dbPTM

KDM3B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KDM3B_HUMAN
UniProt AC	Q7LBC6
Protein Name	Lysine-specific demethylase 3B
Gene Name	KDM3B
Organism	Homo sapiens (Human).
Sequence Length	1761
Subcellular Localization	Nucleus.
Protein Description	Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity..
Protein Sequence	MADAAASPVGKRLLLLFADTAASASASAPAAAAASGDPGPALRTRAWRAGTVRAMSGAVPQDLAIFVEFDGCNWKQHSWVKVHAEEVIVLLLEGSLVWAPREDPVLLQGIRVSIAQWPALTFTPLVDKLGLGSVVPVEYLLDRELRFLSDANGLHLFQMGTDSQNQILLEHAALRETVNALISDQKLQEIFSRGPYSVQGHRVKIYQPEGEEGWLYGVVSHQDSITRLMEVSVTESGEIKSVDPRLIHVMLMDNSAPQSEGGTLKAVKSSKGKKKRESIEGKDGRRRKSASDSGCDPASKKLKGDRGEVDSNGSDGGEASRGPWKGGNASGEPGLDQRAKQPPSTFVPQINRNIRFATYTKENGRTLVVQDEPVGGDTPASFTPYSTATGQTPLAPEVGGAENKEAGKTLEQVGQGIVASAAVVTTASSTPNTVRISDTGLAAGTVPEKQKGSRSQASGENSRNSILASSGFGAPLPSSSQPLTFGSGRSQSNGVLATENKPLGFSFGCSSAQEAQKDTDLSKNLFFQCMSQTLPTSNYFTTVSESLADDSSSRDSFKQSLESLSSGLCKGRSVLGTDTKPGSKAGSSVDRKVPAESMPTLTPAFPRSLLNARTPENHENLFLQPPKLSREEPSNPFLAFVEKVEHSPFSSFASQASGSSSSATTVTSKVAPSWPESHSSADSASLAKKKPLFITTDSSKLVSGVLGSALTSGGPSLSAMGNGRSSSPTSSLTQPIEMPTLSSSPTEERPTVGPGQQDNPLLKTFSNVFGRHSGGFLSSPADFSQENKAPFEAVKRFSLDERSLACRQDSDSSTNSDLSDLSDSEEQLQAKTGLKGIPEHLMGKLGPNGERSAELLLGKSKGKQAPKGRPRTAPLKVGQSVLKDVSKVKKLKQSGEPFLQDGSCINVAPHLHKCRECRLERYRKFKEQEQDDSTVACRFFHFRRLIFTRKGVLRVEGFLSPQQSDPDAMNLWIPSSSLAEGIDLETSKYILANVGDQFCQLVMSEKEAMMMVEPHQKVAWKRAVRGVREMCDVCETTLFNIHWVCRKCGFGVCLDCYRLRKSRPRSETEEMGDEEVFSWLKCAKGQSHEPENLMPTQIIPGTALYNIGDMVHAARGKWGIKANCPCISRQNKSVLRPAVTNGMSQLPSINPSASSGNETTFSGGGGPAPVTTPEPDHVPKADSTDIRSEEPLKTDSSASNSNSELKAIRPPCPDTAPPSSALHWLADLATQKAKEETKEAGSLRSVLNKESHSPFGLDSFNSTAKVSPLTPKLFNSLLLGPTASNNKTEGSSLRDLLHSGPGKLPQTPLDTGIPFPPVFSTSSAGVKSKASLPNFLDHIIASVVENKKTSDASKRACNLTDTQKEVKEMVMGLNVLDPHTSHSWLCDGRLLCLHDPSNKNNWKIFRECWKQGQPVLVSGVHKKLKSELWKPEAFSQEFGDQDVDLVNCRNCAIISDVKVRDFWDGFEIICKRLRSEDGQPMVLKLKDWPPGEDFRDMMPTRFEDLMENLPLPEYTKRDGRLNLASRLPSYFVRPDLGPKMYNAYGLITAEDRRVGTTNLHLDVSDAVNVMVYVGIPIGEGAHDEEVLKTIDEGDADEVTKQRIHDGKEKPGALWHIYAAKDAEKIRELLRKVGEEQGQENPPDHDPIHDQSWYLDQTLRKRLYEEYGVQGWAIVQFLGDAVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFRLTQEFRHLSNTHTNHEDKLQVKNIIYHAVKDAVGTLKAHESKLARS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADAAASPV ------CCHHHCCHH	26.84	19413330
7	Phosphorylation	-MADAAASPVGKRLL -CCHHHCCHHHHHHH	18.52	24719451
11	Ubiquitination	AAASPVGKRLLLLFA HHCCHHHHHHHHHHH	39.86	33845483
35	Phosphorylation	APAAAAASGDPGPAL HHHHHHHHCCCCHHH	38.72	22210691
51	Phosphorylation	TRAWRAGTVRAMSGA HHHHHHHCHHHHCCC	13.06	26853621
143	Methylation	PVEYLLDRELRFLSD CHHHHHHHHHHHHHC	44.83	115480733
186	Ubiquitination	NALISDQKLQEIFSR HHHHCCHHHHHHHHC	58.07	-
191 (in isoform 3)	Ubiquitination	-	3.92	21890473
200	Ubiquitination	RGPYSVQGHRVKIYQ CCCCCCCCEEEEEEC	14.38	24816145
204	Ubiquitination	SVQGHRVKIYQPEGE CCCCEEEEEECCCCC	35.34	29967540
247 (in isoform 3)	Ubiquitination	-	2.13	21890473
263	Phosphorylation	APQSEGGTLKAVKSS CCCCCCCCEEEHHCC	35.62	-
265	Ubiquitination	QSEGGTLKAVKSSKG CCCCCCEEEHHCCCC	51.47	32015554
270 (in isoform 3)	Ubiquitination	-	39.44	21890473
278	Phosphorylation	KGKKKRESIEGKDGR CCCHHHHHCCCCCCC	29.94	30242111
285 (in isoform 3)	Ubiquitination	-	45.42	21890473
289	Phosphorylation	KDGRRRKSASDSGCD CCCCCCCCCCCCCCC	31.06	29255136
