METH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: METH_HUMAN
• UniProt AC: Q99707
• Protein Name: Methionine synthase
• Gene Name: MTR
• Organism: Homo sapiens (Human).
• Sequence Length: 1265
• Subcellular Localization: Cytoplasm.
• Protein Description: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity)..
• Protein Sequence: MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDDGMLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQATETDTKIRVCTRAYHLLVKKLGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHATKVIKETLPGARISGGLSNLSFSFRGMEAIREAMHGVFLYHAIKSGMDMGIVNAGNLPVYDDIHKELLQLCEDLIWNKDPEATEKLLRYAQTQGTGGKKVIQTDEWRNGPVEERLEYALVKGIEKHIIEDTEEARLNQKKYPRPLNIIEGPLMNGMKIVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREETRVLNGTVEEEDPYQGTIVLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIRIPLLIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLKDEYFEEIMEEYEDIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQVFEDYDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTLISQKKLRARGVVGFWPAQSIQDDIHLYAEAAVPQAAEPIATFYGLRQQAEKDSASTEPYYCLSDFIAPLHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTGIRLTESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGPILGYDTD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSPALQDLS ------CCHHHHHHC	30.13	25159151
9	Phosphorylation	SPALQDLSQPEGLKK CHHHHHHCCCCHHHH	52.56	28122231
15	Ubiquitination	LSQPEGLKKTLRDEI HCCCCHHHHHHHHHH	55.35	-
15	Ubiquitination	LSQPEGLKKTLRDEI HCCCCHHHHHHHHHH	55.35	-
16	Ubiquitination	SQPEGLKKTLRDEIN CCCCHHHHHHHHHHH	58.81	21890473
16	Ubiquitination	SQPEGLKKTLRDEIN CCCCHHHHHHHHHHH	58.81	21890473
17	Phosphorylation	QPEGLKKTLRDEINA CCCHHHHHHHHHHHH	25.99	20068231
28	Ubiquitination	EINAILQKRIMVLDG HHHHHHHHHCEEECC	40.21	21890473
28	Ubiquitination	EINAILQKRIMVLDG HHHHHHHHHCEEECC	40.21	21906983
39	Phosphorylation	VLDGGMGTMIQREKL EECCCHHHHHHHHHC	11.38	20068231
45	Ubiquitination	GTMIQREKLNEEHFR HHHHHHHHCCHHHHC	59.82	-
45	Ubiquitination	GTMIQREKLNEEHFR HHHHHHHHCCHHHHC	59.82	-
57	Ubiquitination	HFRGQEFKDHARPLK HHCCCHHHHHCCCCC	48.10	-
57	Ubiquitination	HFRGQEFKDHARPLK HHCCCHHHHHCCCCC	48.10	-
64	Ubiquitination	KDHARPLKGNNDILS HHHCCCCCCCCCCCC	63.38	-
64	Ubiquitination	KDHARPLKGNNDILS HHHCCCCCCCCCCCC	63.38	-
79	Phosphorylation	ITQPDVIYQIHKEYL CCCCCHHHHHCHHHH	10.98	27642862
121	Phosphorylation	AYRMNMCSAGVARKA HHHHHHHHHHHHHHH	19.79	-
