dbPTM

LMNB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LMNB2_HUMAN
UniProt AC	Q03252
Protein Name	Lamin-B2
Gene Name	LMNB2
Organism	Homo sapiens (Human).
Sequence Length	620
Subcellular Localization	Nucleus inner membrane Lipid-anchor Nucleoplasmic side.
Protein Description	Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin..
Protein Sequence	MSPPSPGRRREQRRPRAAATMATPLPGRAGGPATPLSPTRLSRLQEKEELRELNDRLAHYIDRVRALELENDRLLLKISEKEEVTTREVSGIKALYESELADARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRSEVELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELDFRKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALEELRSQHDEQVRLYKLELEQTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESLSYQLSGLQKQASAAEDRIRELEEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQELLDVKLALDMEINAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRKRLEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQSLGNWRIKRQVLEGEEIAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTGESFRTVLVNADGEEVAMRTVKKSSVMRENENGEEEEEEAEFGEEDLFHQQGDPRTTSRGCYVM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSPPSPGRR ------CCCCCCCCC	20.23	29691806
3	Phosphorylation	-----MSPPSPGRRR -----CCCCCCCCCH	24.86	24719451
5	Phosphorylation	---MSPPSPGRRREQ ---CCCCCCCCCHHH	6.45	29691806
14	Phosphorylation	GRRREQRRPRAAATM CCCHHHCCCCHHHCC	28.09	23911959
17	Phosphorylation	REQRRPRAAATMATP HHHCCCCHHHCCCCC	25.98	16964243
19	Phosphorylation	QRRPRAAATMATPLP HCCCCHHHCCCCCCC	40.65	25850435
20	Phosphorylation	RRPRAAATMATPLPG CCCCHHHCCCCCCCC	33.77	27251275
22	Phosphorylation	PRAAATMATPLPGRA CCHHHCCCCCCCCCC	27.88	22199227
23	Phosphorylation	RAAATMATPLPGRAG CHHHCCCCCCCCCCC	45.01	29255136
27	Acetylation	TMATPLPGRAGGPAT CCCCCCCCCCCCCCC	43.45	-
28	Methylation	MATPLPGRAGGPATP CCCCCCCCCCCCCCC	62.60	115481669
34	Phosphorylation	GRAGGPATPLSPTRL CCCCCCCCCCCHHHH	27.83	29255136
37	Phosphorylation	GGPATPLSPTRLSRL CCCCCCCCHHHHHHH	3.72	29255136
39	Phosphorylation	PATPLSPTRLSRLQE CCCCCCHHHHHHHHH	25.36	29255136
42	Phosphorylation	PLSPTRLSRLQEKEE CCCHHHHHHHHHHHH	35.54	26055452
47	Acetylation	RLSRLQEKEELRELN HHHHHHHHHHHHHHH	5.60	22631257
47	Ubiquitination	RLSRLQEKEELRELN HHHHHHHHHHHHHHH	5.60	-
56	Methylation	ELRELNDRLAHYIDR HHHHHHHHHHHHHHH	5.69	115481679
57	Ubiquitination	LRELNDRLAHYIDRV HHHHHHHHHHHHHHH	44.12	21890473
59	Phosphorylation	ELNDRLAHYIDRVRA HHHHHHHHHHHHHHH	40.82	21406692
