TTC37_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TTC37_HUMAN
• UniProt AC: Q6PGP7
• Protein Name: Tetratricopeptide repeat protein 37
• Gene Name: TTC37
• Organism: Homo sapiens (Human).
• Sequence Length: 1564
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C)..
• Protein Sequence: MSSKEVKTALKSARDAIRNKEYKEALKHCKTVLKQEKNNYNAWVFIGVAAAELEQPDQAQSAYKKAAELEPDQLLAWQGLANLYEKYNHINAKDDLPGVYQKLLDLYESVDKQKWCDVCKKLVDLYYQEKKHLEVARTWHKLIKTRQEQGAENEELHQLWRKLTQFLAESTEDQNNETQQLLFTAFENALGLSDKIPSEDHQVLYRHFIQSLSKFPHESARLKKACEGMINIYPTVQYPLEVLCLHLIESGNLTDEGQQYCCRLVEMDSKSGPGLIGLGIKALQDKKYEDAVRNLTEGLKESPVCTSGWYHLAEAQVKMHRPKEAVLSCSQALKIVDNLGASGNSLYQRNLCLHLKAEALIKLSDYDSSEEAIRTLDQISDADNIPGLLVLKSLAYRNKGSFDEAAKIMEDLLSSYPDLAEVHALEALIHFTKKDYLQAEKCFQRALEKDTEVAEYHYQLGLTYWFMGEETRKDKTKALTHFLKAARLDTYMGKVFCYLGHYYRDVVGDKNRARGCYRKAFELDDTDAESGAAAVDLSVELEDMEMALAILTTVTQKASAGTAKWAWLRRGLYYLKAGQHSQAVADLQAALRADPKDFNCWESLGEAYLSRGGYTTALKSFTKASELNPESIYSVFKVAAIQQILGKYKEAVAQYQMIIKKKEDYVPALKGLGECHLMMAKAALVDYLDGKAVDYIEKALEYFTCALQHRADVSCLWKLAGDACTCLYAVAPSKVNVHVLGVLLGQKEGKQVLKKNELLHLGGRCYGRALKLMSTSNTWCDLGINYYRQAQHLAETGSNMNDLKELLEKSLHCLKKAVRLDSNNHLYWNALGVVACYSGIGNYALAQHCFIKSIQSEQINAVAWTNLGVLYLTNENIEQAHEAFKMAQSLDPSYLMCWIGQALIAEAVGSYDTMDLFRHTTELNMHTEGALGYAYWVCTTLQDKSNRETELYQYNILQMNAIPAAQVILNKYVERIQNYAPAFTMLGYLNEHLQLKKEAANAYQRAILLLQTAEDQDTYNVAIRNYGRLLCSTGEYDKAIQAFKSTPLEVLEDIIGFALALFMKGLYKESSKAYERALSIVESEQDKAHILTALAITEYKQGKTDVAKTLLFKCSILKEPTTESLQALCALGLAMQDATLSKAALNELLKHIKHKDSNYQRCLLTSAIYALQGRSVAVQKQISKAVHSNPGDPALWSLLSRVVAQYAQRNAKGGVVAGNVAHILDSNHGKKALLYTAVNQLAMGSSSAEDEKNTALKTIQKAALLSPGDPAIWAGLMAACHADDKLALVNNTQPKRIDLYLALLSAVSASIKDEKFFENYNQSLEKWSLSQAVTGLIDTGRISEAETLCTKNLKSNPDQPAVILLLRQVQCKPLLESQKPLPDAVLEELQKTVMSNSTSVPAWQWLAHVYQSQGMMRAAEMCYRKSLQLASQRGSWSGKLSSLLRLALLALKVCMANISNDHWPSLVQEATTEALKLCFCPLAVLLQALLQFKRKMGARETRRLLERVVYQPGYPKSIASTARWYLLRHLYAKDDYELIDVLVNNAKTHGDTRALELNQRLSSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSSKEVKTA ------CCHHHHHHH	62.51	22814378
11	Ubiquitination	KEVKTALKSARDAIR HHHHHHHHHHHHHHH	39.34	24816145
65	Ubiquitination	QAQSAYKKAAELEPD HHHHHHHHHHHCCHH	39.90	29967540
86	Ubiquitination	GLANLYEKYNHINAK HHHHHHHHHCCCCCC	37.48	29967540
93	Ubiquitination	KYNHINAKDDLPGVY HHCCCCCCCCCCHHH	47.49	29967540
102	Ubiquitination	DLPGVYQKLLDLYES CCCHHHHHHHHHHHH	33.07	29967540