291	Phosphorylation	GRRRKSASDSGCDPA CCCCCCCCCCCCCHH	39.12	29255136
293	Phosphorylation	RRKSASDSGCDPASK CCCCCCCCCCCHHHH	38.53	30576142
299	Phosphorylation	DSGCDPASKKLKGDR CCCCCHHHHCCCCCC	35.39	29396449
300	Acetylation	SGCDPASKKLKGDRG CCCCHHHHCCCCCCC	65.32	25953088
301 (in isoform 3)	Ubiquitination	-	53.59	21890473
311	Phosphorylation	GDRGEVDSNGSDGGE CCCCCCCCCCCCCCC	48.55	20363803
314	Phosphorylation	GEVDSNGSDGGEASR CCCCCCCCCCCCCCC	37.01	23401153
320	Phosphorylation	GSDGGEASRGPWKGG CCCCCCCCCCCCCCC	33.21	20363803
325	Acetylation	EASRGPWKGGNASGE CCCCCCCCCCCCCCC	61.14	26051181
325	Ubiquitination	EASRGPWKGGNASGE CCCCCCCCCCCCCCC	61.14	29967540
325 (in isoform 3)	Ubiquitination	-	61.14	21890473
330	Phosphorylation	PWKGGNASGEPGLDQ CCCCCCCCCCCCCCH	47.92	28985074
335	Ubiquitination	NASGEPGLDQRAKQP CCCCCCCCCHHHCCC	8.09	24816145
343	Ubiquitination	DQRAKQPPSTFVPQI CHHHCCCCCCCHHHC	43.43	24816145
344	Phosphorylation	QRAKQPPSTFVPQIN HHHCCCCCCCHHHCC	40.95	29978859
345	Phosphorylation	RAKQPPSTFVPQINR HHCCCCCCCHHHCCC	34.13	29978859
355	Methylation	PQINRNIRFATYTKE HHCCCCEEEEEEECC	20.78	54556919
358	Phosphorylation	NRNIRFATYTKENGR CCCEEEEEEECCCCC	29.07	29978859
359	Phosphorylation	RNIRFATYTKENGRT CCEEEEEEECCCCCE	16.63	29978859
360	Phosphorylation	NIRFATYTKENGRTL CEEEEEEECCCCCEE	27.77	29978859
361	Acetylation	IRFATYTKENGRTLV EEEEEEECCCCCEEE	38.48	19608861
366	O-linked_Glycosylation	YTKENGRTLVVQDEP EECCCCCEEEEECCC	25.88	30059200
378	Phosphorylation	DEPVGGDTPASFTPY CCCCCCCCCCCCCCC	24.83	-
381	O-linked_Glycosylation	VGGDTPASFTPYSTA CCCCCCCCCCCCCCC	30.75	30059200
383	Phosphorylation	GDTPASFTPYSTATG CCCCCCCCCCCCCCC	20.87	-
384	Ubiquitination	DTPASFTPYSTATGQ CCCCCCCCCCCCCCC	21.04	24816145
386	O-linked_Glycosylation	PASFTPYSTATGQTP CCCCCCCCCCCCCCC	16.87	30059200
392	Ubiquitination	YSTATGQTPLAPEVG CCCCCCCCCCCCCCC	22.93	24816145
401	Ubiquitination	LAPEVGGAENKEAGK CCCCCCCCCCHHHCC	15.97	24816145
405	Ubiquitination	VGGAENKEAGKTLEQ CCCCCCHHHCCCHHH	74.39	24816145
409	O-linked_Glycosylation	ENKEAGKTLEQVGQG CCHHHCCCHHHHCCH	34.31	30059200
420	O-linked_Glycosylation	VGQGIVASAAVVTTA HCCHHHEEEEEEEEC	13.08	30059200
425	O-linked_Glycosylation	VASAAVVTTASSTPN HEEEEEEEECCCCCC	15.28	30059200
426	O-linked_Glycosylation	ASAAVVTTASSTPNT EEEEEEEECCCCCCE	16.97	30059200
428	O-linked_Glycosylation	AAVVTTASSTPNTVR EEEEEECCCCCCEEE	32.43	30059200
429	O-linked_Glycosylation	AVVTTASSTPNTVRI EEEEECCCCCCEEEE	45.48	30059200
433	O-linked_Glycosylation	TASSTPNTVRISDTG ECCCCCCEEEECCCC	16.62	30059200
437	Phosphorylation	TPNTVRISDTGLAAG CCCEEEECCCCCCCC	20.68	24667141
439	Phosphorylation	NTVRISDTGLAAGTV CEEEECCCCCCCCCC	27.57	24667141
445	Phosphorylation	DTGLAAGTVPEKQKG CCCCCCCCCCCCCCC	28.32	28555341
449	Acetylation	AAGTVPEKQKGSRSQ CCCCCCCCCCCCCCC	51.76	23236377
449	Ubiquitination	AAGTVPEKQKGSRSQ CCCCCCCCCCCCCCC	51.76	33845483
455	Phosphorylation	EKQKGSRSQASGENS CCCCCCCCCCCCCCH	31.62	23186163
458	Phosphorylation	KGSRSQASGENSRNS CCCCCCCCCCCHHHH	38.72	23186163
462	Phosphorylation	SQASGENSRNSILAS CCCCCCCHHHHHHHC	28.65	23186163
465	Phosphorylation	SGENSRNSILASSGF CCCCHHHHHHHCCCC	20.19	23186163
469	O-linked_Glycosylation	SRNSILASSGFGAPL HHHHHHHCCCCCCCC	27.78	30059200