60	Phosphorylation	LNDRLAHYIDRVRAL HHHHHHHHHHHHHHH	68.88	28152594
61	Acetylation	NDRLAHYIDRVRALE HHHHHHHHHHHHHHH	53.00	-
61	Ubiquitination	NDRLAHYIDRVRALE HHHHHHHHHHHHHHH	53.00	21890473
66	Phosphorylation	HYIDRVRALELENDR HHHHHHHHHHCCCCE	29.97	21406692
70	Phosphorylation	RVRALELENDRLLLK HHHHHHCCCCEEEEE	30.01	24719451
73	Methylation	ALELENDRLLLKISE HHHCCCCEEEEEEEC	35.55	72659601
73	Ubiquitination	ALELENDRLLLKISE HHHCCCCEEEEEEEC	35.55	21890473
77	Acetylation	ENDRLLLKISEKEEV CCCEEEEEEECCCCC	38.29	25825284
77	Malonylation	ENDRLLLKISEKEEV CCCEEEEEEECCCCC	38.29	26320211
77	Sumoylation	ENDRLLLKISEKEEV CCCEEEEEEECCCCC	38.29	28112733
77	Ubiquitination	ENDRLLLKISEKEEV CCCEEEEEEECCCCC	38.29	21890473
79	Phosphorylation	DRLLLKISEKEEVTT CEEEEEEECCCCCCH	35.72	21406692
81	Acetylation	LLLKISEKEEVTTRE EEEEEECCCCCCHHH	12.36	19608861
81	Sumoylation	LLLKISEKEEVTTRE EEEEEECCCCCCHHH	12.36	28112733
81	Ubiquitination	LLLKISEKEEVTTRE EEEEEECCCCCCHHH	12.36	33845483
85	Phosphorylation	ISEKEEVTTREVSGI EECCCCCCHHHCCHH	34.76	21406692
86	Phosphorylation	SEKEEVTTREVSGIK ECCCCCCHHHCCHHH	7.05	21406692
90	Phosphorylation	EVTTREVSGIKALYE CCCHHHCCHHHHHHH	30.59	24719451
93	Acetylation	TREVSGIKALYESEL HHHCCHHHHHHHHHH	48.50	26051181
93	Ubiquitination	TREVSGIKALYESEL HHHCCHHHHHHHHHH	48.50	29967540
96	Phosphorylation	VSGIKALYESELADA CCHHHHHHHHHHHHH	33.09	28152594
98	Phosphorylation	GIKALYESELADARR HHHHHHHHHHHHHHH	26.22	28152594
103	Ubiquitination	YESELADARRVLDET HHHHHHHHHHHHHHH	40.22	21890473
113	Ubiquitination	VLDETARERARLQIE HHHHHHHHHHHHHHH	57.90	21890473
114	Phosphorylation	LDETARERARLQIEI HHHHHHHHHHHHHHH	39.87	19691289
123	Acetylation	RLQIEIGKLRAELDE HHHHHHHHHHHHHHH	14.97	25953088
123	Malonylation	RLQIEIGKLRAELDE HHHHHHHHHHHHHHH	14.97	26320211
123	Ubiquitination	RLQIEIGKLRAELDE HHHHHHHHHHHHHHH	14.97	23000965
130	Ubiquitination	KLRAELDEVNKSAKK HHHHHHHHHHHHHHH	56.06	21890473
133	Acetylation	AELDEVNKSAKKREG HHHHHHHHHHHHHHC	56.37	25953088
133	Malonylation	AELDEVNKSAKKREG HHHHHHHHHHHHHHC	56.37	26320211
133	Ubiquitination	AELDEVNKSAKKREG HHHHHHHHHHHHHHC	56.37	33845483
134	Phosphorylation	ELDEVNKSAKKREGE HHHHHHHHHHHHHCC	43.57	19691289
136	Ubiquitination	DEVNKSAKKREGELT HHHHHHHHHHHCCEE	6.65	23503661
137	Ubiquitination	EVNKSAKKREGELTV HHHHHHHHHHCCEEE	37.34	23503661
143	Phosphorylation	KKREGELTVAQGRVK HHHHCCEEEEECCCC	4.79	28634120
