| UniProt ID | WNT5B_HUMAN | |
|---|---|---|
| UniProt AC | Q9H1J7 | |
| Protein Name | Protein Wnt-5b | |
| Gene Name | WNT5B | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 359 | |
| Subcellular Localization | Secreted, extracellular space, extracellular matrix. | |
| Protein Description | Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).. | |
| Protein Sequence | MPSLLLLFTAALLSSWAQLLTDANSWWSLALNPVQRPEMFIIGAQPVCSQLPGLSPGQRKLCQLYQEHMAYIGEGAKTGIKECQHQFRQRRWNCSTADNASVFGRVMQIGSRETAFTHAVSAAGVVNAISRACREGELSTCGCSRTARPKDLPRDWLWGGCGDNVEYGYRFAKEFVDAREREKNFAKGSEEQGRVLMNLQNNEAGRRAVYKMADVACKCHGVSGSCSLKTCWLQLAEFRKVGDRLKEKYDSAAAMRVTRKGRLELVNSRFTQPTPEDLVYVDPSPDYCLRNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYNQFKSVQVERCHCKFHWCCFVRCKKCTEIVDQYICK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 93 | N-linked_Glycosylation | QFRQRRWNCSTADNA HHHHHCCCCCCCCCC | 14.19 | UniProtKB CARBOHYD | |
| 99 | N-linked_Glycosylation | WNCSTADNASVFGRV CCCCCCCCCCHHHHE | 31.48 | UniProtKB CARBOHYD | |
| 139 | Phosphorylation | ACREGELSTCGCSRT HHHCCCCCCCCCCCC | 19.83 | 29262532 | |
| 140 | Phosphorylation | CREGELSTCGCSRTA HHCCCCCCCCCCCCC | 26.07 | 29262532 | |
| 144 | Phosphorylation | ELSTCGCSRTARPKD CCCCCCCCCCCCCCC | 20.25 | 29262532 | |
| 173 | Ubiquitination | EYGYRFAKEFVDARE HHHHHHHHHHHHHHH | 49.31 | 21963094 | |
| 210 | Phosphorylation | EAGRRAVYKMADVAC HHHHHHHHHHHHHHH | 8.28 | 21214269 | |
| 223 | O-palmitoleoylation | ACKCHGVSGSCSLKT HHHCCCCCCCCCHHH | 29.58 | - | |
| 225 | Phosphorylation | KCHGVSGSCSLKTCW HCCCCCCCCCHHHHH | 7.94 | 30576142 | |
| 230 | Phosphorylation | SGSCSLKTCWLQLAE CCCCCHHHHHHHHHH | 17.76 | 24719451 | |
| 246 | 2-Hydroxyisobutyrylation | RKVGDRLKEKYDSAA HHHHHHHHHHHCHHH | 53.72 | - | |
| 249 | Phosphorylation | GDRLKEKYDSAAAMR HHHHHHHHCHHHHHH | 19.07 | 22817900 | |
| 291 | N-linked_Glycosylation | SPDYCLRNESTGSLG CCCCCCCCCCCCCCC | 34.32 | UniProtKB CARBOHYD | |
| 293 | Phosphorylation | DYCLRNESTGSLGTQ CCCCCCCCCCCCCCC | 41.43 | - | |
| 305 | N-linked_Glycosylation | GTQGRLCNKTSEGMD CCCCCCCCCCCCCCC | 56.05 | UniProtKB CARBOHYD |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of WNT5B_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of WNT5B_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of WNT5B_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of WNT5B_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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