127	Ubiquitination	CSAGVARKAAEEVTL HHHHHHHHHHHHHHH	42.06	-
133	Phosphorylation	RKAAEEVTLQTGIKR HHHHHHHHHHHHCHH	19.21	-
136	Phosphorylation	AEEVTLQTGIKRFVA HHHHHHHHHCHHHHH	43.94	24719451
139	Ubiquitination	VTLQTGIKRFVAGAL HHHHHHCHHHHHCCC	40.92	-
151	Ubiquitination	GALGPTNKTLSVSPS CCCCCCCCCEECCCC	54.01	-
152	O-linked_Glycosylation	ALGPTNKTLSVSPSV CCCCCCCCEECCCCC	26.74	29351928
156	Phosphorylation	TNKTLSVSPSVERPD CCCCEECCCCCCCCC	14.21	25627689
158	Phosphorylation	KTLSVSPSVERPDYR CCEECCCCCCCCCCC	29.16	26091039
231	Ubiquitination	ISGTIVDKSGRTLSG EEEEEECCCCCEECC	43.87	21890473
231	Ubiquitination	ISGTIVDKSGRTLSG EEEEEECCCCCEECC	43.87	21890473
306	Ubiquitination	ETPSMMAKHLKDFAM CCHHHHHHHHHHHHH	31.41	-
306	Ubiquitination	ETPSMMAKHLKDFAM CCHHHHHHHHHHHHH	31.41	-
309	Ubiquitination	SMMAKHLKDFAMDGL HHHHHHHHHHHHHCC	50.98	-
309	Ubiquitination	SMMAKHLKDFAMDGL HHHHHHHHHHHHHCC	50.98	-
339	Ubiquitination	REIAEAVKNCKPRVP HHHHHHHHCCCCCCC	64.77	-
339	Ubiquitination	REIAEAVKNCKPRVP HHHHHHHHCCCCCCC	64.77	-
385	Ubiquitination	CNVAGSRKFAKLIMA CCCCCCHHHHHHHHC	51.90	-
385	Ubiquitination	CNVAGSRKFAKLIMA CCCCCCHHHHHHHHC	51.90	-
388	Ubiquitination	AGSRKFAKLIMAGNY CCCHHHHHHHHCCCH	41.50	-
388	Ubiquitination	AGSRKFAKLIMAGNY CCCHHHHHHHHCCCH	41.50	-
395	Phosphorylation	KLIMAGNYEEALCVA HHHHCCCHHHEEEEE	17.77	27642862
466	Ubiquitination	GLKCCQGKCIVNSIS HCHHHCCCEEEEEEE	8.56	-
466	Ubiquitination	GLKCCQGKCIVNSIS HCHHHCCCEEEEEEE	8.56	-
471	Phosphorylation	QGKCIVNSISLKEGE CCCEEEEEEECCCCC	11.58	24719451
473	Phosphorylation	KCIVNSISLKEGEDD CEEEEEEECCCCCCH	32.96	24719451
475	Ubiquitination	IVNSISLKEGEDDFL EEEEEECCCCCCHHH	57.81	-
475	Ubiquitination	IVNSISLKEGEDDFL EEEEEECCCCCCHHH	57.81	-
484	Ubiquitination	GEDDFLEKARKIKKY CCCHHHHHHHHHHHH	56.49	-
484	Ubiquitination	GEDDFLEKARKIKKY CCCHHHHHHHHHHHH	56.49	-
491	Phosphorylation	KARKIKKYGAAMVVM HHHHHHHHCCEEEEE	13.64	-
517	Phosphorylation	DTKIRVCTRAYHLLV CHHHHHHHHHHHHHH	18.58	23607784
520	Phosphorylation	IRVCTRAYHLLVKKL HHHHHHHHHHHHHHH	6.96	23607784
526	Ubiquitination	AYHLLVKKLGFNPND HHHHHHHHHCCCCCC	46.49	-
565	Ubiquitination	IHATKVIKETLPGAR HHHHHHHHHHCCCCE	47.86	-
574	Phosphorylation	TLPGARISGGLSNLS HCCCCEEECCCCCCC	22.66	25262027
578	Phosphorylation	ARISGGLSNLSFSFR CEEECCCCCCCEEEH	38.71	25262027
581	Phosphorylation	SGGLSNLSFSFRGME ECCCCCCCEEEHHHH	24.08	23927012
583	Phosphorylation	GLSNLSFSFRGMEAI CCCCCCEEEHHHHHH	15.62	24719451
