCCCCCCCCCCCCH	26.10	29255136
1738	Phosphorylation	ASPIGGPTQEEKTRL CCCCCCCCHHHHHHH	52.46	30266825
1743	Phosphorylation	GPTQEEKTRLLKERL CCCHHHHHHHHHHHH	29.81	23312004
1795	Ubiquitination	SLDGRRGKEAGPAHS CCCCCCCCCCCCCCC	42.45	-
1912	Phosphorylation	ILLQKLKSEGRRVLI HHHHHHHCCCCHHHH	56.57	-
2014	Ubiquitination	CDRIGRCKDIHIYRL HHHHCCCCCEEEEEE	59.36	-
2030	Ubiquitination	SGNSIEEKLLKNGTK CCCCHHHHHHHCCCH	46.45	-
2037	Ubiquitination	KLLKNGTKDLIREVA HHHHCCCHHHHHHHH	52.51	-
2050	Phosphorylation	VAAQGNDYSMAFLTQ HHHCCCCHHHHHHHH	12.35	18077418
2056	Phosphorylation	DYSMAFLTQRTIQEL CHHHHHHHHHHHHHH	15.00	28555341
2062	Ubiquitination	LTQRTIQELFEVYSP HHHHHHHHHHHHHCC	52.13	29967540
2072	Ubiquitination	EVYSPMDDAGFPVKA HHHCCCCCCCCCCCE	42.19	21963094
2072 (in isoform 2)	Ubiquitination	-	42.19	-
2085 (in isoform 4)	Ubiquitination	-	3.53	21890473
2086	Phosphorylation	AEEFVVLSQEPSVTE EEEEEEECCCCCCCC	22.38	25159151
2108	Ubiquitination	RPFIEALKSIEYLEE HHHHHHHHCCHHHHH	57.33	-
2129 (in isoform 3)	Ubiquitination	-	34.28	21890473
2137	Phosphorylation	TDALSSDSENMPCDE CCCCCCCCCCCCCCC	32.58	22210691
2166	Ubiquitination	LTPIEKYALNYLELF CCHHHHHHHHHHHHH	10.61	21890473
2166 (in isoform 2)	Ubiquitination	-	10.61	21890473
2181	Ubiquitination	HTSIEQEKERNSEDA CCCHHHHHHHCCHHH	62.76	-
2202	Ubiquitination	AWEFWNLKTLQEREA HHHHHCCHHHHHHHH	43.93	21890473
2202 (in isoform 1)	Ubiquitination	-	43.93	21890473
2258 (in isoform 2)	Phosphorylation	-	33.91	24719451
2284	Phosphorylation	EAKLPPVYVRKERKR HHHCCCCCCCCCCHH	10.58	-
2286 (in isoform 2)	Phosphorylation	-	19.89	24719451
2291	Ubiquitination	YVRKERKRHKTDPSA CCCCCCHHCCCCCCH	42.63	33845483
2293	Ubiquitination	RKERKRHKTDPSAAG CCCCHHCCCCCCHHC	59.67	-
2294	Phosphorylation	KERKRHKTDPSAAGR CCCHHCCCCCCHHCH	47.20	24719451
2297	Phosphorylation	KRHKTDPSAAGRKKK HHCCCCCCHHCHHHH	33.29	-
2300	Ubiquitination	KTDPSAAGRKKKQRH CCCCCHHCHHHHHHC	41.48	23000965
2301	Ubiquitination	TDPSAAGRKKKQRHG CCCCHHCHHHHHHCC	42.78	23000965
2306	Ubiquitination	AGRKKKQRHGEAVVP HCHHHHHHCCCCCCC	48.97	23000965
2313	Acetylation	RHGEAVVPPRSLFDR HCCCCCCCCHHHHCC	16.40	19608861
2320	Acetylation	PPRSLFDRATPGLLK CCHHHHCCCCCCHHH	32.78	19608861
2320	Ubiquitination	PPRSLFDRATPGLLK CCHHHHCCCCCCHHH	32.78	29967540
2322	Phosphorylation	RSLFDRATPGLLKIR HHHHCCCCCCHHHHH	20.84	28985074
2342	Ubiquitination	QKKNILLKQQVPFAK HHHCEEECCCCCCCC	34.93	-
2349	Acetylation	KQQVPFAKPLPTFAK CCCCCCCCCCCCCCC	47.68	19608861
2353	Phosphorylation	PFAKPLPTFAKPTAE CCCCCCCCCCCCCCC	43.86	20860994
2356	Acetylation	KPLPTFAKPTAEPGQ CCCCCCCCCCCCCCC	38.42	19608861
2435 (in isoform 2)	Phosphorylation	-	34.48	24719451
2440 (in isoform 2)	Phosphorylation	-	51.16	24719451
2457	Ubiquitination	AQDENATHTQLYTSH ECCCCCCCCEEEEHH	14.81	29967540
2471	Phosphorylation	HFDLMKMTAGKRSPP HHHHHHHCCCCCCCC	27.09	24719451
