SYLC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYLC_HUMAN
• UniProt AC: Q9P2J5
• Protein Name: Leucine--tRNA ligase, cytoplasmic
• Gene Name: LARS
• Organism: Homo sapiens (Human).
• Sequence Length: 1176
• Subcellular Localization: Cytoplasm.
• Protein Description: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs..
• Protein Sequence: MAERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPDEEEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHWLDYFPPLAIQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGASLSAPLTSYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRDDMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVDGFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWKKQTSQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVANWDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAVEGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQYLMEVTHDLRLRLKNYMMPAKGKKTDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFEANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVLMENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGHFSTKIEIRQGDNCDSIIRRLMKMNRGIKDLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTPISEHAVFNVDLMSKKIHLTENGIRVDIGDTIIYLVH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Ubiquitination	---MAERKGTAKVDF ---CCCCCCCCCHHH	52.71	-
7	Phosphorylation	-MAERKGTAKVDFLK -CCCCCCCCCHHHHH	26.75	20068231
9	Malonylation	AERKGTAKVDFLKKI CCCCCCCCHHHHHHH	42.02	26320211
9	Ubiquitination	AERKGTAKVDFLKKI CCCCCCCCHHHHHHH	42.02	-
15	Ubiquitination	AKVDFLKKIEKEIQQ CCHHHHHHHHHHHHH	59.24	-
18	2-Hydroxyisobutyrylation	DFLKKIEKEIQQKWD HHHHHHHHHHHHHCC	64.69	-
18	Ubiquitination	DFLKKIEKEIQQKWD HHHHHHHHHHHHHCC	64.69	-
23	2-Hydroxyisobutyrylation	IEKEIQQKWDTERVF HHHHHHHHCCCCCEE	30.57	-
23	Ubiquitination	IEKEIQQKWDTERVF HHHHHHHHCCCCCEE	30.57	21890473
28	Ubiquitination	QQKWDTERVFEVNAS HHHCCCCCEEEEEHH	40.28	-
35	Phosphorylation	RVFEVNASNLEKQTS CEEEEEHHHHHHCCC	36.42	20873877
39	Ubiquitination	VNASNLEKQTSKGKY EEHHHHHHCCCCCCE	63.14	21890473
39	Ubiquitination	VNASNLEKQTSKGKY EEHHHHHHCCCCCCE	63.14	21890473
39	Ubiquitination	VNASNLEKQTSKGKY EEHHHHHHCCCCCCE	63.14	21890473
39	Acetylation	VNASNLEKQTSKGKY EEHHHHHHCCCCCCE	63.14	25953088
39	Malonylation	VNASNLEKQTSKGKY EEHHHHHHCCCCCCE	63.14	26320211
39	Ubiquitination	VNASNLEKQTSKGKY EEHHHHHHCCCCCCE	63.14	21890473
