MYCL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYCL_HUMAN
• UniProt AC: P12524
• Protein Name: Protein L-Myc
• Gene Name: MYCL
• Organism: Homo sapiens (Human).
• Sequence Length: 364
• Subcellular Localization: Nucleus .
• Protein Sequence: MDYDSYQHYFYDYDCGEDFYRSTAPSEDIWKKFELVPSPPTSPPWGLGPGAGDPAPGIGPPEPWPGGCTGDEAESRGHSKGWGRNYASIIRRDCMWSGFSARERLERAVSDRLAPGAPRGNPPKASAAPDCTPSLEAGNPAPAAPCPLGEPKTQACSGSESPSDSENEEIDVVTVEKRQSLGIRKPVTITVRADPLDPCMKHFHISIHQQQHNYAARFPPESCSQEEASERGPQEEVLERDAAGEKEDEEDEEIVSPPPVESEAAQSCHPKPVSSDTEDVTKRKNHNFLERKRRNDLRSRFLALRDQVPTLASCSKAPKVVILSKALEYLQALVGAEKRMATEKRQLRCRQQQLQKRIAYLTGY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MDYDSYQHYF -----CCCCCCCCEE		-
38	Phosphorylation	KKFELVPSPPTSPPW HHCCCCCCCCCCCCC		1312697
41	Phosphorylation	ELVPSPPTSPPWGLG CCCCCCCCCCCCCCC		-
42	Phosphorylation	LVPSPPTSPPWGLGP CCCCCCCCCCCCCCC		1312697
188	Phosphorylation	LGIRKPVTITVRADP CCCCCCEEEEEECCC		-
271	Acetylation	AAQSCHPKPVSSDTE HHHHCCCCCCCCCHH		30589795
299	Phosphorylation	KRRNDLRSRFLALRD HHHHHHHHHHHHHHH		18510355
338	Acetylation	QALVGAEKRMATEKR HHHHHHHHHHHHHHH		20167786

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
38	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
42	S	Phosphorylation	Kinase	GSK3B	P49841	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYCL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYCL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MAX_HUMAN	MAX	physical	2006410
KLC3_HUMAN	KLC3	physical	28514442
KLC4_HUMAN	KLC4	physical	28514442
KAT5_HUMAN	KAT5	physical	28514442
EPC1_HUMAN	EPC1	physical	28514442
ING3_HUMAN	ING3	physical	28514442
EPC2_HUMAN	EPC2	physical	28514442
EP400_HUMAN	EP400	physical	28514442
KIF5A_HUMAN	KIF5A	physical	28514442
TRRAP_HUMAN	TRRAP	physical	28514442
KLC2_HUMAN	KLC2	physical	28514442
MBTD1_HUMAN	MBTD1	physical	28514442
VPS72_HUMAN	VPS72	physical	28514442
EAF6_HUMAN	MEAF6	physical	28514442
JAZF1_HUMAN	JAZF1	physical	28514442
KINH_HUMAN	KIF5B	physical	28514442
KIF5C_HUMAN	KIF5C	physical	28514442
BRD8_HUMAN	BRD8	physical	28514442
DMAP1_HUMAN	DMAP1	physical	28514442
KLC1_HUMAN	KLC1	physical	28514442
MO4L1_HUMAN	MORF4L1	physical	28514442
YETS4_HUMAN	YEATS4	physical	28514442
CCHL_HUMAN	HCCS	physical	28514442
APBP2_HUMAN	APPBP2	physical	28514442
CTU2_HUMAN	CTU2	physical	28514442
ST65G_HUMAN	SUPT7L	physical	28514442
SP20H_HUMAN	SUPT20H	physical	28514442
NAGK_HUMAN	NAGK	physical	28514442
TAF5L_HUMAN	TAF5L	physical	28514442
FA83H_HUMAN	FAM83H	physical	28514442
CSKP_HUMAN	CASK	physical	28514442
DPH1_HUMAN	DPH1	physical	28514442
CTU1_HUMAN	CTU1	physical	28514442
FOXK1_HUMAN	FOXK1	physical	28514442
RUVB1_HUMAN	RUVBL1	physical	28514442
RUVB2_HUMAN	RUVBL2	physical	28514442
FBRS_HUMAN	FBRS	physical	28514442
AURKA_HUMAN	AURKA	physical	28514442
MRGBP_HUMAN	MRGBP	physical	28514442
TAF9_HUMAN	TAF9	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.