| UniProt ID | SP20H_HUMAN | |
|---|---|---|
| UniProt AC | Q8NEM7 | |
| Protein Name | Transcription factor SPT20 homolog | |
| Gene Name | SUPT20H | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 779 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy.. | |
| Protein Sequence | MQQALELALDRAEYVIESARQRPPKRKYLSSGRKSVFQKLYDLYIEECEKEPEVKKLRRNVNLLEKLVMQETLSCLVVNLYPGNEGYSLMLRGKNGSDSETIRLPYEEGELLEYLDAEELPPILVDLLEKSQVNIFHCGCVIAEIRDYRQSSNMKSPGYQSRHILLRPTMQTLICDVHSITSDNHKWTQEDKLLLESQLILATAEPLCLDPSIAVTCTANRLLYNKQKMNTRPMKRCFKRYSRSSLNRQQDLSHCPPPPQLRLLDFLQKRKERKAGQHYDLKISKAGNCVDMWKRSPCNLAIPSEVDVEKYAKVEKSIKSDDSQPTVWPAHDVKDDYVFECEAGTQYQKTKLTILQSLGDPLYYGKIQPCKADEESDSQMSPSHSSTDDHSNWFIIGSKTDAERVVNQYQELVQNEAKCPVKMSHSSSGSASLSQVSPGKETDQTETVSVQSSVLGKGVKHRPPPIKLPSSSGNSSSGNYFTPQQTSSFLKSPTPPPSSKPSSIPRKSSVDLNQVSMLSPAALSPASSSQRTTATQVMANSAGLNFINVVGSVCGAQALMSGSNPMLGCNTGAITPAGINLSGLLPSGGLLPNALPSAMQAASQAGVPFGLKNTSSLRPLNLLQLPGGSLIFNTLQQQQQQLSQFTPQQPQQPTTCSPQQPGEQGSEQGSTSQEQALSAQQAAVINLTGVGSFMQSQAAVLSQLGSAENRPEQSLPQQRFQLSSAFQQQQQQIQQLRFLQHQMAMAAAAAQTAQLHHHRHTGSQSKSKMKRGTPTTPKF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 28 | Phosphorylation | QRPPKRKYLSSGRKS HCCCCCCCCCCCCHH | 20049867 | ||
| 30 | Phosphorylation | PPKRKYLSSGRKSVF CCCCCCCCCCCHHHH | 20049867 | ||
| 31 | Phosphorylation | PKRKYLSSGRKSVFQ CCCCCCCCCCHHHHH | 20049867 | ||
| 34 | Ubiquitination | KYLSSGRKSVFQKLY CCCCCCCHHHHHHHH | - | ||
| 34 | Ubiquitination | KYLSSGRKSVFQKLY CCCCCCCHHHHHHHH | - | ||
| 55 | Ubiquitination | CEKEPEVKKLRRNVN HCCCHHHHHHHHHHH | - | ||
| 56 | Ubiquitination | EKEPEVKKLRRNVNL CCCHHHHHHHHHHHH | - | ||
| 74 | Phosphorylation | LVMQETLSCLVVNLY HHHHHHHHEEEEECC | - | ||
| 87 | Phosphorylation | LYPGNEGYSLMLRGK CCCCCCCEEEEECCC | 18083107 | ||
| 148 | Phosphorylation | VIAEIRDYRQSSNMK EEHHHHHHHHHCCCC | 29759185 | ||
| 155 | Ubiquitination | YRQSSNMKSPGYQSR HHHHCCCCCCCHHHH | - | ||
| 155 | Sumoylation | YRQSSNMKSPGYQSR HHHHCCCCCCCHHHH | - | ||
| 155 | Sumoylation | YRQSSNMKSPGYQSR HHHHCCCCCCCHHHH | - | ||
| 155 | Ubiquitination | YRQSSNMKSPGYQSR HHHHCCCCCCCHHHH | - | ||
| 226 | Ubiquitination | ANRLLYNKQKMNTRP HHHHHHCHHHCCCCC | - | ||
| 226 | Ubiquitination | ANRLLYNKQKMNTRP HHHHHHCHHHCCCCC | - | ||
| 228 | Ubiquitination | RLLYNKQKMNTRPMK HHHHCHHHCCCCCHH | - | ||