148	Phosphorylation	ELTVAQGRVKDLESL CEEEEECCCCCHHHH	36.04	20068231
150	Acetylation	TVAQGRVKDLESLFH EEEECCCCCHHHHHC	45.01	23749302
150	Ubiquitination	TVAQGRVKDLESLFH EEEECCCCCHHHHHC	45.01	23000965
154	Phosphorylation	GRVKDLESLFHRSEV CCCCCHHHHHCHHHH	47.95	28857561
155	Phosphorylation	RVKDLESLFHRSEVE CCCCHHHHHCHHHHH	42.29	-
159	Phosphorylation	LESLFHRSEVELAAA HHHHHCHHHHHHHHH	38.34	20068231
166	Ubiquitination	SEVELAAALSDKRGL HHHHHHHHHHCCCCC	61.98	21890473
168	Phosphorylation	VELAAALSDKRGLES HHHHHHHHCCCCCHH	64.91	30266825
170	Acetylation	LAAALSDKRGLESDV HHHHHHCCCCCHHHH	11.36	30589825
170	Ubiquitination	LAAALSDKRGLESDV HHHHHHCCCCCHHHH	11.36	22817900
171	Methylation	AAALSDKRGLESDVA HHHHHCCCCCHHHHH	29.38	115481719
175	Phosphorylation	SDKRGLESDVAELRA HCCCCCHHHHHHHHH	34.16	28857561
180	Ubiquitination	LESDVAELRAQLAKA CHHHHHHHHHHHHHH	65.67	21890473
186	Acetylation	ELRAQLAKAEDGHAV HHHHHHHHHCCCCHH	6.49	22424773
186	Ubiquitination	ELRAQLAKAEDGHAV HHHHHHHHHCCCCHH	6.49	23000965
195	Acetylation	EDGHAVAKKQLEKET CCCCHHHHHHHHHHH	2.83	30589819
195	Sumoylation	EDGHAVAKKQLEKET CCCCHHHHHHHHHHH	2.83	28112733
195	Ubiquitination	EDGHAVAKKQLEKET CCCCHHHHHHHHHHH	2.83	23000965
196	Ubiquitination	DGHAVAKKQLEKETL CCCHHHHHHHHHHHH	47.57	23000965
200	Acetylation	VAKKQLEKETLMRVD HHHHHHHHHHHHHCC	44.58	23749302
200	Ubiquitination	VAKKQLEKETLMRVD HHHHHHHHHHHHHCC	44.58	21890473
211	Methylation	MRVDLENRCQSLQEE HHCCHHHHHHHHHHH	42.73	115481739
214	Phosphorylation	DLENRCQSLQEELDF CHHHHHHHHHHHHHH	28.96	28348404
223	Malonylation	QEELDFRKSVFEEEV HHHHHHHHHHHHHHH	45.24	26320211
223	Ubiquitination	QEELDFRKSVFEEEV HHHHHHHHHHHHHHH	45.24	29967540
224	Phosphorylation	EELDFRKSVFEEEVR HHHHHHHHHHHHHHH	7.25	27499020
226	Phosphorylation	LDFRKSVFEEEVRET HHHHHHHHHHHHHHH	32.37	19691289
235	Ubiquitination	EEVRETRRRHERRLV HHHHHHHHHHHHHEE	30.35	21890473
236	Sulfoxidation	EVRETRRRHERRLVE HHHHHHHHHHHHEEE	3.18	21406390
246	Phosphorylation	RRLVEVDSSRQQEYD HHEEEECCCHHHHHH	41.43	19691289
247	Phosphorylation	RLVEVDSSRQQEYDF HEEEECCCHHHHHHH	41.65	19691289
252	Phosphorylation	DSSRQQEYDFKMAQA CCCHHHHHHHHHHHH	31.81	30108239
255	Acetylation	RQQEYDFKMAQALEE HHHHHHHHHHHHHHH	39.82	26051181
255	Sumoylation	RQQEYDFKMAQALEE HHHHHHHHHHHHHHH	39.82	28112733
255	Ubiquitination	RQQEYDFKMAQALEE HHHHHHHHHHHHHHH	39.82	29967540
264	Methylation	AQALEELRSQHDEQV HHHHHHHHHCCHHHH	12.17	115481699