112	Ubiquitination	DLYESVDKQKWCDVC HHHHHCCHHHHHHHH	52.18	29967540
114	Ubiquitination	YESVDKQKWCDVCKK HHHCCHHHHHHHHHH	56.37	-
126	Phosphorylation	CKKLVDLYYQEKKHL HHHHHHHHHHHHHHH	9.91	-
214	Ubiquitination	HFIQSLSKFPHESAR HHHHHHHCCCCCHHH	69.11	32015554
270	Ubiquitination	RLVEMDSKSGPGLIG EEEECCCCCCCCCCC	55.99	32015554
271	Phosphorylation	LVEMDSKSGPGLIGL EEECCCCCCCCCCCC	54.92	21712546
281	Ubiquitination	GLIGLGIKALQDKKY CCCCCHHHHHCCCCH	41.04	32015554
300	Ubiquitination	RNLTEGLKESPVCTS HHHHHHHHHCCCCCC	67.98	32015554
323	Ubiquitination	QVKMHRPKEAVLSCS HHHCCCCHHHHHCHH	59.26	29967540
334	Ubiquitination	LSCSQALKIVDNLGA HCHHHHHHHHHHCCC	43.64	32015554
345	Phosphorylation	NLGASGNSLYQRNLC HCCCCCCCHHHCCCH	31.79	28857561
362	Ubiquitination	LKAEALIKLSDYDSS HHHHHHHHHCCCCCH	42.67	33845483
392	Ubiquitination	IPGLLVLKSLAYRNK CCHHHHHHHHHHCCC	35.62	21906983
396	Phosphorylation	LVLKSLAYRNKGSFD HHHHHHHHCCCCCHH	21.73	-
399	Ubiquitination	KSLAYRNKGSFDEAA HHHHHCCCCCHHHHH	47.11	29967540
401	Phosphorylation	LAYRNKGSFDEAAKI HHHCCCCCHHHHHHH	31.00	24719451
434	Ubiquitination	ALIHFTKKDYLQAEK HHHHHHHHHHHHHHH	48.85	29967540
441	Ubiquitination	KDYLQAEKCFQRALE HHHHHHHHHHHHHHH	43.28	33845483
458	Phosphorylation	TEVAEYHYQLGLTYW HHHHHHHHHHCCCEE	12.44	-
464	Phosphorylation	HYQLGLTYWFMGEET HHHHCCCEEECCCCC	11.16	-
484	Methylation	KALTHFLKAARLDTY HHHHHHHHHHHHHHH	38.77	115979439
484	Ubiquitination	KALTHFLKAARLDTY HHHHHHHHHHHHHHH	38.77	29967540
581	Phosphorylation	YLKAGQHSQAVADLQ HHHCCCHHHHHHHHH	16.37	28857561
596	Ubiquitination	AALRADPKDFNCWES HHHHCCCCCCCHHHH	75.42	29967540
619	Ubiquitination	GGYTTALKSFTKASE CCHHHHHHHHHCCHH	40.85	21906983
620	Phosphorylation	GYTTALKSFTKASEL CHHHHHHHHHCCHHC	38.71	24719451
623	Ubiquitination	TALKSFTKASELNPE HHHHHHHCCHHCCHH	48.15	22817900
634	Phosphorylation	LNPESIYSVFKVAAI CCHHHHHHHHHHHHH	21.29	-
637	Ubiquitination	ESIYSVFKVAAIQQI HHHHHHHHHHHHHHH	28.89	-
647	Ubiquitination	AIQQILGKYKEAVAQ HHHHHHHHHHHHHHH	50.10	29967540
648	Phosphorylation	IQQILGKYKEAVAQY HHHHHHHHHHHHHHH	16.56	-
665	Phosphorylation	IIKKKEDYVPALKGL HHHCCHHCHHHHCCH	14.93	22817900
681	Ubiquitination	ECHLMMAKAALVDYL HHHHHHHHHHHHHHH	19.12	32015554
691	Ubiquitination	LVDYLDGKAVDYIEK HHHHHCCCHHHHHHH	44.92	29967540
