ZCH12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZCH12_HUMAN
• UniProt AC: Q6PEW1
• Protein Name: Zinc finger CCHC domain-containing protein 12
• Gene Name: ZCCHC12
• Organism: Homo sapiens (Human).
• Sequence Length: 402
• Protein Description: Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity)..
• Protein Sequence: MASIIARVGNSRRLNAPLPPWAHSMLRSLGRSLGPIMASMADRNMKLFSGRVVPAQGEETFENWLTQVNGVLPDWNMSEEEKLKRLMKTLRGPAREVMRVLQATNPNLSVADFLRAMKLVFGESESSVTAHGKFFNTLQAQGEKASLYVIRLEVQLQNAIQAGIIAEKDANRTRLQQLLLGGELSRDLRLRLKDFLRMYANEQERLPNFLELIRMVREEEDWDDAFIKRKRPKRSESMVERAVSPVAFQGSPPIVIGSADCNVIEIDDTLDDSDEDVILVESQDPPLPSWGAPPLRDRARPQDEVLVIDSPHNSRAQFPSTSGGSGYKNNGPGEMRRARKRKHTIRCSYCGEEGHSKETCDNESDKAQVFENLIITLQELTHTEMERSRVAPGEYNDFSEPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	DRNMKLFSGRVVPAQ CCCCCCCCCCCCCCC	35.81	24719451
129	Phosphorylation	GESESSVTAHGKFFN CCCCCCEEECHHHHC	18.19	28509920
133	Ubiquitination	SSVTAHGKFFNTLQA CCEEECHHHHCHHHH	36.59	32015554
168	Ubiquitination	QAGIIAEKDANRTRL HHCCEEECCCCHHHH	53.79	-
185	Phosphorylation	LLLGGELSRDLRLRL HHHCCCCCHHHHHHH	21.32	24719451
199	Phosphorylation	LKDFLRMYANEQERL HHHHHHHHHCHHHCC	10.39	22817900
228	Ubiquitination	DWDDAFIKRKRPKRS CCCHHHHHCCCCCCC	45.47	21906983
230	Ubiquitination	DDAFIKRKRPKRSES CHHHHHCCCCCCCHH	68.96	22817900
233	Ubiquitination	FIKRKRPKRSESMVE HHHCCCCCCCHHHHH	73.01	22817900
235	Phosphorylation	KRKRPKRSESMVERA HCCCCCCCHHHHHHH	39.90	-
237	Phosphorylation	KRPKRSESMVERAVS CCCCCCHHHHHHHHC	29.40	23403867
310	Phosphorylation	DEVLVIDSPHNSRAQ CEEEEEECCCCCCCC	19.55	-
328	Ubiquitination	TSGGSGYKNNGPGEM CCCCCCCCCCCHHHH	47.68	21906983
366	Ubiquitination	TCDNESDKAQVFENL CCCCHHHHHHHHHHH	50.42	32015554
395	Phosphorylation	SRVAPGEYNDFSEPL HCCCCCCCCCCCCCC	26.41	-
399	Phosphorylation	PGEYNDFSEPL---- CCCCCCCCCCC----	40.96	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZCH12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZCH12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZCH12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SMAD1_HUMAN	SMAD1	physical	18160706
A4_HUMAN	APP	physical	21832049
PGK2_HUMAN	PGK2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.