43	Ubiquitination	NLEKQTSKGKYFVTF HHHHCCCCCCEEEEE	63.91	-
44	Ubiquitination	LEKQTSKGKYFVTFP HHHCCCCCCEEEEEC	29.66	-
45	Acetylation	EKQTSKGKYFVTFPY HHCCCCCCEEEEECC	38.97	7245087
45	Ubiquitination	EKQTSKGKYFVTFPY HHCCCCCCEEEEECC	38.97	-
64	Phosphorylation	GRLHLGHTFSLSKCE CEEEECCEEEHHCCC	17.08	23312004
66	Phosphorylation	LHLGHTFSLSKCEFA EEECCEEEHHCCCEE	32.65	20873877
68	Phosphorylation	LGHTFSLSKCEFAVG ECCEEEHHCCCEEEC	33.78	20873877
69	Ubiquitination	GHTFSLSKCEFAVGY CCEEEHHCCCEEECC	42.97	-
82	Ubiquitination	GYQRLKGKCCLFPFG CCHHHCCCEEEECCC	21.86	-
98	Ubiquitination	HCTGMPIKACADKLK CCCCCCHHHHHHHHH	31.38	-
103	Acetylation	PIKACADKLKREIEL CHHHHHHHHHHHHHH	37.07	25953088
137	Malonylation	KTEDIIIKDKAKGKK CHHHEEEEECCCCCC	42.65	26320211
145	O-linked_Glycosylation	DKAKGKKSKAAAKAG ECCCCCCCHHHHHHC	30.89	23301498
153	Phosphorylation	KAAAKAGSSKYQWGI HHHHHHCCCHHHHHH	28.63	28857561
154	Phosphorylation	AAAKAGSSKYQWGIM HHHHHCCCHHHHHHH	34.17	28857561
155	Acetylation	AAKAGSSKYQWGIMK HHHHCCCHHHHHHHH	43.06	25953088
155	Ubiquitination	AAKAGSSKYQWGIMK HHHHCCCHHHHHHHH	43.06	-
156	Phosphorylation	AKAGSSKYQWGIMKS HHHCCCHHHHHHHHH	16.08	29759185
162	Ubiquitination	KYQWGIMKSLGLSDE HHHHHHHHHCCCCHH	40.38	21906983
163	Phosphorylation	YQWGIMKSLGLSDEE HHHHHHHHCCCCHHH	15.41	28857561
167	Phosphorylation	IMKSLGLSDEEIVKF HHHHCCCCHHHHHHH	40.97	25159151
173	Ubiquitination	LSDEEIVKFSEAEHW CCHHHHHHHHHHHHH	49.16	-
193	Acetylation	PLAIQDLKRMGLKVD CHHHHHHHHCCCCCE	48.94	24431699
193	Ubiquitination	PLAIQDLKRMGLKVD CHHHHHHHHCCCCCE	48.94	21906983
198	Ubiquitination	DLKRMGLKVDWRRSF HHHHCCCCCEEEHHE	32.21	-
204	Phosphorylation	LKVDWRRSFITTDVN CCCEEEHHEEECCCC	16.66	28857561
214	Ubiquitination	TTDVNPYYDSFVRWQ ECCCCHHHHHHHHHH	13.33	21890473
214	Phosphorylation	TTDVNPYYDSFVRWQ ECCCCHHHHHHHHHH	13.33	-
222	Ubiquitination	DSFVRWQFLTLRERN HHHHHHHEEEHHHHC	4.46	21890473
222	Ubiquitination	DSFVRWQFLTLRERN HHHHHHHEEEHHHHC	4.46	21890473
224	Ubiquitination	FVRWQFLTLRERNKI HHHHHEEEHHHHCCC	25.67	21890473
224	Phosphorylation	FVRWQFLTLRERNKI HHHHHEEEHHHHCCC	25.67	28857561
232	Ubiquitination	LRERNKIKFGKRYTI HHHHCCCCCCCCEEE	50.07	21890473
232	Ubiquitination	LRERNKIKFGKRYTI HHHHCCCCCCCCEEE	50.07	21890473
235	Acetylation	RNKIKFGKRYTIYSP HCCCCCCCCEEEECC	45.42	24849033
237	Phosphorylation	KIKFGKRYTIYSPKD CCCCCCCEEEECCCC	10.85	23312004