2476	Phosphorylation	KMTAGKRSPPIKPLL HHCCCCCCCCCCCCC	38.21	30266825
2480	Acetylation	GKRSPPIKPLLGMNP CCCCCCCCCCCCCCC	35.07	23749302
2501	Phosphorylation	HASVLAESGINYDKP HHHHHHHCCCCCCCC	39.09	30206219
2505	Phosphorylation	LAESGINYDKPLPPI HHHCCCCCCCCCCCC	24.35	30206219
2507	Acetylation	ESGINYDKPLPPIQV HCCCCCCCCCCCCHH	37.79	26051181
2568	Phosphorylation	LPQPQAAGSQPPAGP CCCCCCCCCCCCCCC	29.81	20068231
2569	Phosphorylation	PQPQAAGSQPPAGPP CCCCCCCCCCCCCCC	34.48	20068231
2572	Phosphorylation	QAAGSQPPAGPPAVQ CCCCCCCCCCCCCCC	42.06	20068231
2579	Phosphorylation	PAGPPAVQPQPQPQP CCCCCCCCCCCCCCC	32.77	20068231
2604	O-linked_Glycosylation	AKAQPAITTGGSAAV CCCCCCEECCCCEEH	22.84	30059200
2604	Phosphorylation	AKAQPAITTGGSAAV CCCCCCEECCCCEEH	22.84	20068231
2605	Phosphorylation	KAQPAITTGGSAAVL CCCCCEECCCCEEHH	33.17	20068231
2608	O-linked_Glycosylation	PAITTGGSAAVLAGT CCEECCCCEEHHCCE	17.88	30059200
2608	Phosphorylation	PAITTGGSAAVLAGT CCEECCCCEEHHCCE	17.88	22496350
2615	O-linked_Glycosylation	SAAVLAGTIKTSVTG CEEHHCCEEEEECCC	17.44	30059200
2615	Phosphorylation	SAAVLAGTIKTSVTG CEEHHCCEEEEECCC	17.44	20068231
2618	Phosphorylation	VLAGTIKTSVTGTSM HHCCEEEEECCCCCC	25.28	22210691
2619	Phosphorylation	LAGTIKTSVTGTSMP HCCEEEEECCCCCCC	16.81	20068231
2620	Phosphorylation	AGTIKTSVTGTSMPT CCEEEEECCCCCCCC	7.48	20068231
2620 (in isoform 2)	Phosphorylation	-	7.48	24719451
2623	Phosphorylation	IKTSVTGTSMPTGAV EEEECCCCCCCCCCC	16.70	19845377
2631	O-linked_Glycosylation	SMPTGAVSGNVIVNT CCCCCCCCCCEEEEE	24.90	30059200
2631	Phosphorylation	SMPTGAVSGNVIVNT CCCCCCCCCCEEEEE	24.90	19845377
2638	O-linked_Glycosylation	SGNVIVNTIAGVPAA CCCEEEEECCCCCHH	10.99	30059200
2649	Phosphorylation	VPAATFQSINKRLAS CCHHHHHHHHHHCCC	24.76	19845377
2650 (in isoform 2)	Phosphorylation	-	4.98	24719451
2653	Phosphorylation	TFQSINKRLASPVAP HHHHHHHHCCCCCCC	30.88	32142685
2656	Phosphorylation	SINKRLASPVAPGAL HHHHHCCCCCCCCCC	25.21	30266825
2664	Phosphorylation	PVAPGALTTPGGSAP CCCCCCCCCCCCCCC	30.34	24732914
2665	Phosphorylation	VAPGALTTPGGSAPA CCCCCCCCCCCCCCC	22.30	24732914
2669	Phosphorylation	ALTTPGGSAPAQVVH CCCCCCCCCCCEEEE	36.67	24732914
2677	Phosphorylation	APAQVVHTQPPPRAV CCCEEEECCCCCCCC	31.03	27080861
2686	O-linked_Glycosylation	PPPRAVGSPATATPD CCCCCCCCCCCCCCC	12.55	30059200
2686	Phosphorylation	PPPRAVGSPATATPD CCCCCCCCCCCCCCC	12.55	25159151
2689	O-linked_Glycosylation	RAVGSPATATPDLVS CCCCCCCCCCCCHHH	34.15	30059200
2689	Phosphorylation	RAVGSPATATPDLVS CCCCCCCCCCCCHHH	34.15	30108239
2691	Phosphorylation	VGSPATATPDLVSMA CCCCCCCCCCHHHHH	17.00	30108239
2696	O-linked_Glycosylation	TATPDLVSMATTQGV CCCCCHHHHHHHCCC	15.25	30059200
2696	Phosphorylation	TATPDLVSMATTQGV CCCCCHHHHHHHCCC	15.25	-