| 269 | Ubiquitination | RLLDFLQKRKERKAG HHHHHHHHHHHHHCC | - | ||
| 269 | Ubiquitination | RLLDFLQKRKERKAG HHHHHHHHHHHHHCC | - | ||
| 282 | Ubiquitination | AGQHYDLKISKAGNC CCCCCEEEECCCCCC | - | ||
| 282 | Ubiquitination | AGQHYDLKISKAGNC CCCCCEEEECCCCCC | - | ||
| 285 | Ubiquitination | HYDLKISKAGNCVDM CCEEEECCCCCCCCC | - | ||
| 285 | Ubiquitination | HYDLKISKAGNCVDM CCEEEECCCCCCCCC | - | ||
| 294 | Ubiquitination | GNCVDMWKRSPCNLA CCCCCCCCCCCCCCC | - | ||
| 294 | Acetylation | GNCVDMWKRSPCNLA CCCCCCCCCCCCCCC | 26051181 | ||
| 294 | Ubiquitination | GNCVDMWKRSPCNLA CCCCCCCCCCCCCCC | - | ||
| 296 | Phosphorylation | CVDMWKRSPCNLAIP CCCCCCCCCCCCCCC | 30266825 | ||
| 296 (in isoform 3) | Phosphorylation | - | 27251275 | ||
| 304 | Phosphorylation | PCNLAIPSEVDVEKY CCCCCCCCCCCHHHH | 30266825 | ||
| 310 | Ubiquitination | PSEVDVEKYAKVEKS CCCCCHHHHHHHHHH | - | ||
| 319 | Ubiquitination | AKVEKSIKSDDSQPT HHHHHHCCCCCCCCC | - | ||
| 319 | Ubiquitination | AKVEKSIKSDDSQPT HHHHHHCCCCCCCCC | - | ||
| 334 | Ubiquitination | VWPAHDVKDDYVFEC EEECCCCCCCEEEEE | - | ||
| 349 | Ubiquitination | EAGTQYQKTKLTILQ CCCCCEECCEEEHHH | - | ||
| 350 | Phosphorylation | AGTQYQKTKLTILQS CCCCEECCEEEHHHH | - | ||
| 351 | Ubiquitination | GTQYQKTKLTILQSL CCCEECCEEEHHHHH | - | ||
| 351 | Ubiquitination | GTQYQKTKLTILQSL CCCEECCEEEHHHHH | - | ||
| 353 | Phosphorylation | QYQKTKLTILQSLGD CEECCEEEHHHHHCC | - | ||
| 357 | Phosphorylation | TKLTILQSLGDPLYY CEEEHHHHHCCCCCC | 25072903 | ||
| 363 | Phosphorylation | QSLGDPLYYGKIQPC HHHCCCCCCCCEECC | 25072903 | ||
| 364 | Phosphorylation | SLGDPLYYGKIQPCK HHCCCCCCCCEECCC | 25072903 | ||
| 376 | Phosphorylation | PCKADEESDSQMSPS CCCCCCCCCCCCCCC | 28450419 | ||
| 378 | Phosphorylation | KADEESDSQMSPSHS CCCCCCCCCCCCCCC | 25159151 | ||
| 381 | Phosphorylation | EESDSQMSPSHSSTD CCCCCCCCCCCCCCC | 23401153 | ||
| 381 (in isoform 3) | Phosphorylation | - | 27251275 | ||
| 383 | Phosphorylation | SDSQMSPSHSSTDDH CCCCCCCCCCCCCCC | 25159151 | ||
| 385 | Phosphorylation | SQMSPSHSSTDDHSN CCCCCCCCCCCCCCC | 25159151 | ||
| 386 | Phosphorylation | QMSPSHSSTDDHSNW CCCCCCCCCCCCCCE | 25159151 | ||
| 387 | Phosphorylation | MSPSHSSTDDHSNWF CCCCCCCCCCCCCEE | 25159151 | ||
| 391 | Phosphorylation | HSSTDDHSNWFIIGS CCCCCCCCCEEEEEC | 23403867 | ||