733	Phosphorylation	CLYAVAPSKVNVHVL CCHHHCCCCCEEEHH	39.23	25367160
755	Ubiquitination	EGKQVLKKNELLHLG CHHCHHCCCCHHHHC	52.04	29967540
774	Phosphorylation	GRALKLMSTSNTWCD HHHHHHHHCCCCCHH	38.84	24043423
775	Phosphorylation	RALKLMSTSNTWCDL HHHHHHHCCCCCHHH	16.42	24043423
776	Phosphorylation	ALKLMSTSNTWCDLG HHHHHHCCCCCHHHC	25.59	24043423
778	Phosphorylation	KLMSTSNTWCDLGIN HHHHCCCCCHHHCHH	27.51	24043423
786	Phosphorylation	WCDLGINYYRQAQHL CHHHCHHHHHHHHHH	9.71	24043423
787	Phosphorylation	CDLGINYYRQAQHLA HHHCHHHHHHHHHHH	7.55	24043423
796	Phosphorylation	QAQHLAETGSNMNDL HHHHHHHHCCCHHHH	40.06	30576142
798	Phosphorylation	QHLAETGSNMNDLKE HHHHHHCCCHHHHHH	40.08	30576142
815	Ubiquitination	EKSLHCLKKAVRLDS HHHHHHHHHHHCCCC	44.04	29967540
972	Phosphorylation	AQVILNKYVERIQNY HHHHHHHHHHHHHHH	13.38	22817900
979	Phosphorylation	YVERIQNYAPAFTML HHHHHHHHHHHHHHH	9.51	22817900
988	Phosphorylation	PAFTMLGYLNEHLQL HHHHHHHHHHHHHHH	11.46	22817900
997	Ubiquitination	NEHLQLKKEAANAYQ HHHHHHHHHHHHHHH	62.27	29967540
1038	Ubiquitination	CSTGEYDKAIQAFKS ECCCCHHHHHHHHHC	46.62	-
1068	Ubiquitination	LFMKGLYKESSKAYE HHHHHHHHHCHHHHH	57.04	29967540
1087	Ubiquitination	IVESEQDKAHILTAL HHHCHHHHHHHHHHH	41.37	29967540
1104	Phosphorylation	TEYKQGKTDVAKTLL HHHHCCCCHHHHHHH	42.40	-
1108	Ubiquitination	QGKTDVAKTLLFKCS CCCCHHHHHHHHHCC	39.28	29967540
1113	Ubiquitination	VAKTLLFKCSILKEP HHHHHHHHCCCCCCC	27.35	32015554
1115	Phosphorylation	KTLLFKCSILKEPTT HHHHHHCCCCCCCCH	31.39	24719451
1139	Phosphorylation	GLAMQDATLSKAALN HHHHCHHHCCHHHHH	39.59	26074081
1141	Phosphorylation	AMQDATLSKAALNEL HHCHHHCCHHHHHHH	18.85	26074081
1157	Phosphorylation	KHIKHKDSNYQRCLL HHHCCCCCCHHHHHH	42.09	26074081
1159	Phosphorylation	IKHKDSNYQRCLLTS HCCCCCCHHHHHHHH	10.98	26074081
1169	Phosphorylation	CLLTSAIYALQGRSV HHHHHHHHHHCCCCH	10.85	22817900
1180	Acetylation	GRSVAVQKQISKAVH CCCHHHHHHHHHHHH	42.89	27452117
1180	Ubiquitination	GRSVAVQKQISKAVH CCCHHHHHHHHHHHH	42.89	29967540
1197	Phosphorylation	PGDPALWSLLSRVVA CCCHHHHHHHHHHHH	21.93	24719451
1200	Phosphorylation	PALWSLLSRVVAQYA HHHHHHHHHHHHHHH	28.46	24719451
1230	Ubiquitination	ILDSNHGKKALLYTA HHCCCCCHHHHHHHH	27.59	29967540
1231	Ubiquitination	LDSNHGKKALLYTAV HCCCCCHHHHHHHHH	49.19	29967540
1235	Phosphorylation	HGKKALLYTAVNQLA CCHHHHHHHHHHHHH	8.10	21406692