2700	O-linked_Glycosylation	DLVSMATTQGVRAVT CHHHHHHHCCCCEEE	17.49	30059200
2707	O-linked_Glycosylation	TQGVRAVTSVTASAV HCCCCEEEEEEEEEE	19.25	30059200
2708	O-linked_Glycosylation	QGVRAVTSVTASAVV CCCCEEEEEEEEEEE	15.75	30059200
2710	O-linked_Glycosylation	VRAVTSVTASAVVTT CCEEEEEEEEEEEEC	18.05	30059200
2712	O-linked_Glycosylation	AVTSVTASAVVTTNL EEEEEEEEEEEECCC	16.54	30059200
2716	O-linked_Glycosylation	VTASAVVTTNLTPVQ EEEEEEEECCCCCCC	11.90	30059200
2717	O-linked_Glycosylation	TASAVVTTNLTPVQT EEEEEEECCCCCCCC	19.34	30059200
2720	O-linked_Glycosylation	AVVTTNLTPVQTPAR EEEECCCCCCCCCHH	24.39	30059200
2724	O-linked_Glycosylation	TNLTPVQTPARSLVP CCCCCCCCCHHHHCC	21.10	30059200
2728	O-linked_Glycosylation	PVQTPARSLVPQVSQ CCCCCHHHHCCCHHH	35.51	30059200
2728	Phosphorylation	PVQTPARSLVPQVSQ CCCCCHHHHCCCHHH	35.51	27470641
2734	O-linked_Glycosylation	RSLVPQVSQATGVQL HHHCCCHHHCCCCCC	14.62	30059200
2734	Phosphorylation	RSLVPQVSQATGVQL HHHCCCHHHCCCCCC	14.62	27470641
2737	O-linked_Glycosylation	VPQVSQATGVQLPGK CCCHHHCCCCCCCCC	30.19	30059200
2737	Phosphorylation	VPQVSQATGVQLPGK CCCHHHCCCCCCCCC	30.19	27470641
2744	Acetylation	TGVQLPGKTITPAHF CCCCCCCCCCCHHHH	34.51	25953088
2745	Phosphorylation	GVQLPGKTITPAHFQ CCCCCCCCCCHHHHH	35.68	28555341
2747	Phosphorylation	QLPGKTITPAHFQLL CCCCCCCCHHHHHHH	21.47	28555341
2777	Phosphorylation	QQQQQQQQQQQQQQQ HHHHHHHHHHHHHHH	38.42	20068231
2777 (in isoform 2)	Phosphorylation	-	38.42	24719451
2811	Acetylation	AQIKAVGKLTPEHLI HHHHHHHCCCHHHHH	42.46	25953088
2813	Phosphorylation	IKAVGKLTPEHLIKM HHHHHCCCHHHHHHH	30.07	29255136
2814	Phosphorylation	KAVGKLTPEHLIKMQ HHHHCCCHHHHHHHH	37.13	18669648
2878	O-linked_Glycosylation	GALLTGTTVANLQVA CCCCCCCEEEECEEE	20.97	30059200
2934	Ubiquitination	SSPGVTTLPMNVAGI CCCCCCCCCCCCCCE	2.50	29967540
2955	Phosphorylation	PQKAAGQTVVAQPVH CCCCCCCEEECCCCC	18.94	20068231
2965 (in isoform 2)	Phosphorylation	-	40.98	27251275
2978	Acetylation	QQAVQQQKAIQPQAA HHHHHHHHCCCHHHH	43.02	26051181
2996	Phosphorylation	AAVQQKITAQQITTP HHHHHHEEHHCCCCC	26.00	-
3001	Phosphorylation	KITAQQITTPGAQQK HEEHHCCCCCCHHHH	23.70	27251275
3002	Phosphorylation	ITAQQITTPGAQQKV EEHHCCCCCCHHHHH	22.73	25159151
3011	Phosphorylation	GAQQKVAYAAQPALK CHHHHHHHHCCHHHH	12.88	25159151
3018	Acetylation	YAAQPALKTQFLTTP HHCCHHHHCCCCCCC	42.24	25953088
3023	O-linked_Glycosylation	ALKTQFLTTPISQAQ HHHCCCCCCCHHHHH	31.64	30059200
3024	O-linked_Glycosylation	LKTQFLTTPISQAQK HHCCCCCCCHHHHHH	22.29	30059200
3027	O-linked_Glycosylation	QFLTTPISQAQKLAG CCCCCCHHHHHHHCC	22.22	30059200
3081	O-linked_Glycosylation	TVALTQATAAGQQVQ HHHHHHHHHCCCCEE	13.76	30059200
3094	O-linked_Glycosylation	VQMIPAVTATAQVVQ EEECCHHHHHHHHHH	22.01	30059200
3116 (in isoform 2)	Phosphorylation	-	23.62	24719451
3131	Phosphorylation	NPAQVPASSDSPSQQ CCCCCCCCCCCHHHC	28.71	30576142