265	Phosphorylation	QALEELRSQHDEQVR HHHHHHHHCCHHHHH	36.98	27251275
265	Ubiquitination	QALEELRSQHDEQVR HHHHHHHHCCHHHHH	36.98	21890473
270	Ubiquitination	LRSQHDEQVRLYKLE HHHCCHHHHHHEEEH	53.50	21890473
272	Methylation	SQHDEQVRLYKLELE HCCHHHHHHEEEHHH	31.03	115481729
274	Phosphorylation	HDEQVRLYKLELEQT CHHHHHHEEEHHHHH	48.18	28152594
275	Acetylation	DEQVRLYKLELEQTY HHHHHHEEEHHHHHH	63.07	26051181
275	Ubiquitination	DEQVRLYKLELEQTY HHHHHHEEEHHHHHH	63.07	23000965
278	Ubiquitination	VRLYKLELEQTYQAK HHHEEEHHHHHHHHH	54.09	21890473
281	Phosphorylation	YKLELEQTYQAKLDS EEEHHHHHHHHHHCH	27.59	28152594
282	Phosphorylation	KLELEQTYQAKLDSA EEHHHHHHHHHHCHH	13.05	28152594
285	Acetylation	LEQTYQAKLDSAKLS HHHHHHHHHCHHCCC	64.06	23236377
285	Ubiquitination	LEQTYQAKLDSAKLS HHHHHHHHHCHHCCC	64.06	23000965
288	Ubiquitination	TYQAKLDSAKLSSDQ HHHHHHCHHCCCCCC	53.24	21890473
290	Acetylation	QAKLDSAKLSSDQND HHHHCHHCCCCCCCH	14.69	23749302
290	Ubiquitination	QAKLDSAKLSSDQND HHHHCHHCCCCCCCH	14.69	23000965
292	Phosphorylation	KLDSAKLSSDQNDKA HHCHHCCCCCCCHHH	8.06	28348404
293	Phosphorylation	LDSAKLSSDQNDKAA HCHHCCCCCCCHHHH	29.74	28348404
296	Phosphorylation	AKLSSDQNDKAASAA HCCCCCCCHHHHHHH	27.49	25850435
298	Acetylation	LSSDQNDKAASAARE CCCCCCHHHHHHHHH	21.80	23749302
298	Phosphorylation	LSSDQNDKAASAARE CCCCCCHHHHHHHHH	21.80	22817900
298	Ubiquitination	LSSDQNDKAASAARE CCCCCCHHHHHHHHH	21.80	33845483
299	Phosphorylation	SSDQNDKAASAAREE CCCCCHHHHHHHHHH	20.83	24961811
301	Phosphorylation	DQNDKAASAAREELK CCCHHHHHHHHHHHH	3.13	25159151
302	Phosphorylation	QNDKAASAAREELKE CCHHHHHHHHHHHHH	23.18	-
306	Ubiquitination	AASAAREELKEARMR HHHHHHHHHHHHHHH	53.53	21890473
308	Acetylation	SAAREELKEARMRLE HHHHHHHHHHHHHHH	14.26	25953088
308	Ubiquitination	SAAREELKEARMRLE HHHHHHHHHHHHHHH	14.26	33845483
316	Phosphorylation	EARMRLESLSYQLSG HHHHHHHHHHHHHHH	43.26	27273156
318	Phosphorylation	RMRLESLSYQLSGLQ HHHHHHHHHHHHHHH	5.31	30266825
319	Phosphorylation	MRLESLSYQLSGLQK HHHHHHHHHHHHHHH	38.67	25884760
322	Phosphorylation	ESLSYQLSGLQKQAS HHHHHHHHHHHHHHH	5.79	28152594
326	Acetylation	YQLSGLQKQASAAED HHHHHHHHHHHHHHH	52.05	23236377
326	Ubiquitination	YQLSGLQKQASAAED HHHHHHHHHHHHHHH	52.05	23000965
329	Phosphorylation	SGLQKQASAAEDRIR HHHHHHHHHHHHHHH	12.14	23828894
331	Ubiquitination	LQKQASAAEDRIREL HHHHHHHHHHHHHHH	47.12	-