469	Phosphorylation	SRNSILASSGFGAPL HHHHHHHCCCCCCCC	27.78	23186163
470	O-linked_Glycosylation	RNSILASSGFGAPLP HHHHHHCCCCCCCCC	32.31	30059200
470	Phosphorylation	RNSILASSGFGAPLP HHHHHHCCCCCCCCC	32.31	23186163
478	Phosphorylation	GFGAPLPSSSQPLTF CCCCCCCCCCCCCCC	50.75	29523821
479	Phosphorylation	FGAPLPSSSQPLTFG CCCCCCCCCCCCCCC	30.93	29523821
480	O-linked_Glycosylation	GAPLPSSSQPLTFGS CCCCCCCCCCCCCCC	39.91	30059200
480	Phosphorylation	GAPLPSSSQPLTFGS CCCCCCCCCCCCCCC	39.91	27050516
484	Phosphorylation	PSSSQPLTFGSGRSQ CCCCCCCCCCCCCCC	32.41	29523821
487	Phosphorylation	SQPLTFGSGRSQSNG CCCCCCCCCCCCCCC	27.17	29523821
490	Phosphorylation	LTFGSGRSQSNGVLA CCCCCCCCCCCCEEE	41.30	23186163
492	Phosphorylation	FGSGRSQSNGVLATE CCCCCCCCCCEEEEC	36.48	23917254
501	Acetylation	GVLATENKPLGFSFG CEEEECCCCCCEECC	35.07	23954790
506	Phosphorylation	ENKPLGFSFGCSSAQ CCCCCCEECCCCCHH	20.94	23186163
514 (in isoform 3)	Ubiquitination	-	53.43	21890473
531	Phosphorylation	NLFFQCMSQTLPTSN HHHHHHHHCCCCCCC	27.86	23090842
533	Phosphorylation	FFQCMSQTLPTSNYF HHHHHHCCCCCCCCE	27.65	23090842
536	Phosphorylation	CMSQTLPTSNYFTTV HHHCCCCCCCCEEEH	32.49	23090842
536	Ubiquitination	CMSQTLPTSNYFTTV HHHCCCCCCCCEEEH	32.49	24816145
537	Phosphorylation	MSQTLPTSNYFTTVS HHCCCCCCCCEEEHH	27.82	23090842
539	Phosphorylation	QTLPTSNYFTTVSES CCCCCCCCEEEHHHH	11.32	23090842
540	Ubiquitination	TLPTSNYFTTVSESL CCCCCCCEEEHHHHH	5.59	24816145
541	Phosphorylation	LPTSNYFTTVSESLA CCCCCCEEEHHHHHC	18.87	23090842
542	Phosphorylation	PTSNYFTTVSESLAD CCCCCEEEHHHHHCC	16.49	23090842
544	Phosphorylation	SNYFTTVSESLADDS CCCEEEHHHHHCCCC	21.26	23090842
544	Ubiquitination	SNYFTTVSESLADDS CCCEEEHHHHHCCCC	21.26	24816145
546	Phosphorylation	YFTTVSESLADDSSS CEEEHHHHHCCCCCC	22.73	23090842
548	Ubiquitination	TTVSESLADDSSSRD EEHHHHHCCCCCCHH	28.04	24816145
551	Phosphorylation	SESLADDSSSRDSFK HHHHCCCCCCHHHHH	30.66	28450419
552	Phosphorylation	ESLADDSSSRDSFKQ HHHCCCCCCHHHHHH	36.07	28450419
553	Phosphorylation	SLADDSSSRDSFKQS HHCCCCCCHHHHHHH	44.02	28450419
556	Phosphorylation	DDSSSRDSFKQSLES CCCCCHHHHHHHHHH	32.98	28450419
558	Ubiquitination	SSSRDSFKQSLESLS CCCHHHHHHHHHHHH	42.82	32015554
560	Phosphorylation	SRDSFKQSLESLSSG CHHHHHHHHHHHHCC	34.39	29214152
563	Phosphorylation	SFKQSLESLSSGLCK HHHHHHHHHHCCCCC	38.55	25159151
565	Phosphorylation	KQSLESLSSGLCKGR HHHHHHHHCCCCCCC	31.47	25627689
566	Phosphorylation	QSLESLSSGLCKGRS HHHHHHHCCCCCCCC	40.87	28555341
570	Acetylation	SLSSGLCKGRSVLGT HHHCCCCCCCCCCCC	63.50	25953088
570	Ubiquitination	SLSSGLCKGRSVLGT HHHCCCCCCCCCCCC	63.50	32015554
573	Phosphorylation	SGLCKGRSVLGTDTK CCCCCCCCCCCCCCC	30.29	23312004
577	Phosphorylation	KGRSVLGTDTKPGSK CCCCCCCCCCCCCCC	36.01	28555341
579	Phosphorylation	RSVLGTDTKPGSKAG CCCCCCCCCCCCCCC	38.69	-
580	Acetylation	SVLGTDTKPGSKAGS CCCCCCCCCCCCCCC	50.63	25953088
580	Ubiquitination	SVLGTDTKPGSKAGS CCCCCCCCCCCCCCC	50.63	33845483
583	Phosphorylation	GTDTKPGSKAGSSVD CCCCCCCCCCCCCCC	28.05	28674419
584	Ubiquitination	TDTKPGSKAGSSVDR CCCCCCCCCCCCCCC	63.78	32015554
588	Phosphorylation	PGSKAGSSVDRKVPA CCCCCCCCCCCCCCH	27.41	-
592	Sumoylation	AGSSVDRKVPAESMP CCCCCCCCCCHHHCC	48.37	-
592	Sumoylation	AGSSVDRKVPAESMP CCCCCCCCCCHHHCC	48.37	-
