PCAT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCAT1_HUMAN
• UniProt AC: Q8NF37
• Protein Name: Lysophosphatidylcholine acyltransferase 1
• Gene Name: LPCAT1
• Organism: Homo sapiens (Human).
• Sequence Length: 534
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Golgi apparatus membrane ; Single-pass type II membrane protein . Lipid droplet . May adopt a monotopic topology when embedded in the lipid monolayer of the lipid droplet, with b
• Protein Description: Possesses both acyltransferase and acetyltransferase activities. [PubMed: 16864775]
• Protein Sequence: MRLRGCGPRAAPASSAGASDARLLAPPGRNPFVHELRLSALQKAQVALMTLTLFPVRLLVAAAMMLLAWPLALVASLGSAEKEPEQPPALWRKVVDFLLKAIMRTMWFAGGFHRVAVKGRQALPTEAAILTLAPHSSYFDAIPVTMTMSSIVMKAESRDIPIWGTLIQYIRPVFVSRSDQDSRRKTVEEIKRRAQSNGKWPQIMIFPEGTCTNRTCLITFKPGAFIPGAPVQPVVLRYPNKLDTITWTWQGPGALEILWLTLCQFHNQVEIEFLPVYSPSEEEKRNPALYASNVRRVMAEALGVSVTDYTFEDCQLALAEGQLRLPADTCLLEFARLVRGLGLKPEKLEKDLDRYSERARMKGGEKIGIAEFAASLEVPVSDLLEDMFSLFDESGSGEVDLRECVVALSVVCRPARTLDTIQLAFKMYGAQEDGSVGEGDLSCILKTALGVAELTVTDLFRAIDQEEKGKITFADFHRFAEMYPAFAEEYLYPDQTHFESCAETSPAPIPNGFCADFSPENSDAGRKPVRKKLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	GPRAAPASSAGASDA CCCCCCCCCCCCCCC	21.47	29396449
15	Phosphorylation	PRAAPASSAGASDAR CCCCCCCCCCCCCCE	32.59	29396449
19	Phosphorylation	PASSAGASDARLLAP CCCCCCCCCCEECCC	30.77	29396449
39	Phosphorylation	FVHELRLSALQKAQV CHHHHHHHHHHHHHH	22.09	20860994
50	Phosphorylation	KAQVALMTLTLFPVR HHHHHHHHHCHHHHH	19.90	20860994
52	Phosphorylation	QVALMTLTLFPVRLL HHHHHHHCHHHHHHH	19.72	-
93	Ubiquitination	QPPALWRKVVDFLLK CCCHHHHHHHHHHHH	34.72	-
191	Ubiquitination	RKTVEEIKRRAQSNG HHHHHHHHHHHHHCC	38.83	-
199	Ubiquitination	RRAQSNGKWPQIMIF HHHHHCCCCCEEEEE	61.01	-
216	S-palmitoylation	GTCTNRTCLITFKPG CCCCCCEEEEEECCC	2.03	29575903
221	Acetylation	RTCLITFKPGAFIPG CEEEEEECCCCCCCC	33.61	26051181
221	Ubiquitination	RTCLITFKPGAFIPG CEEEEEECCCCCCCC	33.61	-
292	Phosphorylation	RNPALYASNVRRVMA CCHHHHHHHHHHHHH	23.46	-
330	Glutathionylation	LRLPADTCLLEFARL CCCCHHHHHHHHHHH	4.14	22555962
344	Ubiquitination	LVRGLGLKPEKLEKD HHHHCCCCHHHHHHH	49.70	-
347	Ubiquitination	GLGLKPEKLEKDLDR HCCCCHHHHHHHHHH	71.16	-
362	Ubiquitination	YSERARMKGGEKIGI HHHHHHHCCCCEEEH	59.20	-
381	Phosphorylation	ASLEVPVSDLLEDMF HHCCCCHHHHHHHHH	19.23	22210691
381	O-linked_Glycosylation	ASLEVPVSDLLEDMF HHCCCCHHHHHHHHH	19.23	29351928
394	Phosphorylation	MFSLFDESGSGEVDL HHHHHCCCCCCCCCH	39.85	22210691
396	Phosphorylation	SLFDESGSGEVDLRE HHHCCCCCCCCCHHH	40.85	22210691
409	O-linked_Glycosylation	RECVVALSVVCRPAR HHHHHHHHHHCCCCC	11.63	29351928
443	Glutathionylation	VGEGDLSCILKTALG CCCCHHHHHHHHHHC	5.70	22555962
447	Phosphorylation	DLSCILKTALGVAEL HHHHHHHHHHCCEEE	24.54	20860994
470	2-Hydroxyisobutyrylation	IDQEEKGKITFADFH CCHHHCCCCCHHHHH	50.03	-
470	Ubiquitination	IDQEEKGKITFADFH CCHHHCCCCCHHHHH	50.03	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	BTRC	Q9Y297	PMID:21068446

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCAT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCAT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BBS2_HUMAN	BBS2	physical	26186194
MSTO1_HUMAN	MSTO1	physical	26186194
S27A2_HUMAN	SLC27A2	physical	26186194
DOCK7_HUMAN	DOCK7	physical	26186194
DIP2A_HUMAN	DIP2A	physical	26186194
FBW1A_HUMAN	BTRC	physical	21068446
S27A2_HUMAN	SLC27A2	physical	28514442
MSTO1_HUMAN	MSTO1	physical	28514442
METH_HUMAN	MTR	physical	28514442
DIP2A_HUMAN	DIP2A	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.