COOA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COOA1_HUMAN
• UniProt AC: Q17RW2
• Protein Name: Collagen alpha-1(XXIV) chain
• Gene Name: COL24A1
• Organism: Homo sapiens (Human).
• Sequence Length: 1714
• Subcellular Localization: Secreted, extracellular space, extracellular matrix .
• Protein Description: May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development..
• Protein Sequence: MHLRAHRTRRGKVSPTAKTKSLLHFIVLCVAGVVVHAQEQGIDILHQLGLGGKDVRHSSPATAVPSASTPLPQGVHLTESGVIFKNDAYIETPFVKILPVNLGQPFTILTGLQSHRVNNAFLFSIRNKNRLQLGVQLLPKKLVVHIRGKQPAVFNYSVHDEQWHSFAITIRNQSVSMFVECGKKYFSTETIPEVQTFDSNSVFTLGSMNNNSIHFEGIVCQLDIIPSAEASADYCRYVKQQCRQADKYQPETSIPCTTLIPTKIPEHSPPPKLFAEKVLSEDTFTEGKSIPNIIKNDSETVYKRQEHQISRSQLSSLQSGNVSAVDLTNHGIQAKEMITEEDTQTNFSLSVTTHRISEAKMNTKEKFSSLLNMSDNITQHDDRVTGLSLFKKMPSILPQIKQDTITNLKKAITANLHTNELMEMQPILNTSLHRVTNEPSVDNHLDLRKEGEFYPDATYPIENSYETELYDYYYYEDLNTMLEMEYLRGPKGDTGPPGPPGPAGIPGPSGKRGPRGIPGPHGNPGLPGLPGPKGPKGDPGFSPGQPVPGEKGDQGLSGLMGPPGMQGDKGLKGHPGLPGLPGEQGIPGFAGNIGSPGYPGRQGLAGPEGNPGPKGAQGFIGSPGEAGQLGPEGERGIPGIRGKKGFKGRQGFPGDFGDRGPAGLDGSPGLVGGTGPPGFPGLRGSVGPVGPIGPAGIPGPMGLSGNKGLPGIKGDKGEQGTAGELGEPGYPGDKGAVGLPGPPGMRGKSGPSGQTGDPGLQGPSGPPGPEGFPGDIGIPGQNGPEGPKGLLGNRGPPGPPGLKGTQGEEGPIGAFGELGPRGKPGQKGYAGEPGPEGLKGEVGDQGNIGKIGETGPVGLPGEVGMTGSIGEKGERGSPGPLGPQGEKGVMGYPGPPGVPGPIGPLGLPGHVGARGPPGSQGPKGQRGSRGPDGLLGEQGIQGAKGEKGDQGKRGPHGLIGKTGNPGERGFQGKPGLQGLPGSTGDRGLPGEPGLRGLQGDVGPPGEMGMEGPPGTEGESGLQGEPGAKGDVGTAGSVGGTGEPGLRGEPGAPGEEGLQGKDGLKGVPGGRGLPGEDGEKGEMGLPGIIGPLGRSGQTGLPGPEGIVGIPGQRGRPGKKGDKGQIGPTGEVGSRGPPGKIGKSGPKGARGTRGAVGHLGLMGPDGEPGIPGYRGHQGQPGPSGLPGPKGEKGYPGEDSTVLGPPGPRGEPGPVGDQGERGEPGAEGYKGHVGVPGLRGATGQQGPPGEPGDQGEQGLKGERGSEGNKGKKGAPGPSGKPGIPGLQGLLGPKGIQGYHGADGISGNPGKIGPPGKQGLPGIRGGPGRTGLAGAPGPPGVKGSSGLPGSPGIQGPKGEQGLPGQPGIQGKRGHRGAQGDQGPCGDPGLKGQPGEYGVQGLTGFQGFPGPKGPEGDAGIVGISGPKGPIGHRGNTGPLGREGIIGPTGRTGPRGEKGFRGETGPQGPRGQPGPPGPPGAPGPRKQMDINAAIQALIESNTALQMESYQNTEVTLIDHSEEIFKTLNYLSNLLHSIKNPLGTRDNPARICKDLLNCEQKVSDGKYWIDPNLGCPSDAIEVFCNFSAGGQTCLPPVSVTKLEFGVGKVQMNFLHLLSSEATHIITIHCLNTPRWTSTQTSGPGLPIGFKGWNGQIFKVNTLLEPKVLSDDCKIQDGSWHKATFLFHTQEPNQLPVIEVQKLPHLKTERKYYIDSSSVCFL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
89	Phosphorylation	VIFKNDAYIETPFVK EEECCCCEEECCCEE	11.36	24248375
107	Phosphorylation	VNLGQPFTILTGLQS CCCCCCEEEEECCHH	23.04	24248375
110	Phosphorylation	GQPFTILTGLQSHRV CCCEEEEECCHHHCC	31.81	24248375