592	Ubiquitination	AGSSVDRKVPAESMP CCCCCCCCCCHHHCC	48.37	24816145
597	Phosphorylation	DRKVPAESMPTLTPA CCCCCHHHCCCCCCC	31.97	26074081
598 (in isoform 3)	Ubiquitination	-	1.90	21890473
600	Phosphorylation	VPAESMPTLTPAFPR CCHHHCCCCCCCCCH	34.32	26074081
602	Phosphorylation	AESMPTLTPAFPRSL HHHCCCCCCCCCHHH	18.30	26074081
608	Phosphorylation	LTPAFPRSLLNARTP CCCCCCHHHHCCCCC	37.13	28450419
612	Ubiquitination	FPRSLLNARTPENHE CCHHHHCCCCCCCCC	19.38	24816145
614	Phosphorylation	RSLLNARTPENHENL HHHHCCCCCCCCCCC	32.32	30266825
629	Phosphorylation	FLQPPKLSREEPSNP CCCCCCCCCCCCCCC	43.71	28674419
647	O-linked_Glycosylation	FVEKVEHSPFSSFAS HHEEECCCCCHHHCH	17.71	30059200
647	Phosphorylation	FVEKVEHSPFSSFAS HHEEECCCCCHHHCH	17.71	18669648
650	Phosphorylation	KVEHSPFSSFASQAS EECCCCCHHHCHHCC	28.12	21712546
651	O-linked_Glycosylation	VEHSPFSSFASQASG ECCCCCHHHCHHCCC	25.80	30059200
651	Phosphorylation	VEHSPFSSFASQASG ECCCCCHHHCHHCCC	25.80	28348404
654	O-linked_Glycosylation	SPFSSFASQASGSSS CCCHHHCHHCCCCCC	25.03	30059200
654	Phosphorylation	SPFSSFASQASGSSS CCCHHHCHHCCCCCC	25.03	18669648
657	O-linked_Glycosylation	SSFASQASGSSSSAT HHHCHHCCCCCCCCC	31.41	30059200
659	O-linked_Glycosylation	FASQASGSSSSATTV HCHHCCCCCCCCCEE	25.26	30059200
660	O-linked_Glycosylation	ASQASGSSSSATTVT CHHCCCCCCCCCEEC	31.66	30059200
661	O-linked_Glycosylation	SQASGSSSSATTVTS HHCCCCCCCCCEECC	26.20	30059200
661	Ubiquitination	SQASGSSSSATTVTS HHCCCCCCCCCEECC	26.20	24816145
668	O-linked_Glycosylation	SSATTVTSKVAPSWP CCCCEECCCCCCCCC	22.31	30059200
675	Ubiquitination	SKVAPSWPESHSSAD CCCCCCCCCCCCCCC	37.23	24816145
679	O-linked_Glycosylation	PSWPESHSSADSASL CCCCCCCCCCCHHHH	36.18	30059200
679	Phosphorylation	PSWPESHSSADSASL CCCCCCCCCCCHHHH	36.18	28555341
680	Phosphorylation	SWPESHSSADSASLA CCCCCCCCCCHHHHH	30.58	25627689
683	Phosphorylation	ESHSSADSASLAKKK CCCCCCCHHHHHHCC	21.34	28555341
685	Phosphorylation	HSSADSASLAKKKPL CCCCCHHHHHHCCCE	32.58	26546556
688	Acetylation	ADSASLAKKKPLFIT CCHHHHHHCCCEEEE	67.62	25953088
688	Ubiquitination	ADSASLAKKKPLFIT CCHHHHHHCCCEEEE	67.62	29967540
689	Ubiquitination	DSASLAKKKPLFITT CHHHHHHCCCEEEEC	54.75	29967540
690	Ubiquitination	SASLAKKKPLFITTD HHHHHHCCCEEEECC	46.37	29967540
696	O-linked_Glycosylation	KKPLFITTDSSKLVS CCCEEEECCHHHHHH	29.12	30059200
696	Phosphorylation	KKPLFITTDSSKLVS CCCEEEECCHHHHHH	29.12	29116813
698	Phosphorylation	PLFITTDSSKLVSGV CEEEECCHHHHHHHH	27.55	29116813
699	Phosphorylation	LFITTDSSKLVSGVL EEEECCHHHHHHHHH	32.58	29116813
703	Phosphorylation	TDSSKLVSGVLGSAL CCHHHHHHHHHHHHH	33.35	24275569
708	Phosphorylation	LVSGVLGSALTSGGP HHHHHHHHHHCCCCC	18.88	-
711	Phosphorylation	GVLGSALTSGGPSLS HHHHHHHCCCCCCHH	25.66	29116813
716	Phosphorylation	ALTSGGPSLSAMGNG HHCCCCCCHHHCCCC	37.93	29116813
718	Phosphorylation	TSGGPSLSAMGNGRS CCCCCCHHHCCCCCC	22.13	29116813
724	Ubiquitination	LSAMGNGRSSSPTSS HHHCCCCCCCCCCCC	37.05	24816145
725	Phosphorylation	SAMGNGRSSSPTSSL HHCCCCCCCCCCCCC	36.24	26503892
726	Phosphorylation	AMGNGRSSSPTSSLT HCCCCCCCCCCCCCC	38.69	30278072
727	Phosphorylation	MGNGRSSSPTSSLTQ CCCCCCCCCCCCCCC	33.18	23401153
729	Phosphorylation	NGRSSSPTSSLTQPI CCCCCCCCCCCCCCC	32.66	30278072
730	Phosphorylation	GRSSSPTSSLTQPIE CCCCCCCCCCCCCCC	27.08	30278072
