dbPTM

RLGPB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RLGPB_HUMAN
UniProt AC	Q86X10
Protein Name	Ral GTPase-activating protein subunit beta
Gene Name	RALGAPB
Organism	Homo sapiens (Human).
Sequence Length	1494
Subcellular Localization
Protein Description	Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB..
Protein Sequence	MYSEWRSLHLVIQNDQGHTSVLHSYPESVGREVANAVVRPLGQVLGTPSVAGSENLLKTDKEVKWTMEVICYGLTLPLDGETVKYCVDVYTDWIMALVLPKDSIPLPVIKEPNQYVQTILKHLQNLFVPRQEQGSSQIRLCLQVLRAIQKLARESSLMARETWEVLLLFLLQINDILLAPPTVQGGIAENLAEKLIGVLFEVWLLACTRCFPTPPYWKTAKEMVANWRHHPAVVEQWSKVICALTSRLLRFTYGPSFPAFKVPDEDASLIPPEMDNECVAQTWFRFLHMLSNPVDLSNPAIISSTPKFQEQFLNVSGMPQELNQYPCLKHLPQIFFRAMRGISCLVDAFLGISRPRSDSAPPTPVNRLSMPQSAAVSTTPPHNRRHRAVTVNKATMKTSTVSTAHASKVQHQTSSTSPLSSPNQTSSEPRPLPAPRRPKVNSILNLFGSWLFDAAFVHCKLHNGINRDSSMTAITTQASMEFRRKGSQMSTDTMVSNPMFDASEFPDNYEAGRAEACGTLCRIFCSKKTGEEILPAYLSRFYMLLIQGLQINDYVCHPVLASVILNSPPLFCCDLKGIDVVVPYFISALETILPDRELSKFKSYVNPTELRRSSINILLSLLPLPHHFGTVKSEVVLEGKFSNDDSSSYDKPITFLSLKLRLVNILIGALQTETDPNNTQMILGAMLNIVQDSALLEAIGCQMEMGGGENNLKSHSRTNSGISSASGGSTEPTTPDSERPAQALLRDYALNTDSAAGLLIRSIHLVTQRLNSQWRQDMSISLAALELLSGLAKVKVMVDSGDRKRAISSVCTYIVYQCSRPAPLHSRDLHSMIVAAFQCLCVWLTEHPDMLDEKDCLKEVLEIVELGISGSKSKNNEQEVKYKGDKEPNPASMRVKDAAEATLTCIMQLLGAFPSPSGPASPCSLVNETTLIKYSRLPTINKHSFRYFVLDNSVILAMLEQPLGNEQNDFFPSVTVLVRGMSGRLAWAQQLCLLPRGAKANQKLFVPEPRPVPKNDVGFKYSVKHRPFPEEVDKIPFVKADLSIPDLHEIVTEELEERHEKLRSGMAQQIAYEIHLEQQSEEELQKRSFPDPVTDCKPPPPAQEFQTARLFLSHFGFLSLEALKEPANSRLPPHLIALDSTIPGFFDDIGYLDLLPCRPFDTVFIFYMKPGQKTNQEILKNVESSRTVQPHFLEFLLSLGWSVDVGRHPGWTGHVSTSWSINCCDDGEGSQQEVISSEDIGASIFNGQKKVLYYADALTEIAFVVPSPVESLTDSLESNISDQDSDSNMDLMPGILKQPSLTLELFPNHTDNLNSSQRLSPSSRMRKLPQGRPVPPLGPETRVSVVWVERYDDIENFPLSELMTEISTGVETTANSSTSLRSTTLEKEVPVIFIHPLNTGLFRIKIQGATGKFNMVIPLVDGMIVSRRALGFLVRQTVINICRRKRLESDSYSPPHVRRKQKITDIVNKYRNKQLEPEFYTSLFQEVGLKNCSS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	Phosphorylation	PLGQVLGTPSVAGSE CHHHHHCCCCCCCCC	14.29	27251275
49	Phosphorylation	GQVLGTPSVAGSENL HHHHCCCCCCCCCCC	25.16	27251275
110	Ubiquitination	SIPLPVIKEPNQYVQ CCCCCCCCCCHHHHH	68.31	-
155	Phosphorylation	IQKLARESSLMARET HHHHHHHCCCHHHHH	24.18	27966365
221	Ubiquitination	PPYWKTAKEMVANWR CCHHHHHHHHHHCCC	52.12	-
221	Ubiquitination	PPYWKTAKEMVANWR CCHHHHHHHHHHCCC	52.12	-
316	Phosphorylation	QEQFLNVSGMPQELN HHHHHCCCCCCHHHH	28.44	21712546
343	Phosphorylation	FRAMRGISCLVDAFL HHHHHHHHHHHHHHH	12.29	24719451
357	Phosphorylation	LGISRPRSDSAPPTP HCCCCCCCCCCCCCC	38.30	30266825
359	Phosphorylation	ISRPRSDSAPPTPVN CCCCCCCCCCCCCCC	43.87	30266825
