SYTC2_HUMAN - dbPTM
SYTC2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SYTC2_HUMAN
UniProt AC A2RTX5
Protein Name Probable threonine--tRNA ligase 2, cytoplasmic
Gene Name TARSL2
Organism Homo sapiens (Human).
Sequence Length 802
Subcellular Localization Cytoplasm.
Protein Description
Protein Sequence MAAEALAAEAVASRLERQEEDIRWLWSEVERLRDEQLNAPYSCQAEGPCLTREVAQLRAENCDLRHRLCSLRLCLAEERSRQATLESAELEAAQEAGAQPPPSQSQDKDMKKKKMKESEADSEVKHQPIFIKERLKLFEILKKDHQLLLAIYGKKGDTSNIITVRVADGQTVQGEVWKTTPYQVAAEISQELAESTVIAKVNGELWDLDRPLEGDSSLELLTFDNEEAQAVYWHSSAHILGEAMELYYGGHLCYGPPIENGFYYDMFIEDRAVSSTELSALENICKAIIKEKQPFERLEVSKEILLEMFKYNKFKCRILNEKVNTATTTVYRCGPLIDLCKGPHVRHTGKIKTIKIFKNSSTYWEGNPEMETLQRIYGISFPDNKMMRDWEKFQEEAKNRDHRKIGKEQELFFFHDLSPGSCFFLPRGAFIYNTLTDFIREEYHKRDFTEVLSPNMYNSKLWEASGHWQHYSENMFTFEIEKDTFALKPMNCPGHCLMFAHRPRSWREMPIRFADFGVLHRNELSGTLSGLTRVRRFQQDDAHIFCTVEQIEEEIKGCLQFLQSVYSTFGFSFQLNLSTRPENFLGEIEMWNEAEKQLQNSLMDFGEPWKMNPGDGAFYGPKIDIKIKDAIGRYHQCATIQLDFQLPIRFNLTYVSKDGDDKKRPVIIHRAILGSVERMIAILSENYGGKWPFWLSPRQVMVIPVGPTCEKYALQVSSEFFEEGFMADVDLDHSCTLNKKIRNAQLAQYNFILVVGEKEKIDNAVNVRTRDNKIHGEILVTSAIDKLKNLRKTRTLNAEEAF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAAEALAAE
------CHHHHHHHH		17.6322814378
47UbiquitinationPYSCQAEGPCLTREV
CCCCCCCCCCCHHHH		22.6427667366
79UbiquitinationRLCLAEERSRQATLE
HHHHHHHHHHHHHHH		28.7522817900
122PhosphorylationMKESEADSEVKHQPI
HHHHHHCHHHCCCCC		51.8728857561
125UbiquitinationSEADSEVKHQPIFIK
HHHCHHHCCCCCHHH		32.2529967540
132UbiquitinationKHQPIFIKERLKLFE
CCCCCHHHHHHHHHH		26.4932015554
155UbiquitinationLLAIYGKKGDTSNII
EEHHHCCCCCCCCEE		58.6227667366
158PhosphorylationIYGKKGDTSNIITVR
HHCCCCCCCCEEEEE		32.1326074081
159PhosphorylationYGKKGDTSNIITVRV
HCCCCCCCCEEEEEE		30.6726074081
163PhosphorylationGDTSNIITVRVADGQ
CCCCCEEEEEECCCC		9.8520363803
290UbiquitinationNICKAIIKEKQPFER
HHHHHHHHCCCCHHH		53.3927667366
322 (in isoform 1)Ubiquitination-39.4521906983
322UbiquitinationKCRILNEKVNTATTT
EEEECCCCCCCCCCE		39.4522817900
327PhosphorylationNEKVNTATTTVYRCG
CCCCCCCCCEEEECC		22.4422210691
329PhosphorylationKVNTATTTVYRCGPL
CCCCCCCEEEECCCH		15.9322210691
353PhosphorylationRHTGKIKTIKIFKNS
EECCCEEEEEEECCC		30.8628060719
377PhosphorylationMETLQRIYGISFPDN
HHHHHHHHCCCCCCC		15.5922817900
385UbiquitinationGISFPDNKMMRDWEK
CCCCCCCCHHCCHHH		41.26-
398UbiquitinationEKFQEEAKNRDHRKI
HHHHHHHHCCCCHHC		56.6527667366
447UbiquitinationREEYHKRDFTEVLSP
HHHHHCCCHHHCCCC		60.6722817900
449PhosphorylationEYHKRDFTEVLSPNM
HHHCCCHHHCCCCCC		29.4929255136
453PhosphorylationRDFTEVLSPNMYNSK
CCHHHCCCCCCCCCC		21.2830266825
457PhosphorylationEVLSPNMYNSKLWEA
HCCCCCCCCCCHHHC		23.9529255136
459PhosphorylationLSPNMYNSKLWEASG
CCCCCCCCCHHHCCC		16.1929255136
525PhosphorylationVLHRNELSGTLSGLT
EEECCCCCCCCCHHH		24.4529978859
527PhosphorylationHRNELSGTLSGLTRV
ECCCCCCCCCHHHEE		17.8629978859
529PhosphorylationNELSGTLSGLTRVRR
CCCCCCCCHHHEEEE		31.4329978859
619PhosphorylationNPGDGAFYGPKIDIK
CCCCCCCCCCEEEEE		31.80-
662MethylationVSKDGDDKKRPVIIH
EECCCCCCCCCEEEE		56.26-
662"N6,N6-dimethyllysine"VSKDGDDKKRPVIIH
EECCCCCCCCCEEEE		56.26-
663"N6,N6-dimethyllysine"SKDGDDKKRPVIIHR
ECCCCCCCCCEEEEH		69.77-
663MethylationSKDGDDKKRPVIIHR
ECCCCCCCCCEEEEH		69.77-
690UbiquitinationLSENYGGKWPFWLSP
HHCCCCCCCCCCCCC		47.5322817900
712PhosphorylationVGPTCEKYALQVSSE
CCCCHHHHHHHHCHH		7.1130576142
736PhosphorylationVDLDHSCTLNKKIRN
CCCCCCCCCCHHHHH		36.0630576142
760UbiquitinationLVVGEKEKIDNAVNV
EEECCHHHCCCCEEE		67.44-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SYTC2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SYTC2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SYTC2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SYAC_HUMANAARSphysical
26344197
SYFB_HUMANFARSBphysical
26344197
GARS_HUMANGARSphysical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SYTC2_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.

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