114	Phosphorylation	TILTGLQSHRVNNAF EEEECCHHHCCCCEE	20.50	24248375
124	Phosphorylation	VNNAFLFSIRNKNRL CCCEEEEECCCCCCE	23.84	24248375
141	Ubiquitination	GVQLLPKKLVVHIRG EEEECCCEEEEEECC	44.57	-
155	N-linked_Glycosylation	GKQPAVFNYSVHDEQ CCCCEEEEEEECCCC	22.90	UniProtKB CARBOHYD
268	Phosphorylation	PTKIPEHSPPPKLFA CCCCCCCCCCCHHHH	37.12	24719451
277	Ubiquitination	PPKLFAEKVLSEDTF CCHHHHHHHHCCCCC	45.08	-
321	N-linked_Glycosylation	LSSLQSGNVSAVDLT HHHCCCCCCCEEECC	29.80	UniProtKB CARBOHYD
328	Phosphorylation	NVSAVDLTNHGIQAK CCCEEECCCCCEEEE	22.24	-
343	Phosphorylation	EMITEEDTQTNFSLS EEECCHHCCCCEEEE	40.34	22468782
348	Phosphorylation	EDTQTNFSLSVTTHR HHCCCCEEEEEEECC	23.08	22468782
357	Phosphorylation	SVTTHRISEAKMNTK EEEECCCCCCCCCHH	31.30	22468782
376	N-linked_Glycosylation	SLLNMSDNITQHDDR HHHHCCCCCCCCCHH	31.72	UniProtKB CARBOHYD
388	Phosphorylation	DDRVTGLSLFKKMPS CHHHHHHHHHHHCCH	32.86	24719451
454	Phosphorylation	LRKEGEFYPDATYPI HHHCCCCCCCCCCCC	8.90	22817900
472	Phosphorylation	YETELYDYYYYEDLN CCCEEEEEEEECCHH	4.64	22817900
473	Phosphorylation	ETELYDYYYYEDLNT CCEEEEEEEECCHHH	9.18	22817900
474	Phosphorylation	TELYDYYYYEDLNTM CEEEEEEEECCHHHH	8.31	22817900
569	Acetylation	PPGMQGDKGLKGHPG CCCCCCCCCCCCCCC	73.33	19809805
572	Acetylation	MQGDKGLKGHPGLPG CCCCCCCCCCCCCCC	64.93	19809813
962	Phosphorylation	PHGLIGKTGNPGERG CCCCCCCCCCCCCCC	36.66	-
982	Phosphorylation	GLQGLPGSTGDRGLP CCCCCCCCCCCCCCC	27.55	-
983	Phosphorylation	LQGLPGSTGDRGLPG CCCCCCCCCCCCCCC	49.36	-
1033	Phosphorylation	GAKGDVGTAGSVGGT CCCCCCCCCCCCCCC	27.91	-
1127	Phosphorylation	DKGQIGPTGEVGSRG CCCCCCCCCCCCCCC	40.54	30576142
1132	Phosphorylation	GPTGEVGSRGPPGKI CCCCCCCCCCCCCCC	38.96	30576142
1295	Phosphorylation	GPKGIQGYHGADGIS CCCCCCCCCCCCCCC	4.82	-
1302	Phosphorylation	YHGADGISGNPGKIG CCCCCCCCCCCCCCC	37.74	-
1443	Phosphorylation	REGIIGPTGRTGPRG CCCCCCCCCCCCCCC	33.80	27251275
1537	Phosphorylation	SIKNPLGTRDNPARI HCCCCCCCCCCHHHH	42.40	-
1611	Phosphorylation	MNFLHLLSSEATHII HHHHHHHCCCCCEEE	32.28	-
1625	Phosphorylation	ITIHCLNTPRWTSTQ EEEEECCCCCCCCCC	10.98	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COOA1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COOA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COOA1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of COOA1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.