363	Phosphorylation	RSDSAPPTPVNRLSM CCCCCCCCCCCCCCC	38.52	30266825
369	Phosphorylation	PTPVNRLSMPQSAAV CCCCCCCCCCCCCCC	25.77	23403867
373	Phosphorylation	NRLSMPQSAAVSTTP CCCCCCCCCCCCCCC	16.60	22617229
377	Phosphorylation	MPQSAAVSTTPPHNR CCCCCCCCCCCCCCC	23.10	23401153
378	Phosphorylation	PQSAAVSTTPPHNRR CCCCCCCCCCCCCCC	36.40	30266825
379	Phosphorylation	QSAAVSTTPPHNRRH CCCCCCCCCCCCCCC	27.58	30266825
390	Phosphorylation	NRRHRAVTVNKATMK CCCCCEEEEEHHHCC	19.85	20068231
393	Acetylation	HRAVTVNKATMKTST CCEEEEEHHHCCCCC	40.68	25953088
393	Methylation	HRAVTVNKATMKTST CCEEEEEHHHCCCCC	40.68	115976143
395	Phosphorylation	AVTVNKATMKTSTVS EEEEEHHHCCCCCCC	22.32	30576142
397	Methylation	TVNKATMKTSTVSTA EEEHHHCCCCCCCHH	34.66	115976149
398	Phosphorylation	VNKATMKTSTVSTAH EEHHHCCCCCCCHHC	20.86	20068231
399	Phosphorylation	NKATMKTSTVSTAHA EHHHCCCCCCCHHCH	22.69	20068231
400	Phosphorylation	KATMKTSTVSTAHAS HHHCCCCCCCHHCHH	24.57	20068231
402	Phosphorylation	TMKTSTVSTAHASKV HCCCCCCCHHCHHHC	21.69	28348404
403	Phosphorylation	MKTSTVSTAHASKVQ CCCCCCCHHCHHHCC	20.37	28348404
407	Phosphorylation	TVSTAHASKVQHQTS CCCHHCHHHCCCCCC	24.40	30576142
413	Phosphorylation	ASKVQHQTSSTSPLS HHHCCCCCCCCCCCC	23.63	23898821
414	Phosphorylation	SKVQHQTSSTSPLSS HHCCCCCCCCCCCCC	25.67	23911959
415	Phosphorylation	KVQHQTSSTSPLSSP HCCCCCCCCCCCCCC	35.97	25159151
416	Phosphorylation	VQHQTSSTSPLSSPN CCCCCCCCCCCCCCC	33.84	25159151
417	Phosphorylation	QHQTSSTSPLSSPNQ CCCCCCCCCCCCCCC	26.28	25159151
420	Phosphorylation	TSSTSPLSSPNQTSS CCCCCCCCCCCCCCC	47.32	25159151
421	Phosphorylation	SSTSPLSSPNQTSSE CCCCCCCCCCCCCCC	35.24	25159151
425	Phosphorylation	PLSSPNQTSSEPRPL CCCCCCCCCCCCCCC	40.64	23663014
426	Phosphorylation	LSSPNQTSSEPRPLP CCCCCCCCCCCCCCC	23.96	23663014
427	Phosphorylation	SSPNQTSSEPRPLPA CCCCCCCCCCCCCCC	55.82	23663014
469	Phosphorylation	HNGINRDSSMTAITT CCCCCCCCCCCEEHH	20.83	28857561
470	Phosphorylation	NGINRDSSMTAITTQ CCCCCCCCCCEEHHH	25.17	28857561
472	Phosphorylation	INRDSSMTAITTQAS CCCCCCCCEEHHHHC	19.49	26471730
475	Phosphorylation	DSSMTAITTQASMEF CCCCCEEHHHHCHHH	15.47	27690223
476	O-linked_Glycosylation	SSMTAITTQASMEFR CCCCEEHHHHCHHHH	18.94	28657654
476	Phosphorylation	SSMTAITTQASMEFR CCCCEEHHHHCHHHH	18.94	24719451
479	Phosphorylation	TAITTQASMEFRRKG CEEHHHHCHHHHHCC	14.72	27690223
487	Phosphorylation	MEFRRKGSQMSTDTM HHHHHCCCCCCCCCC	26.24	28857561
490	Phosphorylation	RRKGSQMSTDTMVSN HHCCCCCCCCCCCCC	18.59	28857561
491	Phosphorylation	RKGSQMSTDTMVSNP HCCCCCCCCCCCCCC	30.10	28857561
493	Phosphorylation	GSQMSTDTMVSNPMF CCCCCCCCCCCCCCC	21.40	28857561
