DIP2A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DIP2A_HUMAN
• UniProt AC: Q14689
• Protein Name: Disco-interacting protein 2 homolog A
• Gene Name: DIP2A
• Organism: Homo sapiens (Human).
• Sequence Length: 1571
• Subcellular Localization: Nucleus .
• Protein Description: May provide positional cues for axon pathfinding and patterning in the central nervous system..
• Protein Sequence: MADRGCPLEAAPLPAEVRESLAELELELSEGDITQKGYEKKRAKLLARYIPLIQGIDPSLQAENRIPGPSQTTAAAPKQQKSRPTASRDERFRSDVHTEAVQAALAKYKERKMPMPSKRRSVLVHSSVETYTPPDTSSASEDEGSLRRPGRLTSTPLQSHSSVEPWLDRVIQGSSTSSSASSTSSHPGGRPTTAPSAAATPGAAATTALAGLEAHTHIDLHSAPPDVTTGLVEHSYFERPQVASVRSVPRGCSGSMLETADGVPVNSRVSSKIQQLLNTLKRPKRPPLKEFFVDDFEELLEVQQPDPNQPKPEGSETSVLRGEPLTAGVPRPPSLLATLQRWGTTQPKSPCLTALDTTGKAVYTLTYGKLWSRSLKLAYTLLNKLTSKNEPLLKPGDRVALVFPNSDPVMFMVAFYGCLLAELVPVPIEVPLTRKDAGSQQVGFLLGSCGVFLALTTDACQKGLPKAQTGEVAAFKGWPPLSWLVIDGKHLAKPPKDWHPLAQDTGTGTAYIEYKTSKEGSTVGVTVSHASLLAQCRALTQACGYSEAETLTNVLDFKRDAGLWHGVLTSVMNRMHVVSVPYALMKANPLSWIQKVCFYKARAALVKSRDMHWSLLAQRGQRDVSLSSLRMLIVADGANPWSISSCDAFLNVFQSRGLRPEVICPCASSPEALTVAIRRPPDLGGPPPRKAVLSMNGLSYGVIRVDTEEKLSVLTVQDVGQVMPGANVCVVKLEGTPYLCKTDEVGEICVSSSATGTAYYGLLGITKNVFEAVPVTTGGAPIFDRPFTRTGLLGFIGPDNLVFIVGKLDGLMVTGVRRHNADDVVATALAVEPMKFVYRGRIAVFSVTVLHDDRIVLVAEQRPDASEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKAPLGGIHISETKQRFLEGTLHPCNVLMCPHTCVTNLPKPRQKQPEVGPASMIVGNLVAGKRIAQASGRELAHLEDSDQARKFLFLADVLQWRAHTTPDHPLFLLLNAKGTVTSTATCVQLHKRAERVAAALMEKGRLSVGDHVALVYPPGVDLIAAFYGCLYCGCVPVTVRPPHPQNLGTTLPTVKMIVEVSKSACVLTTQAVTRLLRSKEAAAAVDIRTWPTILDTDDIPKKKIASVFRPPSPDVLAYLDFSVSTTGILAGVKMSHAATSALCRSIKLQCELYPSRQIAICLDPYCGLGFALWCLCSVYSGHQSVLVPPLELESNVSLWLSAVSQYKARVTFCSYSVMEMCTKGLGAQTGVLRMKGVNLSCVRTCMVVAEERPRIALTQSFSKLFKDLGLPARAVSTTFGCRVNVAICLQGTAGPDPTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKILPGVKVIIAHTETKGPLGDSHLGEIWVSSPHNATGYYTVYGEEALHADHFSARLSFGDTQTIWARTGYLGFLRRTELTDASGGRHDALYVVGSLDETLELRGMRYHPIDIETSVIRAHRSIAECAVFTWTNLLVVVVELDGLEQDALDLVALVTNVVLEEHYLVVGVVVIVDPGVIPINSRGEKQRMHLRDGFLADQLDPIYVAYNM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	LPAEVRESLAELELE CCHHHHHHHHHCEEE	23.47	-
29	Phosphorylation	AELELELSEGDITQK HHCEEEECCCCCCCC	30.11	-
34	Phosphorylation	ELSEGDITQKGYEKK EECCCCCCCCCHHHH	29.03	-
38	Phosphorylation	GDITQKGYEKKRAKL CCCCCCCHHHHHHHH	31.45	-
49	Phosphorylation	RAKLLARYIPLIQGI HHHHHHHHHHHHCCC	10.98	-
59	Phosphorylation	LIQGIDPSLQAENRI HHCCCCHHHCCCCCC	29.39	-
85	Phosphorylation	KQQKSRPTASRDERF CCCCCCCCCCCCHHH	35.83	27470641
94	Phosphorylation	SRDERFRSDVHTEAV CCCHHHHHHHHHHHH	41.07	29255136
98	Phosphorylation	RFRSDVHTEAVQAAL HHHHHHHHHHHHHHH	26.03	29255136
107	Ubiquitination	AVQAALAKYKERKMP HHHHHHHHHHHCCCC	58.67	-