334	Methylation	QASAAEDRIRELEEA HHHHHHHHHHHHHHH	52.69	115481709
336	Ubiquitination	SAAEDRIRELEEAMA HHHHHHHHHHHHHHC	60.64	-
351	Ubiquitination	GERDKFRKMLDAKEQ CCHHHHHHHHHHHHH	3.21	24816145
354	Phosphorylation	DKFRKMLDAKEQEMT HHHHHHHHHHHHHHH	11.15	19664995
356	Ubiquitination	FRKMLDAKEQEMTEM HHHHHHHHHHHHHHH	50.85	32015554
373	Acetylation	VMQQQLAEYQELLDV HHHHHHHHHHHHHHH	44.76	-
373	Ubiquitination	VMQQQLAEYQELLDV HHHHHHHHHHHHHHH	44.76	21890473
374	Phosphorylation	MQQQLAEYQELLDVK HHHHHHHHHHHHHHH	3.78	19664995
383	Ubiquitination	ELLDVKLALDMEINA HHHHHHHHHHHHHHH	53.81	21890473
385	Phosphorylation	LDVKLALDMEINAYR HHHHHHHHHHHHHHH	23.03	20363803
387	Phosphorylation	VKLALDMEINAYRKL HHHHHHHHHHHHHHH	33.76	20815410
389	Phosphorylation	LALDMEINAYRKLLE HHHHHHHHHHHHHHH	34.80	18669648
390	Phosphorylation	ALDMEINAYRKLLEG HHHHHHHHHHHHHHC	33.87	20068231
393	Sumoylation	MEINAYRKLLEGEEE HHHHHHHHHHHCHHH	16.20	-
393	Acetylation	MEINAYRKLLEGEEE HHHHHHHHHHHCHHH	16.20	22631249
393	Neddylation	MEINAYRKLLEGEEE HHHHHHHHHHHCHHH	16.20	32015554
393	Phosphorylation	MEINAYRKLLEGEEE HHHHHHHHHHHCHHH	16.20	21406692
393	Sumoylation	MEINAYRKLLEGEEE HHHHHHHHHHHCHHH	16.20	-
393	Ubiquitination	MEINAYRKLLEGEEE HHHHHHHHHHHCHHH	16.20	32015554
395	Phosphorylation	INAYRKLLEGEEERL HHHHHHHHHCHHHHH	13.56	21406692
398	Phosphorylation	YRKLLEGEEERLKLS HHHHHHCHHHHHCCC	28.21	20164059
399	Phosphorylation	RKLLEGEEERLKLSP HHHHHCHHHHHCCCC	27.51	22115753
400	Phosphorylation	KLLEGEEERLKLSPS HHHHCHHHHHCCCCC	24.94	19664995
401	Methylation	LLEGEEERLKLSPSP HHHCHHHHHCCCCCC	38.19	-
401	Phosphorylation	LLEGEEERLKLSPSP HHHCHHHHHCCCCCC	38.19	20363803
402	Phosphorylation	LEGEEERLKLSPSPS HHCHHHHHCCCCCCC	34.06	23911959
403	Sumoylation	EGEEERLKLSPSPSS HCHHHHHCCCCCCCC	34.26	-
403	Sumoylation	EGEEERLKLSPSPSS HCHHHHHCCCCCCCC	34.26	-
403	Ubiquitination	EGEEERLKLSPSPSS HCHHHHHCCCCCCCC	34.26	23000965
404	Phosphorylation	GEEERLKLSPSPSSR CHHHHHCCCCCCCCC	22.54	20164059
405	Phosphorylation	EEERLKLSPSPSSRV HHHHHCCCCCCCCCE	4.63	29255136
406	Phosphorylation	EERLKLSPSPSSRVT HHHHCCCCCCCCCEE	26.02	19664995
407	Phosphorylation	ERLKLSPSPSSRVTV HHHCCCCCCCCCEEE	21.26	29255136
408	Phosphorylation	RLKLSPSPSSRVTVS HHCCCCCCCCCEEEE	21.32	20068231
409	Phosphorylation	LKLSPSPSSRVTVSR HCCCCCCCCCEEEEE	23.64	29255136
410	Phosphorylation	KLSPSPSSRVTVSRA CCCCCCCCCEEEEEE	29.61	29255136