| 398 | Phosphorylation | SNWFIIGSKTDAERV CCEEEEECHHHHHHH | 20873877 | ||
| 409 | Phosphorylation | AERVVNQYQELVQNE HHHHHHHHHHHHHCC | 27067055 | ||
| 418 | Ubiquitination | ELVQNEAKCPVKMSH HHHHCCCCCCCCCCC | - | ||
| 418 | Ubiquitination | ELVQNEAKCPVKMSH HHHHCCCCCCCCCCC | - | ||
| 424 | Phosphorylation | AKCPVKMSHSSSGSA CCCCCCCCCCCCCCC | 30108239 | ||
| 426 | Phosphorylation | CPVKMSHSSSGSASL CCCCCCCCCCCCCCC | 30108239 | ||
| 427 | Phosphorylation | PVKMSHSSSGSASLS CCCCCCCCCCCCCCC | 30108239 | ||
| 428 | Phosphorylation | VKMSHSSSGSASLSQ CCCCCCCCCCCCCCC | 30108239 | ||
| 430 | Phosphorylation | MSHSSSGSASLSQVS CCCCCCCCCCCCCCC | 30108239 | ||
| 432 | Phosphorylation | HSSSGSASLSQVSPG CCCCCCCCCCCCCCC | 30108239 | ||
| 434 | Phosphorylation | SSGSASLSQVSPGKE CCCCCCCCCCCCCCC | 30108239 | ||
| 434 (in isoform 3) | Phosphorylation | - | 27251275 | ||
| 437 | Phosphorylation | SASLSQVSPGKETDQ CCCCCCCCCCCCCCC | 25159151 | ||
| 442 | Phosphorylation | QVSPGKETDQTETVS CCCCCCCCCCCEEEE | 30576142 | ||
| 445 | Phosphorylation | PGKETDQTETVSVQS CCCCCCCCEEEEEEH | 30108239 | ||
| 447 | Phosphorylation | KETDQTETVSVQSSV CCCCCCEEEEEEHHH | 27080861 | ||
| 449 | Phosphorylation | TDQTETVSVQSSVLG CCCCEEEEEEHHHCC | 27080861 | ||
| 452 | Phosphorylation | TETVSVQSSVLGKGV CEEEEEEHHHCCCCC | 27080861 | ||
| 453 | Phosphorylation | ETVSVQSSVLGKGVK EEEEEEHHHCCCCCC | 29978859 | ||
| 457 | Ubiquitination | VQSSVLGKGVKHRPP EEHHHCCCCCCCCCC | - | ||
| 467 | Acetylation | KHRPPPIKLPSSSGN CCCCCCCCCCCCCCC | 26051181 | ||
| 482 | Phosphorylation | SSSGNYFTPQQTSSF CCCCCCCCHHHCCHH | 29449344 | ||
| 486 | Phosphorylation | NYFTPQQTSSFLKSP CCCCHHHCCHHCCCC | 23090842 | ||
| 487 | Phosphorylation | YFTPQQTSSFLKSPT CCCHHHCCHHCCCCC | 29978859 | ||
| 488 | Phosphorylation | FTPQQTSSFLKSPTP CCHHHCCHHCCCCCC | 24719451 | ||
| 492 | O-linked_Glycosylation | QTSSFLKSPTPPPSS HCCHHCCCCCCCCCC | 30059200 | ||
| 492 | Phosphorylation | QTSSFLKSPTPPPSS HCCHHCCCCCCCCCC | 23927012 | ||
| 492 (in isoform 3) | Phosphorylation | - | 27251275 | ||
| 494 | O-linked_Glycosylation | SSFLKSPTPPPSSKP CHHCCCCCCCCCCCC | 30059200 | ||
| 494 | Phosphorylation | SSFLKSPTPPPSSKP CHHCCCCCCCCCCCC | 23927012 | ||
| 494 (in isoform 3) | Phosphorylation | - | 27251275 | ||
| 498 | O-linked_Glycosylation | KSPTPPPSSKPSSIP CCCCCCCCCCCCCCC | 30059200 | ||
