ZC3HA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZC3HA_HUMAN
• UniProt AC: Q96K80
• Protein Name: Zinc finger CCCH domain-containing protein 10
• Gene Name: ZC3H10
• Organism: Homo sapiens (Human).
• Sequence Length: 434
• Subcellular Localization: Nucleus .
• Protein Description: Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5'-GCAGCGC-3' on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA..
• Protein Sequence: MPDRDSYANGTGSSGGGPGGGGSEEASGAGVGSGGASSDAICRDFLRNVCKRGKRCRYRHPDMSEVSNLGVSKNEFIFCHDFQNKECSRPNCRFIHGSKEDEDGYKKTGELPPRLRQKVAAGLGLSPADLPNGKEEVPICRDFLKGDCQRGAKCKFRHLQRDFEFDARGGGGTGGGSTGSVLPGRRHDLYDIYDLPDRGFEDHEPGPKRRRGGCCPPDGPHFESYEYSLAPPRGVECRLLEEENAMLRKRVEELKKQVSNLLATNEVLLEQNAQFRNQAKVITLSSTAPATEQTLAPTVGTVATFNHGIAQTHTTLSSQALQPRPVSQQELVAPAGAPAAPPTNAAPPAAPPPPPPHLTPEITPLSAALAQTIAQGMAPPPVSMAPVAVSVAPVAPVAVSMAQPLAGITMSHTTTPMVTYPIASQSMRITAMPH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MPDRDSYANGTGS --CCCCCCCCCCCCC	27.34	25278378
7	Phosphorylation	-MPDRDSYANGTGSS -CCCCCCCCCCCCCC	14.36	22210691
11	Phosphorylation	RDSYANGTGSSGGGP CCCCCCCCCCCCCCC	33.43	25278378
13	Phosphorylation	SYANGTGSSGGGPGG CCCCCCCCCCCCCCC	26.16	25278378
14	Phosphorylation	YANGTGSSGGGPGGG CCCCCCCCCCCCCCC	42.68	22210691
23	Phosphorylation	GGPGGGGSEEASGAG CCCCCCCCCCCCCCC	35.22	25278378
27	Phosphorylation	GGGSEEASGAGVGSG CCCCCCCCCCCCCCC	32.24	25278378
33	Phosphorylation	ASGAGVGSGGASSDA CCCCCCCCCCCCHHH	31.48	25278378
37	Phosphorylation	GVGSGGASSDAICRD CCCCCCCCHHHHHHH	31.83	25278378
38	Phosphorylation	VGSGGASSDAICRDF CCCCCCCHHHHHHHH	30.44	22210691
126	Phosphorylation	VAAGLGLSPADLPNG HHHCCCCCHHHCCCC	19.08	29255136
173	Phosphorylation	DARGGGGTGGGSTGS ECCCCCCCCCCCCCC	35.61	25159151
177	Phosphorylation	GGGTGGGSTGSVLPG CCCCCCCCCCCCCCC	32.63	28258704
180	Phosphorylation	TGGGSTGSVLPGRRH CCCCCCCCCCCCCCC	22.14	28258704
185	Methylation	TGSVLPGRRHDLYDI CCCCCCCCCCCCCCC	30.71	-
186	Methylation	GSVLPGRRHDLYDIY CCCCCCCCCCCCCCC	33.32	-
190	Phosphorylation	PGRRHDLYDIYDLPD CCCCCCCCCCCCCCC	13.32	-
193	Phosphorylation	RHDLYDIYDLPDRGF CCCCCCCCCCCCCCC	14.45	28796482
227	Phosphorylation	PHFESYEYSLAPPRG CCCCCEEEECCCCCC	10.76	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZC3HA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZC3HA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZC3HA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZC3HA_HUMAN	ZC3H10	physical	16189514
DAZP2_HUMAN	DAZAP2	physical	19060904
ZC3HA_HUMAN	ZC3H10	physical	25416956
PR20E_HUMAN	PRR20A	physical	25416956
PR20C_HUMAN	PRR20A	physical	25416956
PR20D_HUMAN	PRR20A	physical	25416956
PR20B_HUMAN	PRR20A	physical	25416956
PR20A_HUMAN	PRR20A	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-126, AND MASSSPECTROMETRY.
PubMed: 19413330