3132	Phosphorylation	PAQVPASSDSPSQQP CCCCCCCCCCHHHCC	44.19	30576142
3134	Phosphorylation	QVPASSDSPSQQPKL CCCCCCCCHHHCCCC	28.53	29496963
3136	Phosphorylation	PASSDSPSQQPKLQM CCCCCCHHHCCCCCC	45.45	22210691
3149	Methylation	QMRVPAVRLKTPTKP CCCCCCEECCCCCCC	32.35	80702299
3151	Acetylation	RVPAVRLKTPTKPPC CCCCEECCCCCCCCC	41.72	25953088
3152	Phosphorylation	VPAVRLKTPTKPPCQ CCCEECCCCCCCCCC	40.56	22617229
3154	Phosphorylation	AVRLKTPTKPPCQ-- CEECCCCCCCCCC--	62.51	24732914
3155	Acetylation	VRLKTPTKPPCQ--- EECCCCCCCCCC---	48.44	23749302

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EP400_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EP400_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EP400_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRRAP_HUMAN	TRRAP	physical	11509179
RUVB2_HUMAN	RUVBL2	physical	11509179
RUVB1_HUMAN	RUVBL1	physical	11509179
ACL6A_HUMAN	ACTL6A	physical	11509179
KAT5_HUMAN	KAT5	physical	11509179
RUVB2_HUMAN	RUVBL2	physical	16601686
KAT5_HUMAN	KAT5	physical	20351180
RUVB1_HUMAN	RUVBL1	physical	22939629
RUVB2_HUMAN	RUVBL2	physical	22939629
MYC_HUMAN	MYC	physical	18413597
HDAC2_HUMAN	HDAC2	physical	26344197
RUVB2_HUMAN	RUVBL2	physical	29028833
TRRAP_HUMAN	TRRAP	physical	29028833
ACL6A_HUMAN	ACTL6A	physical	29028833
ACL6B_HUMAN	ACTL6B	physical	29028833
EAF6_HUMAN	MEAF6	physical	29028833
MRGBP_HUMAN	MRGBP	physical	29028833
KAT5_HUMAN	KAT5	physical	29028833
YETS4_HUMAN	YEATS4	physical	29028833
MO4L1_HUMAN	MORF4L1	physical	29028833
DMAP1_HUMAN	DMAP1	physical	29028833
BRD8_HUMAN	BRD8	physical	29028833
EPC2_HUMAN	EPC2	physical	29028833
MO4L2_HUMAN	MORF4L2	physical	29028833
EPC1_HUMAN	EPC1	physical	29028833
MBTD1_HUMAN	MBTD1	physical	29028833
ING3_HUMAN	ING3	physical	29028833
VPS72_HUMAN	VPS72	physical	29028833
RUVB1_HUMAN	RUVBL1	physical	29028833
PP2AA_HUMAN	PPP2CA	physical	29028833
2AAA_HUMAN	PPP2R1A	physical	29028833
2AAB_HUMAN	PPP2R1B	physical	29028833
PP2AB_HUMAN	PPP2CB	physical	29028833
MAX_HUMAN	MAX	physical	29028833
MYCL_HUMAN	MYCL	physical	29028833
MYCN_HUMAN	MYCN	physical	29028833

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1472; LYS-1553; LYS-1634;LYS-2349 AND LYS-2356, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315 AND SER-321, ANDMASS SPECTROMETRY.
PubMed: 19690332

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-736 AND SER-1732, ANDMASS SPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-314; SER-315; THR-320;SER-941; SER-943; THR-945; SER-1728; SER-1732 AND THR-2813, AND MASSSPECTROMETRY.
PubMed: 18669648

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1547, AND MASSSPECTROMETRY.
PubMed: 17924679

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-736, AND MASSSPECTROMETRY.
PubMed: 15302935