496	Phosphorylation	MSTDTMVSNPMFDAS CCCCCCCCCCCCCHH	25.13	30576142
503	Phosphorylation	SNPMFDASEFPDNYE CCCCCCHHHCCCCHH	41.43	30576142
519	Phosphorylation	GRAEACGTLCRIFCS HHHHHHHHHHHHHHC	23.67	-
526	Phosphorylation	TLCRIFCSKKTGEEI HHHHHHHCCCCCCCH	26.83	-
537	Phosphorylation	GEEILPAYLSRFYML CCCHHHHHHHHHHHH	11.85	22817900
608	Phosphorylation	FKSYVNPTELRRSSI HHHCCCHHHHHHHHH	42.31	24719451
642	Phosphorylation	VVLEGKFSNDDSSSY EEEEECCCCCCCCCC	42.72	28857561
646	Phosphorylation	GKFSNDDSSSYDKPI ECCCCCCCCCCCCCC	24.85	23403867
647	Phosphorylation	KFSNDDSSSYDKPIT CCCCCCCCCCCCCCC	39.65	23403867
648	Phosphorylation	FSNDDSSSYDKPITF CCCCCCCCCCCCCCH	41.10	23403867
649	Phosphorylation	SNDDSSSYDKPITFL CCCCCCCCCCCCCHH	29.90	23312004
651	Ubiquitination	DDSSSYDKPITFLSL CCCCCCCCCCCHHHH	30.04	-
654	Phosphorylation	SSYDKPITFLSLKLR CCCCCCCCHHHHHHH	27.35	23312004
657	Phosphorylation	DKPITFLSLKLRLVN CCCCCHHHHHHHHHH	21.19	23312004
714	Phosphorylation	GGENNLKSHSRTNSG CCCCCCCCCCCCCCC	29.84	23909892
716	Phosphorylation	ENNLKSHSRTNSGIS CCCCCCCCCCCCCCC	48.14	30576142
718	Phosphorylation	NLKSHSRTNSGISSA CCCCCCCCCCCCCCC	36.43	29255136
720	Phosphorylation	KSHSRTNSGISSASG CCCCCCCCCCCCCCC	36.57	23401153
723	Phosphorylation	SRTNSGISSASGGST CCCCCCCCCCCCCCC	24.31	29255136
724	Phosphorylation	RTNSGISSASGGSTE CCCCCCCCCCCCCCC	25.24	29255136
726	Phosphorylation	NSGISSASGGSTEPT CCCCCCCCCCCCCCC	45.71	29255136
729	Phosphorylation	ISSASGGSTEPTTPD CCCCCCCCCCCCCCC	32.87	30278072
730	Phosphorylation	SSASGGSTEPTTPDS CCCCCCCCCCCCCCC	49.62	30278072
733	Phosphorylation	SGGSTEPTTPDSERP CCCCCCCCCCCCCCH	44.74	23401153
734	Phosphorylation	GGSTEPTTPDSERPA CCCCCCCCCCCCCHH	35.50	30278072
737	Phosphorylation	TEPTTPDSERPAQAL CCCCCCCCCCHHHHH	36.39	23927012
748	Phosphorylation	AQALLRDYALNTDSA HHHHHHHHCCCCCCH	13.42	27642862
762	Phosphorylation	AAGLLIRSIHLVTQR HHHHHHHHHHHHHHH	13.84	28188228
767	Phosphorylation	IRSIHLVTQRLNSQW HHHHHHHHHHHHHHH	17.84	27251275
779	Phosphorylation	SQWRQDMSISLAALE HHHHHHHHHHHHHHH	19.81	20068231
781	Phosphorylation	WRQDMSISLAALELL HHHHHHHHHHHHHHH	12.49	20068231
789	Phosphorylation	LAALELLSGLAKVKV HHHHHHHHCCCCEEE	44.37	20068231
892	Phosphorylation	DKEPNPASMRVKDAA CCCCCCCHHHHHHHH	14.37	27134283
921	Phosphorylation	PSPSGPASPCSLVNE CCCCCCCCCCCCCCC	29.58	25627689
924	Phosphorylation	SGPASPCSLVNETTL CCCCCCCCCCCCCEE	38.44	-
958 (in isoform 2)	Ubiquitination	-	3.66	21906983
999	Ubiquitination	CLLPRGAKANQKLFV HCCCCCCCCCCCEEC	51.17	-
1003	Acetylation	RGAKANQKLFVPEPR CCCCCCCCEECCCCC	43.64	18586741
1003	Ubiquitination	RGAKANQKLFVPEPR CCCCCCCCEECCCCC	43.64	-