413	Phosphorylation	PSPSSRVTVSRATSS CCCCCCEEEEEEECC	43.53	30266825
415	Phosphorylation	PSSRVTVSRATSSSS CCCCEEEEEEECCCC	61.65	30266825
418	Phosphorylation	RVTVSRATSSSSGSL CEEEEEEECCCCCCC	39.86	30266825
419	Phosphorylation	VTVSRATSSSSGSLS EEEEEEECCCCCCCC	10.96	29255136
420	Phosphorylation	TVSRATSSSSGSLSA EEEEEECCCCCCCCC	52.49	29255136
421	Phosphorylation	VSRATSSSSGSLSAT EEEEECCCCCCCCCC	13.78	30266825
422	Phosphorylation	SRATSSSSGSLSATG EEEECCCCCCCCCCC	44.51	29255136
424	Phosphorylation	ATSSSSGSLSATGRL EECCCCCCCCCCCCC	28.63	29255136
426	Phosphorylation	SSSSGSLSATGRLGR CCCCCCCCCCCCCCC	41.07	29255136
428	Phosphorylation	SSGSLSATGRLGRSK CCCCCCCCCCCCCCC	19.39	30266825
433	Methylation	SATGRLGRSKRKRLE CCCCCCCCCCCCCEE	21.68	-
472	Phosphorylation	AQQASASGSVSIEEI CHHHCCCCCEEEEEE	56.27	20068231
474	Ubiquitination	QASASGSVSIEEIDL HHCCCCCEEEEEEEC	58.45	21890473
477	Phosphorylation	ASGSVSIEEIDLEGK CCCCEEEEEEECCCC	48.67	25850435
489	Sumoylation	EGKFVQLKNNSDKDQ CCCEEEECCCCCCCC	66.75	28112733
489	Ubiquitination	EGKFVQLKNNSDKDQ CCCEEEECCCCCCCC	66.75	23000965
492	Phosphorylation	FVQLKNNSDKDQSLG EEEECCCCCCCCCCC	43.72	20068231
494	Acetylation	QLKNNSDKDQSLGNW EECCCCCCCCCCCCC	12.54	26051181
494	Malonylation	QLKNNSDKDQSLGNW EECCCCCCCCCCCCC	12.54	26320211
494	Ubiquitination	QLKNNSDKDQSLGNW EECCCCCCCCCCCCC	12.54	23000965
495	Phosphorylation	LKNNSDKDQSLGNWR ECCCCCCCCCCCCCE	16.58	20068231
496	Ubiquitination	KNNSDKDQSLGNWRI CCCCCCCCCCCCCEE	33.47	21890473
497	Phosphorylation	NNSDKDQSLGNWRIK CCCCCCCCCCCCEEE	10.34	25159151
498	Phosphorylation	NSDKDQSLGNWRIKR CCCCCCCCCCCEEEE	18.08	24719451
500	Acetylation	DKDQSLGNWRIKRQV CCCCCCCCCEEEEEE	41.69	-
500	Ubiquitination	DKDQSLGNWRIKRQV CCCCCCCCCEEEEEE	41.69	21890473
515	Phosphorylation	LEGEEIAYKFTPKYI ECCCCCEEECCHHHH	18.34	30266825
516	Acetylation	EGEEIAYKFTPKYIL CCCCCEEECCHHHHC	12.45	23236377
516	Ubiquitination	EGEEIAYKFTPKYIL CCCCCEEECCHHHHC	12.45	23000965
518	Phosphorylation	EEIAYKFTPKYILRA CCCEEECCHHHHCCC	4.25	30266825
520	Acetylation	IAYKFTPKYILRAGQ CEEECCHHHHCCCCC	38.13	25825284
520	Malonylation	IAYKFTPKYILRAGQ CEEECCHHHHCCCCC	38.13	26320211
520	Ubiquitination	IAYKFTPKYILRAGQ CEEECCHHHHCCCCC	38.13	23000965
521	Phosphorylation	AYKFTPKYILRAGQM EEECCHHHHCCCCCE	28.86	24719451
524	Phosphorylation	FTPKYILRAGQMVTV CCHHHHCCCCCEEEE	37.44	20068231
525	Phosphorylation	TPKYILRAGQMVTVW CHHHHCCCCCEEEEE	30.98	22199227
