PAI2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAI2_HUMAN
• UniProt AC: P05120
• Protein Name: Plasminogen activator inhibitor 2
• Gene Name: SERPINB2
• Organism: Homo sapiens (Human).
• Sequence Length: 415
• Subcellular Localization: Cytoplasm. Secreted, extracellular space.
• Protein Description: Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1..
• Protein Sequence: MEDLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQFNEVGANAVTPMTPENFTSCGFMQQIQKGSYPDAILQAQAADKIHSSFRSLSSAINASTGNYLLESVNKLFGEKSASFREEYIRLCQKYYSSEPQAVDFLECAEEARKKINSWVKTQTKGKIPNLLPEGSVDGDTRMVLVNAVYFKGKWKTPFEKKLNGLYPFRVNSAQRTPVQMMYLREKLNIGYIEDLKAQILELPYAGDVSMFLLLPDEIADVSTGLELLESEITYDKLNKWTSKDKMAEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFNKGRANFSGMSERNDLFLSEVFHQAMVDVNEEGTEAAAGTGGVMTGRTGHGGPQFVADHPFLFLIMHKITNCILFFGRFSSP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
69	Phosphorylation	EVGANAVTPMTPENF CCCCCCCCCCCCCCC	12.63	25106551
72	Phosphorylation	ANAVTPMTPENFTSC CCCCCCCCCCCCCCC	28.75	25106551
75	N-linked_Glycosylation	VTPMTPENFTSCGFM CCCCCCCCCCCCCHH	46.85	UniProtKB CARBOHYD
77	O-linked_Glycosylation	PMTPENFTSCGFMQQ CCCCCCCCCCCHHHH	34.39	OGP
78	O-linked_Glycosylation	MTPENFTSCGFMQQI CCCCCCCCCCHHHHH	14.22	OGP
89	O-linked_Glycosylation	MQQIQKGSYPDAILQ HHHHHCCCCHHHHHH	40.29	OGP
89	Phosphorylation	MQQIQKGSYPDAILQ HHHHHCCCCHHHHHH	40.29	30242111
90	Phosphorylation	QQIQKGSYPDAILQA HHHHCCCCHHHHHHH	17.50	25394399
102	Malonylation	LQAQAADKIHSSFRS HHHHHHHHHHHHHHH	37.28	26320211
109	Phosphorylation	KIHSSFRSLSSAINA HHHHHHHHHHHHHHH	30.50	23663014
111	Phosphorylation	HSSFRSLSSAINAST HHHHHHHHHHHHHHH	20.97	23663014
112	Phosphorylation	SSFRSLSSAINASTG HHHHHHHHHHHHHHH	38.16	23663014
115	N-linked_Glycosylation	RSLSSAINASTGNYL HHHHHHHHHHHHHHH	27.79	UniProtKB CARBOHYD
117	Phosphorylation	LSSAINASTGNYLLE HHHHHHHHHHHHHHH	32.15	23663014
118	Phosphorylation	SSAINASTGNYLLES HHHHHHHHHHHHHHH	27.34	23663014
121	Phosphorylation	INASTGNYLLESVNK HHHHHHHHHHHHHHH	17.63	23663014
125	Phosphorylation	TGNYLLESVNKLFGE HHHHHHHHHHHHHCC	30.84	23663014
133	Malonylation	VNKLFGEKSASFREE HHHHHCCCCHHHHHH	52.26	26320211
134	Phosphorylation	NKLFGEKSASFREEY HHHHCCCCHHHHHHH	25.50	22617229
136	Phosphorylation	LFGEKSASFREEYIR HHCCCCHHHHHHHHH	31.74	27422710
168	Ubiquitination	CAEEARKKINSWVKT HHHHHHHHHHHHHHH	41.38	25015289
168	Malonylation	CAEEARKKINSWVKT HHHHHHHHHHHHHHH	41.38	26320211
171	Phosphorylation	EARKKINSWVKTQTK HHHHHHHHHHHHCCC	36.40	21712546
174	Malonylation	KKINSWVKTQTKGKI HHHHHHHHHCCCCCC	28.76	26320211
175	Phosphorylation	KINSWVKTQTKGKIP HHHHHHHHCCCCCCC	31.67	21712546
177	Phosphorylation	NSWVKTQTKGKIPNL HHHHHHCCCCCCCCC	47.17	21712546
203	Phosphorylation	MVLVNAVYFKGKWKT EEEEEEEEECCCCCC	9.36	27259358
296	Phosphorylation	DKLNKWTSKDKMAED HHHHHCCCCCCCCCC	37.43	-
339	N-linked_Glycosylation	AFNKGRANFSGMSER HHHHCCCCCCCCCHH	30.20	UniProtKB CARBOHYD
373	O-linked_Glycosylation	GTEAAAGTGGVMTGR CCCCCCCCCCEECCC	26.49	OGP

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PAI2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAI2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAI2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RB_HUMAN	RB1	physical	12944478
RBL2_HUMAN	RBL2	physical	16397580
RB_HUMAN	RB1	physical	16397580
PRP8_HUMAN	PRPF8	physical	15346200
A4_HUMAN	APP	physical	21832049
ITPA_HUMAN	ITPA	physical	26344197
TPA_HUMAN	PLAT	physical	28514442
MYPT1_HUMAN	PPP1R12A	physical	28514442
RPGF6_HUMAN	RAPGEF6	physical	28514442
VIGLN_HUMAN	HDLBP	physical	28514442
RSPRY_HUMAN	RSPRY1	physical	28514442
FAK1_HUMAN	PTK2	physical	28514442
TAB1_HUMAN	TAB1	physical	28514442
EEA1_HUMAN	EEA1	physical	28514442
MP2K2_HUMAN	MAP2K2	physical	28514442
LIPA1_HUMAN	PPFIA1	physical	28514442
RHG35_HUMAN	ARHGAP35	physical	28514442
LPP_HUMAN	LPP	physical	28514442
SYAP1_HUMAN	SYAP1	physical	28514442
SELO_HUMAN	SELO	physical	28514442
KDM3B_HUMAN	KDM3B	physical	28514442
TT30A_HUMAN	TTC30A	physical	28514442
OSBP1_HUMAN	OSBP	physical	28514442
RLGPB_HUMAN	RALGAPB	physical	28514442
ASPC1_HUMAN	ASPSCR1	physical	28514442
RRP44_HUMAN	DIS3	physical	28514442
KLC2_HUMAN	KLC2	physical	28514442
FKB15_HUMAN	FKBP15	physical	28514442
TBL1X_HUMAN	TBL1X	physical	28514442
MMAB_HUMAN	MMAB	physical	28514442
IFT81_HUMAN	IFT81	physical	28514442
DDX42_HUMAN	DDX42	physical	28514442
IFT74_HUMAN	IFT74	physical	28514442
TAF5L_HUMAN	TAF5L	physical	28514442
TAF5_HUMAN	TAF5	physical	28514442
NU214_HUMAN	NUP214	physical	28514442
DJC13_HUMAN	DNAJC13	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.