SOX4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SOX4_HUMAN
• UniProt AC: Q06945
• Protein Name: Transcription factor SOX-4
• Gene Name: SOX4
• Organism: Homo sapiens (Human).
• Sequence Length: 474
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif..
• Protein Sequence: MVQQTNNAENTEALLAGESSDSGAGLELGIASSPTPGSTASTGGKADDPSWCKTPSGHIKRPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDSDKIPFIREAERLRLKHMADYPDYKYRPRKKVKSGNANSSSSAAASSKPGEKGDKVGGSGGGGHGGGGGGGSSNAGGGGGGASGGGANSKPAQKKSCGSKVAGGAGGGVSKPHAKLILAGGGGGGKAAAAAAASFAAEQAGAAALLPLGAAADHHSLYKARTPSASASASSAASASAALAAPGKHLAEKKVKRVYLFGGLGTSSSPVGGVGAGADPSDPLGLYEEEGAGCSPDAPSLSGRSSAASSPAAGRSPADHRGYASLRAASPAPSSAPSHASSSASSHSSSSSSSGSSSSDDEFEDDLLDLNPSSNFESMSLGSFSSSSALDRDLDFNFEPGSGSHFEFPDYCTPEVSEMISGDWLESSISNLVFTY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Phosphorylation	GLELGIASSPTPGST CEEEEEECCCCCCCC	34.62	26074081
33	Phosphorylation	LELGIASSPTPGSTA EEEEEECCCCCCCCC	24.62	26074081
35	Phosphorylation	LGIASSPTPGSTAST EEEECCCCCCCCCCC	42.08	26074081
38	Phosphorylation	ASSPTPGSTASTGGK ECCCCCCCCCCCCCC	23.23	26074081
39	Phosphorylation	SSPTPGSTASTGGKA CCCCCCCCCCCCCCC	30.46	26074081
50	Phosphorylation	GGKADDPSWCKTPSG CCCCCCCCCCCCCCC	52.69	-
53	Ubiquitination	ADDPSWCKTPSGHIK CCCCCCCCCCCCCCC	58.15	29967540
54	Phosphorylation	DDPSWCKTPSGHIKR CCCCCCCCCCCCCCC	21.39	-
75	Methylation	VWSQIERRKIMEQSP HHHHHHHHHHHHHCC	21.77	115386211
81	Phosphorylation	RRKIMEQSPDMHNAE HHHHHHHCCCHHHHH	15.01	22199227
91	Ubiquitination	MHNAEISKRLGKRWK HHHHHHHHHHHHHHH	58.25	29967540
95	Acetylation	EISKRLGKRWKLLKD HHHHHHHHHHHHCCC	60.73	98364001
101	Ubiquitination	GKRWKLLKDSDKIPF HHHHHHCCCCCCCCH	66.67	-
105	Ubiquitination	KLLKDSDKIPFIREA HHCCCCCCCCHHHHH	57.12	29967540
118	Ubiquitination	EAERLRLKHMADYPD HHHHHCHHHHHCCCC	25.54	29967540
123	Phosphorylation	RLKHMADYPDYKYRP CHHHHHCCCCCCCCC	6.62	22817900
126	Phosphorylation	HMADYPDYKYRPRKK HHHCCCCCCCCCCCC	12.86	18083107
127	Ubiquitination	MADYPDYKYRPRKKV HHCCCCCCCCCCCCC	42.01	-
136	Phosphorylation	RPRKKVKSGNANSSS CCCCCCCCCCCCCCC	40.02	28985074
141	Phosphorylation	VKSGNANSSSSAAAS CCCCCCCCCCCHHHC	29.23	24114839
142	Phosphorylation	KSGNANSSSSAAASS CCCCCCCCCCHHHCC	28.28	22210691
143	Phosphorylation	SGNANSSSSAAASSK CCCCCCCCCHHHCCC	24.66	-
148	Phosphorylation	SSSSAAASSKPGEKG CCCCHHHCCCCCCCC	33.88	22210691
154	Acetylation	ASSKPGEKGDKVGGS HCCCCCCCCCCCCCC	77.61	23749302
161	Phosphorylation	KGDKVGGSGGGGHGG CCCCCCCCCCCCCCC	28.47	28857561
174	Phosphorylation	GGGGGGGSSNAGGGG CCCCCCCCCCCCCCC	24.56	28857561