132	Phosphorylation	HSSVETYTPPDTSSA ECCEEEECCCCCCCC	35.45	24076635
136	Phosphorylation	ETYTPPDTSSASEDE EEECCCCCCCCCCCC	30.29	23898821
137	Phosphorylation	TYTPPDTSSASEDEG EECCCCCCCCCCCCC	31.15	22817900
138	Phosphorylation	YTPPDTSSASEDEGS ECCCCCCCCCCCCCC	37.60	30576142
140	Phosphorylation	PPDTSSASEDEGSLR CCCCCCCCCCCCCCC	47.75	30576142
145	Phosphorylation	SASEDEGSLRRPGRL CCCCCCCCCCCCCCC	19.36	30576142
153	Phosphorylation	LRRPGRLTSTPLQSH CCCCCCCCCCCCCCC	29.24	23403867
154	Phosphorylation	RRPGRLTSTPLQSHS CCCCCCCCCCCCCCC	32.40	25159151
155	Phosphorylation	RPGRLTSTPLQSHSS CCCCCCCCCCCCCCC	23.84	25159151
159	Phosphorylation	LTSTPLQSHSSVEPW CCCCCCCCCCCCCHH	32.78	23403867
161	Phosphorylation	STPLQSHSSVEPWLD CCCCCCCCCCCHHHH	41.13	23403867
162	Phosphorylation	TPLQSHSSVEPWLDR CCCCCCCCCCHHHHH	25.69	23403867
176	Phosphorylation	RVIQGSSTSSSASST HHHCCCCCCCCCCCC	34.03	22817900
217	Ubiquitination	AGLEAHTHIDLHSAP HCHHHHCCEECCCCC	11.16	21890473
238 (in isoform 3)	Ubiquitination	-	56.04	21890473
244	Phosphorylation	FERPQVASVRSVPRG CCCCCEEEEEECCCC	21.14	24719451
247	Phosphorylation	PQVASVRSVPRGCSG CCEEEEEECCCCCCC	34.03	28270605
253	Phosphorylation	RSVPRGCSGSMLETA EECCCCCCCCCEECC	36.40	28270605
255	Phosphorylation	VPRGCSGSMLETADG CCCCCCCCCEECCCC	12.14	28270605
259	Phosphorylation	CSGSMLETADGVPVN CCCCCEECCCCCCCC	26.53	28270605
267	Phosphorylation	ADGVPVNSRVSSKIQ CCCCCCCHHHHHHHH	34.00	28270605
272	Ubiquitination	VNSRVSSKIQQLLNT CCHHHHHHHHHHHHH	36.71	-
279	Phosphorylation	KIQQLLNTLKRPKRP HHHHHHHHCCCCCCC	33.36	23401153
281 (in isoform 4)	Ubiquitination	-	65.69	21890473
281 (in isoform 2)	Ubiquitination	-	65.69	21890473
281	Ubiquitination	QQLLNTLKRPKRPPL HHHHHHCCCCCCCCH	65.69	-
348	Ubiquitination	RWGTTQPKSPCLTAL HHCCCCCCCCCEEEE	58.15	-
363	Phosphorylation	DTTGKAVYTLTYGKL CCCCCEEEEEECHHH	10.82	29496907
367	Phosphorylation	KAVYTLTYGKLWSRS CEEEEEECHHHHHHH	18.51	29496907
384	Ubiquitination	LAYTLLNKLTSKNEP HHHHHHHHHCCCCCC	53.78	-
388	Ubiquitination	LLNKLTSKNEPLLKP HHHHHCCCCCCCCCC	61.16	-
394	Ubiquitination	SKNEPLLKPGDRVAL CCCCCCCCCCCEEEE	55.42	-
466	Ubiquitination	ACQKGLPKAQTGEVA HHHCCCCCCCCCCEE	59.16	-
496	Ubiquitination	KHLAKPPKDWHPLAQ CCCCCCCCCCCCCCC	80.24	-
515	Ubiquitination	GTAYIEYKTSKEGST CEEEEEEEECCCCCE	33.27	-
518	Ubiquitination	YIEYKTSKEGSTVGV EEEEEECCCCCEEEE	71.91	-
558	Ubiquitination	LTNVLDFKRDAGLWH HHHHHHHHCCCCCHH	49.38	-
569	Phosphorylation	GLWHGVLTSVMNRMH CCHHHHHHHHHHHHC	19.50	-
582	Phosphorylation	MHVVSVPYALMKANP HCCEEHHHHHHHHCC	15.37	-
586	Acetylation	SVPYALMKANPLSWI EHHHHHHHHCCCHHH	45.95	18585193
600	Ubiquitination	IQKVCFYKARAALVK HHHHHHHHHHHHHHH	15.90	-
625	Phosphorylation	QRGQRDVSLSSLRML HCCCCCCCHHHEEEE	27.16	22167270
