HIPK4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HIPK4_HUMAN
• UniProt AC: Q8NE63
• Protein Name: Homeodomain-interacting protein kinase 4
• Gene Name: HIPK4
• Organism: Homo sapiens (Human).
• Sequence Length: 616
• Subcellular Localization: Cytoplasm.
• Protein Description: Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential)..
• Protein Sequence: MSTIQSETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTHYYQLSLRSYRLSLQVEGKPPTPVVAAEDGTPYYCLAEEKEAAGMGSVAGSSPFFREEKAPGMQRAIDQLDDLSLQEAGHGLWGETCTNAVSDMMVPLKAAITGHHVPDSGPEPILAFYSSRLAGRHKARKPPAGSKSDSNFSNLIRLSQVSPEDDRPCRGSSWEEGEHLGASAEPLAILQRDEDGPNIDNMTMEAERPDPELFDPSSCPGEWLSEPDCTLESVRGPRAQGLPPRRSHQHGPPRGATSFLQHVTGHH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Acetylation	DIIEVLGKGTFGEVA HHHHHHCCCCHHHHH	51.09	30589171
27	Acetylation	GTFGEVAKGWRRSTG CCHHHHHCCHHHCCC	65.27	30589177
40	Ubiquitination	TGEMVAIKILKNDAY CCCEEEEEEHHCHHH	32.04	-
122	Phosphorylation	TVTLQVLTALARLKE HHHHHHHHHHHHHHH	22.29	-
166	Phosphorylation	FGSASIFSEVRYVKE CCCCCHHHCCEECCC	33.25	24719451
265	Phosphorylation	ANPWQLKSSADYLAE CCHHHCCCHHHHHHH	39.07	29083192
266	Phosphorylation	NPWQLKSSADYLAET CHHHCCCHHHHHHHC	24.46	29083192
269	Phosphorylation	QLKSSADYLAETKVR HCCCHHHHHHHCCCC	13.92	29083192
283	Phosphorylation	RPLERRKYMLKSLDQ CHHHHHHHHHHHHHH	13.08	26425664
298	Phosphorylation	IETVNGGSVASRLTF EEEECCCCHHHHCCC	18.86	26425664
301	Phosphorylation	VNGGSVASRLTFPDR ECCCCHHHHCCCCCH	26.18	-
304	Phosphorylation	GSVASRLTFPDREAL CCHHHHCCCCCHHHH	31.82	28961369
337	Phosphorylation	WESHERISPSAALRH CCCCCCCCHHHHHHC	21.01	28111955
339	Phosphorylation	SHERISPSAALRHPF CCCCCCHHHHHHCCC	21.27	28111955
365	Phosphorylation	TTHYYQLSLRSYRLS HCCEEEEECCEEEEE	13.25	24719451
381	Phosphorylation	QVEGKPPTPVVAAED EECCCCCCCEEECCC	36.92	19835603
390	Phosphorylation	VVAAEDGTPYYCLAE EEECCCCCEEEEEEH	22.05	19835603
392	Phosphorylation	AAEDGTPYYCLAEEK ECCCCCEEEEEEHHH	13.47	19835603
393	Phosphorylation	AEDGTPYYCLAEEKE CCCCCEEEEEEHHHH	5.12	19835603
511	Phosphorylation	LIRLSQVSPEDDRPC HHHHHCCCCCCCCCC	18.22	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HIPK4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HIPK4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HIPK4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AKAP8_HUMAN	AKAP8	physical	23602568
EF2_HUMAN	EEF2	physical	23602568
TECR_HUMAN	TECR	physical	23602568
SFXN2_HUMAN	SFXN2	physical	23602568
CATB_HUMAN	CTSB	physical	23602568
YMEL1_HUMAN	YME1L1	physical	23602568
ARAF_HUMAN	ARAF	physical	23602568
RBBP4_HUMAN	RBBP4	physical	23602568
PFKAP_HUMAN	PFKP	physical	23602568
ZN281_HUMAN	ZNF281	physical	23602568
NU188_HUMAN	NUP188	physical	23602568
ACSL3_HUMAN	ACSL3	physical	23602568
YTHD2_HUMAN	YTHDF2	physical	23602568
MCM7_HUMAN	MCM7	physical	23602568
CDN2A_HUMAN	CDKN2A	physical	23602568
ARF_HUMAN	CDKN2A	physical	23602568
WDR6_HUMAN	WDR6	physical	23602568
AFG32_HUMAN	AFG3L2	physical	23602568
TRABD_HUMAN	TRABD	physical	23602568
PCAT1_HUMAN	LPCAT1	physical	23602568
RCN1_HUMAN	RCN1	physical	23602568
LBR_HUMAN	LBR	physical	23602568
UBL4A_HUMAN	UBL4A	physical	23602568
OZF_HUMAN	ZNF146	physical	23602568
AT1A1_HUMAN	ATP1A1	physical	23602568
RAF1_HUMAN	RAF1	physical	23602568
SUGP2_HUMAN	SUGP2	physical	23602568
ABCD3_HUMAN	ABCD3	physical	23602568

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.