238	O-linked_Glycosylation	IKFGKRYTIYSPKDG CCCCCCEEEECCCCC	19.92	23301498
238	Phosphorylation	IKFGKRYTIYSPKDG CCCCCCEEEECCCCC	19.92	28857561
240	Phosphorylation	FGKRYTIYSPKDGQP CCCCEEEECCCCCCC	15.89	23312004
241	Phosphorylation	GKRYTIYSPKDGQPC CCCEEEECCCCCCCC	22.94	27499020
243	Acetylation	RYTIYSPKDGQPCMD CEEEECCCCCCCCCC	69.42	24849041
243	Ubiquitination	RYTIYSPKDGQPCMD CEEEECCCCCCCCCC	69.42	-
264	Phosphorylation	EGVGPQEYTLLKLKV CCCCHHHEEEEEEEE	9.46	28152594
265	Phosphorylation	GVGPQEYTLLKLKVL CCCHHHEEEEEEEEC	25.51	28152594
268	Ubiquitination	PQEYTLLKLKVLEPY HHHEEEEEEEECCCC	49.74	21890473
268	Ubiquitination	PQEYTLLKLKVLEPY HHHEEEEEEEECCCC	49.74	21890473
270	2-Hydroxyisobutyrylation	EYTLLKLKVLEPYPS HEEEEEEEECCCCCH	43.09	-
270	Ubiquitination	EYTLLKLKVLEPYPS HEEEEEEEECCCCCH	43.09	-
275	Phosphorylation	KLKVLEPYPSKLSGL EEEECCCCCHHHCCC	15.68	-
277	Phosphorylation	KVLEPYPSKLSGLKG EECCCCCHHHCCCCC	40.15	-
278	Ubiquitination	VLEPYPSKLSGLKGK ECCCCCHHHCCCCCC	42.01	21890473
278	2-Hydroxyisobutyrylation	VLEPYPSKLSGLKGK ECCCCCHHHCCCCCC	42.01	-
278	Acetylation	VLEPYPSKLSGLKGK ECCCCCHHHCCCCCC	42.01	23236377
278	Ubiquitination	VLEPYPSKLSGLKGK ECCCCCHHHCCCCCC	42.01	21890473
283	Ubiquitination	PSKLSGLKGKNIFLV CHHHCCCCCCCEEEE	71.95	-
285	Ubiquitination	KLSGLKGKNIFLVAA HHCCCCCCCEEEEEE	45.33	-
287	Ubiquitination	SGLKGKNIFLVAATL CCCCCCCEEEEEEEC	3.00	21890473
293	Phosphorylation	NIFLVAATLRPETMF CEEEEEEECCHHHCC	17.35	-
295	Ubiquitination	FLVAATLRPETMFGQ EEEEEECCHHHCCCC	23.74	21890473
295	Ubiquitination	FLVAATLRPETMFGQ EEEEEECCHHHCCCC	23.74	21890473
298	Phosphorylation	AATLRPETMFGQTNC EEECCHHHCCCCCCE	22.08	26270265
303	Phosphorylation	PETMFGQTNCWVRPD HHHCCCCCCEEECCC	32.49	26270265
313	Phosphorylation	WVRPDMKYIGFETVN EECCCCEEEEEEEEC	10.31	21406692
318	Phosphorylation	MKYIGFETVNGDIFI CEEEEEEEECCCEEE	19.60	21406692
327	Phosphorylation	NGDIFICTQKAARNM CCCEEEEEHHHHHCC	28.43	25404012
329	Ubiquitination	DIFICTQKAARNMSY CEEEEEHHHHHCCCC	26.34	-
335	Phosphorylation	QKAARNMSYQGFTKD HHHHHCCCCCCCCCC	20.18	20873877
336	Nitration	KAARNMSYQGFTKDN HHHHCCCCCCCCCCC	11.24	-
336	Phosphorylation	KAARNMSYQGFTKDN HHHHCCCCCCCCCCC	11.24	21406692
340	Phosphorylation	NMSYQGFTKDNGVVP CCCCCCCCCCCCCCC	44.29	21406692
341	Ubiquitination	MSYQGFTKDNGVVPV CCCCCCCCCCCCCCC	47.11	21890473