731	Phosphorylation	RSSSPTSSLTQPIEM CCCCCCCCCCCCCCC	37.60	30278072
733	Phosphorylation	SSPTSSLTQPIEMPT CCCCCCCCCCCCCCC	33.96	30278072
740	Phosphorylation	TQPIEMPTLSSSPTE CCCCCCCCCCCCCCC	37.65	26503892
742	Phosphorylation	PIEMPTLSSSPTEER CCCCCCCCCCCCCCC	31.11	30278072
743	Phosphorylation	IEMPTLSSSPTEERP CCCCCCCCCCCCCCC	43.37	30278072
744	Phosphorylation	EMPTLSSSPTEERPT CCCCCCCCCCCCCCC	32.25	30278072
746	Phosphorylation	PTLSSSPTEERPTVG CCCCCCCCCCCCCCC	53.04	30278072
751	Phosphorylation	SPTEERPTVGPGQQD CCCCCCCCCCCCCCC	44.29	21955146
764	Phosphorylation	QDNPLLKTFSNVFGR CCCHHHHHHHHHHCC	32.06	28450419
766	Phosphorylation	NPLLKTFSNVFGRHS CHHHHHHHHHHCCCC	37.00	28348404
771	Methylation	TFSNVFGRHSGGFLS HHHHHHCCCCCCCCC	14.88	115480739
773	Phosphorylation	SNVFGRHSGGFLSSP HHHHCCCCCCCCCCC	38.97	23401153
778	Phosphorylation	RHSGGFLSSPADFSQ CCCCCCCCCCCCCCC	31.82	29255136
779	Phosphorylation	HSGGFLSSPADFSQE CCCCCCCCCCCCCCC	26.67	29255136
784	Phosphorylation	LSSPADFSQENKAPF CCCCCCCCCCCCCCH	36.81	23403867
788	Sumoylation	ADFSQENKAPFEAVK CCCCCCCCCCHHHHH	57.60	-
788	Sumoylation	ADFSQENKAPFEAVK CCCCCCCCCCHHHHH	57.60	28112733
788	Ubiquitination	ADFSQENKAPFEAVK CCCCCCCCCCHHHHH	57.60	32015554
795	Acetylation	KAPFEAVKRFSLDER CCCHHHHHHCCCCHH	55.57	23749302
795	Ubiquitination	KAPFEAVKRFSLDER CCCHHHHHHCCCCHH	55.57	29967540
798	Phosphorylation	FEAVKRFSLDERSLA HHHHHHCCCCHHHHH	38.66	28176443
803	Phosphorylation	RFSLDERSLACRQDS HCCCCHHHHHHCCCC	20.47	20068231
810	Phosphorylation	SLACRQDSDSSTNSD HHHHCCCCCCCCCCC	30.93	25137130
812	Phosphorylation	ACRQDSDSSTNSDLS HHCCCCCCCCCCCHH	42.91	25137130
813	Phosphorylation	CRQDSDSSTNSDLSD HCCCCCCCCCCCHHH	36.28	25137130
813	Ubiquitination	CRQDSDSSTNSDLSD HCCCCCCCCCCCHHH	36.28	24816145
814	Phosphorylation	RQDSDSSTNSDLSDL CCCCCCCCCCCHHHC	42.57	25137130
816	Phosphorylation	DSDSSTNSDLSDLSD CCCCCCCCCHHHCCC	39.76	25137130
817	Ubiquitination	SDSSTNSDLSDLSDS CCCCCCCCHHHCCCC	52.87	24816145
819	Phosphorylation	SSTNSDLSDLSDSEE CCCCCCHHHCCCCHH	41.31	25137130
822	Phosphorylation	NSDLSDLSDSEEQLQ CCCHHHCCCCHHHHH	44.04	25137130
824	Phosphorylation	DLSDLSDSEEQLQAK CHHHCCCCHHHHHHH	39.39	20068231
832	Phosphorylation	EEQLQAKTGLKGIPE HHHHHHHHCCCCCCH	51.25	20068231
835	Ubiquitination	LQAKTGLKGIPEHLM HHHHHCCCCCCHHHC	57.02	29967540
844	Acetylation	IPEHLMGKLGPNGER CCHHHCCCCCCCCHH	35.98	25953088
844	Ubiquitination	IPEHLMGKLGPNGER CCHHHCCCCCCCCHH	35.98	29967540
849 (in isoform 2)	Ubiquitination	-	34.52	21890473
852	Phosphorylation	LGPNGERSAELLLGK CCCCCHHHHHHHCCC	23.07	28674419
859	Acetylation	SAELLLGKSKGKQAP HHHHHCCCCCCCCCC	49.30	25953088
859	Ubiquitination	SAELLLGKSKGKQAP HHHHHCCCCCCCCCC	49.30	32015554
861	Ubiquitination	ELLLGKSKGKQAPKG HHHCCCCCCCCCCCC	73.87	24816145
876	Acetylation	RPRTAPLKVGQSVLK CCCCCCCCCCHHHHH	43.17	25953088
876	Ubiquitination	RPRTAPLKVGQSVLK CCCCCCCCCCHHHHH	43.17	33845483
880	Ubiquitination	APLKVGQSVLKDVSK CCCCCCHHHHHCHHH	24.40	24816145
883	Ubiquitination	KVGQSVLKDVSKVKK CCCHHHHHCHHHHHH	54.66	29967540
892	Ubiquitination	VSKVKKLKQSGEPFL HHHHHHHHHCCCCCC	51.83	29967540
903	Phosphorylation	EPFLQDGSCINVAPH CCCCCCCCCEECCCC	21.80	27080861
905 (in isoform 2)	Ubiquitination	-	5.07	21890473
913	Ubiquitination	NVAPHLHKCRECRLE ECCCCCHHHHHHHHH	41.15	32015554
