GPT2L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GPT2L_HUMAN
• UniProt AC: Q9NWQ4
• Protein Name: G patch domain-containing protein 2-like
• Gene Name: GPATCH2L
• Organism: Homo sapiens (Human).
• Sequence Length: 482
• Protein Sequence: MDELVHDLASALEQTSEQNKLGELWEEMALSPRQQRRQLRKRRGRKRRSDFTHLAEHTCCYSEASESSLDEATKDCREVAPVTNFSDSDDTMVAKRHPALNAIVKSKQHSWHESDSFTENAPCRPLRRRRKVKRVTSEVAASLQQKLKVSDWSYERGCRFKSAKKQRLSRWKENTPWTSSGHGLCESAENRTFLSKTGRKERMECETDEQKQGSDENMSECETSSVCSSSDTGLFTNDEGRQGDDEQSDWFYEGECVPGFTVPNLLPKWAPDHCSEVERMDSGLDKFSDSTFLLPSRPAQRGYHTRLNRLPGAAARCLRKGRRRLVGKETSINTLGTERISHIISDPRQKEKNKALASDFPHISACAHEFNPLSPLYSLDVLADASHRRCSPAHCSARQANVHWGPPCSRDIKRKRKPVATASLSSPSAVHMDAVEPTTPASQAPKSPSSEWLVRTSAAEKATDATTATFFKMPQEKSPGYS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	ELVHDLASALEQTSE HHHHHHHHHHHHHHH		25159151
15	Phosphorylation	LASALEQTSEQNKLG HHHHHHHHHHHHHHH		27732954
16	Phosphorylation	ASALEQTSEQNKLGE HHHHHHHHHHHHHHH		25159151
31	Phosphorylation	LWEEMALSPRQQRRQ HHHHHCCCHHHHHHH		28674151
65	Phosphorylation	TCCYSEASESSLDEA HHCCCHHCCCCHHHH		27251275
67	Phosphorylation	CYSEASESSLDEATK CCCHHCCCCHHHHHC		27251275
68	Phosphorylation	YSEASESSLDEATKD CCHHCCCCHHHHHCH		27251275
83	Phosphorylation	CREVAPVTNFSDSDD HHHHCCCCCCCCCCC		29255136
86 (in isoform 4)	Phosphorylation	-		-
86	Phosphorylation	VAPVTNFSDSDDTMV HCCCCCCCCCCCCHH		29255136
88 (in isoform 4)	Phosphorylation	-		-
88	Phosphorylation	PVTNFSDSDDTMVAK CCCCCCCCCCCHHHH		29255136
91 (in isoform 4)	Phosphorylation	-		-
91	Phosphorylation	NFSDSDDTMVAKRHP CCCCCCCCHHHHHCH		23927012
105	Sumoylation	PALNAIVKSKQHSWH HHHHHHHHCCCCCCC		-
110	Phosphorylation	IVKSKQHSWHESDSF HHHCCCCCCCCCCCC		27732954
114	Phosphorylation	KQHSWHESDSFTENA CCCCCCCCCCCCCCC		27732954
116	Phosphorylation	HSWHESDSFTENAPC CCCCCCCCCCCCCCC		27732954
118	Phosphorylation	WHESDSFTENAPCRP CCCCCCCCCCCCCHH		27732954
136	Phosphorylation	RRKVKRVTSEVAASL HHHHHHHHHHHHHHH		28450419
137	Phosphorylation	RKVKRVTSEVAASLQ HHHHHHHHHHHHHHH		28450419
142	Phosphorylation	VTSEVAASLQQKLKV HHHHHHHHHHHHHCC		23532336
146	Sumoylation	VAASLQQKLKVSDWS HHHHHHHHHCCCCCC		-
148	Sumoylation	ASLQQKLKVSDWSYE HHHHHHHCCCCCCHH		-
154	Phosphorylation	LKVSDWSYERGCRFK HCCCCCCHHCCCCCH		23532336
179	Phosphorylation	KENTPWTSSGHGLCE HHCCCCCCCCCCCCC		28555341
196	Ubiquitination	ENRTFLSKTGRKERM HHCCCCCCCCCHHHC		-
196	Sumoylation	ENRTFLSKTGRKERM HHCCCCCCCCCHHHC		28112733
214	Phosphorylation	TDEQKQGSDENMSEC CHHHHCCCCCCHHHH		30576142
225	Phosphorylation	MSECETSSVCSSSDT HHHHHHCCCCCCCCC		30576142
228	Phosphorylation	CETSSVCSSSDTGLF HHHCCCCCCCCCCCC		30576142
232	Phosphorylation	SVCSSSDTGLFTNDE CCCCCCCCCCCCCCC		30576142
275	Phosphorylation	KWAPDHCSEVERMDS CCCCCCCHHHHHHHC		23312004
282	Phosphorylation	SEVERMDSGLDKFSD HHHHHHHCCHHHCCC		-
290	Phosphorylation	GLDKFSDSTFLLPSR CHHHCCCCCEECCCC		28555341
296	Phosphorylation	DSTFLLPSRPAQRGY CCCEECCCCCHHCCC		25278378