627	Phosphorylation	GQRDVSLSSLRMLIV CCCCCCHHHEEEEEE	21.59	22167270
628	Phosphorylation	QRDVSLSSLRMLIVA CCCCCHHHEEEEEEC	25.86	22167270
694	Phosphorylation	PPRKAVLSMNGLSYG CCCCEEEECCCCEEE	12.00	21406692
699	Phosphorylation	VLSMNGLSYGVIRVD EEECCCCEEEEEEEC	22.65	21406692
700	Phosphorylation	LSMNGLSYGVIRVDT EECCCCEEEEEEECC	22.06	21406692
736	Phosphorylation	CVVKLEGTPYLCKTD EEEEECCCEEEEECC	10.21	-
738	Phosphorylation	VKLEGTPYLCKTDEV EEECCCEEEEECCCC	25.27	-
883	Phosphorylation	RVLQAIDSIHQVGVY HHHHHHHHHHHHCCE	18.83	-
890	Phosphorylation	SIHQVGVYCLALVPA HHHHHCCEEEEEEEC	3.94	-
911	Phosphorylation	PLGGIHISETKQRFL CCCCEEEHHHHHHHH	25.67	21406692
913	Phosphorylation	GGIHISETKQRFLEG CCEEEHHHHHHHHHC	26.20	21406692
914	Ubiquitination	GIHISETKQRFLEGT CEEEHHHHHHHHHCC	35.11	2190698
915 (in isoform 1)	Ubiquitination	-	49.10	21890473
962	Acetylation	VGNLVAGKRIAQASG CCHHHHCHHHHHHCC	30.78	30588171
1101	Phosphorylation	SKSACVLTTQAVTRL CCHHHHHHHHHHHHH	9.10	24667141
1106	Phosphorylation	VLTTQAVTRLLRSKE HHHHHHHHHHHHCHH	20.72	24667141
1111	Phosphorylation	AVTRLLRSKEAAAAV HHHHHHHCHHHHHCC	34.51	-
1112	Ubiquitination	VTRLLRSKEAAAAVD HHHHHHCHHHHHCCC	44.96	-
1139	Phosphorylation	IPKKKIASVFRPPSP CCHHHHHHCCCCCCC	25.84	-
1173	Phosphorylation	KMSHAATSALCRSIK CCCHHHHHHHHHHHH	17.95	22210691
1186	Phosphorylation	IKLQCELYPSRQIAI HHHEEEECCCCCEEE	4.11	25690035
1273	Phosphorylation	RMKGVNLSCVRTCMV EECCCCHHHEEEEEH	12.83	-
1293	Phosphorylation	PRIALTQSFSKLFKD CCEEEEHHHHHHHHH	26.67	24719451
1296	Ubiquitination	ALTQSFSKLFKDLGL EEEHHHHHHHHHHCC	56.80	-
1352	Phosphorylation	VRLVERGSPHSLPLM EEEHHCCCCCCCCCC	26.17	23403867
1355	Phosphorylation	VERGSPHSLPLMESG HHCCCCCCCCCCCCC	34.76	23403867
1384	Phosphorylation	TKGPLGDSHLGEIWV CCCCCCCCCCEEEEE	20.86	23401153
1392	Phosphorylation	HLGEIWVSSPHNATG CCEEEEECCCCCCCE	24.13	23401153
1393	Phosphorylation	LGEIWVSSPHNATGY CEEEEECCCCCCCEE	22.13	23401153
1400	Phosphorylation	SPHNATGYYTVYGEE CCCCCCEEEEEECCC	7.51	23401153
1401	Phosphorylation	PHNATGYYTVYGEEA CCCCCEEEEEECCCC	7.35	23401153
1404	Phosphorylation	ATGYYTVYGEEALHA CCEEEEEECCCCCCC	15.83	23401153

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DIP2A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DIP2A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DIP2A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JMJD6_HUMAN	JMJD6	physical	23455924
MBIP1_HUMAN	MBIP	physical	25416956
ATL4_HUMAN	ADAMTSL4	physical	25416956
GPT2L_HUMAN	GPATCH2L	physical	25416956
TRI39_HUMAN	TRIM39	physical	25416956
CCD33_HUMAN	CCDC33	physical	25416956
F214B_HUMAN	FAM214B	physical	25416956
CEP44_HUMAN	CEP44	physical	25416956
STAC3_HUMAN	STAC3	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.