341	Ubiquitination	MSYQGFTKDNGVVPV CCCCCCCCCCCCCCC	47.11	21890473
350	Ubiquitination	NGVVPVVKELMGEEI CCCCCCHHHHCCCCH	45.42	-
361	Phosphorylation	GEEILGASLSAPLTS CCCHHCCCCCCCCCC	22.51	22468782
363	Phosphorylation	EILGASLSAPLTSYK CHHCCCCCCCCCCCE	25.91	24905233
367	Phosphorylation	ASLSAPLTSYKVIYV CCCCCCCCCCEEEEE	29.02	24905233
368	Phosphorylation	SLSAPLTSYKVIYVL CCCCCCCCCEEEEEE	30.55	22468782
369	Phosphorylation	LSAPLTSYKVIYVLP CCCCCCCCEEEEEEE	12.21	24905233
379	Phosphorylation	IYVLPMLTIKEDKGT EEEEEEEEEEECCCC	24.61	22468782
381	Acetylation	VLPMLTIKEDKGTGV EEEEEEEEECCCCCE	55.41	25953088
384	Acetylation	MLTIKEDKGTGVVTS EEEEEECCCCCEEEE	60.51	23236377
384	Ubiquitination	MLTIKEDKGTGVVTS EEEEEECCCCCEEEE	60.51	21890473
386	Phosphorylation	TIKEDKGTGVVTSVP EEEECCCCCEEEECC	32.32	23186163
390	Phosphorylation	DKGTGVVTSVPSDSP CCCCCEEEECCCCCH	22.92	20873877
391	Phosphorylation	KGTGVVTSVPSDSPD CCCCEEEECCCCCHH	22.03	20873877
394	Phosphorylation	GVVTSVPSDSPDDIA CEEEECCCCCHHHHH	48.87	20873877
396	Phosphorylation	VTSVPSDSPDDIAAL EEECCCCCHHHHHHH	34.27	28985074
407	Ubiquitination	IAALRDLKKKQALRA HHHHHHHHHHHHHHH	63.31	-
459	Ubiquitination	QSQNDREKLAEAKEK CCCCHHHHHHHHHHH	54.62	-
464	2-Hydroxyisobutyrylation	REKLAEAKEKIYLKG HHHHHHHHHHHHHHC	51.55	-
466	Ubiquitination	KLAEAKEKIYLKGFY HHHHHHHHHHHHCHH	35.62	-
468	Phosphorylation	AEAKEKIYLKGFYEG HHHHHHHHHHCHHHC	17.27	-
473	Phosphorylation	KIYLKGFYEGIMLVD HHHHHCHHHCEEEEC	23.16	27642862
477	Sulfoxidation	KGFYEGIMLVDGFKG HCHHHCEEEECCCCC	4.36	30846556
483	2-Hydroxyisobutyrylation	IMLVDGFKGQKVQDV EEEECCCCCCCHHHH	66.99	-
483	Ubiquitination	IMLVDGFKGQKVQDV EEEECCCCCCCHHHH	66.99	-
486	2-Hydroxyisobutyrylation	VDGFKGQKVQDVKKT ECCCCCCCHHHHHHH	51.00	-
486	Ubiquitination	VDGFKGQKVQDVKKT ECCCCCCCHHHHHHH	51.00	-
497	2-Hydroxyisobutyrylation	VKKTIQKKMIDAGDA HHHHHHHHHHCCCCE	25.39	-
497	Ubiquitination	VKKTIQKKMIDAGDA HHHHHHHHHHCCCCE	25.39	-
507	Phosphorylation	DAGDALIYMEPEKQV CCCCEEEEECHHHHH	9.04	27642862
512	Acetylation	LIYMEPEKQVMSRSS EEEECHHHHHCCCCC	59.93	25953088
512	Ubiquitination	LIYMEPEKQVMSRSS EEEECHHHHHCCCCC	59.93	21890473
516	Phosphorylation	EPEKQVMSRSSDECV CHHHHHCCCCCCCHH	30.10	29396449
540	Acetylation	DYGEENWKKQTSQCL HCCHHHHHHHHHHHH	46.73	24471321
541	Ubiquitination	YGEENWKKQTSQCLK CCHHHHHHHHHHHHH	50.88	-