1236	Phosphorylation	GKKALLYTAVNQLAM CHHHHHHHHHHHHHC	24.89	21406692
1245	Phosphorylation	VNQLAMGSSSAEDEK HHHHHCCCCCHHHHH	14.18	21406692
1246	Phosphorylation	NQLAMGSSSAEDEKN HHHHCCCCCHHHHHH	28.04	22210691
1247	Phosphorylation	QLAMGSSSAEDEKNT HHHCCCCCHHHHHHH	37.06	22210691
1254	Phosphorylation	SAEDEKNTALKTIQK CHHHHHHHHHHHHHH	44.42	21406692
1257	Ubiquitination	DEKNTALKTIQKAAL HHHHHHHHHHHHHHH	40.91	29967540
1300	Phosphorylation	QPKRIDLYLALLSAV CCHHHHHHHHHHHHH	6.03	25247763
1310	Phosphorylation	LLSAVSASIKDEKFF HHHHHHHHHCCHHHH	23.75	25247763
1328	Phosphorylation	NQSLEKWSLSQAVTG HHHHHHHCHHHHHHH	29.25	-
1330	Phosphorylation	SLEKWSLSQAVTGLI HHHHHCHHHHHHHHH	15.58	-
1334	Phosphorylation	WSLSQAVTGLIDTGR HCHHHHHHHHHHCCC	29.32	-
1339	Phosphorylation	AVTGLIDTGRISEAE HHHHHHHCCCCCHHH	22.74	-
1351	Acetylation	EAETLCTKNLKSNPD HHHHHHHHCCCCCCC	60.32	26051181
1351	Malonylation	EAETLCTKNLKSNPD HHHHHHHHCCCCCCC	60.32	32601280
1351	Ubiquitination	EAETLCTKNLKSNPD HHHHHHHHCCCCCCC	60.32	29967540
1354	Ubiquitination	TLCTKNLKSNPDQPA HHHHHCCCCCCCCHH	58.54	33845483
1372	Ubiquitination	LLRQVQCKPLLESQK HHHHCCCHHHHHCCC	22.93	29967540
1377	Phosphorylation	QCKPLLESQKPLPDA CCHHHHHCCCCCCHH	43.40	22210691
1379	Ubiquitination	KPLLESQKPLPDAVL HHHHHCCCCCCHHHH	58.77	29967540
1431	Phosphorylation	RKSLQLASQRGSWSG HHHHHHHHHCCCCCH	29.06	29449344
1435	Phosphorylation	QLASQRGSWSGKLSS HHHHHCCCCCHHHHH	21.91	29449344
1437	Phosphorylation	ASQRGSWSGKLSSLL HHHCCCCCHHHHHHH	27.96	29449344
1442	Phosphorylation	SWSGKLSSLLRLALL CCCHHHHHHHHHHHH	41.69	24719451
1471	Phosphorylation	PSLVQEATTEALKLC HHHHHHHHHHHHHHC	25.15	20068231
1472	Phosphorylation	SLVQEATTEALKLCF HHHHHHHHHHHHHCH	26.72	20068231
1516	Ubiquitination	VYQPGYPKSIASTAR HCCCCCCHHHHHHHH	46.11	22817900
1533	Acetylation	LLRHLYAKDDYELID HHHHHHCCCCHHHHH	37.26	26051181
1547	Ubiquitination	DVLVNNAKTHGDTRA HHHHHCCCCCCCHHH	43.08	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TTC37_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TTC37_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TTC37_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAF1_HUMAN	PAF1	physical	16024656
TLN1_HUMAN	TLN1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 222470: Trichohepatoenteric syndrome 1 (THES1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.