FOXH1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FOXH1_HUMAN
• UniProt AC: O75593
• Protein Name: Forkhead box protein H1
• Gene Name: FOXH1
• Organism: Homo sapiens (Human).
• Sequence Length: 365
• Subcellular Localization: Nucleus.
• Protein Description: Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element)..
• Protein Sequence: MGPCSGSRLGPPEAESPSQPPKRRKKRYLRHDKPPYTYLAMIALVIQAAPSRRLKLAQIIRQVQAVFPFFREDYEGWKDSIRHNLSSNRCFRKVPKDPAKPQAKGNFWAVDVSLIPAEALRLQNTALCRRWQNGGARGAFAKDLGPYVLHGRPYRPPSPPPPPSEGFSIKSLLGGSGEGAPWPGLAPQSSPVPAGTGNSGEEAVPTPPLPSSERPLWPLCPLPGPTRVEGETVQGGAIGPSTLSPEPRAWPLHLLQGTAVPGGRSSGGHRASLWGQLPTSYLPIYTPNVVMPLAPPPTSCPQCPSTSPAYWGVAPETRGPPGLLCDLDALFQGVPPNKSIYDVWVSHPRDLAAPGPGWLLSWCSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
86	Phosphorylation	DSIRHNLSSNRCFRK HHHHHHCCCCCCEEE	30.77	27135362
125	Phosphorylation	EALRLQNTALCRRWQ HHHHHCCHHHHHHHH	14.19	30257219
232	Phosphorylation	PTRVEGETVQGGAIG CCEEECEEECCCCCC	29.05	30257219
265	Phosphorylation	TAVPGGRSSGGHRAS EECCCCCCCCCCCCH	36.29	18452278
266	Phosphorylation	AVPGGRSSGGHRASL ECCCCCCCCCCCCHH	47.65	18452278

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FOXH1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FOXH1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FOXH1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TGIF1_HUMAN	TGIF1	physical	10199400
SMAD2_HUMAN	SMAD2	physical	10199400
NC2A_HUMAN	DRAP1	physical	12471260
SMAD3_HUMAN	SMAD3	physical	9858566
SMAD2_HUMAN	SMAD2	physical	9858566
SMAD2_HUMAN	SMAD2	physical	9389648
SMAD2_HUMAN	SMAD2	physical	9288972
SMAD4_HUMAN	SMAD4	physical	9288972
SMAD2_HUMAN	SMAD2	physical	12732634
SMAD2_HUMAN	SMAD2	physical	21828274
SMAD3_HUMAN	SMAD3	physical	21828274
TFE2_HUMAN	TCF3	physical	21828274
SMAD2_HUMAN	SMAD2	physical	16916642
SCRIB_HUMAN	SCRIB	physical	25609649
SYVC_HUMAN	VARS	physical	25609649
SYYC_HUMAN	YARS	physical	25609649
PDS5A_HUMAN	PDS5A	physical	25609649
BTAF1_HUMAN	BTAF1	physical	25609649
PA2G4_HUMAN	PA2G4	physical	25609649
NSMA3_HUMAN	SMPD4	physical	25609649
DSRAD_HUMAN	ADAR	physical	25609649
ARI3B_HUMAN	ARID3B	physical	25609649
SYDM_HUMAN	DARS2	physical	25609649
DX39A_HUMAN	DDX39A	physical	25609649
HXK2_HUMAN	HK2	physical	25609649
SYLC_HUMAN	LARS	physical	25609649
RCC1_HUMAN	RCC1	physical	25609649
SMC4_HUMAN	SMC4	physical	25609649
KAISO_HUMAN	ZBTB33	physical	25609649
ARI3A_HUMAN	ARID3A	physical	25609649
CX7A2_HUMAN	COX7A2	physical	25609649
HEAT1_HUMAN	HEATR1	physical	25609649
SYIC_HUMAN	IARS	physical	25609649
CCAR2_HUMAN	CCAR2	physical	25609649
MYEF2_HUMAN	MYEF2	physical	25609649
NISCH_HUMAN	NISCH	physical	25609649
SYMPK_HUMAN	SYMPK	physical	25609649
QCR1_HUMAN	UQCRC1	physical	25609649
WAPL_HUMAN	WAPAL	physical	25609649
SPB3_HUMAN	SERPINB3	physical	25609649
TRM2A_HUMAN	TRMT2A	physical	25609649
GSDMA_HUMAN	GSDMA	physical	25609649

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.