548	Ubiquitination	KQTSQCLKNLETFCE HHHHHHHHHHHHHHH	68.09	-
564	Phosphorylation	TRRNFEATLGWLQEH HHHHHHHHHHHHHHH	20.71	20873877
573	Glutathionylation	GWLQEHACSRTYGLG HHHHHHHCCCCCCCC	2.82	22555962
574	Phosphorylation	WLQEHACSRTYGLGT HHHHHHCCCCCCCCC	28.57	20873877
637	Phosphorylation	MTKEVWDYVFFKEAP CCHHHHHHHEECCCC	5.39	27642862
641	Ubiquitination	VWDYVFFKEAPFPKT HHHHHEECCCCCCHH	41.31	21890473
647	Ubiquitination	FKEAPFPKTQIAKEK ECCCCCCHHHHHHHH	54.14	-
648	Phosphorylation	KEAPFPKTQIAKEKL CCCCCCHHHHHHHHH	25.99	-
652	Ubiquitination	FPKTQIAKEKLDQLK CCHHHHHHHHHHHHH	57.94	-
659	Ubiquitination	KEKLDQLKQEFEFWY HHHHHHHHHHHCEEE	41.99	21906983
666	Phosphorylation	KQEFEFWYPVDLRVS HHHHCEEEECEEEEC	9.94	20860994
679	Ubiquitination	VSGKDLVPNHLSYYL ECCCCCCCCHHHHHH	29.80	21890473
687	Ubiquitination	NHLSYYLYNHVAMWP CHHHHHHHHCCCCCC	6.26	21890473
687	Ubiquitination	NHLSYYLYNHVAMWP CHHHHHHHHCCCCCC	6.26	21890473
702	Phosphorylation	EQSDKWPTAVRANGH CCCCCCCCCCCCCCE	36.35	-
714	Phosphorylation	NGHLLLNSEKMSKST CCEEEECCHHHCCCC	38.27	28857561
716	Acetylation	HLLLNSEKMSKSTGN EEEECCHHHCCCCCC	48.58	25953088
716	Ubiquitination	HLLLNSEKMSKSTGN EEEECCHHHCCCCCC	48.58	-
718	Phosphorylation	LLNSEKMSKSTGNFL EECCHHHCCCCCCCH	34.23	17924679
719	Ubiquitination	LNSEKMSKSTGNFLT ECCHHHCCCCCCCHH	48.84	21906983
720	Phosphorylation	NSEKMSKSTGNFLTL CCHHHCCCCCCCHHH	33.95	25159151
721	Phosphorylation	SEKMSKSTGNFLTLT CHHHCCCCCCCHHHH	39.62	25159151
728	Phosphorylation	TGNFLTLTQAIDKFS CCCCHHHHHHHHHCC	15.66	17924679
733	Ubiquitination	TLTQAIDKFSADGMR HHHHHHHHCCCCCCE	34.80	21890473
733	Ubiquitination	TLTQAIDKFSADGMR HHHHHHHHCCCCCCE	34.80	21890473
735	Phosphorylation	TQAIDKFSADGMRLA HHHHHHCCCCCCEEE	31.06	21406692
759	Sulfoxidation	DANFVEAMADAGILR CCCHHHHHHHCCHHH	1.88	30846556
760	Ubiquitination	ANFVEAMADAGILRL CCHHHHHHHCCHHHH	15.56	21890473
768	Ubiquitination	DAGILRLYTWVEWVK HCCHHHHHHHHHHHH	7.66	21890473
768	Ubiquitination	DAGILRLYTWVEWVK HCCHHHHHHHHHHHH	7.66	21890473
795	Methylation	PASTFNDRVFASELN CCCHHCCHHHHHHHC	26.93	115481855
807	Ubiquitination	ELNAGIIKTDQNYEK HHCCCEEECCCCHHH	44.09	21906983
814	Ubiquitination	KTDQNYEKMMFKEAL ECCCCHHHHHHHHHH	25.88	21890473
814	Acetylation	KTDQNYEKMMFKEAL ECCCCHHHHHHHHHH	25.88	26822725
814	Ubiquitination	KTDQNYEKMMFKEAL ECCCCHHHHHHHHHH	25.88	21890473
818	Ubiquitination	NYEKMMFKEALKTGF CHHHHHHHHHHHHCC	24.96	-