620	Phosphorylation	NAGNLPVYDDIHKEL CCCCCCCCHHHHHHH	13.12	27642862
638	Ubiquitination	CEDLIWNKDPEATEK HHHHHHCCCHHHHHH	60.71	-
645	Ubiquitination	KDPEATEKLLRYAQT CCHHHHHHHHHHHHH	48.76	21906983
658	Ubiquitination	QTQGTGGKKVIQTDE HHCCCCCCEEEECCC	45.25	-
659	Ubiquitination	TQGTGGKKVIQTDEW HCCCCCCEEEECCCC	48.09	-
677	Phosphorylation	PVEERLEYALVKGIE CHHHHHHHHHHHCHH	15.16	28796482
681	Ubiquitination	RLEYALVKGIEKHII HHHHHHHHCHHHHHC	55.83	-
685	Acetylation	ALVKGIEKHIIEDTE HHHHCHHHHHCCCHH	37.88	25953088
685	Ubiquitination	ALVKGIEKHIIEDTE HHHHCHHHHHCCCHH	37.88	21890473
699	Ubiquitination	EEARLNQKKYPRPLN HHHHHHCCCCCCCCC	53.88	-
700	Ubiquitination	EARLNQKKYPRPLNI HHHHHCCCCCCCCCC	51.20	-
701	Phosphorylation	ARLNQKKYPRPLNII HHHHCCCCCCCCCCC	16.12	-
727	Ubiquitination	GDLFGAGKMFLPQVI HHHHCCCCCCHHHHH	26.41	21890473
735	Ubiquitination	MFLPQVIKSARVMKK CCHHHHHHHHHHHHH	38.92	-
742	Ubiquitination	KSARVMKKAVGHLIP HHHHHHHHHHHHHHH	30.15	-
753	Ubiquitination	HLIPFMEKEREETRV HHHHHHHHHHHHHEE	50.73	-
758	Phosphorylation	MEKEREETRVLNGTV HHHHHHHHEECCCCC	22.71	-
764	Phosphorylation	ETRVLNGTVEEEDPY HHEECCCCCCCCCCC	24.54	-
771	Phosphorylation	TVEEEDPYQGTIVLA CCCCCCCCCCEEEEE	31.71	29978859
774	Phosphorylation	EEDPYQGTIVLATVK CCCCCCCEEEEEEEE	7.74	-
781	Ubiquitination	TIVLATVKGDVHDIG EEEEEEEECCHHHCC	45.07	-
789	Ubiquitination	GDVHDIGKNIVGVVL CCHHHCCCCCEEEEE	43.78	21890473
814	Ubiquitination	GVMTPCDKILKAALD ECCCCHHHHHHHHHH	57.57	21890473
814	Ubiquitination	GVMTPCDKILKAALD ECCCCHHHHHHHHHH	57.57	21890473
817	Methylation	TPCDKILKAALDHKA CCHHHHHHHHHHCCC	34.78	30786249
817	Ubiquitination	TPCDKILKAALDHKA CCHHHHHHHHHHCCC	34.78	21906983
823	Ubiquitination	LKAALDHKADIIGLS HHHHHHCCCCEEECC	47.63	-
865	Ubiquitination	IGGATTSKTHTAVKI ECCCCCCCCCCCCCC	42.08	21890473
871	Ubiquitination	SKTHTAVKIAPRYSA CCCCCCCCCCCCCCC	30.59	-
876	Phosphorylation	AVKIAPRYSAPVIHV CCCCCCCCCCCEEEE	14.23	28555341
877	Phosphorylation	VKIAPRYSAPVIHVL CCCCCCCCCCEEEEE	27.63	27251275
905	Phosphorylation	DENLKDEYFEEIMEE CCCCCHHHHHHHHHH	26.82	-
913	Phosphorylation	FEEIMEEYEDIRQDH HHHHHHHHHHHHHHH	12.95	-
921	Phosphorylation	EDIRQDHYESLKERR HHHHHHHHHHHHHHC	18.59	28796482
923	Phosphorylation	IRQDHYESLKERRYL HHHHHHHHHHHHCCC	37.26	28796482
925	Ubiquitination	QDHYESLKERRYLPL HHHHHHHHHHCCCCH	59.46	-
929	Phosphorylation	ESLKERRYLPLSQAR HHHHHHCCCCHHHHH	20.92	20068231