924	Ubiquitination	CRLERYRKFKEQEQD HHHHHHHHHHHHHCC	52.43	24816145
926	Methylation	LERYRKFKEQEQDDS HHHHHHHHHHHCCCC	62.62	115971585
926	Ubiquitination	LERYRKFKEQEQDDS HHHHHHHHHHHCCCC	62.62	33845483
928 (in isoform 2)	Ubiquitination	-	55.00	21890473
943 (in isoform 2)	Ubiquitination	-	24.75	21890473
944	Ubiquitination	CRFFHFRRLIFTRKG HHHHHHHHHCCCCCC	31.06	22817900
959 (in isoform 2)	Ubiquitination	-	12.27	21890473
975	Phosphorylation	AMNLWIPSSSLAEGI HHHCCCCCHHHHCCC	24.35	26552605
976	Phosphorylation	MNLWIPSSSLAEGID HHCCCCCHHHHCCCC	24.82	26552605
977	Phosphorylation	NLWIPSSSLAEGIDL HCCCCCHHHHCCCCH	35.62	26552605
983 (in isoform 2)	Ubiquitination	-	49.67	21890473
986	Phosphorylation	AEGIDLETSKYILAN HCCCCHHHHCCHHHH	37.50	26552605
987	Phosphorylation	EGIDLETSKYILANV CCCCHHHHCCHHHHC	17.68	26552605
989	Phosphorylation	IDLETSKYILANVGD CCHHHHCCHHHHCHH	10.84	26552605
993	Ubiquitination	TSKYILANVGDQFCQ HHCCHHHHCHHHHHH	34.55	22817900
1000	Ubiquitination	NVGDQFCQLVMSEKE HCHHHHHHHHHCHHH	38.08	21890473
1004	Phosphorylation	QFCQLVMSEKEAMMM HHHHHHHCHHHHHHH	37.73	24719451
1023	Ubiquitination	QKVAWKRAVRGVREM HHHHHHHHHHHHHHH	7.51	21890473
1038	Ubiquitination	CDVCETTLFNIHWVC HHHHHHHHHEHHHHH	3.95	22817900
1049	Ubiquitination	HWVCRKCGFGVCLDC HHHHHHCCCEEHHHH	25.94	21890473
1054	Ubiquitination	KCGFGVCLDCYRLRK HCCCEEHHHHHHHHC	4.78	22817900
1072	Ubiquitination	RSETEEMGDEEVFSW CCCCCCCCCHHHHHH	42.32	21890473
1078	Ubiquitination	MGDEEVFSWLKCAKG CCCHHHHHHHHHHCC	36.35	22817900
1080	Ubiquitination	DEEVFSWLKCAKGQS CHHHHHHHHHHCCCC	2.94	22817900
1081	Ubiquitination	EEVFSWLKCAKGQSH HHHHHHHHHHCCCCC	26.36	32015554
1087	Ubiquitination	LKCAKGQSHEPENLM HHHHCCCCCCCCCCC	38.19	22817900
1103	Ubiquitination	TQIIPGTALYNIGDM CCCCCCCEEEEHHHH	17.60	22817900
1121	Ubiquitination	ARGKWGIKANCPCIS HCCCCCCCCCCCCCC	29.61	32015554
1127	Ubiquitination	IKANCPCISRQNKSV CCCCCCCCCCCCCCC	1.99	22817900
1129	Ubiquitination	ANCPCISRQNKSVLR CCCCCCCCCCCCCCC	24.95	22817900
1145	Ubiquitination	AVTNGMSQLPSINPS HCCCCCCCCCCCCCC	48.80	22817900
1149	Ubiquitination	GMSQLPSINPSASSG CCCCCCCCCCCCCCC	9.20	22817900
1154	Phosphorylation	PSINPSASSGNETTF CCCCCCCCCCCCCCC	43.02	24247654
1171	Phosphorylation	GGGPAPVTTPEPDHV CCCCCCCCCCCCCCC	35.26	24247654
1172	Phosphorylation	GGPAPVTTPEPDHVP CCCCCCCCCCCCCCC	26.37	27251275
1172 (in isoform 2)	Ubiquitination	-	26.37	21890473
1193	Ubiquitination	IRSEEPLKTDSSASN CCCCCCCCCCCCCCC	62.09	22817900
1193 (in isoform 1)	Ubiquitination	-	62.09	21890473
1194	Phosphorylation	RSEEPLKTDSSASNS CCCCCCCCCCCCCCC	49.12	-
1196	Phosphorylation	EEPLKTDSSASNSNS CCCCCCCCCCCCCCH	32.79	-
1197	Phosphorylation	EPLKTDSSASNSNSE CCCCCCCCCCCCCHH	38.23	-
1199	Phosphorylation	LKTDSSASNSNSELK CCCCCCCCCCCHHHE	42.62	29396449
1201	Phosphorylation	TDSSASNSNSELKAI CCCCCCCCCHHHEEC	38.96	28985074
1201	Ubiquitination	TDSSASNSNSELKAI CCCCCCCCCHHHEEC	38.96	21890473
1203	Phosphorylation	SSASNSNSELKAIRP CCCCCCCHHHEECCC	44.09	29396449
1205	Ubiquitination	ASNSNSELKAIRPPC CCCCCHHHEECCCCC	4.57	21890473
1206	Ubiquitination	SNSNSELKAIRPPCP CCCCHHHEECCCCCC	37.40	29967540
1224	Ubiquitination	PPSSALHWLADLATQ CCHHHHHHHHHHHHH	8.29	21890473
1228	Ubiquitination	ALHWLADLATQKAKE HHHHHHHHHHHHHHH	4.64	21890473