822	Ubiquitination	MMFKEALKTGFFEFQ HHHHHHHHHCCCCHH	54.36	-
832	Ubiquitination	FFEFQAAKDKYRELA CCCHHHHHHHHHHHH	58.74	21906983
834	Ubiquitination	EFQAAKDKYRELAVE CHHHHHHHHHHHHHH	45.56	-
914	Ubiquitination	HDLRLRLKNYMMPAK HHHHHHHHHHCCCCC	39.33	-
921	Acetylation	KNYMMPAKGKKTDKQ HHHCCCCCCCCCCCC	66.45	7615569
923	Acetylation	YMMPAKGKKTDKQPL HCCCCCCCCCCCCCC	52.36	11925893
924	Acetylation	MMPAKGKKTDKQPLQ CCCCCCCCCCCCCCC	71.30	7615579
927	Ubiquitination	AKGKKTDKQPLQKPS CCCCCCCCCCCCCCC	60.07	-
932	Ubiquitination	TDKQPLQKPSHCTIY CCCCCCCCCCCEEEE	57.05	-
939	Phosphorylation	KPSHCTIYVAKNYPP CCCCEEEEEECCCCC	4.00	28064214
944	Phosphorylation	TIYVAKNYPPWQHTT EEEEECCCCCCCCCH	15.23	-
950	Phosphorylation	NYPPWQHTTLSVLRK CCCCCCCCHHHHHHH	17.84	20873877
951	Phosphorylation	YPPWQHTTLSVLRKH CCCCCCCHHHHHHHH	18.21	20873877
953	Phosphorylation	PWQHTTLSVLRKHFE CCCCCHHHHHHHHHH	19.60	24719451
965	Ubiquitination	HFEANNGKLPDNKVI HHHHHCCCCCCCHHH	59.99	-
970	Acetylation	NGKLPDNKVIASELG CCCCCCCHHHHHHCC	42.26	26822725
970	Malonylation	NGKLPDNKVIASELG CCCCCCCHHHHHHCC	42.26	26320211
970	Ubiquitination	NGKLPDNKVIASELG CCCCCCCHHHHHHCC	42.26	-
974	O-linked_Glycosylation	PDNKVIASELGSMPE CCCHHHHHHCCCCHH	23.41	23301498
978	O-linked_Glycosylation	VIASELGSMPELKKY HHHHHCCCCHHHHHH	43.73	23301498
979	Sulfoxidation	IASELGSMPELKKYM HHHHCCCCHHHHHHH	2.58	21406390
983	Acetylation	LGSMPELKKYMKKVM CCCCHHHHHHHHHHH	39.95	23236377
983	Malonylation	LGSMPELKKYMKKVM CCCCHHHHHHHHHHH	39.95	26320211
983	Ubiquitination	LGSMPELKKYMKKVM CCCCHHHHHHHHHHH	39.95	983
984	Ubiquitination	GSMPELKKYMKKVMP CCCHHHHHHHHHHHH	64.30	-
985	Phosphorylation	SMPELKKYMKKVMPF CCHHHHHHHHHHHHH	16.75	-
988	Ubiquitination	ELKKYMKKVMPFVAM HHHHHHHHHHHHHHH	27.51	-
1002	2-Hydroxyisobutyrylation	MIKENLEKMGPRILD HHHHHHHHHCCCEEE	52.93	-
1002	Ubiquitination	MIKENLEKMGPRILD HHHHHHHHHCCCEEE	52.93	-
1021	Sulfoxidation	FDEKAVLMENIVYLT ECHHHHHHHHEEEHH	2.73	30846556
1042	Phosphorylation	HIEVKFASEAEDKIR EEEEEECHHHHHHHH	40.24	21406692
1047	Acetylation	FASEAEDKIREDCCP ECHHHHHHHHHCCCC	34.86	-
1047	Ubiquitination	FASEAEDKIREDCCP ECHHHHHHHHHCCCC	34.86	-
1056	Acetylation	REDCCPGKPLNVFRI HHCCCCCCCCCEEEE	31.32	27452117
1056	Ubiquitination	REDCCPGKPLNVFRI HHCCCCCCCCCEEEE	31.32	-
1095	Phosphorylation	RQGDNCDSIIRRLMK ECCCCHHHHHHHHHH	23.32	24719451