1014	Ubiquitination	PEPRPVPKNDVGFKY CCCCCCCCCCCCCEE	67.04	-
1020	Ubiquitination	PKNDVGFKYSVKHRP CCCCCCCEEEECCCC	30.59	-
1021	Phosphorylation	KNDVGFKYSVKHRPF CCCCCCEEEECCCCC	19.21	28152594
1022	Phosphorylation	NDVGFKYSVKHRPFP CCCCCEEEECCCCCC	25.86	28152594
1024	Ubiquitination	VGFKYSVKHRPFPEE CCCEEEECCCCCCHH	28.14	-
1167	Phosphorylation	FDTVFIFYMKPGQKT CCEEEEEEECCCCCC	10.22	-
1176	Ubiquitination	KPGQKTNQEILKNVE CCCCCCCHHHHHHHH	44.32	-
1176 (in isoform 3)	Ubiquitination	-	44.32	21906983
1176 (in isoform 4)	Ubiquitination	-	44.32	21906983
1180	Ubiquitination	KTNQEILKNVESSRT CCCHHHHHHHHHCCC	65.69	2190698
1180 (in isoform 1)	Ubiquitination	-	65.69	21906983
1278	Phosphorylation	SLTDSLESNISDQDS HHHHHHHHCCCCCCC	44.77	24275569
1281	Phosphorylation	DSLESNISDQDSDSN HHHHHCCCCCCCCCC	33.21	24275569
1285	Phosphorylation	SNISDQDSDSNMDLM HCCCCCCCCCCCCCC	36.99	10574462
1300	Phosphorylation	PGILKQPSLTLELFP CHHHCCCCEEEEECC	31.34	30266825
1302	Phosphorylation	ILKQPSLTLELFPNH HHCCCCEEEEECCCC	23.64	26657352
1310	Phosphorylation	LELFPNHTDNLNSSQ EEECCCCCCCCCHHC	32.97	25159151
1315	Phosphorylation	NHTDNLNSSQRLSPS CCCCCCCHHCCCCCC	30.89	23401153
1316	Phosphorylation	HTDNLNSSQRLSPSS CCCCCCHHCCCCCCH	20.46	26657352
1320	Phosphorylation	LNSSQRLSPSSRMRK CCHHCCCCCCHHHCC	25.56	25159151
1322	Phosphorylation	SSQRLSPSSRMRKLP HHCCCCCCHHHCCCC	27.48	20068231
1323	Phosphorylation	SQRLSPSSRMRKLPQ HCCCCCCHHHCCCCC	33.22	20068231
1351	Phosphorylation	SVVWVERYDDIENFP EEEEEEECCCCCCCC	12.40	-
1405	Acetylation	NTGLFRIKIQGATGK CCCEEEEEEECCCCC	25.40	12431619
1410	Phosphorylation	RIKIQGATGKFNMVI EEEEECCCCCEEEEE	47.96	-
1412	Acetylation	KIQGATGKFNMVIPL EEECCCCCEEEEEEC	29.25	12431631
1449	Phosphorylation	CRRKRLESDSYSPPH HHHHCCCCCCCCCHH	36.13	23403867
1451	Phosphorylation	RKRLESDSYSPPHVR HHCCCCCCCCCHHHC	36.47	23403867
1452	Phosphorylation	KRLESDSYSPPHVRR HCCCCCCCCCHHHCC	30.13	23403867
1453	Phosphorylation	RLESDSYSPPHVRRK CCCCCCCCCHHHCCH	35.59	23403867
1466	Ubiquitination	RKQKITDIVNKYRNK CHHHHHHHHHHHHCC	2.48	-
1469	Ubiquitination	KITDIVNKYRNKQLE HHHHHHHHHHCCCCC	34.39	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RLGPB_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RLGPB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RLGPB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RLGPB_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RLGPB_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-417 AND SER-421, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-734, AND MASSSPECTROMETRY.	19690332 [Abstract]