SELO_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SELO_HUMAN
• UniProt AC: Q9BVL4
• Protein Name: Selenoprotein O {ECO:0000303|PubMed:27645994}
• Gene Name: SELENOO {ECO:0000312|HGNC:HGNC:30395}
• Organism: Homo sapiens (Human).
• Sequence Length: 669
• Subcellular Localization: Mitochondrion .
• Protein Description: May be a redox-active mitochondrial selenoprotein which interacts with a redox target protein..
• Protein Sequence: MAVYRAALGASLAAARLLPLGRCSPSPAPRSTLSGAAMEPAPRWLAGLRFDNRALRALPVEAPPPGPEGAPSAPRPVPGACFTRVQPTPLRQPRLVALSEPALALLGLGAPPAREAEAEAALFFSGNALLPGAEPAAHCYCGHQFGQFAGQLGDGAAMYLGEVCTATGERWELQLKGAGPTPFSRQADGRKVLRSSIREFLCSEAMFHLGVPTTRAGACVTSESTVVRDVFYDGNPKYEQCTVVLRVASTFIRFGSFEIFKSADEHTGRAGPSVGRNDIRVQLLDYVISSFYPEIQAAHASDSVQRNAAFFREVTRRTARMVAEWQCVGFCHGVLNTDNMSILGLTIDYGPFGFLDRYDPDHVCNASDNTGRYAYSKQPEVCRWNLRKLAEALQPELPLELGEAILAEEFDAEFQRHYLQKMRRKLGLVQVELEEDGALVSKLLETMHLTGADFTNTFYLLSSFPVELESPGLAEFLARLMEQCASLEELRLAFRPQMDPRQLSMMLMLAQSNPQLFALMGTRAGIARELERVEQQSRLEQLSAAELQSRNQGHWADWLQAYRARLDKDLEGAGDAAAWQAEHVRVMHANNPKYVLRNYIAQNAIEAAERGDFSEVRRVLKLLETPYHCEAGAATDAEATEADGADGRQRSYSSKPPLWAAELCVTUSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	SPSPAPRSTLSGAAM CCCCCCCCCCCCCCC	32.42	24275569
32	Phosphorylation	PSPAPRSTLSGAAME CCCCCCCCCCCCCCC	26.65	24275569
34	Phosphorylation	PAPRSTLSGAAMEPA CCCCCCCCCCCCCCC	26.86	24275569
176	Ubiquitination	ERWELQLKGAGPTPF CCEEEEECCCCCCCC	33.48	21963094
203	Phosphorylation	SIREFLCSEAMFHLG HHHHHHHHHHHHHCC	30.45	-
213	Phosphorylation	MFHLGVPTTRAGACV HHHCCCCCCCCCCCC	26.89	-
214	Phosphorylation	FHLGVPTTRAGACVT HHCCCCCCCCCCCCC	16.67	-
225	Phosphorylation	ACVTSESTVVRDVFY CCCCCCCCEEEEEEE	20.97	24719451
237	Ubiquitination	VFYDGNPKYEQCTVV EEECCCCCHHHCEEE	66.47	21963094
261	Ubiquitination	FGSFEIFKSADEHTG HCCEEEECCCCCCCC	50.85	21963094
262	Phosphorylation	GSFEIFKSADEHTGR CCEEEECCCCCCCCC	30.15	-
267	Phosphorylation	FKSADEHTGRAGPSV ECCCCCCCCCCCCCC	26.73	-
358	Phosphorylation	PFGFLDRYDPDHVCN CCCCHHCCCCCCCCC	31.34	-
373	Phosphorylation	ASDNTGRYAYSKQPE CCCCCCCCCCCCCHH	15.96	-
375	Phosphorylation	DNTGRYAYSKQPEVC CCCCCCCCCCCHHHH	13.89	-
377	Ubiquitination	TGRYAYSKQPEVCRW CCCCCCCCCHHHHHH	58.14	21963094
421	Ubiquitination	FQRHYLQKMRRKLGL HHHHHHHHHHHHHCC	31.60	29967540
441	Phosphorylation	EEDGALVSKLLETMH CCCCHHHHHHHHHHH	20.59	-
543	Phosphorylation	QSRLEQLSAAELQSR HHHHHHHHHHHHHHC	25.73	21082442
562	Phosphorylation	WADWLQAYRARLDKD HHHHHHHHHHHHCCC	7.58	-
568	Ubiquitination	AYRARLDKDLEGAGD HHHHHHCCCCCCCCC	69.66	-
593	Ubiquitination	VMHANNPKYVLRNYI EECCCCHHHHHHHHH	50.55	29967540
593	Acetylation	VMHANNPKYVLRNYI EECCCCHHHHHHHHH	50.55	25953088
599	Phosphorylation	PKYVLRNYIAQNAIE HHHHHHHHHHHHHHH	7.39	23532336
614	Phosphorylation	AAERGDFSEVRRVLK HHHCCCHHHHHHHHH	39.66	24719451
621	Ubiquitination	SEVRRVLKLLETPYH HHHHHHHHHHCCCCC	48.44	-
625	Phosphorylation	RVLKLLETPYHCEAG HHHHHHCCCCCCCCC	29.17	29978859
627	Phosphorylation	LKLLETPYHCEAGAA HHHHCCCCCCCCCCC	26.90	29978859
635	Phosphorylation	HCEAGAATDAEATEA CCCCCCCCCHHHHHC	34.90	29978859
640	Phosphorylation	AATDAEATEADGADG CCCCHHHHHCCCCCC	24.18	29978859
653	Phosphorylation	DGRQRSYSSKPPLWA CCCCCCCCCCCCCEE	32.88	30270044

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SELO_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SELO_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
635	Phosphorylation	645 (10)	A ⇒ G;V	rs144505070	Serum uric acid levels	29559957
653	Phosphorylation	645 (8)	A ⇒ G;V	rs144505070	Serum uric acid levels	29559957

Protein-Protein Interaction

Oops, there are no PPI records of SELO_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.