1108	Ubiquitination	MKMNRGIKDLSKVKL HHHCCCCCCHHHCCE	56.28	-
1112	Ubiquitination	RGIKDLSKVKLMRFD CCCCCHHHCCEEECC	51.16	-
1133	Ubiquitination	RRVPVLGKEYTEKTP CCCCCCCCCCCCCCC	43.30	-
1135	Phosphorylation	VPVLGKEYTEKTPIS CCCCCCCCCCCCCCC	24.55	-
1138	Ubiquitination	LGKEYTEKTPISEHA CCCCCCCCCCCCCCE	52.37	-
1154	2-Hydroxyisobutyrylation	FNVDLMSKKIHLTEN EEEECCCCEEEECCC	41.61	-
1154	Ubiquitination	FNVDLMSKKIHLTEN EEEECCCCEEEECCC	41.61	-
1155	2-Hydroxyisobutyrylation	NVDLMSKKIHLTENG EEECCCCEEEECCCC	28.22	-
1173	Phosphorylation	DIGDTIIYLVH---- ECCCEEEEECC----	9.98	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
293	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYLC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYLC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYRC_HUMAN	RARS	physical	22939629
SYQ_HUMAN	QARS	physical	22939629
SYMC_HUMAN	MARS	physical	22939629
UBA1_HUMAN	UBA1	physical	22939629
SYNC_HUMAN	NARS	physical	22939629
SYVC_HUMAN	VARS	physical	22939629
MTOR_HUMAN	MTOR	physical	22424946
RPTOR_HUMAN	RPTOR	physical	22424946
RRAGD_HUMAN	RRAGD	physical	22424946
SYEP_HUMAN	EPRS	physical	22863883
SYIC_HUMAN	IARS	physical	22863883
RS13_HUMAN	RPS13	physical	22863883
SRP14_HUMAN	SRP14	physical	22863883
SRP09_HUMAN	SRP9	physical	22863883
AIMP1_HUMAN	AIMP1	physical	26344197
RHG01_HUMAN	ARHGAP1	physical	26344197
SYEP_HUMAN	EPRS	physical	26344197
ERF1_HUMAN	ETF1	physical	26344197
SYK_HUMAN	KARS	physical	26344197
MCMBP_HUMAN	MCMBP	physical	26344197
NMD3_HUMAN	NMD3	physical	26344197
SYQ_HUMAN	QARS	physical	26344197
TIPRL_HUMAN	TIPRL	physical	26344197
TRM1_HUMAN	TRMT1	physical	26344197
TTC37_HUMAN	TTC37	physical	26344197
SDCG8_HUMAN	SDCCAG8	physical	28514442
SYTC2_HUMAN	TARSL2	physical	28514442
AIMP1_HUMAN	AIMP1	physical	28514442
MCA3_HUMAN	EEF1E1	physical	28514442
SYDC_HUMAN	DARS	physical	28514442
SYEP_HUMAN	EPRS	physical	28514442
SYIC_HUMAN	IARS	physical	28514442
SYMC_HUMAN	MARS	physical	28514442
OFD1_HUMAN	OFD1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615438: Infantile liver failure syndrome 1 (ILFS1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00149: L-Leucine

Related Literatures of Post-Translational Modification

Phosphorylation

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-718; THR-721 ANDTHR-728, AND MASS SPECTROMETRY.
PubMed: 17924679