| 498 | Phosphorylation | KSPTPPPSSKPSSIP CCCCCCCCCCCCCCC | 29978859 | ||
| 499 | O-linked_Glycosylation | SPTPPPSSKPSSIPR CCCCCCCCCCCCCCC | 30059200 | ||
| 499 | Phosphorylation | SPTPPPSSKPSSIPR CCCCCCCCCCCCCCC | 23927012 | ||
| 500 | Acetylation | PTPPPSSKPSSIPRK CCCCCCCCCCCCCCC | 26051181 | ||
| 502 | O-linked_Glycosylation | PPPSSKPSSIPRKSS CCCCCCCCCCCCCCC | 30059200 | ||
| 502 | Phosphorylation | PPPSSKPSSIPRKSS CCCCCCCCCCCCCCC | 20068231 | ||
| 503 | O-linked_Glycosylation | PPSSKPSSIPRKSSV CCCCCCCCCCCCCCC | 30059200 | ||
| 503 | Phosphorylation | PPSSKPSSIPRKSSV CCCCCCCCCCCCCCC | 20068231 | ||
| 507 | Ubiquitination | KPSSIPRKSSVDLNQ CCCCCCCCCCCCHHH | - | ||
| 507 | Ubiquitination | KPSSIPRKSSVDLNQ CCCCCCCCCCCCHHH | - | ||
| 508 | Phosphorylation | PSSIPRKSSVDLNQV CCCCCCCCCCCHHHC | 23401153 | ||
| 508 (in isoform 3) | Phosphorylation | - | 27251275 | ||
| 509 | Phosphorylation | SSIPRKSSVDLNQVS CCCCCCCCCCHHHCC | 21712546 | ||
| 516 | Phosphorylation | SVDLNQVSMLSPAAL CCCHHHCCCCCHHHC | 28102081 | ||
| 516 (in isoform 3) | Phosphorylation | - | 27251275 | ||
| 519 | Phosphorylation | LNQVSMLSPAALSPA HHHCCCCCHHHCCCC | 21712546 | ||
| 519 (in isoform 3) | Phosphorylation | - | 27251275 | ||
| 524 | Phosphorylation | MLSPAALSPASSSQR CCCHHHCCCCCCCCC | 21712546 | ||
| 524 (in isoform 3) | Phosphorylation | - | 27251275 | ||
| 527 | Phosphorylation | PAALSPASSSQRTTA HHHCCCCCCCCCCCH | 21712546 | ||
| 528 | Phosphorylation | AALSPASSSQRTTAT HHCCCCCCCCCCCHH | 30108239 | ||
| 529 | Phosphorylation | ALSPASSSQRTTATQ HCCCCCCCCCCCHHH | 21712546 | ||
| 723 | Phosphorylation | PQQRFQLSSAFQQQQ CHHHHHHHHHHHHHH | 24043423 | ||
| 724 | Phosphorylation | QQRFQLSSAFQQQQQ HHHHHHHHHHHHHHH | 24043423 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SP20H_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SP20H_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SP20H_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MK14_HUMAN | MAPK14 | physical | 21988832 | |
| MK01_HUMAN | MAPK1 | physical | 21988832 | |
| STAT3_HUMAN | STAT3 | physical | 21988832 | |
| ATG9A_HUMAN | ATG9A | physical | 19893488 | |
| MK14_HUMAN | MAPK14 | physical | 19893488 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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