530	Phosphorylation	LRAGQMVTVWAAGAG CCCCCEEEEEECCCC	19.52	28102081
532	Phosphorylation	AGQMVTVWAAGAGVA CCCEEEEEECCCCCC	36.41	24719451
533	Phosphorylation	GQMVTVWAAGAGVAH CCEEEEEECCCCCCC	22.95	25627689
536	Phosphorylation	VTVWAAGAGVAHSPP EEEEECCCCCCCCCC	31.36	25627689
541	Phosphorylation	AGAGVAHSPPSTLVW CCCCCCCCCCCEEEE	32.95	22199227
544	Phosphorylation	GVAHSPPSTLVWKGQ CCCCCCCCEEEEECC	2.13	22199227
545	Phosphorylation	VAHSPPSTLVWKGQS CCCCCCCEEEEECCC	4.89	22199227
552	Phosphorylation	TLVWKGQSSWGTGES EEEEECCCCCCCCCC	4.39	30108239
553	Phosphorylation	LVWKGQSSWGTGESF EEEECCCCCCCCCCE	5.75	30108239
554	Sulfoxidation	VWKGQSSWGTGESFR EEECCCCCCCCCCEE	4.45	21406390
556	Phosphorylation	KGQSSWGTGESFRTV ECCCCCCCCCCEEEE	24.48	30108239
559	Phosphorylation	SSWGTGESFRTVLVN CCCCCCCCEEEEEEC	43.56	30108239
561	Phosphorylation	WGTGESFRTVLVNAD CCCCCCEEEEEECCC	28.89	23898821
576	Phosphorylation	GEEVAMRTVKKSSVM CCEEEHHHHHHHHHH	22.24	28555341
581	Phosphorylation	MRTVKKSSVMRENEN HHHHHHHHHHCCCCC	61.46	23898821
617	Farnesylation	PRTTSRGCYVM---- CCCCCCCEECC----		-
617	Methylation	PRTTSRGCYVM---- CCCCCCCEECC----		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
37	S	Phosphorylation	Kinase	CDK2	P24941	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LMNB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LMNB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SOX4_HUMAN	SOX4	physical	25969425
MK01_HUMAN	MAPK1	physical	26344197
MK03_HUMAN	MAPK3	physical	26344197

Drug and Disease Associations

Kegg Disease
H00420	Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodys
OMIM Disease
608709	Partial acquired lipodystrophy (APLD)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LMNB2_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-27; LYS-61; LYS-373 ANDLYS-500, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14 AND SER-17, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14; SER-17; SER-401;SER-402 AND SER-406, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14; SER-17; SER-385;SER-389; SER-399; SER-402; SER-404 AND SER-406, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14; SER-17; SER-385 ANDSER-387, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17 AND THR-19, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14; SER-17; SER-385 ANDSER-387, AND MASS SPECTROMETRY.	17081983 [Abstract]