1232	Ubiquitination	LADLATQKAKEETKE HHHHHHHHHHHHHHH	58.01	32015554
1239	Ubiquitination	KAKEETKEAGSLRSV HHHHHHHHHHHHHHH	66.73	22817900
1243	Ubiquitination	ETKEAGSLRSVLNKE HHHHHHHHHHHHCCC	4.65	22817900
1245	Phosphorylation	KEAGSLRSVLNKESH HHHHHHHHHHCCCCC	35.93	21712546
1249	Ubiquitination	SLRSVLNKESHSPFG HHHHHHCCCCCCCCC	57.33	22817900
1249 (in isoform 1)	Ubiquitination	-	57.33	21890473
1251	Phosphorylation	RSVLNKESHSPFGLD HHHHCCCCCCCCCCC	30.76	30266825
1253	Phosphorylation	VLNKESHSPFGLDSF HHCCCCCCCCCCCCC	31.07	30266825
1255	Ubiquitination	NKESHSPFGLDSFNS CCCCCCCCCCCCCCC	19.91	22817900
1256 (in isoform 2)	Ubiquitination	-	31.77	21890473
1259	Phosphorylation	HSPFGLDSFNSTAKV CCCCCCCCCCCCCCC	31.22	23401153
1259	Ubiquitination	HSPFGLDSFNSTAKV CCCCCCCCCCCCCCC	31.22	22817900
1262	Phosphorylation	FGLDSFNSTAKVSPL CCCCCCCCCCCCCCC	27.94	20068231
1263	Phosphorylation	GLDSFNSTAKVSPLT CCCCCCCCCCCCCCC	31.44	25159151
1265	Ubiquitination	DSFNSTAKVSPLTPK CCCCCCCCCCCCCHH	43.25	32015554
1267	Phosphorylation	FNSTAKVSPLTPKLF CCCCCCCCCCCHHHH	17.31	25159151
1267	Ubiquitination	FNSTAKVSPLTPKLF CCCCCCCCCCCHHHH	17.31	21963094
1270	Phosphorylation	TAKVSPLTPKLFNSL CCCCCCCCHHHHHHH	23.04	25159151
1272	Ubiquitination	KVSPLTPKLFNSLLL CCCCCCHHHHHHHHC	61.55	23000965
1272 (in isoform 1)	Ubiquitination	-	61.55	21890473
1276	Phosphorylation	LTPKLFNSLLLGPTA CCHHHHHHHHCCCCC	17.04	29396449
1279	Ubiquitination	KLFNSLLLGPTASNN HHHHHHHCCCCCCCC	10.54	22817900
1281	Ubiquitination	FNSLLLGPTASNNKT HHHHHCCCCCCCCCC	25.43	22817900
1282	Phosphorylation	NSLLLGPTASNNKTE HHHHCCCCCCCCCCC	40.70	21406692
1283	Ubiquitination	SLLLGPTASNNKTEG HHHCCCCCCCCCCCC	17.25	22817900
1284	Phosphorylation	LLLGPTASNNKTEGS HHCCCCCCCCCCCCC	43.33	25159151
1285	Ubiquitination	LLGPTASNNKTEGSS HCCCCCCCCCCCCCC	52.10	22817900
1287	Ubiquitination	GPTASNNKTEGSSLR CCCCCCCCCCCCCHH	52.80	21906983
1287 (in isoform 1)	Ubiquitination	-	52.80	21890473
1288	Phosphorylation	PTASNNKTEGSSLRD CCCCCCCCCCCCHHH	47.94	21712546
1291	Phosphorylation	SNNKTEGSSLRDLLH CCCCCCCCCHHHHHH	21.70	28555341
1292	Phosphorylation	NNKTEGSSLRDLLHS CCCCCCCCHHHHHHC	37.98	28555341
1299	Phosphorylation	SLRDLLHSGPGKLPQ CHHHHHHCCCCCCCC	46.80	28674419
1303	Ubiquitination	LLHSGPGKLPQTPLD HHHCCCCCCCCCCCC	61.19	21906983
1303 (in isoform 1)	Ubiquitination	-	61.19	21890473
1307	Phosphorylation	GPGKLPQTPLDTGIP CCCCCCCCCCCCCCC	24.71	27273156
1311	Phosphorylation	LPQTPLDTGIPFPPV CCCCCCCCCCCCCCC	44.70	25394399
1316	Ubiquitination	LDTGIPFPPVFSTSS CCCCCCCCCCCCCCC	20.84	21963094
1320	Phosphorylation	IPFPPVFSTSSAGVK CCCCCCCCCCCCCCC	27.84	25627689
1321	Phosphorylation	PFPPVFSTSSAGVKS CCCCCCCCCCCCCCC	18.42	25627689
1322	Phosphorylation	FPPVFSTSSAGVKSK CCCCCCCCCCCCCCC	19.59	25627689
1323	Phosphorylation	PPVFSTSSAGVKSKA CCCCCCCCCCCCCCC	29.18	25627689
1327	Ubiquitination	STSSAGVKSKASLPN CCCCCCCCCCCCCCC	45.37	21906983
1327 (in isoform 1)	Ubiquitination	-	45.37	21890473
1328	Phosphorylation	TSSAGVKSKASLPNF CCCCCCCCCCCCCCH	30.92	28450419
1329	Ubiquitination	SSAGVKSKASLPNFL CCCCCCCCCCCCCHH	35.96	22817900
1331	Phosphorylation	AGVKSKASLPNFLDH CCCCCCCCCCCHHHH	48.36	28450419
1347	Ubiquitination	IASVVENKKTSDASK HHHHHHCCCCCHHHH	43.87	33845483
1348	Ubiquitination	ASVVENKKTSDASKR HHHHHCCCCCHHHHH	65.92	-