303	Phosphorylation	SRPAQRGYHTRLNRL CCCHHCCCHHHHHCC		-
305	Phosphorylation	PAQRGYHTRLNRLPG CHHCCCHHHHHCCCH		-
309	Methylation	GYHTRLNRLPGAAAR CCHHHHHCCCHHHHH		-
316	Methylation	RLPGAAARCLRKGRR CCCHHHHHHHHHCCH		-
328	Ubiquitination	GRRRLVGKETSINTL CCHHHCCCCCCCCCC		-
328	Sumoylation	GRRRLVGKETSINTL CCHHHCCCCCCCCCC		-
330	Phosphorylation	RRLVGKETSINTLGT HHHCCCCCCCCCCCH		24719451
331	Phosphorylation	RLVGKETSINTLGTE HHCCCCCCCCCCCHH		24245541
334	Phosphorylation	GKETSINTLGTERIS CCCCCCCCCCHHHHH		24719451
337	Phosphorylation	TSINTLGTERISHII CCCCCCCHHHHHHHH		24719451
341	Phosphorylation	TLGTERISHIISDPR CCCHHHHHHHHCCHH		27732954
345	Phosphorylation	ERISHIISDPRQKEK HHHHHHHCCHHHHHH		27732954
374	Phosphorylation	AHEFNPLSPLYSLDV HHHCCCCCCCCCHHH		25159151
391	Phosphorylation	DASHRRCSPAHCSAR CCCCCCCCHHHHCCC		-
421	Phosphorylation	RKRKPVATASLSSPS HHCCCCCEEECCCCC		27251275
425	Phosphorylation	PVATASLSSPSAVHM CCCEEECCCCCCCCC		28348404
426	Phosphorylation	VATASLSSPSAVHMD CCEEECCCCCCCCCC		25627689
428	Phosphorylation	TASLSSPSAVHMDAV EEECCCCCCCCCCCC		28348404
439	Phosphorylation	MDAVEPTTPASQAPK CCCCCCCCCHHHCCC		25627689
442 (in isoform 4)	Phosphorylation	-		-
442	Phosphorylation	VEPTTPASQAPKSPS CCCCCCHHHCCCCCC		20068231
447	Phosphorylation	PASQAPKSPSSEWLV CHHHCCCCCCCCCEE		23401153
449	Phosphorylation	SQAPKSPSSEWLVRT HHCCCCCCCCCEEEC		22167270
450	Phosphorylation	QAPKSPSSEWLVRTS HCCCCCCCCCEEECH		22167270
472	Sumoylation	ATTATFFKMPQEKSP CCCCCCCCCCCCCCC		-
478	Phosphorylation	FKMPQEKSPGYS--- CCCCCCCCCCCC---		19581576
481	Phosphorylation	PQEKSPGYS------ CCCCCCCCC------		26074081
482	Phosphorylation	QEKSPGYS------- CCCCCCCC-------		26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GPT2L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GPT2L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GPT2L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SUV91_HUMAN	SUV39H1	physical	23455924
KDM1A_HUMAN	KDM1A	physical	23455924
ANM1_HUMAN	PRMT1	physical	23455924
ANM8_HUMAN	PRMT8	physical	23455924
ZN398_HUMAN	ZNF398	physical	25416956
PRD14_HUMAN	PRDM14	physical	25416956
ZN408_HUMAN	ZNF408	physical	25416956
CCD33_HUMAN	CCDC33	physical	25416956
CEP70_HUMAN	CEP70	physical	25416956
KR412_HUMAN	KRTAP4-12	physical	25416956
LZTS2_HUMAN	LZTS2	physical	25416956
TRI41_HUMAN	TRIM41	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
KR109_HUMAN	KRTAP10-9	physical	25416956
ZBT8A_HUMAN	ZBTB8A	physical	25416956
CSK22_HUMAN	CSNK2A2	physical	28514442
TYPH_HUMAN	TYMP	physical	28514442
PLBL1_HUMAN	PLBD1	physical	28514442
CSK21_HUMAN	CSNK2A1	physical	28514442
SPB8_HUMAN	SERPINB8	physical	28514442
PAI2_HUMAN	SERPINB2	physical	28514442
PLAK_HUMAN	JUP	physical	28514442
NFH_HUMAN	NEFH	physical	28514442
POF1B_HUMAN	POF1B	physical	28514442
CDSN_HUMAN	CDSN	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.