| UniProt ID | APBP2_HUMAN | |
|---|---|---|
| UniProt AC | Q92624 | |
| Protein Name | Amyloid protein-binding protein 2 | |
| Gene Name | APPBP2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 585 | |
| Subcellular Localization |
Nucleus. Cytoplasm, cytoskeleton. Membrane Peripheral membrane protein . Associated with membranes and microtubules. |
|
| Protein Description | May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.. | |
| Protein Sequence | MAAVELEWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAIQIKEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLEYDYRGLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVSTSPQSTEEVVQSFLISQNVEGPSC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 68 | Ubiquitination | CELEVFAKVLRALDK HHHHHHHHHHHHHCH | 30.27 | - | |
| 68 | Methylation | CELEVFAKVLRALDK HHHHHHHHHHHHHCH | 30.27 | - | |
| 99 | Phosphorylation | KVASVLAYSFSRRCS HHHHHHHHHHHCCCC | 13.19 | 22210691 | |
| 102 | Phosphorylation | SVLAYSFSRRCSYIA HHHHHHHHCCCCHHH | 16.93 | 22210691 | |
| 106 | Phosphorylation | YSFSRRCSYIAESDA HHHHCCCCHHHHCCH | 20.12 | 28348404 | |
| 107 | Phosphorylation | SFSRRCSYIAESDAA HHHCCCCHHHHCCHH | 14.05 | 23312004 | |
| 111 | Phosphorylation | RCSYIAESDAAVKEK CCCHHHHCCHHHHHH | 24.43 | 22210691 | |
| 178 | Ubiquitination | HVRNGNCKYHLGEET HHCCCCCEEECCHHH | 39.44 | - | |
| 187 | Ubiquitination | HLGEETFKLAQTYMD ECCHHHHHHHHHHHH | 50.78 | - | |
| 195 | Ubiquitination | LAQTYMDKLSKHGQQ HHHHHHHHHHHHHHH | 37.82 | 21890473 | |
| 198 | Ubiquitination | TYMDKLSKHGQQANK HHHHHHHHHHHHHHH | 63.29 | - | |
| 220 | Phosphorylation | CALLFAKSHYDEAYK HHHHHHHHCHHHHHH | 24.69 | 22468782 | |
| 222 | Phosphorylation | LLFAKSHYDEAYKWC HHHHHHCHHHHHHHH | 23.67 | 22468782 | |
| 226 | Phosphorylation | KSHYDEAYKWCIEAM HHCHHHHHHHHHHHH | 11.72 | 22468782 | |
| 237 | Phosphorylation | IEAMKEITAGLPVKV HHHHHHHHCCCCHHH | 18.76 | - | |
| 243 | Ubiquitination | ITAGLPVKVVVDVLR HHCCCCHHHHHHHHH | 27.63 | - | |
| 254 | Ubiquitination | DVLRQASKACVVKRE HHHHHHHHHHHHHHC | 49.15 | - | |
| 264 | Ubiquitination | VVKREFKKAEQLIKH HHHHCHHHHHHHHHH | 63.58 | - | |
| 283 | Ubiquitination | ARDHFGSKHPKYSDT HHHCCCCCCCCCHHH | 65.39 | - | |
| 349 | Ubiquitination | VHQYSSGKFDNALFH HHHHCCCCHHHHHHH | 52.04 | - | |
| 379 | Ubiquitination | HLLLASSKRVKALIL CCHHHCCHHHHHHHH | 59.73 | 21890473 | |
| 396 | Ubiquitination | IAIDCHNKETEQRLL HHHHCCCHHHHHHHH | 42.20 | - | |
| 418 | Ubiquitination | LSSLQLAKKAFGEFN HHHHHHHHHHHCCCH | 53.91 | - | |
| 419 | Ubiquitination | SSLQLAKKAFGEFNV HHHHHHHHHHCCCHH | 43.25 | - | |
| 430 | Ubiquitination | EFNVQTAKHYGNLGR CCHHHHHHHHCCHHH | 40.52 | 21890473 | |
| 446 | Ubiquitination | YQSMRKFKEAEEMHI HHHHHHHHHHHHHHH | 60.08 | - | |
| 454 | Ubiquitination | EAEEMHIKAIQIKEQ HHHHHHHHHHHHHHH | 25.43 | - | |
| 504 | Ubiquitination | RSIAIGKKLFGEGYS HHHHHCHHHHCCCCC | 43.78 | - | |
| 510 | Phosphorylation | KKLFGEGYSGLEYDY HHHHCCCCCCCCCCH | 8.68 | 23663014 | |
| 511 | Phosphorylation | KLFGEGYSGLEYDYR HHHCCCCCCCCCCHH | 48.00 | 23663014 | |
| 515 | Phosphorylation | EGYSGLEYDYRGLIK CCCCCCCCCHHHHHH | 24.26 | 23663014 | |
| 517 | Phosphorylation | YSGLEYDYRGLIKLY CCCCCCCHHHHHHHH | 12.99 | 23663014 | |
| 522 | Ubiquitination | YDYRGLIKLYNSIGN CCHHHHHHHHHHCCC | 50.38 | 21890473 | |
| 524 | Phosphorylation | YRGLIKLYNSIGNYE HHHHHHHHHHCCCHH | 11.23 | 22210691 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of APBP2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of APBP2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of APBP2_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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