175	Phosphorylation	GGGGGGSSNAGGGGG CCCCCCCCCCCCCCC	33.69	28857561
185	Phosphorylation	GGGGGGASGGGANSK CCCCCCCCCCCCCCC	41.04	25159151
191	Phosphorylation	ASGGGANSKPAQKKS CCCCCCCCCCCCCCC	39.21	28111955
192	Acetylation	SGGGANSKPAQKKSC CCCCCCCCCCCCCCC	44.15	30585815
196	Acetylation	ANSKPAQKKSCGSKV CCCCCCCCCCCCCCC	49.08	12435255
197	Acetylation	NSKPAQKKSCGSKVA CCCCCCCCCCCCCCC	38.61	7718235
202	Ubiquitination	QKKSCGSKVAGGAGG CCCCCCCCCCCCCCC	22.76	-
213	Acetylation	GAGGGVSKPHAKLIL CCCCCCCCCCCEEEE	38.11	23749302
213	Ubiquitination	GAGGGVSKPHAKLIL CCCCCCCCCCCEEEE	38.11	29967540
217	Acetylation	GVSKPHAKLILAGGG CCCCCCCEEEECCCC	32.78	23749302
217	Ubiquitination	GVSKPHAKLILAGGG CCCCCCCEEEECCCC	32.78	29967540
260	Phosphorylation	AADHHSLYKARTPSA HCCCCHHHHCCCCCC	12.96	27642862
261	Ubiquitination	ADHHSLYKARTPSAS CCCCHHHHCCCCCCC	36.36	-
286	Acetylation	AALAAPGKHLAEKKV HHHHCCCHHHHHHCC	34.09	25953088
307	Phosphorylation	GGLGTSSSPVGGVGA CCCCCCCCCCCCCCC	24.30	15345747
343	Phosphorylation	APSLSGRSSAASSPA CCCCCCCCCCCCCCC	28.05	23403867
344	Phosphorylation	PSLSGRSSAASSPAA CCCCCCCCCCCCCCC	26.88	23403867
347	Phosphorylation	SGRSSAASSPAAGRS CCCCCCCCCCCCCCC	36.25	20363803
348	Phosphorylation	GRSSAASSPAAGRSP CCCCCCCCCCCCCCC	17.52	25849741
354	Phosphorylation	SSPAAGRSPADHRGY CCCCCCCCCCCCCCC	24.42	23898821
363	Phosphorylation	ADHRGYASLRAASPA CCCCCCHHHCCCCCC	15.20	24719451
440	Phosphorylation	DFNFEPGSGSHFEFP CCCCCCCCCCCCCCC	48.08	26074081
442	Phosphorylation	NFEPGSGSHFEFPDY CCCCCCCCCCCCCCC	27.05	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SOX4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SOX4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SOX4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P53_HUMAN	TP53	physical	19234109
UBC9_HUMAN	UBE2I	physical	16631117
TAF5_HUMAN	TAF5	physical	23884650
TNNI3_HUMAN	TNNI3	physical	25969425
SCNNG_HUMAN	SCNN1G	physical	25969425
MINP1_HUMAN	MINPP1	physical	25969425
IGF1_HUMAN	IGF1	physical	25969425
PLD3_HUMAN	PLD3	physical	25969425
CAN15_HUMAN	CAPN15	physical	25969425
FOXH1_HUMAN	FOXH1	physical	25969425
RGSL_HUMAN	RGSL1	physical	25969425
LMNB2_HUMAN	LMNB2	physical	25969425
CTR9_HUMAN	CTR9	physical	25969425
ITIH1_HUMAN	ITIH1	physical	25969425
APOC3_HUMAN	APOC3	physical	25969425
EDF1_HUMAN	EDF1	physical	25969425
NANGN_HUMAN	NANOGNB	physical	25969425
MNT_HUMAN	MNT	physical	25969425
PLXB1_HUMAN	PLXNB1	physical	25969425
BAF_HUMAN	BANF1	physical	25969425

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.