1351	Ubiquitination	VENKKTSDASKRACN HHCCCCCHHHHHHCC	61.16	22817900
1354	Ubiquitination	KKTSDASKRACNLTD CCCCHHHHHHCCCCH	45.82	29967540
1364	Ubiquitination	CNLTDTQKEVKEMVM CCCCHHHHHHHHHHH	67.57	32015554
1399	Ubiquitination	CLHDPSNKNNWKIFR EECCCCCCCCHHHHH	56.87	32015554
1400	Ubiquitination	LHDPSNKNNWKIFRE ECCCCCCCCHHHHHH	64.94	22817900
1403	Ubiquitination	PSNKNNWKIFRECWK CCCCCCHHHHHHHHH	33.81	-
1410	Ubiquitination	KIFRECWKQGQPVLV HHHHHHHHCCCCEEE	57.09	29967540
1422	Ubiquitination	VLVSGVHKKLKSELW EEEECHHHHHHHHHC	58.35	32015554
1423	Ubiquitination	LVSGVHKKLKSELWK EEECHHHHHHHHHCC	46.39	29967540
1425	Ubiquitination	SGVHKKLKSELWKPE ECHHHHHHHHHCCHH	51.25	29967540
1430	Ubiquitination	KLKSELWKPEAFSQE HHHHHHCCHHHHHHH	45.67	29967540
1458	Ubiquitination	CAIISDVKVRDFWDG CEEEECCEEECCCCC	36.22	33845483
1468	Ubiquitination	DFWDGFEIICKRLRS CCCCCEEHHHHHHHC	4.12	21963094
1471	Ubiquitination	DGFEIICKRLRSEDG CCEEHHHHHHHCCCC	44.02	32015554
1472	Ubiquitination	GFEIICKRLRSEDGQ CEEHHHHHHHCCCCC	30.81	21963094
1484	Ubiquitination	DGQPMVLKLKDWPPG CCCCCEEEECCCCCC	41.92	29967540
1486	Ubiquitination	QPMVLKLKDWPPGED CCCEEEECCCCCCCC	57.04	29967540
1516	Ubiquitination	LPLPEYTKRDGRLNL CCCCCCCCCCCCCCH	47.81	21906983
1516 (in isoform 1)	Ubiquitination	-	47.81	21890473
1541	Phosphorylation	PDLGPKMYNAYGLIT CCCCCCHHCCCEEEE	11.63	22817900
1544	Phosphorylation	GPKMYNAYGLITAED CCCHHCCCEEEEHHH	14.61	-
1552	Ubiquitination	GLITAEDRRVGTTNL EEEEHHHCCCCCCEE	27.04	22817900
1556	Ubiquitination	AEDRRVGTTNLHLDV HHHCCCCCCEEECCH	15.06	22817900
1600	Ubiquitination	GDADEVTKQRIHDGK CCHHHHHHHHCCCCC	42.63	22817900
1600 (in isoform 1)	Ubiquitination	-	42.63	21890473
1607	Ubiquitination	KQRIHDGKEKPGALW HHHCCCCCCCCCCEE	69.49	29967540
1609	Ubiquitination	RIHDGKEKPGALWHI HCCCCCCCCCCEEEE	52.84	29967540
1620	Ubiquitination	LWHIYAAKDAEKIRE EEEEEECCCHHHHHH	49.66	-
1631	Ubiquitination	KIRELLRKVGEEQGQ HHHHHHHHHHHHCCC	55.34	29967540
1706	Phosphorylation	KVAEDFVSPEHVKHC HHHHCCCCHHHHHHH	25.27	25850435
1711	Ubiquitination	FVSPEHVKHCFRLTQ CCCHHHHHHHHHHHH	36.24	-
1733	Ubiquitination	THTNHEDKLQVKNII CCCCCCHHHHHHHHH	37.52	29967540
1752	"N6,N6-dimethyllysine"	KDAVGTLKAHESKLA HHHHHHHHHHHHHHH	47.76	-
1752	Methylation	KDAVGTLKAHESKLA HHHHHHHHHHHHHHH	47.76	-
1752	Ubiquitination	KDAVGTLKAHESKLA HHHHHHHHHHHHHHH	47.76	29967540
1757	Ubiquitination	TLKAHESKLARS--- HHHHHHHHHHCC---	43.09	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KDM3B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KDM3B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KDM3B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
H31T_HUMAN	HIST3H3	physical	22615488
CBP_HUMAN	CREBBP	physical	22615488
SRP68_HUMAN	SRP68	physical	22863883
DEP1A_HUMAN	DEPDC1	physical	26496610
LMNB2_HUMAN	LMNB2	physical	26496610

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KDM3B_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-361, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-766, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-773 AND SER-779, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-798, AND MASSSPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-291, AND MASSSPECTROMETRY.	15302935 [Abstract]