933	Phosphorylation	ERRYLPLSQARKSGF HHCCCCHHHHHHCCC	21.61	20068231
952	Ubiquitination	LSEPHPVKPTFIGTQ CCCCCCCCCCEEECE	42.67	-
973	Ubiquitination	LQKLVDYIDWKPFFD HHHHHHHCCCCCCCC	4.39	21890473
995	Ubiquitination	YPNRGFPKIFNDKTV CCCCCCCCCCCCCCC	58.63	-
1000	Ubiquitination	FPKIFNDKTVGGEAR CCCCCCCCCCCCHHH	46.33	21890473
1008	Ubiquitination	TVGGEARKVYDDAHN CCCCHHHHHHHHHHH	52.79	-
1010	Phosphorylation	GGEARKVYDDAHNML CCHHHHHHHHHHHHH	15.90	27642862
1019	Phosphorylation	DAHNMLNTLISQKKL HHHHHHHHHHHHHHH	22.85	23312004
1022	Phosphorylation	NMLNTLISQKKLRAR HHHHHHHHHHHHHHC	38.77	23312004
1024	Ubiquitination	LNTLISQKKLRARGV HHHHHHHHHHHHCCC	47.16	2190698
1025	Ubiquitination	NTLISQKKLRARGVV HHHHHHHHHHHCCCC	35.25	-
1071	Ubiquitination	GLRQQAEKDSASTEP HHHHHHHHCCCCCCC	61.06	-
1127	Ubiquitination	DYSSIMVKALGDRLA CHHHHHHHHHHHHHH	22.10	-
1132	Methylation	MVKALGDRLAEAFAE HHHHHHHHHHHHHHH	33.72	115484069
1155	Phosphorylation	ELWAYCGSEQLDVAD HHHHHHCCCCCCHHH	20.71	-
1169	Ubiquitination	DLRRLRYKGIRPAPG HHHHHHHCCCCCCCC	41.23	-
1186	Ubiquitination	SQPDHTEKLTMWRLA CCCCCCCCEEHHHHH	50.87	-
1206	Phosphorylation	TGIRLTESLAMAPAS HCCCCCHHHHCCCHH	19.05	-
1219	Phosphorylation	ASAVSGLYFSNLKSK HHHCCCCCCCCCCCC	14.42	-
1221	Phosphorylation	AVSGLYFSNLKSKYF HCCCCCCCCCCCCEE	27.91	-
1224	Ubiquitination	GLYFSNLKSKYFAVG CCCCCCCCCCEEEEE	49.50	-
1226	Ubiquitination	YFSNLKSKYFAVGKI CCCCCCCCEEEEEEC	42.68	-
1232	Ubiquitination	SKYFAVGKISKDQVE CCEEEEEECCHHHHH	36.89	-
1235	Ubiquitination	FAVGKISKDQVEDYA EEEEECCHHHHHHHH	56.50	-
1245	Ubiquitination	VEDYALRKNISVAEV HHHHHHHCCCCHHHH	60.53	-
1262	Phosphorylation	WLGPILGYDTD---- HHHHHCCCCCC----	16.54	25841592
1264	Phosphorylation	GPILGYDTD------ HHHCCCCCC------	34.82	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of METH_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of METH_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of METH_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SNAG_HUMAN	NAPG	physical	22939629
DPP9_HUMAN	DPP9	physical	22863883

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 250940: Homocystinuria-megaloblastic anemia, cblG complementation type (HMAG)
• 601634: Neural tube defects, folate-sensitive (NTDFS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00115: Cyanocobalamin
• DB00200: Hydroxocobalamin
• DB00134: L-Methionine
• DB00116: Tetrahydrofolic acid